NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|558472775|ref|NP_001273738|]
View 

calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3 precursor [Mus musculus]

Protein Classification

calcium/calmodulin-dependent protein kinase type II( domain architecture ID 10550987)

calcium/calmodulin-dependent protein kinase type II is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates

CATH:  3.10.450.50
EC:  2.7.11.17
Gene Ontology:  GO:0005516|GO:0004683|GO:0006468
SCOP:  3000472

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
CaMKII_AD pfam08332
Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the ...
57-184 3.55e-81

Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (pfam00069) at their N-terminus. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers.


:

Pssm-ID: 285524  Cd Length: 128  Bit Score: 236.65  E-value: 3.55e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   57 RKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDE 136
Cdd:pfam08332   1 RKQEIIKVTETLLEAISTGDFETYTKLCDPDLTAFEPEVLGNLVEGLEFHRFYFENFLGKRPKAVHTTILNPHVHLLGDD 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 558472775  137 SACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAP 184
Cdd:pfam08332  81 SACIAYVRLTTYLDKNGKAHTRQSEETRVWHKRDGKWQIVHVHRSAAP 128
 
Name Accession Description Interval E-value
CaMKII_AD pfam08332
Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the ...
57-184 3.55e-81

Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (pfam00069) at their N-terminus. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers.


Pssm-ID: 285524  Cd Length: 128  Bit Score: 236.65  E-value: 3.55e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   57 RKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDE 136
Cdd:pfam08332   1 RKQEIIKVTETLLEAISTGDFETYTKLCDPDLTAFEPEVLGNLVEGLEFHRFYFENFLGKRPKAVHTTILNPHVHLLGDD 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 558472775  137 SACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAP 184
Cdd:pfam08332  81 SACIAYVRLTTYLDKNGKAHTRQSEETRVWHKRDGKWQIVHVHRSAAP 128
 
Name Accession Description Interval E-value
CaMKII_AD pfam08332
Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the ...
57-184 3.55e-81

Calcium/calmodulin dependent protein kinase II association domain; This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (pfam00069) at their N-terminus. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers.


Pssm-ID: 285524  Cd Length: 128  Bit Score: 236.65  E-value: 3.55e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   57 RKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDE 136
Cdd:pfam08332   1 RKQEIIKVTETLLEAISTGDFETYTKLCDPDLTAFEPEVLGNLVEGLEFHRFYFENFLGKRPKAVHTTILNPHVHLLGDD 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 558472775  137 SACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAP 184
Cdd:pfam08332  81 SACIAYVRLTTYLDKNGKAHTRQSEETRVWHKRDGKWQIVHVHRSAAP 128
DUF4440 pfam14534
Domain of unknown function (DUF4440);
61-175 2.25e-09

Domain of unknown function (DUF4440);


Pssm-ID: 434023 [Multi-domain]  Cd Length: 107  Bit Score: 52.40  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   61 IIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPeaLGNLVEGLDFHRFYFENLwsrnSKPVHTTILNPHIHLMGDeSACI 140
Cdd:pfam14534   1 IRALEEALLEALVAGDPAALAALLAPDFVLVGP--SGPVLDKDEILEALASGG----LDYSSIELEDEKVRVLGD-TAVV 73
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 558472775  141 AYiRITQYLDAGGIPRTAQSEETRVWHRRDGKWQI 175
Cdd:pfam14534  74 RG-RVTVTGRGDGEPVTVRGRFTSVWKKEGGGWKI 107
SnoaL_3 pfam13474
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
61-181 1.87e-05

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 433238  Cd Length: 121  Bit Score: 42.34  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   61 IIKVTEQLIEAISNGDFESYTKMCDPGMTAFEP---EALGNLVEGLDFHRFYFENlwsrnSKPVHTTILNPHIHLMGDES 137
Cdd:pfam13474   1 VNALNDAWYEAAAEGDFDALFALWSDDISCIGTgagELWRGREEFRRSWKQDFAQ-----AQGWQFELLDRRVTVLGDVA 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 558472775  138 ACIAYIRITqyLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRS 181
Cdd:pfam13474  76 WVTELLNIT--AAADGTEAYGPFRLTGVLRRTDGGWKIVHHHLS 117
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
66-173 1.75e-03

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 36.11  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472775   66 EQLIEAISNGDFESYTKMCDPGMTAFEPealGNLVEGLDFHRFYFENLWSRNSKPVHTTilnphIHLMGDESACIAYIRI 145
Cdd:pfam12680   2 RRFYEALNAGDLDALAALFAPDAVFHDP---GGPLRGRDAIRAFFAALFAAFPDLRFEI-----HDVIADGDRVAVRWTV 73
                          90       100       110
                  ....*....|....*....|....*....|.
gi 558472775  146 TqyldaGGIPRTAQSEETR---VWHRRDGKW 173
Cdd:pfam12680  74 T-----GTIPPTGRGVRVRgvdVFRFRDGKI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH