NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|575771876|ref|NP_001276554|]
View 

suppressor of tumorigenicity 7 protein isoform 4 [Mus musculus]

Protein Classification

ST7 domain-containing protein( domain architecture ID 11148215)

ST7 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-571 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


:

Pssm-ID: 461214  Cd Length: 532  Bit Score: 975.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAE 257
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEIN----------------------PDCATALVLLAEEEAETISDAE 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  258 KLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHEN 337
Cdd:pfam04184 214 KLLRQALKAGESNYRKSQQSQHLSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHEN 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  338 LLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVP 417
Cdd:pfam04184 294 LIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVP 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  418 KYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLH-----SFRMIPYPLEKGHLFYPYPICTETADREL 492
Cdd:pfam04184 374 KYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRVEGALNLLHctwegTFRMIPYPLEKGHLFYPYPSCTENADREL 453
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 575771876  493 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 571
Cdd:pfam04184 454 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-571 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 975.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAE 257
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEIN----------------------PDCATALVLLAEEEAETISDAE 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  258 KLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHEN 337
Cdd:pfam04184 214 KLLRQALKAGESNYRKSQQSQHLSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHEN 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  338 LLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVP 417
Cdd:pfam04184 294 LIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVP 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  418 KYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLH-----SFRMIPYPLEKGHLFYPYPICTETADREL 492
Cdd:pfam04184 374 KYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRVEGALNLLHctwegTFRMIPYPLEKGHLFYPYPSCTENADREL 453
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 575771876  493 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 571
Cdd:pfam04184 454 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
54-536 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 926.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  54 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 133
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 134 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 213
Cdd:cd11557   73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 214 eirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTN 293
Cdd:cd11557  153 ----------------------PECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTN 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 294 VLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTA 373
Cdd:cd11557  211 VLVYIKRRLAMCARKLGRLKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 374 ALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWK 453
Cdd:cd11557  291 ALLKARAVADKFSPEVASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWK 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 454 RVEGALNLLHS-----FRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLT 528
Cdd:cd11557  371 RVEGALNLLHCtwegtFRMIPYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLT 450

                 ....*...
gi 575771876 529 HQFPELMG 536
Cdd:cd11557  451 HQFPEPMG 458
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
18-571 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 975.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   18 WSWTYLWTVWFFLVLFLVYILRVPLRINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 97
Cdd:pfam04184   2 WSWTYLWLIWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876   98 VSHLRPLLGGvdnnssNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFT 177
Cdd:pfam04184  82 LNHLSPLIGG------GDNASDNGENEENRQSVPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  178 CDSDHLRPADAIMQKAWRERNPQARISAAHEALEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAE 257
Cdd:pfam04184 156 CDTDSGRPADEIMQKAWRERNPQARIKAAHQALEIN----------------------PDCATALVLLAEEEAETISDAE 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  258 KLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHEN 337
Cdd:pfam04184 214 KLLRQALKAGESNYRKSQQSQHLSSNHEAQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHEN 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  338 LLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVP 417
Cdd:pfam04184 294 LIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVP 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  418 KYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLH-----SFRMIPYPLEKGHLFYPYPICTETADREL 492
Cdd:pfam04184 374 KYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRVEGALNLLHctwegTFRMIPYPLEKGHLFYPYPSCTENADREL 453
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 575771876  493 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 571
Cdd:pfam04184 454 LPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
54-536 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 926.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876  54 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 133
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 134 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 213
Cdd:cd11557   73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 214 eirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTN 293
Cdd:cd11557  153 ----------------------PECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTN 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 294 VLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTA 373
Cdd:cd11557  211 VLVYIKRRLAMCARKLGRLKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 374 ALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWK 453
Cdd:cd11557  291 ALLKARAVADKFSPEVASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWK 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771876 454 RVEGALNLLHS-----FRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLT 528
Cdd:cd11557  371 RVEGALNLLHCtwegtFRMIPYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLT 450

                 ....*...
gi 575771876 529 HQFPELMG 536
Cdd:cd11557  451 HQFPEPMG 458
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH