Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 894216091   138 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 181
Cdd:smart00135   1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Calcium-binding EGF domain;

                          10        20
                  ....*....|....*....|....*....
gi 894216091  418 DIDECQRGAHNCGENAACTNTEGGYNCTC 446
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRC 29

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 894216091  376 DIDECVLARSDCPSTSSrCINTEGGYVCRCSEG 408
Cdd:pfam07645   1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32

EGF-like protein; Provisional

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 894216091 481 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 518
Cdd:PHA02887  86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 894216091   138 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 181
Cdd:smart00135   1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 894216091    52 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 94
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 894216091     9 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 51
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 894216091  159 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 199
Cdd:pfam00058   1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 894216091  250 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 285
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20
                 ....*....|....*....|....*....
gi 894216091 418 DIDECQRGaHNCGENAACTNTEGGYNCTC 446
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 894216091 376 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 412
Cdd:cd00054    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216091  71 GRRIYWTDSGKSVVGGSDL-SGKHHRIIIQerISRPRGIAVHPRARRLFWTDvgmspriesaslQGSDRVLI---ASSNL 146
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLaTGKVVATIPV--GGGPRGLAVDPDGGRLYVAD------------SGNGRVSVidtATGKV 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 894216091 147 L-------EPSGITIDYLTDTLYWCDTKR-------SVIEMAnlDGSKRRRLiqnDVG-HPFSLAVFED--HLWVSD 206
Cdd:COG3391  145 VatipvgaGPHGIAVDPDGKRLYVANSGSntvsvivSVIDTA--TGKVVATI---PVGgGPVGVAVSPDgrRLYVAN 216

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 894216091   182 RRLIQNDVGHPFSLAV--FEDHLWVSDWAIPsVIRVNKRTGQNR 223
Cdd:smart00135   1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 894216091   138 RVLIaSSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKR 181
Cdd:smart00135   1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 894216091    52 ERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHH 94
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 894216091     9 KVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQR 51
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 894216091  159 DTLYWCDTK-RSVIEMANLDGSKRRRLIQNDVGHPFSLAVFE 199
Cdd:pfam00058   1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 894216091  250 CLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 285
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20
                  ....*....|....*....|...
gi 894216091  394 CINTEGGYVCRCSEGYEGDGISC 416
Cdd:pfam12947  14 CTNTGGSFTCTCNDGYTGDGVTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20
                 ....*....|....*....|....*....
gi 894216091 418 DIDECQRGaHNCGENAACTNTEGGYNCTC 446
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 894216091 376 DIDECVLaRSDCPStSSRCINTEGGYVCRCSEGYEGD 412
Cdd:cd00054    1 DIDECAS-GNPCQN-GGTCVNTVGSYRCSCPPGYTGR 35

epidermal growth factor-like protein (EGF-like protein); Provisional

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 894216091 481 CPSSYDGYCLNGgVCMHIESLDSYTCNCVIGYSGDRCQ 518
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|
gi 894216091 489 CLNGGVCmhIESLDSYTCNCVIGYSGDRCQ 518
Cdd:cd00054   11 CQNGGTC--VNTVGSYRCSCPPGYTGRNCE 38