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Conserved domains on  [gi|663429558|ref|NP_001287701|]
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lysophospholipase-like protein 1 isoform d [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 13-184 1.88e-29

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam02230:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 217  Bit Score: 108.23  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   13 FQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMA 92
Cdd:pfam02230  40 LPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDEAGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   93 IHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPElFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVY 172
Cdd:pfam02230 120 LYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPI-FLIHGEEDPVVPLALGKLAKEYLKTSLNKVELKIYEGLA 198

                         170
                  ....*....|..
gi 663429558  173 HELSKTELDILK 184
Cdd:pfam02230 199 HSICGREMQDIK 210
 
Name Accession Description Interval E-value
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 13-184 1.88e-29

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 108.23  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   13 FQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMA 92
Cdd:pfam02230  40 LPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDEAGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   93 IHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPElFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVY 172
Cdd:pfam02230 120 LYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPI-FLIHGEEDPVVPLALGKLAKEYLKTSLNKVELKIYEGLA 198

                         170
                  ....*....|..
gi 663429558  173 HELSKTELDILK 184
Cdd:pfam02230 199 HSICGREMQDIK 210
YpfH COG0400
Predicted esterase [General function prediction only];
18-192 5.20e-28

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 104.22  E-value: 5.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  18 IIYPTAPPRSYTPMkggisNVWFDRFKITNDcpEHLESIDVMCQVLTDLIDE-EVKSGIKKNRILIGGFSMGGCMAIHLA 96
Cdd:COG0400   35 VLAPRAPVPEGPGG-----RAWFDLSFLEGR--EDEEGLAAAAEALAAFIDElEARYGIDPERIVLAGFSQGAAMALSLA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  97 YRNHQDVAGVFALSSFLNKASAVYQALQKSNGvlPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPnVYHELS 176
Cdd:COG0400  108 LRRPELLAGVVALSGYLPGEEALPAPEAALAG--TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP-GGHEIS 184

                        170
                 ....*....|....*.
gi 663429558 177 KTELDILKLWILTKLP 192
Cdd:COG0400  185 PEELADARAWLAERLA 200
 
Name Accession Description Interval E-value
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 13-184 1.88e-29

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 108.23  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   13 FQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMA 92
Cdd:pfam02230  40 LPNIKFIFPHGPEIPVTLNGGMRMPAWFDLVGLSPNAKEDEAGIKNSAETIEELIDAEQKKGIPSSRIIIGGFSQGAMLA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   93 IHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPElFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVY 172
Cdd:pfam02230 120 LYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPI-FLIHGEEDPVVPLALGKLAKEYLKTSLNKVELKIYEGLA 198

                         170
                  ....*....|..
gi 663429558  173 HELSKTELDILK 184
Cdd:pfam02230 199 HSICGREMQDIK 210
YpfH COG0400
Predicted esterase [General function prediction only];
18-192 5.20e-28

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 104.22  E-value: 5.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  18 IIYPTAPPRSYTPMkggisNVWFDRFKITNDcpEHLESIDVMCQVLTDLIDE-EVKSGIKKNRILIGGFSMGGCMAIHLA 96
Cdd:COG0400   35 VLAPRAPVPEGPGG-----RAWFDLSFLEGR--EDEEGLAAAAEALAAFIDElEARYGIDPERIVLAGFSQGAAMALSLA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  97 YRNHQDVAGVFALSSFLNKASAVYQALQKSNGvlPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPnVYHELS 176
Cdd:COG0400  108 LRRPELLAGVVALSGYLPGEEALPAPEAALAG--TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP-GGHEIS 184

                        170
                 ....*....|....*.
gi 663429558 177 KTELDILKLWILTKLP 192
Cdd:COG0400  185 PEELADARAWLAERLA 200
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
49-173 5.61e-10

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 56.42  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  49 CPEH--LESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQD----VAGVFALSSFLN-KASAVYQ 121
Cdd:COG0657   55 APEHpfPAALEDAYAALRWLRANAAELGIDPDRIAVAGDSAGGHLAAALALRARDRggprPAAQVLIYPVLDlTASPLRA 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 663429558 122 ALQKsngvLPELFQCHGTADELVLHS--WAEetnsMLKSLGVTTKFHSFPNVYH 173
Cdd:COG0657  135 DLAG----LPPTLIVTGEADPLVDESeaLAA----ALRAAGVPVELHVYPGGGH 180
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
72-179 6.30e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 56.56  E-value: 6.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  72 KSGIKKNRILIGGFSMGGCMAIHLAYRNHQ------DVAGVFALSSFLNKASAVYQALQKSNGVLPELFQ---------- 135
Cdd:COG1506   87 RPYVDPDRIGIYGHSYGGYMALLAAARHPDrfkaavALAGVSDLRSYYGTTREYTERLMGGPWEDPEAYAarsplayadk 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 663429558 136 -------CHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTE 179
Cdd:COG1506  167 lktplllIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG 217
COG4099 COG4099
Predicted peptidase [General function prediction only];
61-173 1.27e-09

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 55.74  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  61 QVLTDLIDEEVKS-GIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAvyQALQKsngvLPeLFQCHGT 139
Cdd:COG4099  107 DAVLALLDDLIAEyRIDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPICGGGDPANA--ANLKK----VP-VWIFHGA 179

                         90       100       110
                 ....*....|....*....|....*....|....
gi 663429558 140 ADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYH 173
Cdd:COG4099  180 KDDVVPVEESRAMVEALKAAGADVKYTEYPGVGH 213
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
52-175 1.54e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 46.92  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  52 HLESIDVMCQVLTDLIDEEVKSGikKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNK------------ASAV 119
Cdd:COG2267   75 HVDSFDDYVDDLRAALDALRARP--GLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRAdpllgpsarwlrALRL 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 663429558 120 YQALQKSNgvLPELFqCHGTADELVLhswAEETNSMLKSLGVTTKFHSFPNVYHEL 175
Cdd:COG2267  153 AEALARID--VPVLV-LHGGADRVVP---PEAARRLAARLSPDVELVLLPGARHEL 202
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
73-173 1.33e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 44.19  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  73 SGIKKNRILIGGFSMGGCMAIHLAyRNHQDVAGVFALSSFLNKASAVyQALQKSNGvlPELFqCHGTADELVLHSWAEET 152
Cdd:COG0412  104 PEVDAGRVGVVGFCFGGGLALLAA-ARGPDLAAAVSFYGGLPADDLL-DLAARIKA--PVLL-LYGEKDPLVPPEQVAAL 178

                         90       100
                 ....*....|....*....|.
gi 663429558 153 NSMLKSLGVTTKFHSFPNVYH 173
Cdd:COG0412  179 EAALAAAGVDVELHVYPGAGH 199
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
78-114 1.73e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 44.16  E-value: 1.73e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 663429558  78 NRILIGGFSMGGCMAIHLAYRnHQDVAGVFALSSFLN 114
Cdd:COG1647   84 DKVIVIGLSMGGLLALLLAAR-YPDVAGLVLLSPALK 119
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 48-173 2.43e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 40.37  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  48 DCPEHLESIDVMCQVLTDLIDEEvksGIKknRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSN 127
Cdd:COG0596   64 DKPAGGYTLDDLADDLAALLDAL---GLE--RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVLAALAEPLRRPGLAP 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663429558 128 GVLPELFQ--------------------CHGTADELVLHSWAEETNSMLKslgvTTKFHSFPNVYH 173
Cdd:COG0596  139 EALAALLRalartdlrerlaritvptlvIWGEKDPIVPPALARRLAELLP----NAELVVLPGAGH 200
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
62-169 3.66e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.22  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558  62 VLTDL---IDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNgVLPE------ 132
Cdd:COG2382  177 LAEELipfVEKNYRVSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSGSFWWPPGDADRGGWAE-LLAAgapkkp 255

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 663429558 133 --LFQCHGTADELVLHswAEETNSMLKSLGVTTKFHSFP 169
Cdd:COG2382  256 lrFYLDVGTEDDLLEA--NRALAAALKAKGYDVEYREFP 292
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 56-109 2.56e-03

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 37.18  E-value: 2.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 663429558   56 IDVMCQVLTDLIDEEVKSGikkNRILIGGFSMGGCMAIHLAyrNHQDVAGVFAL 109
Cdd:pfam20408  57 APKLLEAFRAVIAALRGPD---LPLFIGGKSMGGRVASLLA--DDSGVKGVIAL 105
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 52-111 5.47e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 36.42  E-value: 5.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429558   52 HLESIDVMCQVLTDLIDEEVKSGIKKNRILIGgFSMGGCMAIHLAYRNHQDVAGVfALSS 111
Cdd:pfam12146  51 HVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG-HSMGGLIAALYALRYPDKVDGL-ILSA 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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