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Conserved domains on  [gi|926234440|ref|NP_001300817|]
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interleukin-7 isoform b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL7 super family cl11602
Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid ...
1-111 1.99e-65

Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


The actual alignment was detected with superfamily member smart00127:

Pssm-ID: 448322  Cd Length: 146  Bit Score: 194.50  E-value: 1.99e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926234440     1 MISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSK-- 78
Cdd:smart00127  16 MVSIDQLDKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLTVSQGTQTLLNCTSKgk 95
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 926234440    79 -----------------EEKNVKEQKK-NDACFLKRLLREIKTCWNKILKG 111
Cdd:smart00127  96 grkppslgeaqptknleENKSLKEQKKqNDLCFLKRLLQEIKTCWNKILKG 146
 
Name Accession Description Interval E-value
IL7 smart00127
Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for ...
1-111 1.99e-65

Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 128432  Cd Length: 146  Bit Score: 194.50  E-value: 1.99e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926234440     1 MISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSK-- 78
Cdd:smart00127  16 MVSIDQLDKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLTVSQGTQTLLNCTSKgk 95
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 926234440    79 -----------------EEKNVKEQKK-NDACFLKRLLREIKTCWNKILKG 111
Cdd:smart00127  96 grkppslgeaqptknleENKSLKEQKKqNDLCFLKRLLQEIKTCWNKILKG 146
IL7 pfam01415
Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid ...
1-112 9.64e-47

Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 426253  Cd Length: 134  Bit Score: 146.54  E-value: 9.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926234440    1 MISIDEL-DKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSKE 79
Cdd:pfam01415  17 MVSINELlDKMIEFDSNCLNNESNFFKKHSCDDNKEATFLNRAACKLKQFLKMNISEDFNLHLSKVSEGTLKLLNCTSKE 96
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 926234440   80 EKNVKEQKK--NDACFLKRLLREIKTCWNKILKGS 112
Cdd:pfam01415  97 ENKSLKEQKkqNDFCFLKTLLQKIKTCWNKILMGS 131
 
Name Accession Description Interval E-value
IL7 smart00127
Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for ...
1-111 1.99e-65

Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 128432  Cd Length: 146  Bit Score: 194.50  E-value: 1.99e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926234440     1 MISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSK-- 78
Cdd:smart00127  16 MVSIDQLDKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLTVSQGTQTLLNCTSKgk 95
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 926234440    79 -----------------EEKNVKEQKK-NDACFLKRLLREIKTCWNKILKG 111
Cdd:smart00127  96 grkppslgeaqptknleENKSLKEQKKqNDLCFLKRLLQEIKTCWNKILKG 146
IL7 pfam01415
Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid ...
1-112 9.64e-47

Interleukin 7/9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 426253  Cd Length: 134  Bit Score: 146.54  E-value: 9.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926234440    1 MISIDEL-DKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSKE 79
Cdd:pfam01415  17 MVSINELlDKMIEFDSNCLNNESNFFKKHSCDDNKEATFLNRAACKLKQFLKMNISEDFNLHLSKVSEGTLKLLNCTSKE 96
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 926234440   80 EKNVKEQKK--NDACFLKRLLREIKTCWNKILKGS 112
Cdd:pfam01415  97 ENKSLKEQKkqNDFCFLKTLLQKIKTCWNKILMGS 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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