NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|547235630|ref|NP_001271281|]
View 

endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ephrin_rec_like super family cl06646
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 170-209 5.25e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


The actual alignment was detected with superfamily member pfam07699:

Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 5.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 547235630  170 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 209
Cdd:pfam07699   8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP super family cl31427
Giardia variant-specific surface protein;
173-312 9.14e-03

Giardia variant-specific surface protein;


The actual alignment was detected with superfamily member pfam03302:

Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 39.57  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235630  173 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 247
Cdd:pfam03302   1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547235630  248 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 312
Cdd:pfam03302  74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 170-209 5.25e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 5.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 547235630  170 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 209
Cdd:pfam07699   8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP pfam03302
Giardia variant-specific surface protein;
173-312 9.14e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 39.57  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235630  173 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 247
Cdd:pfam03302   1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547235630  248 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 312
Cdd:pfam03302  74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Name Accession Description Interval E-value
Ephrin_rec_like pfam07699
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ...
 170-209 5.25e-03

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.


Pssm-ID: 429604 [Multi-domain]  Cd Length: 48  Bit Score: 35.79  E-value: 5.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 547235630  170 TSECFPCKPGTYADKQGSSFCKLCPANSYSNK-GETSCHQC 209
Cdd:pfam07699   8 LEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSpGATSISDC 48
VSP pfam03302
Giardia variant-specific surface protein;
173-312 9.14e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 39.57  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235630  173 CFPCKPGT--YADKQ---GSSFCKLCPANSYSNKGETSCHQCDPDKYSEKgSSSCNvrPACTDKDYFYTHTACDANgetq 247
Cdd:pfam03302   1 CDECKPGYelSADKTkctSSAPCKTENCKACSNDKREVCEECNSNNYLTP-TSQCI--DDCAKIGNYYYTTNANNK---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547235630  248 lmykwakpKICSEDLEGAVKLPASgvKTHCPPCNPGFFKtNNSTCQPC--PYGSYSNG--SDCTRCPAG 312
Cdd:pfam03302  74 --------KICKECTVANCKTCED--QGQCQACNDGFYK-SGDACSPCheSCKTCSGGtaSDCTECLTG 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH