TSSK6-activating co-chaperone protein isoform b [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SSTK-IP super family | cl24415 | SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting ... |
1-57 | 6.91e-26 | ||
SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, thus represents the first germ cell-specific co-chaperone and protein kinase that requires the HSP90 machinery for catalytic activation. The actual alignment was detected with superfamily member pfam15836: Pssm-ID: 406308 Cd Length: 125 Bit Score: 93.13 E-value: 6.91e-26
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| Name | Accession | Description | Interval | E-value | ||
| SSTK-IP | pfam15836 | SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting ... |
1-57 | 6.91e-26 | ||
SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, thus represents the first germ cell-specific co-chaperone and protein kinase that requires the HSP90 machinery for catalytic activation. Pssm-ID: 406308 Cd Length: 125 Bit Score: 93.13 E-value: 6.91e-26
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| Name | Accession | Description | Interval | E-value | ||
| SSTK-IP | pfam15836 | SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting ... |
1-57 | 6.91e-26 | ||
SSTK-interacting protein, TSSK6-activating co-chaperone protein; SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, thus represents the first germ cell-specific co-chaperone and protein kinase that requires the HSP90 machinery for catalytic activation. Pssm-ID: 406308 Cd Length: 125 Bit Score: 93.13 E-value: 6.91e-26
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