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Conserved domains on  [gi|625180323|ref|NP_001278743|]
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mitochondrial basic amino acids transporter isoform 2 [Homo sapiens]

Protein Classification

solute carrier family 25 protein( domain architecture ID 10445172)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
119-202 3.01e-25

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 95.03  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  119 DRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAA 198
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80

                  ....
gi 625180323  199 TFAT 202
Cdd:pfam00153  81 YFGT 84
Mito_carr pfam00153
Mitochondrial carrier protein;
22-114 1.89e-24

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 93.10  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323   22 GHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 101
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 625180323  102 YFLTYDALTRALG 114
Cdd:pfam00153  81 YFGTYETLKRLLL 93
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
119-202 3.01e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 95.03  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  119 DRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAA 198
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80

                  ....
gi 625180323  199 TFAT 202
Cdd:pfam00153  81 YFGT 84
Mito_carr pfam00153
Mitochondrial carrier protein;
22-114 1.89e-24

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 93.10  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323   22 GHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 101
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 625180323  102 YFLTYDALTRALG 114
Cdd:pfam00153  81 YFGTYETLKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
31-193 6.13e-13

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 66.72  E-value: 6.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  31 LAGAAAGAIQCVICCPMELAKTRLQlQDAGP--ARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDA 108
Cdd:PTZ00169 118 LSGGLAGASSLLIVYPLDFARTRLA-SDIGKggDREFTGLFDCLMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDS 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323 109 LTRALGCEPGDRLLVPKLLLAGgTSGIVSWLSTYPVDVVKSRLQA-DGLRGAPR--YRGILDCVHQSYRAEGWRVFTRGL 185
Cdd:PTZ00169 197 AKALLFGNDKNTNILYKWAVAQ-TVTILAGLISYPFDTVRRRMMMmSGRKAKSEiqYTGTLDCWKKILKNEGLGGFFKGA 275

                 ....*...
gi 625180323 186 ASTLLRAF 193
Cdd:PTZ00169 276 WANVLRGA 283
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
128-201 3.65e-05

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 43.99  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323 128 LAGGTSGIVSWLSTYPVDVVKSRLQA-----DGLRG-APRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFA 201
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTqdsipEIKSGkVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFA 91
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
119-202 3.01e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 95.03  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  119 DRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAA 198
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80

                  ....
gi 625180323  199 TFAT 202
Cdd:pfam00153  81 YFGT 84
Mito_carr pfam00153
Mitochondrial carrier protein;
22-114 1.89e-24

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 93.10  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323   22 GHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 101
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|...
gi 625180323  102 YFLTYDALTRALG 114
Cdd:pfam00153  81 YFGTYETLKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
31-193 6.13e-13

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 66.72  E-value: 6.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  31 LAGAAAGAIQCVICCPMELAKTRLQlQDAGP--ARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDA 108
Cdd:PTZ00169 118 LSGGLAGASSLLIVYPLDFARTRLA-SDIGKggDREFTGLFDCLMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDS 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323 109 LTRALGCEPGDRLLVPKLLLAGgTSGIVSWLSTYPVDVVKSRLQA-DGLRGAPR--YRGILDCVHQSYRAEGWRVFTRGL 185
Cdd:PTZ00169 197 AKALLFGNDKNTNILYKWAVAQ-TVTILAGLISYPFDTVRRRMMMmSGRKAKSEiqYTGTLDCWKKILKNEGLGGFFKGA 275

                 ....*...
gi 625180323 186 ASTLLRAF 193
Cdd:PTZ00169 276 WANVLRGA 283
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
30-184 1.13e-12

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 65.95  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323  30 FLAGAAAGAIQCVICCPMELAKTRLQLQDAGP------ARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYF 103
Cdd:PTZ00169  11 FLMGGISAAISKTAVAPIERVKMLIQTQDSIPeiksgkVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323 104 LTYDALTRalgcepgdrlLVPKL-------------LLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPR-YRGILDCV 169
Cdd:PTZ00169  91 AFKDYFKN----------MFPKYnqktdfwkffgvnILSGGLAGASSLLIVYPLDFARTRLASDIGKGGDReFTGLFDCL 160
                        170
                 ....*....|....*
gi 625180323 170 HQSYRAEGWRVFTRG 184
Cdd:PTZ00169 161 MKISKQTGFLSLYQG 175
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
128-201 3.65e-05

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 43.99  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625180323 128 LAGGTSGIVSWLSTYPVDVVKSRLQA-----DGLRG-APRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFA 201
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTqdsipEIKSGkVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFA 91
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
42-113 1.17e-03

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 39.37  E-value: 1.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 625180323  42 VICCPMELAKTRLQLQdAGPART----YKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLtYDALTRAL 113
Cdd:PTZ00169 226 LISYPFDTVRRRMMMM-SGRKAKseiqYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGGALVLVF-YDELQKLL 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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