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Conserved domains on  [gi|962305318|ref|NP_001304875|]
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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 190-372 8.54e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


:

Pssm-ID: 428158  Cd Length: 186  Bit Score: 207.43  E-value: 8.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  190 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 257
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  258 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 325
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 962305318  326 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 372
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-98 2.24e-54

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


:

Pssm-ID: 411036  Cd Length: 88  Bit Score: 174.34  E-value: 2.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHDHgyTTLATSVTLLKASEVE 88
Cdd:cd21086    1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVELGLSQ--HSLATNVTLLKASEVE 78

                         90
                 ....*....|
gi 962305318  89 EILDGNDEKY 98
Cdd:cd21086   79 EILAGNDEKY 88
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 190-372 8.54e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 207.43  E-value: 8.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  190 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 257
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  258 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 325
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 962305318  326 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 372
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-98 2.24e-54

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411036  Cd Length: 88  Bit Score: 174.34  E-value: 2.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHDHgyTTLATSVTLLKASEVE 88
Cdd:cd21086    1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVELGLSQ--HSLATNVTLLKASEVE 78

                         90
                 ....*....|
gi 962305318  89 EILDGNDEKY 98
Cdd:cd21086   79 EILAGNDEKY 88
 
Name Accession Description Interval E-value
SNF5 pfam04855
SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ...
 190-372 8.54e-66

SNF5 / SMARCB1 / INI1; SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterized so far. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs).


Pssm-ID: 428158  Cd Length: 186  Bit Score: 207.43  E-value: 8.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  190 SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPL---TFVPAIASAIRQQIESY--------- 257
Cdd:pfam04855   1 ELPETLVPIRIDLDIDKYRLRDTFTWNLHETLITPEQFAQTLCEDLDLPNEpapAFADQIAKQIREQLEEYagvalhplp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  258 ------------PTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIR 325
Cdd:pfam04855  81 yphveeeddpldPDLPYLNPDDDLRILIKLDITIGNHLLTDQFEWDLLSPLNTPEEFAKQTCADLGLSGEFVTAIAHAIR 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 962305318  326 GQLSWHQKtYAFSenplptveiairntgdadqwcPLLETLTDAEMEK 372
Cdd:pfam04855 161 EQVLRYKK-SLCT---------------------PKLEELSEEELEK 185
WH_NTD_SMARCB1 cd21086
N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated ...
 9-98 2.24e-54

N-terminal winged helix DNA-binding domain found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and similar proteins; SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The model corresponds to the N-terminal winged helix DNA binding domain of SMARCB1, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411036  Cd Length: 88  Bit Score: 174.34  E-value: 2.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318   9 TFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHDHgyTTLATSVTLLKASEVE 88
Cdd:cd21086    1 TYGEKPRSFQLEEDGERYMIGSEVGNYLRLFRGSLYKKYPGLWRRQATSEERKKLVELGLSQ--HSLATNVTLLKASEVE 78

                         90
                 ....*....|
gi 962305318  89 EILDGNDEKY 98
Cdd:cd21086   79 EILAGNDEKY 88
WH_NTD_SMARCB1_like cd21055
N-terminal winged helix DNA-binding domain found in SMARCB1, PHF10 and similar proteins; The ...
 13-93 1.85e-33

N-terminal winged helix DNA-binding domain found in SMARCB1, PHF10 and similar proteins; The family includes SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) and PHD finger protein 10 (PHF10), both of which have an N-terminal winged helix DNA-binding domain that is structurally related to the SKI/SNO/DAC domain found in a number of metazoan chromatin-associated proteins. SMARCB1, also termed BRG1-associated factor 47 (BAF47), or integrase interactor 1 protein (INI1), or SNF5, or SNF5L1, is a core component of the BAF (hSWI/SNF) complex, an ATP-dependent chromatin-remodeling complex that plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. PHF10, also termed BRG1-associated factor 45a (BAF45a), or XAP135, is involved in transcription activity regulation by chromatin remodeling. It is a component of the neural progenitors-specific chromatin remodeling complex (npBAF complex) and plays a role in the proliferation of neural progenitors.


Pssm-ID: 411034  Cd Length: 80  Bit Score: 119.53  E-value: 1.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  13 KPVKFQLED-DGEFYMIGSEVGNYLRMfRGSLYKRYPSLWRRLATVEERKKIVASSHDHGyTTLATSVTLLKASEVEEIL 91
Cdd:cd21055    1 KPFEYQWPPkSGEYYMLQSQVGEYLGV-RGSLYRKYPDLWRRQATAEERKYLKELGLVTE-TQLALGLTALKASEVEDLM 78


                 ..
gi 962305318  92 DG 93
Cdd:cd21055   79 AG 80
WH_NTD_PHF10 cd21085
N-terminal winged helix DNA-binding domain found in PHD finger protein 10 (PHF10) and similar ...
 19-99 2.58e-05

N-terminal winged helix DNA-binding domain found in PHD finger protein 10 (PHF10) and similar proteins; PHF10, also termed BRG1-associated factor 45a (BAF45a), or XAP135, is involved in transcription activity regulation by chromatin remodeling. It is a component of the neural progenitors-specific chromatin remodeling complex (npBAF complex) and plays a role in the proliferation of neural progenitors. The model corresponds to the N-terminal winged helix DNA-binding domain of PHF10, which is structurally related to the SKI/SNO/DAC domain that is found in a number of metazoan chromatin-associated proteins.


Pssm-ID: 411035  Cd Length: 89  Bit Score: 42.56  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962305318  19 LEDDGEFYMIGSEVGNYLRMfrGSLYKRYPSLWRRLATVEER-----KKIVASSH-DHGyttlatsVTLLKASEVEEIL- 91
Cdd:cd21085    9 PDKSGEYYMLQEQVSEFLGV--KSFKRKYPDLERRPVEAEEReylreKGVVTETQcDLG-------LTALRSDEVLDLMa 79


                 ....*...
gi 962305318  92 DGNDEKYK 99
Cdd:cd21085   80 KDYPDKYE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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