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Conserved domains on  [gi|817473231|ref|NP_001295324|]
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EF-hand domain-containing protein D1 isoform 3 [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 502)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
2-40 7.87e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 7.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 817473231   2 ELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFL 40
Cdd:cd00051   21 ELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFL 59
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
2-40 7.87e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 7.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 817473231   2 ELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFL 40
Cdd:cd00051   21 ELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFL 59
PTZ00184 PTZ00184
calmodulin; Provisional
2-40 3.38e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 35.12  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 817473231   2 ELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFL 40
Cdd:PTZ00184  32 ELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL 70
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
2-40 7.87e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 7.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 817473231   2 ELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFL 40
Cdd:cd00051   21 ELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFL 59
PTZ00184 PTZ00184
calmodulin; Provisional
2-40 3.38e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 35.12  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 817473231   2 ELKLMMEKLGAPQTHLGLKSMIKEVDEDFDGKLSFREFL 40
Cdd:PTZ00184  32 ELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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