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Conserved domains on  [gi|733606555|ref|NP_001290025|]
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WD repeat-containing protein 75 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-461 3.65e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 143 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 222
Cdd:COG2319  124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 223 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 302
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 303 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 382
Cdd:COG2319  279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 383 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 461
Cdd:COG2319  335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-252 2.60e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   7 KELYSCSLDGTIKLWDYIDGILIKTFivGCKLHALFTLAQAEDSvfvivnkekpdifQLVSvklpkSSSQ-------EVE 79
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-------------RILS-----SSSRdktikvwDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  80 AKELSFVLDYINQSPKCIAF-GNEGVYVAAVREFYLSVYFFKkkttsrfTLSSSRNKKHAKNNFTCVACHPTEDCIASGH 158
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 159 MDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAG 238
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                        250
                 ....*....|....
gi 733606555 239 DLFCTSHSDNKIII 252
Cdd:cd00200  274 KRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-461 3.65e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 143 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 222
Cdd:COG2319  124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 223 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 302
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 303 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 382
Cdd:COG2319  279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 383 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 461
Cdd:COG2319  335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-252 2.60e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   7 KELYSCSLDGTIKLWDYIDGILIKTFivGCKLHALFTLAQAEDSvfvivnkekpdifQLVSvklpkSSSQ-------EVE 79
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-------------RILS-----SSSRdktikvwDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  80 AKELSFVLDYINQSPKCIAF-GNEGVYVAAVREFYLSVYFFKkkttsrfTLSSSRNKKHAKNNFTCVACHPTEDCIASGH 158
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 159 MDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAG 238
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                        250
                 ....*....|....
gi 733606555 239 DLFCTSHSDNKIII 252
Cdd:cd00200  274 KRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-308 7.55e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 7.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   9 LYSCSLDGTIKLWDYIDGILIKTFivgcKLHALFtlaqAEDSVFVivnkekPDIFQLVSVKLPKSSSqeveakelsfVLD 88
Cdd:cd00200   24 LATGSGDGTIKVWDLETGELLRTL----KGHTGP----VRDVAAS------ADGTYLASGSSDKTIR----------LWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  89 YinQSPKCIafgnegvyvaavREFylsvyffkkkttsrftlsssrnkKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRN 168
Cdd:cd00200   80 L--ETGECV------------RTL-----------------------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 169 FYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDN 248
Cdd:cd00200  123 ETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 249 KIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNL 308
Cdd:cd00200  200 TIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
9-252 7.96e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 7.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   9 LYSCSLDGTIKLWDYIDGILIKTFivgcKLHalftlaqaEDSVF-VIVNkekPDIFQLVS------VKLPksssqEVEAK 81
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL----TGH--------TGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATG 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  82 ELSFVLDYINQSPKCIAFGNEGVYVAAVREfYLSVYFFKKKTTSRFTLsssrnKKHAKNNFTCVACHPTEDCIASGHMDG 161
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 162 KIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLF 241
Cdd:COG2319  311 TVRLWD--LATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        250
                 ....*....|.
gi 733606555 242 CTSHSDNKIII 252
Cdd:COG2319  388 ASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 143-166 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20
                   ....*....|....*....|....
gi 733606555   143 TCVACHPTEDCIASGHMDGKIRLW 166
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
143-166 5.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.92e-03
                          10        20
                  ....*....|....*....|....
gi 733606555  143 TCVACHPTEDCIASGHMDGKIRLW 166
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
143-461 3.65e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 143 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 222
Cdd:COG2319  124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 223 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 302
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 303 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 382
Cdd:COG2319  279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 383 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 461
Cdd:COG2319  335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-252 2.60e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   7 KELYSCSLDGTIKLWDYIDGILIKTFivGCKLHALFTLAQAEDSvfvivnkekpdifQLVSvklpkSSSQ-------EVE 79
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGECVRTL--TGHTSYVSSVAFSPDG-------------RILS-----SSSRdktikvwDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  80 AKELSFVLDYINQSPKCIAF-GNEGVYVAAVREFYLSVYFFKkkttsrfTLSSSRNKKHAKNNFTCVACHPTEDCIASGH 158
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFsPDGTFVASSSQDGTIKLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 159 MDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAG 238
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                        250
                 ....*....|....
gi 733606555 239 DLFCTSHSDNKIII 252
Cdd:cd00200  274 KRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-308 7.55e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 7.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   9 LYSCSLDGTIKLWDYIDGILIKTFivgcKLHALFtlaqAEDSVFVivnkekPDIFQLVSVKLPKSSSqeveakelsfVLD 88
Cdd:cd00200   24 LATGSGDGTIKVWDLETGELLRTL----KGHTGP----VRDVAAS------ADGTYLASGSSDKTIR----------LWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  89 YinQSPKCIafgnegvyvaavREFylsvyffkkkttsrftlsssrnkKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRN 168
Cdd:cd00200   80 L--ETGECV------------RTL-----------------------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 169 FYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDN 248
Cdd:cd00200  123 ETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 249 KIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNL 308
Cdd:cd00200  200 TIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
145-506 8.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 8.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 145 VACHPTEDCIASGHMDGKIRLWRnfyDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPR 224
Cdd:COG2319   84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 225 LGATIEHISVSPAGDLFCTSHSDNKIIIihRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQ 304
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 305 LYNLDiIQQEYINDygliqieltkAAF--GcfGNWLATVEQRQeketelelQMKLWmyNKKTqGFILNTKinMPHEDCIT 382
Cdd:COG2319  239 LRTLT-GHSGSVRS----------VAFspD--GRLLASGSADG--------TVRLW--DLAT-GELLRTL--TGHSGGVN 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 383 ALCFCNAEKseqpTLVTASKDGYFKVWiltddsDIYKKAVGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 461
Cdd:COG2319  293 SVAFSPDGK----LLASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 733606555 462 SVTWELKCTFCQRAGKIRHLCF---GRltcskYLLGATENGILCCWNL 506
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFspdGR-----TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
9-252 7.96e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 7.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   9 LYSCSLDGTIKLWDYIDGILIKTFivgcKLHalftlaqaEDSVF-VIVNkekPDIFQLVS------VKLPksssqEVEAK 81
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL----TGH--------TGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATG 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  82 ELSFVLDYINQSPKCIAFGNEGVYVAAVREfYLSVYFFKKKTTSRFTLsssrnKKHAKNNFTCVACHPTEDCIASGHMDG 161
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 162 KIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLF 241
Cdd:COG2319  311 TVRLWD--LATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                        250
                 ....*....|.
gi 733606555 242 CTSHSDNKIII 252
Cdd:COG2319  388 ASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
180-506 2.22e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 180 LHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIihRNLEA 259
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL--WDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 260 SAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDIiQQEYINDygliqieltkAAFGCFGNWLA 339
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTS----------VAFSPDGKLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 340 TVEQRQeketelelQMKLWmyNKKTQGFILNTKinmPHEDCITALCFCNAEKseqpTLVTASKDGYFKVWiltddsDIYK 419
Cdd:COG2319  179 SGSDDG--------TVRLW--DLATGKLLRTLT---GHTGAVRSVAFSPDGK----LLASGSADGTVRLW------DLAT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 420 KAVGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWDSVTWELKCTFCQRAGKIRHLCF---GRltcskYLLGA 495
Cdd:COG2319  236 GKLLRT--LTG--HSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspdGK-----LLASG 306

                        330
                 ....*....|.
gi 733606555 496 TENGILCCWNL 506
Cdd:COG2319  307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-471 4.04e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 4.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 143 TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWR-DATEKNKEF 221
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 222 LPRLGAtIEHISVSPAGDLFCTSHSDNKIIIihrnleasaviqglvkdrsiftglmidprtkalvlngkpghlqfYSLQS 301
Cdd:cd00200   90 TGHTSY-VSSVAFSPDGRILSSSSRDKTIKV--------------------------------------------WDVET 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 302 DKQLYNLdiiqqEYINDYgliqieLTKAAFGCFGNWLATVEQrqeketelELQMKLWmyNKKTQGFIlntKINMPHEDCI 381
Cdd:cd00200  125 GKCLTTL-----RGHTDW------VNSVAFSPDGTFVASSSQ--------DGTIKLW--DLRTGKCV---ATLTGHTGEV 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 382 TALCFCNAEKSeqptLVTASKDGYFKVWiltddsDIYKKAvgWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIVT-IW 460
Cdd:cd00200  181 NSVAFSPDGEK----LLSSSSDGTIKLW------DLSTGK--CLGTLRG--HENGVNSVAFSPDGYLLASGSEDGTIrVW 246

                        330
                 ....*....|.
gi 733606555 461 DSVTWELKCTF 471
Cdd:cd00200  247 DLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-409 1.60e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 143 TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 222
Cdd:cd00200   55 RDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 223 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 302
Cdd:cd00200  132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 303 KQLYNLdIIQQEYINDygliqieltkAAFGCFGNWLATVEQRQeketelelqmKLWMYNKKTQGFIlnTKINMpHEDCIT 382
Cdd:cd00200  210 KCLGTL-RGHENGVNS----------VAFSPDGYLLASGSEDG----------TIRVWDLRTGECV--QTLSG-HTNSVT 265

                        250       260
                 ....*....|....*....|....*..
gi 733606555 383 ALCFCNaeksEQPTLVTASKDGYFKVW 409
Cdd:cd00200  266 SLAWSP----DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
9-215 9.63e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 9.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555   9 LYSCSLDGTIKLWDYIDGILIKTFivgcKLHalftlaqaEDSVF-VIVNkekPDIFQLVSVklpkSSSQEV-----EAKE 82
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTL----TGH--------SGSVRsVAFS---PDGRLLASG----SADGTVrlwdlATGE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555  83 LSFVLDYINQSPKCIAFGNEGVYVAAVREFYlSVYFFKKKT-TSRFTLSSSRNKkhaknnFTCVACHPTEDCIASGHMDG 161
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDG-TVRLWDLATgKLLRTLTGHTGA------VRSVAFSPDGKTLASGSDDG 352

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 733606555 162 KIRLWRNfyDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDAT 215
Cdd:COG2319  353 TVRLWDL--ATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 377-509 1.15e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 377 HEDCITALCFCnaekSEQPTLVTASKDGYFKVWiltDDSDIYKKAVgwtcdFVGsyHKYQATNCCFSEDGSLLAVSFEE- 455
Cdd:cd00200  134 HTDWVNSVAFS----PDGTFVASSSQDGTIKLW---DLRTGKCVAT-----LTG--HTGEVNSVAFSPDGEKLLSSSSDg 199

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 733606555 456 IVTIWDSVTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGATENGILCCWNLLSC 509
Cdd:cd00200  200 TIKLWDLSTGKCLGTLRGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRTG 251
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 143-166 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.41e-03
                           10        20
                   ....*....|....*....|....
gi 733606555   143 TCVACHPTEDCIASGHMDGKIRLW 166
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 377-508 3.37e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 377 HEDCITALCFCNaeksEQPTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGSYHKYQATNCCfSEDGSLLAVSFEEI 456
Cdd:cd00200    8 HTGGVTCVAFSP----DGKLLATGSGDGTIKVWDLETGELLRT--------LKGHTGPVRDVAAS-ADGTYLASGSSDKT 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 733606555 457 VTIWDSVTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGATENGILCCWNLLS 508
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
143-166 5.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.92e-03
                          10        20
                  ....*....|....*....|....
gi 733606555  143 TCVACHPTEDCIASGHMDGKIRLW 166
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 377-483 8.67e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 8.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606555 377 HEDCITALCFcnaeKSEQPTLVTASKDGYFKVWiltdDSDIYKkavgwtCDFVGSYHKYQATNCCFSEDGSLLAV-SFEE 455
Cdd:cd00200   92 HTSYVSSVAF----SPDGRILSSSSRDKTIKVW----DVETGK------CLTTLRGHTDWVNSVAFSPDGTFVASsSQDG 157

                         90       100
                 ....*....|....*....|....*...
gi 733606555 456 IVTIWDSVTWELKCTFCQRAGKIRHLCF 483
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAF 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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