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Conserved domains on  [gi|525507368|ref|NP_001267484|]
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paired box protein Pax-5 isoform 10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 16-80 2.29e-37

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00351:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 125  Bit Score: 128.98  E-value: 2.29e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507368    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQP 80
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRP 65
Pax2_C super family cl13792
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 213-290 1.04e-19

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


The actual alignment was detected with superfamily member pfam12403:

Pssm-ID: 463563  Cd Length: 113  Bit Score: 82.52  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507368  213 ANLASP-TPADIGSSVPGPQSYPIVTG----------------------------------SEFSGSPYSHPQYSSYNDS 257
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGrdmasttlpgypphvpptgqgsyststlagmvpgSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507368  258 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 290
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
16-80 2.29e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 128.98  E-value: 2.29e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507368    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQP 80
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRP 65
PAX cd00131
Paired Box domain
 16-75 5.37e-35

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 122.91  E-value: 5.37e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507368  16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRT 75
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYET 60
PAX pfam00292
'Paired box' domain;
16-80 9.69e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 119.59  E-value: 9.69e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507368   16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQP 80
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRP 65
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 213-290 1.04e-19

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 82.52  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507368  213 ANLASP-TPADIGSSVPGPQSYPIVTG----------------------------------SEFSGSPYSHPQYSSYNDS 257
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGrdmasttlpgypphvpptgqgsyststlagmvpgSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507368  258 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 290
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
16-80 2.29e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 128.98  E-value: 2.29e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507368    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQP 80
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRP 65
PAX cd00131
Paired Box domain
 16-75 5.37e-35

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 122.91  E-value: 5.37e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507368  16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRT 75
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYET 60
PAX pfam00292
'Paired box' domain;
16-80 9.69e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 119.59  E-value: 9.69e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507368   16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQP 80
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRP 65
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 213-290 1.04e-19

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 82.52  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507368  213 ANLASP-TPADIGSSVPGPQSYPIVTG----------------------------------SEFSGSPYSHPQYSSYNDS 257
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGrdmasttlpgypphvpptgqgsyststlagmvpgSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507368  258 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 290
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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