NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|525507370|ref|NP_001267485|]
View 

paired box protein Pax-5 isoform 11 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 171-282 3.44e-48

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


:

Pssm-ID: 463563  Cd Length: 113  Bit Score: 156.09  E-value: 3.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507370  171 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 249
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507370  250 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 282
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-34 1.99e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member cd00131:

Pssm-ID: 481197  Cd Length: 128  Bit Score: 68.60  E-value: 1.99e-14
                         10        20        30
                 ....*....|....*....|....*....|....
gi 525507370   1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 34
Cdd:cd00131   94 MFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
 
Name Accession Description Interval E-value
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 171-282 3.44e-48

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 156.09  E-value: 3.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507370  171 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 249
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507370  250 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 282
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
PAX cd00131
Paired Box domain
 1-34 1.99e-14

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 68.60  E-value: 1.99e-14
                         10        20        30
                 ....*....|....*....|....*....|....
gi 525507370   1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 34
Cdd:cd00131   94 MFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX smart00351
Paired Box domain;
1-32 2.66e-14

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 68.12  E-value: 2.66e-14
                           10        20        30
                   ....*....|....*....|....*....|..
gi 525507370     1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 32
Cdd:smart00351  94 IFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
1-32 7.27e-13

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 64.12  E-value: 7.27e-13
                          10        20        30
                  ....*....|....*....|....*....|..
gi 525507370    1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 32
Cdd:pfam00292  94 IFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
 
Name Accession Description Interval E-value
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
 171-282 3.44e-48

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 156.09  E-value: 3.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507370  171 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 249
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507370  250 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 282
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
PAX cd00131
Paired Box domain
 1-34 1.99e-14

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 68.60  E-value: 1.99e-14
                         10        20        30
                 ....*....|....*....|....*....|....
gi 525507370   1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 34
Cdd:cd00131   94 MFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX smart00351
Paired Box domain;
1-32 2.66e-14

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 68.12  E-value: 2.66e-14
                           10        20        30
                   ....*....|....*....|....*....|..
gi 525507370     1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 32
Cdd:smart00351  94 IFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
1-32 7.27e-13

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 64.12  E-value: 7.27e-13
                          10        20        30
                  ....*....|....*....|....*....|..
gi 525507370    1 MFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 32
Cdd:pfam00292  94 IFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH