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Conserved domains on  [gi|565671701|ref|NP_001274328|]
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zinc finger protein 596 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-369 2.72e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 228 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 299
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 565671701 300 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 369
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-212 2.37e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701  64 CRVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRR 135
Cdd:COG5048  292 SKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEP 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 136 HEMIH-------TREKAQICHLCGKAFTHCSDLRKHERTHLGDKPYGC--LLCGKAFSKCSYLRQHERTHNGEKPYECHL 206
Cdd:COG5048  372 PQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451


                 ....*.
gi 565671701 207 CGKAFS 212
Cdd:COG5048  452 LKSFRR 457
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-369 2.72e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 228 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 299
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 565671701 300 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 369
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-212 2.37e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701  64 CRVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRR 135
Cdd:COG5048  292 SKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEP 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 136 HEMIH-------TREKAQICHLCGKAFTHCSDLRKHERTHLGDKPYGC--LLCGKAFSKCSYLRQHERTHNGEKPYECHL 206
Cdd:COG5048  372 PQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451


                 ....*.
gi 565671701 207 CGKAFS 212
Cdd:COG5048  452 LKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 6.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 565671701  272 DLRRHERTHTGEKPYECHLCGKAFNH 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-213 5.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 565671701  188 YLRQHERTHNGEKPYECHLCGKAFSH 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-369 2.72e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 228 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 299
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 565671701 300 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 369
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-366 1.05e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 200 KPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGKAFTESS 271
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 272 DLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHRRVHTgEKPY 342
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170       180
                 ....*....|....*....|....
gi 565671701 343 VCPLCgkafSKFFNLRQHERTHTK 366
Cdd:COG5048  447 LLCSI----LKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-212 2.37e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701  64 CRVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRR 135
Cdd:COG5048  292 SKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEP 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 136 HEMIH-------TREKAQICHLCGKAFTHCSDLRKHERTHLGDKPYGC--LLCGKAFSKCSYLRQHERTHNGEKPYECHL 206
Cdd:COG5048  372 PQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451


                 ....*.
gi 565671701 207 CGKAFS 212
Cdd:COG5048  452 LKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-326 4.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 4.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 171 DKPYGCLLCGKAFSKCSYLRQHERT--HNGE--KPYEC--HLCGKAFSHCSHLRQHERSHNGEKPHGCHL--CGKAFTES 242
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 243 SVLKRHERIH-----TGEKPYEC--HVCGKAFTESSDLRRHERTHTGEKPYECH--LCGKAFNHSSVLRRHERTHTGEKP 313
Cdd:COG5048  367 LNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|...
gi 565671701 314 YECNICGKAFNRS 326
Cdd:COG5048  447 LLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-367 3.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701  88 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHT----REKAQICHLCGKAFTHCSDL 161
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHnnpsDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 162 RKHERTHLGDKPYGCLLCGKAF--------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 222
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 223 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 296
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 565671701 297 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHRR--VHTGE--KPYVCP--LCGKAFSKFFNLRQHERTHTKK 367
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 198-281 3.53e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 3.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 198 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 274
Cdd:COG5189  346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 565671701 275 RHeRTHT 281
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 6.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 565671701  272 DLRRHERTHTGEKPYECHLCGKAFNH 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 210-309 6.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 210 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 283
Cdd:COG5189  326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 565671701 284 KPYECHLCGKAFNHSSVLRRHeRTHT 309
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-325 8.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 8.98e-04
                          10        20
                  ....*....|....*....|....*
gi 565671701  301 LRRHERTHTGEKPYECNICGKAFNR 325
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 114-196 1.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565671701 114 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 191
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 565671701 192 HeRTH 196
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....
gi 565671701  245 LKRHERIHTGEKPYECHVCGKAFT 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-365 1.73e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 565671701 310 GEKPYECNI--CGKAFNRSYNFRLHRR-------------------VHTGEKPYVCPLCGKAFSKFFNLRQHeRTHT 365
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-213 5.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 565671701  188 YLRQHERTHNGEKPYECHLCGKAFSH 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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