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Conserved domains on  [gi|669250861|ref|NP_001288204|]
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zinc finger protein 169 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
31-392 2.93e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861  31 SKKSSLFSHQKHHVCPECGRGFCQRSDLIKHQRTHTGEKPYLCPECGR--RFSQKASLSIHQRKHSGEKPYVCRECGRHF 108
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 109 RYTSSLTNHkRIHSGERPFVCQECGRGF----RQKIALLLHQRTHLEEKPfvCPECGRGFCQ--KASLLQHQSSHTgerp 182
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVNtpQSNSLHPPLPAN---- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 183 flcLECGRSFRQQSLLLSHQVTHSGEKPYVCAEcGHSFRQKVTLIRHQRTHTGEKPYLCPQCGRGFSQKVTLIGHQRTHT 262
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 263 GEKPYLCPDCGRGFGQKVTLIRHQRTHTGE-------KPYLCPKCGRAFGFKSLLTRHQRthseeelyvdrvcgqglgQK 335
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR------------------SV 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 669250861 336 SHLISDQRTHSgekpCICDECGRGFGFKSALIRHQRTHSGEKPYVCRECGRGFSQKS 392
Cdd:COG5048  313 NHSGESLKPFS----CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
31-392 2.93e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861  31 SKKSSLFSHQKHHVCPECGRGFCQRSDLIKHQRTHTGEKPYLCPECGR--RFSQKASLSIHQRKHSGEKPYVCRECGRHF 108
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 109 RYTSSLTNHkRIHSGERPFVCQECGRGF----RQKIALLLHQRTHLEEKPfvCPECGRGFCQ--KASLLQHQSSHTgerp 182
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVNtpQSNSLHPPLPAN---- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 183 flcLECGRSFRQQSLLLSHQVTHSGEKPYVCAEcGHSFRQKVTLIRHQRTHTGEKPYLCPQCGRGFSQKVTLIGHQRTHT 262
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 263 GEKPYLCPDCGRGFGQKVTLIRHQRTHTGE-------KPYLCPKCGRAFGFKSLLTRHQRthseeelyvdrvcgqglgQK 335
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR------------------SV 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 669250861 336 SHLISDQRTHSgekpCICDECGRGFGFKSALIRHQRTHSGEKPYVCRECGRGFSQKS 392
Cdd:COG5048  313 NHSGESLKPFS----CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 48-89 5.02e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 5.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 669250861  48 CGRGFCQRSDLIKHQRTHTgekpYLCPECGRRFSQKASLSIH 89
Cdd:cd20908    7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-82 9.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 669250861   57 DLIKHQRTHTGEKPYLCPECGRRFSQ 82
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 70-117 2.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 2.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 669250861  70 PYLCPECGRRFSQKASLSIHQRkhSGEKPYVCRECGRHFRYTSSLTNH 117
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
31-392 2.93e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861  31 SKKSSLFSHQKHHVCPECGRGFCQRSDLIKHQRTHTGEKPYLCPECGR--RFSQKASLSIHQRKHSGEKPYVCRECGRHF 108
Cdd:COG5048   22 STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 109 RYTSSLTNHkRIHSGERPFVCQECGRGF----RQKIALLLHQRTHLEEKPfvCPECGRGFCQ--KASLLQHQSSHTgerp 182
Cdd:COG5048  102 NSKASSSSL-SSSSSNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVNtpQSNSLHPPLPAN---- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 183 flcLECGRSFRQQSLLLSHQVTHSGEKPYVCAEcGHSFRQKVTLIRHQRTHTGEKPYLCPQCGRGFSQKVTLIGHQRTHT 262
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669250861 263 GEKPYLCPDCGRGFGQKVTLIRHQRTHTGE-------KPYLCPKCGRAFGFKSLLTRHQRthseeelyvdrvcgqglgQK 335
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLR------------------SV 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 669250861 336 SHLISDQRTHSgekpCICDECGRGFGFKSALIRHQRTHSGEKPYVCRECGRGFSQKS 392
Cdd:COG5048  313 NHSGESLKPFS----CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 48-89 5.02e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 5.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 669250861  48 CGRGFCQRSDLIKHQRTHTgekpYLCPECGRRFSQKASLSIH 89
Cdd:cd20908    7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-82 9.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 9.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 669250861   57 DLIKHQRTHTGEKPYLCPECGRRFSQ 82
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-250 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 669250861  226 LIRHQRTHTGEKPYLCPQCGRGFSQ 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-304 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|...
gi 669250861  282 LIRHQRTHTGEKPYLCPKCGRAF 304
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 70-117 2.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 2.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 669250861  70 PYLCPECGRRFSQKASLSIHQRkhSGEKPYVCRECGRHFRYTSSLTNH 117
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 669250861  365 ALIRHQRTHSGEKPYVCRECGRGFSQ 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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