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Conserved domains on  [gi|557357729|ref|NP_001273444|]
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activating transcription factor 7-interacting protein 1 isoform 4 [Homo sapiens]

Protein Classification

ATF7IP_BD domain-containing protein( domain architecture ID 11245572)

ATF7IP_BD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATF7IP_BD pfam16788
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
 563-774 5.01e-76

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


:

Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 249.59  E-value: 5.01e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   563 NVQSKRRRYMEEeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQ 642
Cdd:pfam16788    1 KENVKRMKTSEQ-----INENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIATELQ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   643 AKIARLTKRFEAAKEDLKKrhehpPNPPVSPGKTVND--VNSNNNMSYRNAGTVRQMLESKRNVSESAPpsFQTPVNTVS 720
Cdd:pfam16788   76 AKIARLTKRFKAALEDLKK-----CLPPNSPSSNAASkvANSNTINLYRNAGSVRSMLESKRSVGESSP--FQPPEKASK 148

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557357729   721 STNLVTPPAVVSSQPKLQTPVTSGSLT----ATSVLPAPNTATVV---ATTQVPSGNPQPT 774
Cdd:pfam16788  149 KINLTSPQNEVVSESNNQDDVMLISVEspnlTTPVTSNPTDTRKVtsgNSSNSPSAETEVM 209
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
 319-549 1.69e-08

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 59.03  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  319 KNGADEKLEQIQSKDSLDEKNKADNNIDAN-EETLEtddtticsdrppEN-EKKVEEDIitelalgEDAISSSMEIDQGE 396
Cdd:PTZ00341  929 KNQNENVPEHLKEHAEANIEEDAEENVEEDaEENVE------------ENvEENVEENV-------EENVEENVEENVEE 989

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  397 KNEDETSADLVETINENViEDNKSENILENTDSMETDEIIPILEKLAPSEDEltcfsktsllPIDETNPDLEEKMESSFG 476
Cdd:PTZ00341  990 NVEENVEENVEENIEENV-EENVEENIEENVEEYDEENVEEVEENVEEYDEE----------NVEEIEENAEENVEENIE 1058

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557357729  477 SPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEE-EEQVIHEDDERPSEKNE 549
Cdd:PTZ00341 1059 ENIEEYDEENVEEIEENIEENIEENVEENVEENVEEIEENVEENVEENAEENAEENaEENAEEYDDENPEEHNE 1132
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 665-1093 5.30e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  665 HPPNPPVSPGKTvndvnsnnNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSG 744
Cdd:PHA03247 2622 HAPDPPPPSPSP--------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  745 SLTATSVLPAPNtatvvattQVPSGNPQPTISLQPLPvilhvPVAVSSQpqllQSHPGTLVTNQPsgnvefisvqsPPTV 824
Cdd:PHA03247 2694 SLTSLADPPPPP--------PTPEPAPHALVSATPLP-----PGPAAAR----QASPALPAAPAP-----------PAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  825 SGltknPVSlpslpnPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRG 904
Cdd:PHA03247 2746 AG----PAT------PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  905 PI--QMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVskkaadstsqcgkATGSdssgviDLTMDDEESGASQDPK 982
Cdd:PHA03247 2816 AAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV-------------APGG------DVRRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  983 KLNHTPVSTMSSSqPVSRPLQPiQPAPPLQPSGVPTSGPSQTtihllPTAPTTVNVTHRPVTQVTTR-LPVPRAPANHQV 1061
Cdd:PHA03247 2877 APARPPVRRLARP-AVSRSTES-FALPPDQPERPPQPQAPPP-----PQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDP 2949

                         410       420       430
                  ....*....|....*....|....*....|....
gi 557357729 1062 VYTTLPAPPAQAPLRGTVM--QAPAVRQVNPQNS 1093
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVpgRVAVPRFRVPQPA 2983
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 110-287 2.39e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  110 EPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGD------PASGVLASGDSTSGdPTSSEPSSSDAASGDATSGDAPSGD 183
Cdd:PHA03307   78 EAPANESRSTPTWSLSTLAPASPAREGSPTPPGPsspdppPPTPPPASPPPSPA-PDLSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  184 VSPGDATSGDAT---ADDLSSGDPTSSDPI--PGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGD 258
Cdd:PHA03307  157 ASPAAVASDAASsrqAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236

                         170       180
                  ....*....|....*....|....*....
gi 557357729  259 LSSSELASDDLATGELASDELTSESTFDR 287
Cdd:PHA03307  237 SDSSSSESSGCGWGPENECPLPRPAPITL 265
 
Name Accession Description Interval E-value
ATF7IP_BD pfam16788
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
 563-774 5.01e-76

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 249.59  E-value: 5.01e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   563 NVQSKRRRYMEEeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQ 642
Cdd:pfam16788    1 KENVKRMKTSEQ-----INENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIATELQ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   643 AKIARLTKRFEAAKEDLKKrhehpPNPPVSPGKTVND--VNSNNNMSYRNAGTVRQMLESKRNVSESAPpsFQTPVNTVS 720
Cdd:pfam16788   76 AKIARLTKRFKAALEDLKK-----CLPPNSPSSNAASkvANSNTINLYRNAGSVRSMLESKRSVGESSP--FQPPEKASK 148

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557357729   721 STNLVTPPAVVSSQPKLQTPVTSGSLT----ATSVLPAPNTATVV---ATTQVPSGNPQPT 774
Cdd:pfam16788  149 KINLTSPQNEVVSESNNQDDVMLISVEspnlTTPVTSNPTDTRKVtsgNSSNSPSAETEVM 209
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 319-549 1.69e-08

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 59.03  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  319 KNGADEKLEQIQSKDSLDEKNKADNNIDAN-EETLEtddtticsdrppEN-EKKVEEDIitelalgEDAISSSMEIDQGE 396
Cdd:PTZ00341  929 KNQNENVPEHLKEHAEANIEEDAEENVEEDaEENVE------------ENvEENVEENV-------EENVEENVEENVEE 989

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  397 KNEDETSADLVETINENViEDNKSENILENTDSMETDEIIPILEKLAPSEDEltcfsktsllPIDETNPDLEEKMESSFG 476
Cdd:PTZ00341  990 NVEENVEENVEENIEENV-EENVEENIEENVEEYDEENVEEVEENVEEYDEE----------NVEEIEENAEENVEENIE 1058

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557357729  477 SPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEE-EEQVIHEDDERPSEKNE 549
Cdd:PTZ00341 1059 ENIEEYDEENVEEIEENIEENIEENVEENVEENVEEIEENVEENVEENAEENAEENaEENAEEYDDENPEEHNE 1132
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-1093 5.30e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  665 HPPNPPVSPGKTvndvnsnnNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSG 744
Cdd:PHA03247 2622 HAPDPPPPSPSP--------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  745 SLTATSVLPAPNtatvvattQVPSGNPQPTISLQPLPvilhvPVAVSSQpqllQSHPGTLVTNQPsgnvefisvqsPPTV 824
Cdd:PHA03247 2694 SLTSLADPPPPP--------PTPEPAPHALVSATPLP-----PGPAAAR----QASPALPAAPAP-----------PAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  825 SGltknPVSlpslpnPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRG 904
Cdd:PHA03247 2746 AG----PAT------PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  905 PI--QMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVskkaadstsqcgkATGSdssgviDLTMDDEESGASQDPK 982
Cdd:PHA03247 2816 AAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV-------------APGG------DVRRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  983 KLNHTPVSTMSSSqPVSRPLQPiQPAPPLQPSGVPTSGPSQTtihllPTAPTTVNVTHRPVTQVTTR-LPVPRAPANHQV 1061
Cdd:PHA03247 2877 APARPPVRRLARP-AVSRSTES-FALPPDQPERPPQPQAPPP-----PQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDP 2949

                         410       420       430
                  ....*....|....*....|....*....|....
gi 557357729 1062 VYTTLPAPPAQAPLRGTVM--QAPAVRQVNPQNS 1093
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVpgRVAVPRFRVPQPA 2983
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 110-287 2.39e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  110 EPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGD------PASGVLASGDSTSGdPTSSEPSSSDAASGDATSGDAPSGD 183
Cdd:PHA03307   78 EAPANESRSTPTWSLSTLAPASPAREGSPTPPGPsspdppPPTPPPASPPPSPA-PDLSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  184 VSPGDATSGDAT---ADDLSSGDPTSSDPI--PGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGD 258
Cdd:PHA03307  157 ASPAAVASDAASsrqAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236

                         170       180
                  ....*....|....*....|....*....
gi 557357729  259 LSSSELASDDLATGELASDELTSESTFDR 287
Cdd:PHA03307  237 SDSSSSESSGCGWGPENECPLPRPAPITL 265
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 707-1025 5.80e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 5.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   707 SAPPSFQTPVNTVSSTNLVTP------PAVVSSQPKLQTPVTSGSLTATSVL--PAPNTATVVATTQVPSGNPQ------ 772
Cdd:pfam05109  422 SKAPESTTTSPTLNTTGFAAPntttglPSSTHVPTNLTAPASTGPTVSTADVtsPTPAGTTSGASPVTPSPSPRdngtes 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   773 --PTISLQPLPVILHVPVAVSSQPQLLQSHPGTlvTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVP 850
Cdd:pfam05109  502 kaPDMTSPTSAVTTPTPNATSPTPAVTTPTPNA--TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSP 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   851 SPSIQR-NPTASAAPLGTTlAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRgpiQMKIPISAFSTSSAAEQNSNTTP 929
Cdd:pfam05109  580 TSAVTTpTPNATSPTVGET-SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG---QHNITSSSTSSMSLRPSSISETL 655

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   930 RIENQTNKT----IDASVSKKAADSTSQCGKAtgSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPI 1005
Cdd:pfam05109  656 SPSTSDNSTshmpLLTSAHPTGGENITQVTPA--STSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPK 733

                          330       340
                   ....*....|....*....|
gi 557357729  1006 QPAPPLQPSGVPTSGPSQTT 1025
Cdd:pfam05109  734 NATSPQAPSGQKTAVPTVTS 753
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 122-433 8.44e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.83  E-value: 8.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  122 VSKLPAEPVSGDPAPGDLDA------GDPASGVLASGDSTSGDPTSSEP-SSSDAASGDATSGDAPSGDVSPGDATSGDA 194
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSdpgsdsGSDSSNSDSGSDSGSDSTSDSGSdSASDSDSASDSDSASDSDSASDSDSASDSD 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  195 TADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGEL 274
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  275 ASDELTSESTFDRTFEPKSVPVCEPVPEIDNiEPSSNKDDDFLEKNGADEKLEQIQSKDSlDEKNKADNNIDANEETLET 354
Cdd:NF033609  704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 781

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557357729  355 DDTTICSDRPPENEKKVEEDIITELALGEDAISSSmEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETD 433
Cdd:NF033609  782 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESD 859
BMS1 COG5192
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ...
 347-605 8.01e-03

GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227519 [Multi-domain]  Cd Length: 1077  Bit Score: 40.49  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  347 ANEETLETDDTTICSDRPPENEKKVEEDI-ITELALGEDAISSSMEIDQGE--------KNEDETSADLVETINENVIED 417
Cdd:COG5192   395 VDRESSEIDNVGRKTRRQPTGKAIAEETSrEDELSFDDSDVSTSDENEDVDftgkkgaiNNEDESDNEEVAFDSDSQFDE 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  418 NKSE--------NILENTDSMETDEIIPIL---EKLAPSE--------------------DELTCFSKTSLLPIDETNPD 466
Cdd:COG5192   475 SEGNlrwkeglaSKLAYSQSGKRGRNIQKIfydESLSPEEcieeykgesakssesdlvvqDEPEDFFDVSKVANESISSN 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  467 LEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKdesEVISQNEtcspevESNEKDNKPEEEEQvihEDDERPSE 546
Cdd:COG5192   555 HEKLMESEFEELKKKWSSLAQLKSRFQKDATLDSIEGEE---ELIQDDE------KGNFEDLEDEENSS---DNEMEESR 622

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557357729  547 KNEFSRRKRSKSEDMDNVQSKRRRYMEEEyEAEFQVKITAKGDINqklQKVIQWLLEEK 605
Cdd:COG5192   623 GSSVTAENEESADEVDYETEREENARKKE-ELRGNFELEERGDPE---KKDVDWYTEEK 677
 
Name Accession Description Interval E-value
ATF7IP_BD pfam16788
ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating ...
 563-774 5.01e-76

ATF-interacting protein binding domain; ATF7IP-BD is a short conserved region of activating transcription factor 7-interacting protein 1 found in higher eukaryotes. This domain appears to bind several key proteins such as TFIIE-alpha and TFIIE-beta as well the transcriptional regulator Sp1 which are part of the transcriptional machinery.


Pssm-ID: 465271 [Multi-domain]  Cd Length: 214  Bit Score: 249.59  E-value: 5.01e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   563 NVQSKRRRYMEEeyeaeFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQ 642
Cdd:pfam16788    1 KENVKRMKTSEQ-----INENICVALEKQTALLEQVKHLIEQEICSINYKLFDKKLKELNERVEKTECRKKHEAIATELQ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   643 AKIARLTKRFEAAKEDLKKrhehpPNPPVSPGKTVND--VNSNNNMSYRNAGTVRQMLESKRNVSESAPpsFQTPVNTVS 720
Cdd:pfam16788   76 AKIARLTKRFKAALEDLKK-----CLPPNSPSSNAASkvANSNTINLYRNAGSVRSMLESKRSVGESSP--FQPPEKASK 148

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557357729   721 STNLVTPPAVVSSQPKLQTPVTSGSLT----ATSVLPAPNTATVV---ATTQVPSGNPQPT 774
Cdd:pfam16788  149 KINLTSPQNEVVSESNNQDDVMLISVEspnlTTPVTSNPTDTRKVtsgNSSNSPSAETEVM 209
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 319-549 1.69e-08

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 59.03  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  319 KNGADEKLEQIQSKDSLDEKNKADNNIDAN-EETLEtddtticsdrppEN-EKKVEEDIitelalgEDAISSSMEIDQGE 396
Cdd:PTZ00341  929 KNQNENVPEHLKEHAEANIEEDAEENVEEDaEENVE------------ENvEENVEENV-------EENVEENVEENVEE 989

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  397 KNEDETSADLVETINENViEDNKSENILENTDSMETDEIIPILEKLAPSEDEltcfsktsllPIDETNPDLEEKMESSFG 476
Cdd:PTZ00341  990 NVEENVEENVEENIEENV-EENVEENIEENVEEYDEENVEEVEENVEEYDEE----------NVEEIEENAEENVEENIE 1058

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557357729  477 SPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEE-EEQVIHEDDERPSEKNE 549
Cdd:PTZ00341 1059 ENIEEYDEENVEEIEENIEENIEENVEENVEENVEEIEENVEENVEENAEENAEENaEENAEEYDDENPEEHNE 1132
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-1093 5.30e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  665 HPPNPPVSPGKTvndvnsnnNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSG 744
Cdd:PHA03247 2622 HAPDPPPPSPSP--------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  745 SLTATSVLPAPNtatvvattQVPSGNPQPTISLQPLPvilhvPVAVSSQpqllQSHPGTLVTNQPsgnvefisvqsPPTV 824
Cdd:PHA03247 2694 SLTSLADPPPPP--------PTPEPAPHALVSATPLP-----PGPAAAR----QASPALPAAPAP-----------PAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  825 SGltknPVSlpslpnPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRG 904
Cdd:PHA03247 2746 AG----PAT------PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  905 PI--QMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVskkaadstsqcgkATGSdssgviDLTMDDEESGASQDPK 982
Cdd:PHA03247 2816 AAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV-------------APGG------DVRRRPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  983 KLNHTPVSTMSSSqPVSRPLQPiQPAPPLQPSGVPTSGPSQTtihllPTAPTTVNVTHRPVTQVTTR-LPVPRAPANHQV 1061
Cdd:PHA03247 2877 APARPPVRRLARP-AVSRSTES-FALPPDQPERPPQPQAPPP-----PQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDP 2949

                         410       420       430
                  ....*....|....*....|....*....|....
gi 557357729 1062 VYTTLPAPPAQAPLRGTVM--QAPAVRQVNPQNS 1093
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVpgRVAVPRFRVPQPA 2983
PTZ00121 PTZ00121
MAEBL; Provisional
 319-683 1.44e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  319 KNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSD--RPPENEKKVEEDIITELALGEDAISSSMEIDQGE 396
Cdd:PTZ00121 1437 KKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEeaKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  397 KNEDETSADLVETINE--------NVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDEtNPDLE 468
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEakkadeakKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIE 1595

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  469 EKMEssFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPEVESNEKDNKPEEEEQVIHEDDERPSEKN 548
Cdd:PTZ00121 1596 EVMK--LYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEED 1673

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  549 EFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDInQKLQKVIQWLLEEKLCALQC---AVFDKTLAElKTRV 625
Cdd:PTZ00121 1674 KKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK-KKAEELKKAEEENKIKAEEAkkeAEEDKKKAE-EAKK 1751

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557357729  626 EKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEhppNPPVSPGKTVNDVNSN 683
Cdd:PTZ00121 1752 DEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDE---KRRMEVDKKIKDIFDN 1806
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 110-287 2.39e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  110 EPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGD------PASGVLASGDSTSGdPTSSEPSSSDAASGDATSGDAPSGD 183
Cdd:PHA03307   78 EAPANESRSTPTWSLSTLAPASPAREGSPTPPGPsspdppPPTPPPASPPPSPA-PDLSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  184 VSPGDATSGDAT---ADDLSSGDPTSSDPI--PGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGD 258
Cdd:PHA03307  157 ASPAAVASDAASsrqAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236

                         170       180
                  ....*....|....*....|....*....
gi 557357729  259 LSSSELASDDLATGELASDELTSESTFDR 287
Cdd:PHA03307  237 SDSSSSESSGCGWGPENECPLPRPAPITL 265
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 142-291 5.12e-05

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 47.28  E-value: 5.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  142 GDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDvsPGDATSGDATADDLSS-------------------- 201
Cdd:PRK13108  278 GREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVG--PGEPNQPDDVAEAVKAevaevtdevaaesvvqvadr 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  202 -GDPTSSDPIPGEPVPVEPISGDCAADDIASSEitsVDLASGAPASTDPAsdDLASGDLSSSELASDDLATGELAS---D 277
Cdd:PRK13108  356 dGESTPAVEETSEADIEREQPGDLAGQAPAAHQ---VDAEAASAAPEEPA--ALASEAHDETEPEVPEKAAPIPDPakpD 430

                         170
                  ....*....|....
gi 557357729  278 ELTSESTFDRTFEP 291
Cdd:PRK13108  431 ELAVAGPGDDPAEP 444
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 707-1025 5.80e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 5.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   707 SAPPSFQTPVNTVSSTNLVTP------PAVVSSQPKLQTPVTSGSLTATSVL--PAPNTATVVATTQVPSGNPQ------ 772
Cdd:pfam05109  422 SKAPESTTTSPTLNTTGFAAPntttglPSSTHVPTNLTAPASTGPTVSTADVtsPTPAGTTSGASPVTPSPSPRdngtes 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   773 --PTISLQPLPVILHVPVAVSSQPQLLQSHPGTlvTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVP 850
Cdd:pfam05109  502 kaPDMTSPTSAVTTPTPNATSPTPAVTTPTPNA--TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSP 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   851 SPSIQR-NPTASAAPLGTTlAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRgpiQMKIPISAFSTSSAAEQNSNTTP 929
Cdd:pfam05109  580 TSAVTTpTPNATSPTVGET-SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG---QHNITSSSTSSMSLRPSSISETL 655

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   930 RIENQTNKT----IDASVSKKAADSTSQCGKAtgSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPI 1005
Cdd:pfam05109  656 SPSTSDNSTshmpLLTSAHPTGGENITQVTPA--STSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPK 733

                          330       340
                   ....*....|....*....|
gi 557357729  1006 QPAPPLQPSGVPTSGPSQTT 1025
Cdd:pfam05109  734 NATSPQAPSGQKTAVPTVTS 753
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 122-433 8.44e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.83  E-value: 8.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  122 VSKLPAEPVSGDPAPGDLDA------GDPASGVLASGDSTSGDPTSSEP-SSSDAASGDATSGDAPSGDVSPGDATSGDA 194
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSdpgsdsGSDSSNSDSGSDSGSDSTSDSGSdSASDSDSASDSDSASDSDSASDSDSASDSD 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  195 TADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGEL 274
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  275 ASDELTSESTFDRTFEPKSVPVCEPVPEIDNiEPSSNKDDDFLEKNGADEKLEQIQSKDSlDEKNKADNNIDANEETLET 354
Cdd:NF033609  704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD 781

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557357729  355 DDTTICSDRPPENEKKVEEDIITELALGEDAISSSmEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETD 433
Cdd:NF033609  782 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESD 859
PTZ00121 PTZ00121
MAEBL; Provisional
 317-599 8.74e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  317 LEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTicsdRPPENEKKVEEDIITELALGEDAISSSMEIDQGE 396
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEEL----KKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE 1755

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  397 KN-------EDETSADLVETINENVIEDNKSENilENTDSMETDEIIPilEKLAPSEDELTCFSKTSLLPIDETNPDLEE 469
Cdd:PTZ00121 1756 KKkiahlkkEEEKKAEEIRKEKEAVIEEELDEE--DEKRRMEVDKKIK--DIFDNFANIIEGGKEGNLVINDSKEMEDSA 1831

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  470 KMESSFGSPSKQESSESLPKEAFlvlsDEEDISGEKDESEVISqnetcspeveSNEKDNKPEEEEQVIHEDDERPSEKNE 549
Cdd:PTZ00121 1832 IKEVADSKNMQLEEADAFEKHKF----NKNNENGEDGNKEADF----------NKEKDLKEDDEEEIEEADEIEKIDKDD 1897

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 557357729  550 FSRRKRSKSEDMDNVQSKRRRYMEEEYEaefqvkitaKGDINQKLQKVIQ 599
Cdd:PTZ00121 1898 IEREIPNNNMAGKNNDIIDDKLDKDEYI---------KRDAEETREEIIK 1938
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 684-1074 9.47e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 9.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   684 NNMSYRNAGTVRQMLESKRNVSES---APPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATV 760
Cdd:pfam03154  153 DNESDSDSSAQQQILQTQPPVLQAqsgAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   761 VATTQVPSGNPQPTISLQPLPV---------------ILHVPvaVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVS 825
Cdd:pfam03154  233 QTPTLHPQRLPSPHPPLQPMTQppppsqvspqplpqpSLHGQ--MPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVP 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   826 GLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGT-------TLAVQAVPTAHSIVQATRTSlptvGPSGLYS 898
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMphikpppTTPIPQLPNPQSHKHPPHLS----GPSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   899 PSTNRGPIQMKiPISAFSTSSAAeqNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSgvidlTMDDEESGAS 978
Cdd:pfam03154  387 NSNLPPPPALK-PLSSLSTHHPP--SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHP-----PTSGLHQVPS 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   979 QDPkklnHTPVSTMSSSQPVSRPlqPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPAN 1058
Cdd:pfam03154  459 QSP----FPQHPFVPGGPPPITP--PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPES 532

                          410
                   ....*....|....*.
gi 557357729  1059 hqvvyttlPAPPAQAP 1074
Cdd:pfam03154  533 --------PPPPPRSP 540
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
366-662 1.01e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  366 ENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDS--METDEIIPILEKLA 443
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKevKELEELKEEIEELE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  444 PSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEA--------FLVLSDEEDISGEKDESEVISQNE 515
Cdd:PRK03918  245 KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAeeyiklseFYEEYLDELREIEKRLSRLEEEIN 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  516 TCSPEVESNEKD----NKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDIN 591
Cdd:PRK03918  325 GIEERIKELEEKeerlEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIE 404

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557357729  592 QKLQKVIQWL--LEEKLCALQCAVFDKTLAELKTRVEKIECNKRH-KTVLTELQAKIARLTKR---FEAAKEDLKKR 662
Cdd:PRK03918  405 EEISKITARIgeLKKEIKELKKAIEELKKAKGKCPVCGRELTEEHrKELLEEYTAELKRIEKElkeIEEKERKLRKE 481
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 126-252 1.19e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  126 PAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLS---SG 202
Cdd:PRK07764  649 APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQaaqGA 728

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 557357729  203 DPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASD 252
Cdd:PRK07764  729 SAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
PHA03247 PHA03247
large tegument protein UL36; Provisional
 707-1016 1.87e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  707 SAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHV 786
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  787 PVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSP--PTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASA-- 862
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAParPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPqp 2923

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  863 -----------------APLGTTLAVQAVPTAHSI-------------VQATRTSLPTVGPSGLYSPSTNRGPIQMKIP- 911
Cdd:PHA03247 2924 ppppqpqppppppprpqPPLAPTTDPAGAGEPSGAvpqpwlgalvpgrVAVPRFRVPQPAPSREAPASSTPPLTGHSLSr 3003

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  912 ISAFSTSSAAEQNSNTTPRIENQtnkTIDASVSKKAADSTSqcgkATGSDsSGVIDLTMDDEESGASQDPkkLNHTPVST 991
Cdd:PHA03247 3004 VSSWASSLALHEETDPPPVSLKQ---TLWPPDDTEDSDADS----LFDSD-SERSDLEALDPLPPEPHDP--FAHEPDPA 3073

                         330       340
                  ....*....|....*....|....*
gi 557357729  992 MSSSQPVSRPLQPIQPaPPLQPSGV 1016
Cdd:PHA03247 3074 TPEAGARESPSSQFGP-PPLSANAA 3097
PHA02664 PHA02664
hypothetical protein; Provisional
 126-282 2.85e-03

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 41.52  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  126 PAEP----VSGDPApgdLDAGDPASGVLASGDSTSGdptssePSSSDAASGDATSgdapsgdvSPGDATSGDATADDLSS 201
Cdd:PHA02664  368 PAEPaalfVDGNEV---IAAGAAAAMIAAAERAANG------ARGSPMAAPEEGR--------AAAAAAAANAPADQDVE 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  202 GDPtSSDPIPGEPVPVEPISGDCAADDIASSEIT-----------SVDLASGAPASTDPASDDLASGDLSSSELASDDLA 270
Cdd:PHA02664  431 AEA-HDEFDQDPGAPAHADRADSDEDDMDEQESGderadgeddsdSSYSYSTTSSEDESDSADDSWGDESDSGIEHDDGG 509

                         170
                  ....*....|..
gi 557357729  271 TGELASDELTSE 282
Cdd:PHA02664  510 VGQAIEEEEEEE 521
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
121-313 3.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  121 PVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPtSSEPSSSDAASGDATSGDAPSGDVSPgdATSGDATADDLS 200
Cdd:PRK07003  368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAA-GAALAPKAAAAAAATRAEAPPAAPAP--PATADRGDDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  201 SGDPTSSDpipgEPVPVEPisgDCAADDIASSEITSVDLASGAPASTDPASddlASGDLSSSELASDDLATGELASDELT 280
Cdd:PRK07003  445 GDAPVPAK----ANARASA---DSRCDERDAQPPADSGSASAPASDAPPDA---AFEPAPRAAAPSAATPAAVPDARAPA 514

                         170       180       190
                  ....*....|....*....|....*....|...
gi 557357729  281 SESTFDRtfepkSVPVCEPVPEIDNIEPSSNKD 313
Cdd:PRK07003  515 AASREDA-----PAAAAPPAPEARPPTPAAAAP 542
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 654-1075 3.54e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  654 AAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTvSSTNLVTPPAVVSS 733
Cdd:PHA03307   56 VAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPT-PPPASPPPSPAPDL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  734 QPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVilHVPVAVSSQPQLLQSHPGTLVTNQPSGNV 813
Cdd:PHA03307  135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETA--RAPSSPPAEPPPSTPPAAASPRPPRRSSP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  814 EFISVQSPPtvsgltknpvslPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTlavqAVPTAHSIVQATR--TSLPTV 891
Cdd:PHA03307  213 ISASASSPA------------PAPGRSAADDAGASSSDSSSSESSGCGWGPENEC----PLPRPAPITLPTRiwEASGWN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  892 GPSGLYSPSTNRGPIQMKIPISAFSTSSAAEqnSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSgvidltmd 971
Cdd:PHA03307  277 GPSSRPGPASSSSSPRERSPSPSPSSPGSGP--APSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPS-------- 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  972 DEESGASQDPkklnhtPVSTMSSSQPVSRPLQPIQPAPPlQPSGVPTSgpsqttihllPTAPTTVNVTHRPvTQVTTRLP 1051
Cdd:PHA03307  347 PSRSPSPSRP------PPPADPSSPRKRPRPSRAPSSPA-ASAGRPTR----------RRARAAVAGRARR-RDATGRFP 408

                         410       420
                  ....*....|....*....|....
gi 557357729 1052 VPRAPANHQVVYTTLPAPPAQAPL 1075
Cdd:PHA03307  409 AGRPRPSPLDAGAASGAFYARYPL 432
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
991-1090 4.24e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  991 TMSSSQPVSRPLQPI--QPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRApanhqvvyttLPA 1068
Cdd:PRK14971  368 DASGGRGPKQHIKPVftQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAA----------VPV 437

                          90       100
                  ....*....|....*....|..
gi 557357729 1069 PPAQAPLRGTVMQAPAVRQVNP 1090
Cdd:PRK14971  438 NPPSTAPQAVRPAQFKEEKKIP 459
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 707-1083 5.64e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.71  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   707 SAPPSFQTPVNTVSSTNLVTPPAVVSSQPK---LQTPVTSGSLTATSVLPAPNTATvvattqvpsgnpqptiSLQPLPVI 783
Cdd:pfam17823   64 TAAPAPVTLTKGTSAAHLNSTEVTAEHTPHgtdLSEPATREGAADGAASRALAAAA----------------SSSPSSAA 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   784 LHVPVAVSSQPQLLQSHPGTLVTNQPsgnvefiSVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAA 863
Cdd:pfam17823  128 QSLPAAIAALPSEAFSAPRAAACRAN-------ASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAAS 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   864 PLGTTLavqaVPTAHSIVQATRTSLPtvgpsglyspstnrgpiqmkipisAFSTSSAAEQNSNTTPRienqtnkTIDASV 943
Cdd:pfam17823  201 SAPATL----TPARGISTAATATGHP------------------------AAGTALAAVGNSSPAAG-------TVTAAV 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729   944 SKKAADSTSQCGKATGSDSSGVIDLTMDDEesgASQDPKKLNHTPVSTMSSSQ-PVSRP------LQPIQPAPPLQPSGV 1016
Cdd:pfam17823  246 GTVTPAALATLAAAAGTVASAAGTINMGDP---HARRLSPAKHMPSDTMARNPaAPMGAqaqgpiIQVSTDQPVHNTAGE 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  1017 PTSGPSQTTihLLPTAPTTVNVTHRPV---TQVTTR---------LPVPRAPANHQVVYTTLPAP--PAQAPLRGTVMQA 1082
Cdd:pfam17823  323 PTPSPSNTT--LEPNTPKSVASTNLAVvttTKAQAKepsaspvpvLHTSMIPEVEATSPTTQPSPllPTQGAAGPGILLA 400


                   .
gi 557357729  1083 P 1083
Cdd:pfam17823  401 P 401
BMS1 COG5192
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ...
 347-605 8.01e-03

GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227519 [Multi-domain]  Cd Length: 1077  Bit Score: 40.49  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  347 ANEETLETDDTTICSDRPPENEKKVEEDI-ITELALGEDAISSSMEIDQGE--------KNEDETSADLVETINENVIED 417
Cdd:COG5192   395 VDRESSEIDNVGRKTRRQPTGKAIAEETSrEDELSFDDSDVSTSDENEDVDftgkkgaiNNEDESDNEEVAFDSDSQFDE 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  418 NKSE--------NILENTDSMETDEIIPIL---EKLAPSE--------------------DELTCFSKTSLLPIDETNPD 466
Cdd:COG5192   475 SEGNlrwkeglaSKLAYSQSGKRGRNIQKIfydESLSPEEcieeykgesakssesdlvvqDEPEDFFDVSKVANESISSN 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  467 LEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKdesEVISQNEtcspevESNEKDNKPEEEEQvihEDDERPSE 546
Cdd:COG5192   555 HEKLMESEFEELKKKWSSLAQLKSRFQKDATLDSIEGEE---ELIQDDE------KGNFEDLEDEENSS---DNEMEESR 622

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557357729  547 KNEFSRRKRSKSEDMDNVQSKRRRYMEEEyEAEFQVKITAKGDINqklQKVIQWLLEEK 605
Cdd:COG5192   623 GSSVTAENEESADEVDYETEREENARKKE-ELRGNFELEERGDPE---KKDVDWYTEEK 677
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 119-268 8.76e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 8.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357729  119 PEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSgdvSPGDATSGDATADD 198
Cdd:PHA03307  205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT---RIWEASGWNGPSSR 281

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557357729  199 LSSGDPTSSDPIP-GEPVPVEPISGDCAADDIASSEITSVDlaSGAPASTDPASDdlASGDLSSSELASDD 268
Cdd:PHA03307  282 PGPASSSSSPRERsPSPSPSSPGSGPAPSSPRASSSSSSSR--ESSSSSTSSSSE--SSRGAAVSPGPSPS 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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