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Conserved domains on  [gi|597517955|ref|NP_001277969|]
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phosphatidate cytidylyltransferase 2 isoform c [Mus musculus]

Protein Classification

cytidylyltransferase family protein( domain architecture ID 229704)

cytidylyltransferase family protein may catalyze the transfer of a cytidylyl group or a phosphate group from CTP to various substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTP_transf_1 super family cl21502
Cytidylyltransferase family; The members of this family are integral membrane protein ...
 69-129 2.34e-13

Cytidylyltransferase family; The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.


The actual alignment was detected with superfamily member pfam01148:

Pssm-ID: 451277  Cd Length: 264  Bit Score: 64.55  E-value: 2.34e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597517955   69 WVRGILTLAMIAFFFIIIYLGPMVLMMIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSW 129
Cdd:pfam01148   1 KQRIITALVLIPIFLAILYLGGLYFMLLVAAVVILALWELIRLVRIKGPDYRLLLLLSWYF 61
 
Name Accession Description Interval E-value
CTP_transf_1 pfam01148
Cytidylyltransferase family; The members of this family are integral membrane protein ...
 69-129 2.34e-13

Cytidylyltransferase family; The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.


Pssm-ID: 426080  Cd Length: 264  Bit Score: 64.55  E-value: 2.34e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597517955   69 WVRGILTLAMIAFFFIIIYLGPMVLMMIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSW 129
Cdd:pfam01148   1 KQRIITALVLIPIFLAILYLGGLYFMLLVAAVVILALWELIRLVRIKGPDYRLLLLLSWYF 61
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 43-116 5.61e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 35.29  E-value: 5.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597517955  43 LPTSVDDTPEVLNRALSNLSSRWK-NWWVrGILTLAMIAFFFIIIYLG-PMVLMMIVMCVqikCFHEIITIGYNVY 116
Cdd:cd17336  146 FLLRIYVDFSRVPLGITPDDPRWIgAWWL-GFLILGILLLIVSIPLFFfPPIFILLLLAI---VFESFAISGFSTF 217
 
Name Accession Description Interval E-value
CTP_transf_1 pfam01148
Cytidylyltransferase family; The members of this family are integral membrane protein ...
 69-129 2.34e-13

Cytidylyltransferase family; The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.


Pssm-ID: 426080  Cd Length: 264  Bit Score: 64.55  E-value: 2.34e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597517955   69 WVRGILTLAMIAFFFIIIYLGPMVLMMIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSW 129
Cdd:pfam01148   1 KQRIITALVLIPIFLAILYLGGLYFMLLVAAVVILALWELIRLVRIKGPDYRLLLLLSWYF 61
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 43-116 5.61e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 35.29  E-value: 5.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597517955  43 LPTSVDDTPEVLNRALSNLSSRWK-NWWVrGILTLAMIAFFFIIIYLG-PMVLMMIVMCVqikCFHEIITIGYNVY 116
Cdd:cd17336  146 FLLRIYVDFSRVPLGITPDDPRWIgAWWL-GFLILGILLLIVSIPLFFfPPIFILLLLAI---VFESFAISGFSTF 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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