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Conserved domains on  [gi|567316146|ref|NP_001274524|]
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excitatory amino acid transporter 5 isoform 1 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10448728)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
19-535 9.89e-108

Sodium:dicarboxylate symporter family;


:

Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 329.87  E-value: 9.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   19 LLILSVLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYL 97
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   98 WTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPImSSADALLDLIRNMFPANLVEATFKQyrtkttpvvkspkvapeea 177
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLALIAASLKEAKA-AEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  178 pprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:pfam00375 135 -------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVM 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  258 MKIVAVAVWYFPFGIVFLIAGKILEMDdpRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLI 337
Cdd:pfam00375 172 MKVIGWVMKLAPIGVFALIANTVGTYG--LGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLT 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  338 ALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITFKCLLEN 417
Cdd:pfam00375 250 AFSTAS-----------------------------------------------------------SAATLPVTLECAEKN 270

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  418 NHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG 497
Cdd:pfam00375 271 LGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALG 350

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 567316146  498 LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHI 535
Cdd:pfam00375 351 LPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
19-535 9.89e-108

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 329.87  E-value: 9.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   19 LLILSVLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYL 97
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   98 WTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPImSSADALLDLIRNMFPANLVEATFKQyrtkttpvvkspkvapeea 177
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLALIAASLKEAKA-AEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  178 pprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:pfam00375 135 -------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVM 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  258 MKIVAVAVWYFPFGIVFLIAGKILEMDdpRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLI 337
Cdd:pfam00375 172 MKVIGWVMKLAPIGVFALIANTVGTYG--LGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLT 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  338 ALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITFKCLLEN 417
Cdd:pfam00375 250 AFSTAS-----------------------------------------------------------SAATLPVTLECAEKN 270

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  418 NHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG 497
Cdd:pfam00375 271 LGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALG 350

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 567316146  498 LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHI 535
Cdd:pfam00375 351 LPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
15-534 7.62e-107

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 328.23  E-value: 7.62e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  15 RRNGLLILSVLSVIVGCLLGFFLRtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTV 93
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLP-----ELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  94 AYYLWTTFMAVIVGIFMVSIIHPGSAAQkETTEQSGKPIMSSADALLDLIRNMFPANLVEAtfkqyrtkttpvvkspkva 173
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLN-LDLADAAAAEAAEAPSLLDFLLNIIPSNIFEA------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 174 peeapprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCL 253
Cdd:COG1301  136 ------------------------FA------------------EG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESL 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 254 NESVMKIVAVAVWYFPFGIVFLIAGKILEMDDprAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ 333
Cdd:COG1301  173 SEVMFKIVGWVMKLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 334 ALLIALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITFKC 413
Cdd:COG1301  251 ALLLAFSTSS-----------------------------------------------------------SEATLPVTMEK 271

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 414 LLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVL 493
Cdd:COG1301  272 AEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVL 351

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 567316146 494 TSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAH 534
Cdd:COG1301  352 SAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 19-533 7.56e-33

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 131.42  E-value: 7.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  19 LLILSVLSVIVGCLLGFFLRTRR------LSPQeisyfqfpGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVL 91
Cdd:PRK11283  12 ILIALVLGILLGAYLHYHSDSRDwlvsnlLSPA--------GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  92 TVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETT--------EQSGKPIMSSADALLDLIRNMFPANLVEATFKQyrtkt 163
Cdd:PRK11283  84 TIIYFEVITTVAIILGITLANVFQPGAGIDMSQLatvdiskyQSTTEEVQSHSHGLMGTILSLIPTNIFASMAKG----- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 164 tpvvkspkvapeeapprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRM-GDS 242
Cdd:PRK11283 159 ---------------------------------------------------------EMLPIIFFSVLFGLGLSSLpATH 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 243 GAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKIlemddpravgKKLGFYSVTVVCGLVLhglfilpLLYFfitkk 322
Cdd:PRK11283 182 REPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTV----------ANFGFASLWPLAKLVL-------LVYF----- 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 323 nPIVFIRgilqalLIALATSSRKNQVRAlqcprslppagaalqrhkhsWRGGCLGRGELPdrgpshpgggcwadTGPSNR 402
Cdd:PRK11283 240 -AILFFA------LVVLGIVARLCGLSI--------------------WILIRILKDELI--------------LAYSTA 278

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 403 SSAT-LPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGI 481
Cdd:PRK11283 279 SSETvLPRIIE-KMEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGV 357

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 567316146 482 PQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMA 533
Cdd:PRK11283 358 PGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIA 409
 
Name Accession Description Interval E-value
SDF pfam00375
Sodium:dicarboxylate symporter family;
19-535 9.89e-108

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 329.87  E-value: 9.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   19 LLILSVLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYL 97
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146   98 WTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPImSSADALLDLIRNMFPANLVEATFKQyrtkttpvvkspkvapeea 177
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLALIAASLKEAKA-AEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  178 pprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:pfam00375 135 -------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVM 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  258 MKIVAVAVWYFPFGIVFLIAGKILEMDdpRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLI 337
Cdd:pfam00375 172 MKVIGWVMKLAPIGVFALIANTVGTYG--LGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLT 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  338 ALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITFKCLLEN 417
Cdd:pfam00375 250 AFSTAS-----------------------------------------------------------SAATLPVTLECAEKN 270

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  418 NHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG 497
Cdd:pfam00375 271 LGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALG 350

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 567316146  498 LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHI 535
Cdd:pfam00375 351 LPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
15-534 7.62e-107

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 328.23  E-value: 7.62e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  15 RRNGLLILSVLSVIVGCLLGFFLRtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTV 93
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLP-----ELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  94 AYYLWTTFMAVIVGIFMVSIIHPGSAAQkETTEQSGKPIMSSADALLDLIRNMFPANLVEAtfkqyrtkttpvvkspkva 173
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLN-LDLADAAAAEAAEAPSLLDFLLNIIPSNIFEA------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 174 peeapprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCL 253
Cdd:COG1301  136 ------------------------FA------------------EG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESL 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 254 NESVMKIVAVAVWYFPFGIVFLIAGKILEMDDprAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ 333
Cdd:COG1301  173 SEVMFKIVGWVMKLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 334 ALLIALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITFKC 413
Cdd:COG1301  251 ALLLAFSTSS-----------------------------------------------------------SEATLPVTMEK 271

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 414 LLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVL 493
Cdd:COG1301  272 AEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVL 351

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 567316146 494 TSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAH 534
Cdd:COG1301  352 SAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 19-533 7.56e-33

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 131.42  E-value: 7.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  19 LLILSVLSVIVGCLLGFFLRTRR------LSPQeisyfqfpGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVL 91
Cdd:PRK11283  12 ILIALVLGILLGAYLHYHSDSRDwlvsnlLSPA--------GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  92 TVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETT--------EQSGKPIMSSADALLDLIRNMFPANLVEATFKQyrtkt 163
Cdd:PRK11283  84 TIIYFEVITTVAIILGITLANVFQPGAGIDMSQLatvdiskyQSTTEEVQSHSHGLMGTILSLIPTNIFASMAKG----- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 164 tpvvkspkvapeeapprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRM-GDS 242
Cdd:PRK11283 159 ---------------------------------------------------------EMLPIIFFSVLFGLGLSSLpATH 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 243 GAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKIlemddpravgKKLGFYSVTVVCGLVLhglfilpLLYFfitkk 322
Cdd:PRK11283 182 REPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTV----------ANFGFASLWPLAKLVL-------LVYF----- 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 323 nPIVFIRgilqalLIALATSSRKNQVRAlqcprslppagaalqrhkhsWRGGCLGRGELPdrgpshpgggcwadTGPSNR 402
Cdd:PRK11283 240 -AILFFA------LVVLGIVARLCGLSI--------------------WILIRILKDELI--------------LAYSTA 278

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 403 SSAT-LPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGI 481
Cdd:PRK11283 279 SSETvLPRIIE-KMEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGV 357

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 567316146 482 PQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMA 533
Cdd:PRK11283 358 PGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIA 409
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 24-533 3.82e-25

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 108.22  E-value: 3.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  24 VLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFM 102
Cdd:PRK13027  13 VIALVLGVALGAFF------PHFAESLKPLGDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 103 AVIVGIFMVSIIHPGSAAqketteqsgkpimssadalldlirNMFPANLVEATFKQYrTKTTPVVKSpkvapeeapprri 182
Cdd:PRK13027  87 ALVIGLVLAYLTGPGVGM------------------------NIDLRSLDAASLAGY-AKNAQSLKG------------- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 183 liygvqeengshVQNFALDLTPPPEVvyksePGTSDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVA 262
Cdd:PRK13027 129 ------------TAGFLLKLIPTTAV-----DAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSHVLFRIMG 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 263 VAVWYFPFGIVFLIA---GKiLEMDDPRAVGKKLG-FYS-----VTVVCGLV--LHGLFILPLlyffitkknpivfIRGI 331
Cdd:PRK13027 191 FIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAvFYLtcfvfVVVVLGAVmrLAGFSVFKL-------------IRYL 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 332 LQALLIALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnrSSATLPITF 411
Cdd:PRK13027 257 REELLIVLGTAS-----------------------------------------------------------SDAVLPQVM 277

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 412 KcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVI 491
Cdd:PRK13027 278 R-KLEHMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSKGAHGIPGSAIVILAA 356

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 567316146 492 VLTSVG-LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMA 533
Cdd:PRK13027 357 TLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVVA 399
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 24-543 8.04e-24

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 104.60  E-value: 8.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  24 VLSVIVGCLLGFFlrtrrlSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFM 102
Cdd:PRK01663  14 LVAIIIGILLGHF------YPELGAQMKPLGDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 103 AVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADA-----LLDLIRNMFPANLVEAtfkqyrtkttpvvkspkvapeea 177
Cdd:PRK01663  88 ALIIGLIVVNVVQPGAGMNIDPATLDAKAVAQYAAQaheqgTVDFLMDIIPTTVVGA----------------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 178 pprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:PRK01663 145 --------------------FA------------------SG-DILQVLLFAVLFGFALARLGEKGKPVFDFIESLSHVL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 258 MKIVAVAVWYFPFG----IVFLIaGKIlemddprAVG--KKLG-----FYS-----VTVVCGLV--LHGLFILPllyffi 319
Cdd:PRK01663 186 FGIVNMIMKLAPIGafgaMAFTI-GKY-------GVGslVQLGqligcFYItcilfVFVVLGAIarLTGFSIFK------ 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 320 tkknpivFIRGILQALLIALATSSrknqvralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgp 399
Cdd:PRK01663 252 -------FIRYIKEELLIVLGTSS-------------------------------------------------------- 268

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 400 snrSSATLP-ITFKclLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGA 478
Cdd:PRK01663 269 ---SESALPrMMEK--MEKLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLSIGHQITLLAVLLLTSKGA 343

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 567316146 479 AGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICrKDFARD 543
Cdd:PRK01663 344 AGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGVATVVVAKWE-KELDRE 408
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 45-538 6.97e-14

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 74.09  E-value: 6.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146  45 QEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSI-------IHP 116
Cdd:COG1823   61 QSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLkNASSLGKISGLIIGILLGTTAIAALVGILVALLfgltaegLTQ 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 117 GSAaqkETTEqsGKPIMSSADALLDL-----IRNMFPANLveatfkqyrtkttpvvkspkvapeeapprriliygvqeen 191
Cdd:COG1823  141 GAA---ETAR--GEALEERLGEVEDLslpqqILSFIPTNP---------------------------------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 192 gshvqnFAlDLTpppevvyKSEPgTSdgmnVLGIVFFSATMGI----MLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWY 267
Cdd:COG1823  176 ------FA-DLT-------GARP-TS----TIAVVIFAAFLGIaalgLRRKKPEQAETFLKGIDALQAIVMRLVRLVLRL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 268 FPFGIVFLIAgKILEMDDPRAVGKKLGFysvTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALaTSsrknq 347
Cdd:COG1823  237 TPYGVLALMT-KVVATSDFADILNLGKF---VVASYVALIIMFIVHLLLLALAGLNPLTYFKKVWPVLTFAF-TS----- 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 348 vralqcprslppagaalqrhkhswrggclgrgelpdrgpshpgggcwadtgpsnRSSA-TLPITFKCLLENNHIDRRIAR 426
Cdd:COG1823  307 ------------------------------------------------------RSSAgTIPLNIETQTKRLGVPEGIAN 332

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 427 FVLPVGATINMDGTA-LYEAVAAIFIA-QVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDIT 504
Cdd:COG1823  333 FAASFGATIGQNGCAgIYPAMLAVMIApTVGINPLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAG 412

                        490       500       510
                 ....*....|....*....|....*....|....
gi 567316146 505 LIIAVDWALDRFRTMINVLGDALAAGIMAHICRK 538
Cdd:COG1823  413 LLISIEPLIDMGRTALNVSGSMTAGTVTSRLLGQ 446
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 402-531 1.27e-03

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 41.19  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567316146 402 RSSAT-LPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAG 480
Cdd:PRK14695 177 RSSATnIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMAGVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASG 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 567316146 481 IPQAGLVTMVIVLTSVGLPTDDITLIIAVDWAL----DRFRTMINVLGDALAAGI 531
Cdd:PRK14695 256 IAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqDSCETALNSSTDVLFTAV 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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