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Conserved domains on  [gi|948284388|ref|NP_001303887|]
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mth938 domain-containing protein isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mth938-like super family cl00182
Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and ...
 5-93 4.44e-31

Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. 2P1 is a partially characterized nuclear protein which is homologous to E3-3 from rat and known to be alternately spliced. Xcr35 and Rpa2829 are hypothetical proteins of unknown function from the Xanthomonas campestris and Rhodopseudomonas palustris genomes, respectively, for which the crystal structures have been determined.


The actual alignment was detected with superfamily member cd05126:

Pssm-ID: 469644  Cd Length: 117  Bit Score: 107.42  E-value: 4.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284388   5 EIASLSWGQMKVKGSNTTYkDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYEH-DIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284388  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-93 4.44e-31

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 107.42  E-value: 4.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284388   5 EIASLSWGQMKVKGSNTTYkDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYEH-DIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284388  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-88 8.28e-06

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 41.74  E-value: 8.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284388    6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGM-----SEALKAPT 79
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGArvlflPPELREAL 72


                  ....*....
gi 948284388   80 QQLPSGVHV 88
Cdd:pfam04430  73 RKRGIGVEV 81
 
Name Accession Description Interval E-value
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 5-93 4.44e-31

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 107.42  E-value: 4.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284388   5 EIASLSWGQMKVKGSNTTYkDCKVWPGGSRTWDWRETG--TEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKAP--TQ 80
Cdd:cd05126    1 EIESTSFGSITVGGETYEH-DIVVYPDGSRARRWKELSkkTGTSHGLQPEELEELLEEGVEVIVIGTGQSGALKVPpeTV 79

                         90
                 ....*....|...
gi 948284388  81 QLPSGVHVRAVVQ 93
Cdd:cd05126   80 EKLEKRGVEVLVL 92
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 6-88 8.28e-06

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 41.74  E-value: 8.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284388    6 IASLSWGQMKVKGsnTTY-KDCKVWPGGSRTWDwretgTEHSPGVQPADVKEVVEKgVQTLVIGRGM-----SEALKAPT 79
Cdd:pfam04430   1 IDGYGFGGFRVNG--VRYrGSLLVLPGGVFAWD-----VTKGEDLTPEDLALLLAD-PEVLIIGTGArvlflPPELREAL 72


                  ....*....
gi 948284388   80 QQLPSGVHV 88
Cdd:pfam04430  73 RKRGIGVEV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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