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Conserved domains on  [gi|725503325|ref|NP_001289763|]
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putative methyltransferase NSUN7 isoform 2 [Mus musculus]

Protein Classification

RsmB family protein( domain architecture ID 1002937)

RsmB family protein such as 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB, which specifically methylates cytosine(967) at C(5) in 16S rRNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK14902 super family cl36439
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
214-427 1.00e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


The actual alignment was detected with superfamily member PRK14902:

Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 51.72  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 214 INTSKISLEEVYNNLRRKGYSKVKSitSVNEKVYAVDqhcfnvlifpahlKTDLLNIDLIKDYKLIFQDKSRSLAVHSVK 293
Cdd:PRK14902 183 VNTLKISVEELIEKLEEEGYEVEES--LLSPEALVIE-------------KGNIAGTDLFKDGLITIQDESSMLVAPALD 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 294 alINIDDDVL----------------MVNTGswyTVAHMSIltsgHTSKIFVcgIQQeekdfNARklftRMGCQNIEI-- 355
Cdd:PRK14902 248 --PKGGDTVLdacaapggktthiaelLKNTG---KVVALDI----HEHKLKL--IEE-----NAK----RLGLTNIETka 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 356 -----LHETFlsIESKDhrlqnvKVILLLPrCSSLGV----------SNPVEFilneHEVTKVQ---------------A 405
Cdd:PRK14902 308 ldarkVHEKF--AEKFD------KILVDAP-CSGLGVirrkpdikynKTKEDI----ESLQEIQleilesvaqylkkggI 374
                        250       260
                 ....*....|....*....|..
gi 725503325 406 IVYCTCSVSKEENEDVVEKALE 427
Cdd:PRK14902 375 LVYSTCTIEKEENEEVIEAFLE 396
RsmB super family cl33775
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
406-464 4.09e-06

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG0144:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 49.62  E-value: 4.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 725503325 406 IVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIEL-----SMDRFF--RLE 464
Cdd:COG0144  374 LVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLRLlphrhGTDGFFiaRLR 438
 
Name Accession Description Interval E-value
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
214-427 1.00e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 51.72  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 214 INTSKISLEEVYNNLRRKGYSKVKSitSVNEKVYAVDqhcfnvlifpahlKTDLLNIDLIKDYKLIFQDKSRSLAVHSVK 293
Cdd:PRK14902 183 VNTLKISVEELIEKLEEEGYEVEES--LLSPEALVIE-------------KGNIAGTDLFKDGLITIQDESSMLVAPALD 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 294 alINIDDDVL----------------MVNTGswyTVAHMSIltsgHTSKIFVcgIQQeekdfNARklftRMGCQNIEI-- 355
Cdd:PRK14902 248 --PKGGDTVLdacaapggktthiaelLKNTG---KVVALDI----HEHKLKL--IEE-----NAK----RLGLTNIETka 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 356 -----LHETFlsIESKDhrlqnvKVILLLPrCSSLGV----------SNPVEFilneHEVTKVQ---------------A 405
Cdd:PRK14902 308 ldarkVHEKF--AEKFD------KILVDAP-CSGLGVirrkpdikynKTKEDI----ESLQEIQleilesvaqylkkggI 374
                        250       260
                 ....*....|....*....|..
gi 725503325 406 IVYCTCSVSKEENEDVVEKALE 427
Cdd:PRK14902 375 LVYSTCTIEKEENEEVIEAFLE 396
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
406-464 4.09e-06

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 49.62  E-value: 4.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 725503325 406 IVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIEL-----SMDRFF--RLE 464
Cdd:COG0144  374 LVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLRLlphrhGTDGFFiaRLR 438
 
Name Accession Description Interval E-value
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
214-427 1.00e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 51.72  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 214 INTSKISLEEVYNNLRRKGYSKVKSitSVNEKVYAVDqhcfnvlifpahlKTDLLNIDLIKDYKLIFQDKSRSLAVHSVK 293
Cdd:PRK14902 183 VNTLKISVEELIEKLEEEGYEVEES--LLSPEALVIE-------------KGNIAGTDLFKDGLITIQDESSMLVAPALD 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 294 alINIDDDVL----------------MVNTGswyTVAHMSIltsgHTSKIFVcgIQQeekdfNARklftRMGCQNIEI-- 355
Cdd:PRK14902 248 --PKGGDTVLdacaapggktthiaelLKNTG---KVVALDI----HEHKLKL--IEE-----NAK----RLGLTNIETka 307
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725503325 356 -----LHETFlsIESKDhrlqnvKVILLLPrCSSLGV----------SNPVEFilneHEVTKVQ---------------A 405
Cdd:PRK14902 308 ldarkVHEKF--AEKFD------KILVDAP-CSGLGVirrkpdikynKTKEDI----ESLQEIQleilesvaqylkkggI 374
                        250       260
                 ....*....|....*....|..
gi 725503325 406 IVYCTCSVSKEENEDVVEKALE 427
Cdd:PRK14902 375 LVYSTCTIEKEENEEVIEAFLE 396
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
406-464 4.09e-06

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 49.62  E-value: 4.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 725503325 406 IVYCTCSVSKEENEDVVEKALEyQSSGVKMQPYRLSPPVLPLCTLKEIEL-----SMDRFF--RLE 464
Cdd:COG0144  374 LVYSTCSLLPEENEEVVEAFLA-RHPDFELVPLAELLPGLALTDGGYLRLlphrhGTDGFFiaRLR 438
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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