ketohexokinase isoform 3 [Mus musculus]
ketohexokinase( domain architecture ID 10112592)
ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose; it can also phosphorylate several other furanose sugars
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
Ketohexokinase | cd01939 | Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to ... |
5-250 | 1.39e-128 | |||||
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes where it is believed to function as a dimer and requires K(+) and ATP to be active. In humans, hepatic KHK deficiency causes fructosuria, a benign inborn error of metabolism. : Pssm-ID: 238914 [Multi-domain] Cd Length: 290 Bit Score: 365.58 E-value: 1.39e-128
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
Ketohexokinase | cd01939 | Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to ... |
5-250 | 1.39e-128 | |||||
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes where it is believed to function as a dimer and requires K(+) and ATP to be active. In humans, hepatic KHK deficiency causes fructosuria, a benign inborn error of metabolism. Pssm-ID: 238914 [Multi-domain] Cd Length: 290 Bit Score: 365.58 E-value: 1.39e-128
|
|||||||||
RbsK | COG0524 | Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ... |
5-244 | 1.93e-26 | |||||
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis Pssm-ID: 440290 [Multi-domain] Cd Length: 301 Bit Score: 104.20 E-value: 1.93e-26
|
|||||||||
PfkB | pfam00294 | pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ... |
6-248 | 5.13e-14 | |||||
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases. Pssm-ID: 425587 [Multi-domain] Cd Length: 294 Bit Score: 70.06 E-value: 5.13e-14
|
|||||||||
D_ribokin_bact | TIGR02152 | ribokinase; This model describes ribokinase, an enzyme catalyzing the first step in ribose ... |
156-240 | 1.91e-09 | |||||
ribokinase; This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars] Pssm-ID: 274000 [Multi-domain] Cd Length: 293 Bit Score: 56.84 E-value: 1.91e-09
|
|||||||||
PRK11142 | PRK11142 | ribokinase; Provisional |
188-236 | 1.72e-05 | |||||
ribokinase; Provisional Pssm-ID: 236858 [Multi-domain] Cd Length: 306 Bit Score: 44.86 E-value: 1.72e-05
|
|||||||||
Name | Accession | Description | Interval | E-value | |||||
Ketohexokinase | cd01939 | Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to ... |
5-250 | 1.39e-128 | |||||
Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes where it is believed to function as a dimer and requires K(+) and ATP to be active. In humans, hepatic KHK deficiency causes fructosuria, a benign inborn error of metabolism. Pssm-ID: 238914 [Multi-domain] Cd Length: 290 Bit Score: 365.58 E-value: 1.39e-128
|
|||||||||
RbsK | COG0524 | Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar ... |
5-244 | 1.93e-26 | |||||
Sugar or nucleoside kinase, ribokinase family [Carbohydrate transport and metabolism]; Sugar or nucleoside kinase, ribokinase family is part of the Pathway/BioSystem: Glycolysis Pssm-ID: 440290 [Multi-domain] Cd Length: 301 Bit Score: 104.20 E-value: 1.93e-26
|
|||||||||
ribokinase_group_B | cd01945 | Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ... |
5-251 | 2.21e-20 | |||||
Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. . Pssm-ID: 238920 [Multi-domain] Cd Length: 284 Bit Score: 87.35 E-value: 2.21e-20
|
|||||||||
ribokinase_pfkB_like | cd00287 | ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ... |
6-223 | 1.65e-14 | |||||
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase). Pssm-ID: 238177 [Multi-domain] Cd Length: 196 Bit Score: 69.82 E-value: 1.65e-14
|
|||||||||
PfkB | pfam00294 | pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine ... |
6-248 | 5.13e-14 | |||||
pfkB family carbohydrate kinase; This family includes a variety of carbohydrate and pyrimidine kinases. Pssm-ID: 425587 [Multi-domain] Cd Length: 294 Bit Score: 70.06 E-value: 5.13e-14
|
|||||||||
ribokinase_group_A | cd01942 | Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ... |
6-243 | 5.21e-14 | |||||
Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238917 [Multi-domain] Cd Length: 279 Bit Score: 69.65 E-value: 5.21e-14
|
|||||||||
KdgK | cd01166 | 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form ... |
127-248 | 7.98e-12 | |||||
2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources. Pssm-ID: 238571 [Multi-domain] Cd Length: 294 Bit Score: 63.75 E-value: 7.98e-12
|
|||||||||
ribokinase | cd01174 | Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This ... |
188-241 | 2.65e-10 | |||||
Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution. Pssm-ID: 238579 [Multi-domain] Cd Length: 292 Bit Score: 59.10 E-value: 2.65e-10
|
|||||||||
D_ribokin_bact | TIGR02152 | ribokinase; This model describes ribokinase, an enzyme catalyzing the first step in ribose ... |
156-240 | 1.91e-09 | |||||
ribokinase; This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars] Pssm-ID: 274000 [Multi-domain] Cd Length: 293 Bit Score: 56.84 E-value: 1.91e-09
|
|||||||||
Fructoselysine_kinase_like | cd01940 | Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a ... |
18-248 | 8.02e-09 | |||||
Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the lysine side chains. Fructoseamines are typically metabolized by fructoseamine-3-kinase, especially in higher eukaryotes. In E. coli, fructoselysine kinase has been shown in vitro to catalyze the phosphorylation of fructoselysine. It is proposed that fructoselysine is released from glycated proteins during human digestion and is partly metabolized by bacteria in the hind gut using a protein such as fructoselysine kinase. This family is found only in bacterial sequences, and its oligomeric state is currently unknown. Pssm-ID: 238915 [Multi-domain] Cd Length: 264 Bit Score: 54.67 E-value: 8.02e-09
|
|||||||||
adenosine_kinase | cd01168 | Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside ... |
3-248 | 2.28e-08 | |||||
Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway. Pssm-ID: 238573 [Multi-domain] Cd Length: 312 Bit Score: 53.77 E-value: 2.28e-08
|
|||||||||
FruK | COG1105 | 1-phosphofructokinase or 6-phosphofructokinase II [Carbohydrate transport and metabolism]; |
156-236 | 3.90e-08 | |||||
1-phosphofructokinase or 6-phosphofructokinase II [Carbohydrate transport and metabolism]; Pssm-ID: 440722 [Multi-domain] Cd Length: 304 Bit Score: 52.83 E-value: 3.90e-08
|
|||||||||
bac_FRK | cd01167 | Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for ... |
180-248 | 5.50e-08 | |||||
Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate. Pssm-ID: 238572 [Multi-domain] Cd Length: 295 Bit Score: 52.64 E-value: 5.50e-08
|
|||||||||
FruK_PfkB_like | cd01164 | 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. ... |
73-236 | 8.92e-08 | |||||
1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis. Pssm-ID: 238570 [Multi-domain] Cd Length: 289 Bit Score: 51.76 E-value: 8.92e-08
|
|||||||||
Guanosine_kinase_like | cd01947 | Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like ... |
182-242 | 4.27e-06 | |||||
Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238922 [Multi-domain] Cd Length: 265 Bit Score: 46.64 E-value: 4.27e-06
|
|||||||||
YegV_kinase_like | cd01944 | YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase ... |
156-241 | 4.76e-06 | |||||
YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238919 [Multi-domain] Cd Length: 289 Bit Score: 46.65 E-value: 4.76e-06
|
|||||||||
YeiC_kinase_like | cd01941 | YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ... |
188-243 | 7.40e-06 | |||||
YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238916 [Multi-domain] Cd Length: 288 Bit Score: 46.15 E-value: 7.40e-06
|
|||||||||
RfaE | COG2870 | ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane ... |
157-241 | 1.48e-05 | |||||
ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442117 [Multi-domain] Cd Length: 321 Bit Score: 45.19 E-value: 1.48e-05
|
|||||||||
PRK11142 | PRK11142 | ribokinase; Provisional |
188-236 | 1.72e-05 | |||||
ribokinase; Provisional Pssm-ID: 236858 [Multi-domain] Cd Length: 306 Bit Score: 44.86 E-value: 1.72e-05
|
|||||||||
ribokinase_group_D | cd01937 | Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ... |
5-243 | 2.57e-05 | |||||
Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238912 [Multi-domain] Cd Length: 254 Bit Score: 44.31 E-value: 2.57e-05
|
|||||||||
ribokinase_group_C | cd01946 | Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase ... |
127-237 | 3.92e-05 | |||||
Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time. Pssm-ID: 238921 [Multi-domain] Cd Length: 277 Bit Score: 43.99 E-value: 3.92e-05
|
|||||||||
PRK09813 | PRK09813 | fructoselysine 6-kinase; Provisional |
166-248 | 5.65e-05 | |||||
fructoselysine 6-kinase; Provisional Pssm-ID: 182090 [Multi-domain] Cd Length: 260 Bit Score: 43.19 E-value: 5.65e-05
|
|||||||||
RfaE_like | cd01172 | RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the ... |
182-245 | 5.96e-05 | |||||
RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer membrane of gram-negative bacteria. RfaE consists of two domains, a sugar kinase domain, represented here, and a domain belonging to the cytidylyltransferase superfamily. Pssm-ID: 238577 [Multi-domain] Cd Length: 304 Bit Score: 43.32 E-value: 5.96e-05
|
|||||||||
PTZ00292 | PTZ00292 | ribokinase; Provisional |
3-63 | 5.19e-04 | |||||
ribokinase; Provisional Pssm-ID: 185541 [Multi-domain] Cd Length: 326 Bit Score: 40.49 E-value: 5.19e-04
|
|||||||||
fruK | PRK09513 | 1-phosphofructokinase; Provisional |
174-240 | 1.44e-03 | |||||
1-phosphofructokinase; Provisional Pssm-ID: 181923 [Multi-domain] Cd Length: 312 Bit Score: 39.29 E-value: 1.44e-03
|
|||||||||
PRK09434 | PRK09434 | aminoimidazole riboside kinase; Provisional |
157-231 | 2.35e-03 | |||||
aminoimidazole riboside kinase; Provisional Pssm-ID: 236514 [Multi-domain] Cd Length: 304 Bit Score: 38.38 E-value: 2.35e-03
|
|||||||||
PLN02379 | PLN02379 | pfkB-type carbohydrate kinase family protein |
75-237 | 8.27e-03 | |||||
pfkB-type carbohydrate kinase family protein Pssm-ID: 178005 [Multi-domain] Cd Length: 367 Bit Score: 37.08 E-value: 8.27e-03
|
|||||||||
Blast search parameters | ||||
|