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Conserved domains on  [gi|941355818|ref|NP_001303678|]
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ras-GEF domain-containing family member 1A isoform 2 [Mus musculus]

Protein Classification

guanine nucleotide exchange factor (domain architecture ID 10153535)

Ras-GEF domain-containing protein functions as a guanine nucleotide exchange factor (GEF) that activates GTPase by mediating the replacement of GDP with GTP

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
217-411 7.94e-57

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


:

Pssm-ID: 395492  Cd Length: 179  Bit Score: 186.23  E-value: 7.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  217 VLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNhrcrgdmtKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEF 296
Cdd:pfam00617   1 ELARQLTLIEFELFRKIKPRELLGYAWSKKDKKK--------ASPNIEAMIARFNKLSNWVASEILSEEDPKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  297 FIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRsqtanss 373
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKLLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 941355818  374 rekiVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFW 411
Cdd:pfam00617 146 ----CIPFLGLYLKDLTFIEEGNPDFLEDGLINFEKRR 179
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
49-176 2.60e-21

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


:

Pssm-ID: 100121  Cd Length: 122  Bit Score: 89.01  E-value: 2.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  49 SLEALMEHLVPTVDYyPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFST--KIVQLLKEWTE 126
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWDKKKSKPIrlRVLNVLRTWVE 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 941355818 127 AFPYDFQ-DEKVMAELKAIAHRVTQCDeengtvkkAIAQMIQSLLLSLAAR 176
Cdd:cd06224   80 NYPYDFFdDEELLELLEEFLNRLVQEG--------ALLQELKKLLRKLLKL 122
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
217-411 7.94e-57

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 395492  Cd Length: 179  Bit Score: 186.23  E-value: 7.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  217 VLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNhrcrgdmtKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEF 296
Cdd:pfam00617   1 ELARQLTLIEFELFRKIKPRELLGYAWSKKDKKK--------ASPNIEAMIARFNKLSNWVASEILSEEDPKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  297 FIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRsqtanss 373
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKLLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 941355818  374 rekiVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFW 411
Cdd:pfam00617 146 ----CIPFLGLYLKDLTFIEEGNPDFLEDGLINFEKRR 179
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
214-462 4.89e-52

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 175.90  E-value: 4.89e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   214 DPLVLAQQLTHIELERVNSIRPEDLMQIISHmdsldnhRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRM 293
Cdd:smart00147   5 DPKELAEQLTLLDFELFRKIDPSELLGSVWG-------KRSKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAEL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   294 LEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQGATQrsqta 370
Cdd:smart00147  78 LSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLpsKYKKlFEELEELLSPERNYKNYREALSSCNL----- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   371 nssreKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKK-IQSYV--LTAPIYS 447
Cdd:smart00147 153 -----PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSdIQSLLqqLLDHLDE 227
                          250
                   ....*....|....*
gi 941355818   448 EEALFIASFESEGPE 462
Cdd:smart00147 228 EEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
214-457 7.02e-51

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087  Cd Length: 237  Bit Score: 172.82  E-value: 7.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 214 DPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRgdmtktfSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRM 293
Cdd:cd00155    5 DPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKNIHLSP-------NLERFIERFNNLSNWVASEILLCTNPKKRARL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 294 LEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALqgatqrsqtA 370
Cdd:cd00155   78 LSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLssKLKKlFEELEELVDPSRNFKNYRKLL---------K 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 371 NSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLT--APIYSE 448
Cdd:cd00155  149 SVGPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKllELILNE 228

                 ....*....
gi 941355818 449 EALFIASFE 457
Cdd:cd00155  229 DELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
49-176 2.60e-21

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 89.01  E-value: 2.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  49 SLEALMEHLVPTVDYyPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFST--KIVQLLKEWTE 126
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWDKKKSKPIrlRVLNVLRTWVE 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 941355818 127 AFPYDFQ-DEKVMAELKAIAHRVTQCDeengtvkkAIAQMIQSLLLSLAAR 176
Cdd:cd06224   80 NYPYDFFdDEELLELLEEFLNRLVQEG--------ALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
47-138 9.32e-15

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 395493  Cd Length: 104  Bit Score: 70.03  E-value: 9.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   47 SGSLEALMEHLVPTvDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFST---KIVQLLKE 123
Cdd:pfam00618   4 AGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSVLRH 82
                          90
                  ....*....|....*
gi 941355818  124 WTEAFPYDFQDEKVM 138
Cdd:pfam00618  83 WVENYFSDFNDDPVL 97
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
41-169 6.10e-12

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 62.74  E-value: 6.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818    41 QDGRLTSGSLEALMEHLVPTvDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQ--ICLEQRQQLEAGPEKAKLKSfstKIV 118
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLYryNAIPPESWVEEKVNPRRVKN---RVL 76
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 941355818   119 QLLKEWTEAFPYDFQDEKVMAE-LKAIAHRVTQcDEENGTVKKaIAQMIQSL 169
Cdd:smart00229  77 NILRTWVENYWEDFEDDPKLISfLLEFLELVDD-EKYPGLVTS-LLNLLRRL 126
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
217-411 7.94e-57

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 395492  Cd Length: 179  Bit Score: 186.23  E-value: 7.94e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  217 VLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNhrcrgdmtKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEF 296
Cdd:pfam00617   1 ELARQLTLIEFELFRKIKPRELLGYAWSKKDKKK--------ASPNIEAMIARFNKLSNWVASEILSEEDPKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  297 FIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRsqtanss 373
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKLLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 941355818  374 rekiVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFW 411
Cdd:pfam00617 146 ----CIPFLGLYLKDLTFIEEGNPDFLEDGLINFEKRR 179
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
214-462 4.89e-52

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 175.90  E-value: 4.89e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   214 DPLVLAQQLTHIELERVNSIRPEDLMQIISHmdsldnhRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRM 293
Cdd:smart00147   5 DPKELAEQLTLLDFELFRKIDPSELLGSVWG-------KRSKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAEL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   294 LEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQGATQrsqta 370
Cdd:smart00147  78 LSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLpsKYKKlFEELEELLSPERNYKNYREALSSCNL----- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   371 nssreKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKK-IQSYV--LTAPIYS 447
Cdd:smart00147 153 -----PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSdIQSLLqqLLDHLDE 227
                          250
                   ....*....|....*
gi 941355818   448 EEALFIASFESEGPE 462
Cdd:smart00147 228 EEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
214-457 7.02e-51

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087  Cd Length: 237  Bit Score: 172.82  E-value: 7.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 214 DPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRgdmtktfSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRM 293
Cdd:cd00155    5 DPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKNIHLSP-------NLERFIERFNNLSNWVASEILLCTNPKKRARL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 294 LEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALqgatqrsqtA 370
Cdd:cd00155   78 LSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLssKLKKlFEELEELVDPSRNFKNYRKLL---------K 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818 371 NSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLT--APIYSE 448
Cdd:cd00155  149 SVGPNPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKllELILNE 228

                 ....*....
gi 941355818 449 EALFIASFE 457
Cdd:cd00155  229 DELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
49-176 2.60e-21

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 89.01  E-value: 2.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818  49 SLEALMEHLVPTVDYyPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFST--KIVQLLKEWTE 126
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPENLEYNDWDKKKSKPIrlRVLNVLRTWVE 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 941355818 127 AFPYDFQ-DEKVMAELKAIAHRVTQCDeengtvkkAIAQMIQSLLLSLAAR 176
Cdd:cd06224   80 NYPYDFFdDEELLELLEEFLNRLVQEG--------ALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
47-138 9.32e-15

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 395493  Cd Length: 104  Bit Score: 70.03  E-value: 9.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818   47 SGSLEALMEHLVPTvDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFST---KIVQLLKE 123
Cdd:pfam00618   4 AGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSVLRH 82
                          90
                  ....*....|....*
gi 941355818  124 WTEAFPYDFQDEKVM 138
Cdd:pfam00618  83 WVENYFSDFNDDPVL 97
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
41-169 6.10e-12

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 62.74  E-value: 6.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941355818    41 QDGRLTSGSLEALMEHLVPTvDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQ--ICLEQRQQLEAGPEKAKLKSfstKIV 118
Cdd:smart00229   1 DGGLIKGGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLYryNAIPPESWVEEKVNPRRVKN---RVL 76
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 941355818   119 QLLKEWTEAFPYDFQDEKVMAE-LKAIAHRVTQcDEENGTVKKaIAQMIQSL 169
Cdd:smart00229  77 NILRTWVENYWEDFEDDPKLISfLLEFLELVDD-EKYPGLVTS-LLNLLRRL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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