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Conserved domains on  [gi|557128979|ref|NP_001273390|]
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NEDD4-binding protein 2-like 1 isoform 4 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 12153064)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase; similar to NEDD4-binding protein 2-like 1/2 (N4BP2L1 and N4BP2L2), whose functions are not clear

Gene Ontology:  GO:0005524
PubMed:  15037234|18208389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-177 3.82e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 78.89  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979   44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNT 119
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128979  120 NLHAWEMKPYAVMALENNYE---VIFREPDTRWKFNVQELARRNIHG--VSREKIHRMKERLE 177
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPvriVVFEAPEEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-177 3.82e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 78.89  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979   44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNT 119
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128979  120 NLHAWEMKPYAVMALENNYE---VIFREPDTRWKFNVQELARRNIHG--VSREKIHRMKERLE 177
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPvriVVFEAPEEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
41-177 7.75e-18

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 75.64  E-value: 7.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIID 117
Cdd:COG4639    1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVD 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128979 118 NTNLHAWEMKPYAVMALENNYEVIFrepdtrWKFNV--QELARRNI---HGVSREKIHRMKERLE 177
Cdd:COG4639   73 ATNLQREARRRLLALARAYGALVVA------VVLDVplEVCLARNAardRQVPEEVIRRMLRRLR 131
pseT PHA02530
polynucleotide kinase; Provisional
 42-161 3.53e-09

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 54.64  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  42 KHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFF-----REDGAYEFNPDFLEEAHEWNQKRARKAMRNGISpIII 116
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLRQslfghGEWGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VII 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 557128979 117 DNTNLHAWEMKPYAVMALENNYEviFREPDtrwkFNV--QELARRNI 161
Cdd:PHA02530  81 SDTNLNPERRRKWKELAKELGAE--FEEKV----FDVpvEELVKRNR 121
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 8.39e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.16  E-value: 8.39e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 557128979  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024    4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-118 5.58e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.51  E-value: 5.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979    41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKRARKAM----RNGIS 112
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALalarKLKPD 80


                   ....*.
gi 557128979   113 PIIIDN 118
Cdd:smart00382  81 VLILDE 86
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-177 3.82e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 78.89  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979   44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNT 119
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128979  120 NLHAWEMKPYAVMALENNYE---VIFREPDTRWKFNVQELARRNIHG--VSREKIHRMKERLE 177
Cdd:pfam13671  79 NLRRDERARLLALAREYGVPvriVVFEAPEEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
41-177 7.75e-18

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 75.64  E-value: 7.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIID 117
Cdd:COG4639    1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVD 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128979 118 NTNLHAWEMKPYAVMALENNYEVIFrepdtrWKFNV--QELARRNI---HGVSREKIHRMKERLE 177
Cdd:COG4639   73 ATNLQREARRRLLALARAYGALVVA------VVLDVplEVCLARNAardRQVPEEVIRRMLRRLR 131
pseT PHA02530
polynucleotide kinase; Provisional
 42-161 3.53e-09

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 54.64  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  42 KHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFF-----REDGAYEFNPDFLEEAHEWNQKRARKAMRNGISpIII 116
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLRQslfghGEWGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VII 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 557128979 117 DNTNLHAWEMKPYAVMALENNYEviFREPDtrwkFNV--QELARRNI 161
Cdd:PHA02530  81 SDTNLNPERRRKWKELAKELGAE--FEEKV----FDVpvEELVKRNR 121
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-177 1.36e-08

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 51.45  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  44 LYLLRGLPGSGKTTLARQLQHDFPrALIFSTDDF---FFRED-GAYEFNPDFLEEAHEWNQKRARKAMRNGISpIIIDNT 119
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLG-AVRLRSDVVrkrLFGAGlAPLERSPEATARTYARLLALARELLAAGRS-VILDAT 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128979 120 NLHAWEMKPYAVMALENNYEVIFRE----PDTRWKFNVQELARRNIHGVSREKIHRMKERLE 177
Cdd:COG0645   79 FLRRAQREAFRALAEEAGAPFVLIWldapEEVLRERLEARNAEGGDSDATWEVLERQLAFEE 140
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 44-178 1.42e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 48.95  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  44 LYLLRGLPGSGKTTLARQLQHDFPR----ALIFSTDDffFREDGAYEFNPD-----FLEEAHEwnqKRARKAMRNGISpI 114
Cdd:COG4088    6 LLILTGPPGSGKTTFAKALAQRLYAegiaVALLHSDD--FRRFLVNESFPKetyeeVVEDVRT---TTADNALDNGYS-V 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128979 115 IIDNTNLHAWEMKPYAVMALEN-NYEVIF-REPDtrwkfnvQELARRNIH---GVSREKIHRMKERLES 178
Cdd:COG4088   80 IVDGTFYYRSWQRDFRNLAKHKaPIHIIYlKAPL-------ETALRRNRErgePIPERVIARMYRKFDK 141
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 41-119 3.59e-05

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 42.35  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979   41 RKHLYLLRGLPGSGKTTLARQLQHDFPR---ALIFSTDDF--FFRE-DGAYEFNPD-----FLEEAHEWNQKRARKAMRN 109
Cdd:pfam06414  10 RPKAILLGGQPGAGKTELARALLDELGRqgnVVRIDPDDFreLHPHyRELQAADPKtaseyTQPDASRWVEKLLQHAIEN 89

                          90
                  ....*....|
gi 557128979  110 GISpIIIDNT 119
Cdd:pfam06414  90 GYN-IILEGT 98
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 8.39e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.16  E-value: 8.39e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 557128979  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024    4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-61 2.94e-04

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 40.02  E-value: 2.94e-04
                         10        20
                 ....*....|....*....|.
gi 557128979  41 RKHLYLLRGLPGSGKTTLARQ 61
Cdd:cd19488   18 PRRLYLVEGAPGTGKTTLALQ 38
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 49-98 3.56e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.44  E-value: 3.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 557128979  49 GLPGSGKTTLARQLQHDFP--RALIFSTDDFFF-REDGAYE--FNPDFLE-EAHEW 98
Cdd:COG0572   14 GPSGSGKTTFARRLAEQLGadKVVVISLDDYYKdREHLPLDerGKPNFDHpEAFDL 69
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-118 5.58e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.51  E-value: 5.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979    41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKRARKAM----RNGIS 112
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALalarKLKPD 80


                   ....*.
gi 557128979   113 PIIIDN 118
Cdd:smart00382  81 VLILDE 86
COG4185 COG4185
Predicted ABC-type ATPase or kinase [General function prediction only];
41-171 8.44e-04

Predicted ABC-type ATPase or kinase [General function prediction only];


Pssm-ID: 443339  Cd Length: 197  Bit Score: 38.33  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979  41 RKHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDgaYEFNPDF-LEEAHEWNQKRARKAMRNGISpIIIDnT 119
Cdd:COG4185    3 MPRLYIIAGPNGAGKSTFARTILPEELGGLEFVNADLIARGL--SPFNPETaAYEAGRLALERREELLAAGRS-FAFE-T 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979 120 NLHAWEMKPYAVMALENNYEV--IF---REPDTrwkfNVQELARRNIHG---VSREKIHR 171
Cdd:COG4185   79 TLSGPSKLDLIREAKAAGYRVrlIFvglDSPEL----AIARVAQRVAEGghdVPEDKIRR 134
AAA_18 pfam13238
AAA domain;
46-174 1.57e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.02  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128979   46 LLRGLPGSGKTTLARQLQhdfpRALIFSTD--DFFFREDGAYEFNPDFLE--EAHEWNQKRARKAMRNGIS-----PIII 116
Cdd:pfam13238   2 LITGTPGVGKTTLAKELS----KRLGFGDNvrDLALENGLVLGDDPETREskRLDEDKLDRLLDLLEENAAleeggNLII 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128979  117 DNTNLHawemkPYAVMALENNYEVIFREPDTRWkfnvQELARRnihGVSREKIHRMKE 174
Cdd:pfam13238  78 DGHLAE-----LEPERAKDLVGIVLRASPEELL----ERLEKR---GYEEAKIKENEE 123
PRK06762 PRK06762
hypothetical protein; Provisional
 44-71 1.61e-03

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 37.26  E-value: 1.61e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 557128979  44 LYLLRGLPGSGKTTLARQLQHDFPR--ALI 71
Cdd:PRK06762   4 LIIIRGNSGSGKTTIAKQLQERLGRgtLLV 33
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 41-62 5.75e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 36.30  E-value: 5.75e-03
                         10        20
                 ....*....|....*....|..
gi 557128979  41 RKHLyLLRGLPGSGKTTLARQL 62
Cdd:COG0714   31 GGHL-LLEGVPGVGKTTLAKAL 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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