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Conserved domains on  [gi|995970183|ref|NP_001307151|]
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U2 snRNP-associated SURP motif-containing protein isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPR smart00582
domain present in proteins, which are involved in regulation of nuclear pre-mRNA;
108-243 2.70e-31

domain present in proteins, which are involved in regulation of nuclear pre-mRNA;


:

Pssm-ID: 214731  Cd Length: 124  Bit Score: 117.76  E-value: 2.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183   108 KLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITEslSILKTPLPKKIARLYLVSDVLYNSSAKvanasyYRKFFE 187
Cdd:smart00582   1 AFEQKLESLNNSQESIQTLTKWAIEHASHAKEIVELWEK--YIKKAPVPRKLPLLYLLDSIVQNSKRK------YGSEFG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 995970183   188 TKLCQIFSDlnaTYRTIQGHLQSENfKQRVMTCFRAWEDWAIYPEPFLIKLQNIFL 243
Cdd:smart00582  73 DELGPVFQD---ALRRVLGAAPEEL-KKKIRRLLNIWEERGIFPPEVLRPLREKLN 124
cwf21_SR140 cd21370
cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 ...
 403-451 1.83e-22

cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 snRNP-associated SURP motif-containing protein, U2SURP, or 140 kDa Ser/Arg-rich domain protein, is a putative splicing factor mainly found in higher eukaryotes. Although it was initially identified as a 17S U2 snRNP-associated protein, the molecular and physiological function of SR140 remains unclear. This model represents the cwf21 domain of SR140 and similar proteins. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


:

Pssm-ID: 410597  Cd Length: 50  Bit Score: 90.34  E-value: 1.83e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 995970183 403 MSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ 451
Cdd:cd21370    1 IDEERRAKLREIELKVMKYQDELESGKRSRKPGESISEQVEQYRKKLLK 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 1-47 3.18e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 3.18e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 995970183    1 MIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSI 47
Cdd:pfam01805   6 TAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
 
Name Accession Description Interval E-value
RPR smart00582
domain present in proteins, which are involved in regulation of nuclear pre-mRNA;
108-243 2.70e-31

domain present in proteins, which are involved in regulation of nuclear pre-mRNA;


Pssm-ID: 214731  Cd Length: 124  Bit Score: 117.76  E-value: 2.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183   108 KLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITEslSILKTPLPKKIARLYLVSDVLYNSSAKvanasyYRKFFE 187
Cdd:smart00582   1 AFEQKLESLNNSQESIQTLTKWAIEHASHAKEIVELWEK--YIKKAPVPRKLPLLYLLDSIVQNSKRK------YGSEFG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 995970183   188 TKLCQIFSDlnaTYRTIQGHLQSENfKQRVMTCFRAWEDWAIYPEPFLIKLQNIFL 243
Cdd:smart00582  73 DELGPVFQD---ALRRVLGAAPEEL-KKKIRRLLNIWEERGIFPPEVLRPLREKLN 124
cwf21_SR140 cd21370
cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 ...
 403-451 1.83e-22

cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 snRNP-associated SURP motif-containing protein, U2SURP, or 140 kDa Ser/Arg-rich domain protein, is a putative splicing factor mainly found in higher eukaryotes. Although it was initially identified as a 17S U2 snRNP-associated protein, the molecular and physiological function of SR140 remains unclear. This model represents the cwf21 domain of SR140 and similar proteins. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410597  Cd Length: 50  Bit Score: 90.34  E-value: 1.83e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 995970183 403 MSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ 451
Cdd:cd21370    1 IDEERRAKLREIELKVMKYQDELESGKRSRKPGESISEQVEQYRKKLLK 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 1-47 3.18e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 3.18e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 995970183    1 MIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSI 47
Cdd:pfam01805   6 TAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 1-49 1.45e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 68.00  E-value: 1.45e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 995970183     1 MIEFVVREGPMFEAMIMNREINNPMFRFLFENqTPAHVYYRWKLYSILQ 49
Cdd:smart00648   7 TAQFVARNGPEFEAKLMERERNNPQFDFLKPN-DPYHAYYRKKLAEYRQ 54
CID_RPRD_like cd16981
CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing proteins; ...
 106-241 1.83e-09

CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing proteins; This family is composed of Regulation of nuclear pre-mRNA domain-containing proteins 1A (RPRD1A), 1B (RPRD1B), 2 (RPRD2), yeast Rtt103, and similar proteins. RPRD1A, RPRD1B, and RPRD2 are CID (CTD-Interacting Domain) containing proteins that co-purify with RNA polymerase (Pol) II (RNAP II) and three other RNAP II-associated proteins, RPAP2, GRINL1A and RECQL5, but not with the Mediator complex. Yeast transcription termination factor Rtt103 is a CID containing protein that functions in DNA damage response. CID binds tightly to the carboxy-terminal domain (CTD) of RNAP II. During transcription, RNAP II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing through the CTD, which consists of up to 52 repeats of the sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. CID contains eight alpha-helices in a right-handed superhelical arrangement, which closely resembles that of the VHS domains and ARM (Armadillo) repeat proteins, except for its two amino-terminal helices.


Pssm-ID: 340778  Cd Length: 125  Bit Score: 55.66  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183 106 RDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLsiLKTPLPKKIARLYLVSDVLYNSSAKvaNASYYRKF 185
Cdd:cd16981    1 EEALEKKLRSLNNTQQSIQTLSLWCLFHKKHAKQIVKIWLKEL--KKAKPERKLTLLYLANDVLQNSRRK--GAPEFVEA 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 995970183 186 FETKLCQIFSDLNATyrtiqghlQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNI 241
Cdd:cd16981   77 FKKVLPEALALVRSE--------GDESVRKKVLRVLNIWEERNVFGSEFLAELRAI 124
CID pfam04818
CID domain; This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase ...
 107-235 2.30e-09

CID domain; This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II. This domain is known as the CTD-interacting domain (CID).


Pssm-ID: 461442  Cd Length: 117  Bit Score: 55.29  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183  107 DKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLsiLKTPLPKKIARLYLVSDVLYNSSAKvaNASYYRKFF 186
Cdd:pfam04818   1 EALEKKLSSLNNSQESIQTLSKWILFHRKHAKAIVEVWEKYL--KKAKPEKKLHLLYLANDVLQNSRKK--GKSEFADAF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 995970183  187 ETKLCQIFSDLNATYrtiqghlqSENFKQRVMTCFRAWEDWAIYPEPFL 235
Cdd:pfam04818  77 EPVLPEAFASAYKKC--------DEKLKKKLERLLNIWEERNVFSPEVI 117
cwf21 pfam08312
cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a ...
 403-451 1.78e-06

cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.


Pssm-ID: 462421 [Multi-domain]  Cd Length: 44  Bit Score: 44.73  E-value: 1.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 995970183  403 MSEEKRaklREIELKVMKFQDELESGKRpkkPGQSFQEQVEHYRDKLLQ 451
Cdd:pfam08312   1 LEHERK---REIEVKVLELRDELEEQGL---SEEEIEEKVDELRKKLLA 43
 
Name Accession Description Interval E-value
RPR smart00582
domain present in proteins, which are involved in regulation of nuclear pre-mRNA;
108-243 2.70e-31

domain present in proteins, which are involved in regulation of nuclear pre-mRNA;


Pssm-ID: 214731  Cd Length: 124  Bit Score: 117.76  E-value: 2.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183   108 KLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITEslSILKTPLPKKIARLYLVSDVLYNSSAKvanasyYRKFFE 187
Cdd:smart00582   1 AFEQKLESLNNSQESIQTLTKWAIEHASHAKEIVELWEK--YIKKAPVPRKLPLLYLLDSIVQNSKRK------YGSEFG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 995970183   188 TKLCQIFSDlnaTYRTIQGHLQSENfKQRVMTCFRAWEDWAIYPEPFLIKLQNIFL 243
Cdd:smart00582  73 DELGPVFQD---ALRRVLGAAPEEL-KKKIRRLLNIWEERGIFPPEVLRPLREKLN 124
cwf21_SR140 cd21370
cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 ...
 403-451 1.83e-22

cwf21 domain found in U2-associated protein SR140 and similar proteins; SR140, also called U2 snRNP-associated SURP motif-containing protein, U2SURP, or 140 kDa Ser/Arg-rich domain protein, is a putative splicing factor mainly found in higher eukaryotes. Although it was initially identified as a 17S U2 snRNP-associated protein, the molecular and physiological function of SR140 remains unclear. This model represents the cwf21 domain of SR140 and similar proteins. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410597  Cd Length: 50  Bit Score: 90.34  E-value: 1.83e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 995970183 403 MSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ 451
Cdd:cd21370    1 IDEERRAKLREIELKVMKYQDELESGKRSRKPGESISEQVEQYRKKLLK 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 1-47 3.18e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 3.18e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 995970183    1 MIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSI 47
Cdd:pfam01805   6 TAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 1-49 1.45e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 68.00  E-value: 1.45e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 995970183     1 MIEFVVREGPMFEAMIMNREINNPMFRFLFENqTPAHVYYRWKLYSILQ 49
Cdd:smart00648   7 TAQFVARNGPEFEAKLMERERNNPQFDFLKPN-DPYHAYYRKKLAEYRQ 54
cwf21 cd21369
cwf21 domain; The cwf21 domain is involved in mRNA splicing; it binds directly to the ...
 403-451 2.19e-11

cwf21 domain; The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevents its binding to Prp8. The domain is composed of two alpha helices. Proteins containing the cwf21 domain include complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. This domain family also includes U2-associated protein SR140 from Eumetazoa, protein RRC1, and similar proteins from plants.


Pssm-ID: 410596 [Multi-domain]  Cd Length: 48  Bit Score: 59.02  E-value: 2.19e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 995970183 403 MSEEKRAKLREIELKVMKFQDELESGKRpkKPGQSFQEQVEHYRDKLLQ 451
Cdd:cd21369    1 MDEEKRAKKREIELKVMELRDELEEQGR--KPEQQIQEKVEHYRDKLLQ 47
CID_RPRD_like cd16981
CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing proteins; ...
 106-241 1.83e-09

CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing proteins; This family is composed of Regulation of nuclear pre-mRNA domain-containing proteins 1A (RPRD1A), 1B (RPRD1B), 2 (RPRD2), yeast Rtt103, and similar proteins. RPRD1A, RPRD1B, and RPRD2 are CID (CTD-Interacting Domain) containing proteins that co-purify with RNA polymerase (Pol) II (RNAP II) and three other RNAP II-associated proteins, RPAP2, GRINL1A and RECQL5, but not with the Mediator complex. Yeast transcription termination factor Rtt103 is a CID containing protein that functions in DNA damage response. CID binds tightly to the carboxy-terminal domain (CTD) of RNAP II. During transcription, RNAP II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing through the CTD, which consists of up to 52 repeats of the sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. CID contains eight alpha-helices in a right-handed superhelical arrangement, which closely resembles that of the VHS domains and ARM (Armadillo) repeat proteins, except for its two amino-terminal helices.


Pssm-ID: 340778  Cd Length: 125  Bit Score: 55.66  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183 106 RDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLsiLKTPLPKKIARLYLVSDVLYNSSAKvaNASYYRKF 185
Cdd:cd16981    1 EEALEKKLRSLNNTQQSIQTLSLWCLFHKKHAKQIVKIWLKEL--KKAKPERKLTLLYLANDVLQNSRRK--GAPEFVEA 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 995970183 186 FETKLCQIFSDLNATyrtiqghlQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNI 241
Cdd:cd16981   77 FKKVLPEALALVRSE--------GDESVRKKVLRVLNIWEERNVFGSEFLAELRAI 124
CID pfam04818
CID domain; This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase ...
 107-235 2.30e-09

CID domain; This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II. This domain is known as the CTD-interacting domain (CID).


Pssm-ID: 461442  Cd Length: 117  Bit Score: 55.29  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183  107 DKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLsiLKTPLPKKIARLYLVSDVLYNSSAKvaNASYYRKFF 186
Cdd:pfam04818   1 EALEKKLSSLNNSQESIQTLSKWILFHRKHAKAIVEVWEKYL--KKAKPEKKLHLLYLANDVLQNSRKK--GKSEFADAF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 995970183  187 ETKLCQIFSDLNATYrtiqghlqSENFKQRVMTCFRAWEDWAIYPEPFL 235
Cdd:pfam04818  77 EPVLPEAFASAYKKC--------DEKLKKKLERLLNIWEERNVFSPEVI 117
cwf21 pfam08312
cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a ...
 403-451 1.78e-06

cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.


Pssm-ID: 462421 [Multi-domain]  Cd Length: 44  Bit Score: 44.73  E-value: 1.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 995970183  403 MSEEKRaklREIELKVMKFQDELESGKRpkkPGQSFQEQVEHYRDKLLQ 451
Cdd:pfam08312   1 LEHERK---REIEVKVLELRDELEEQGL---SEEEIEEKVDELRKKLLA 43
cwf21_RRC1-like cd21371
cwf21 domain found in Arabidopsis thaliana protein RRC1 and similar proteins; RRC1, also ...
 403-450 1.10e-03

cwf21 domain found in Arabidopsis thaliana protein RRC1 and similar proteins; RRC1, also called reduced red-light responses in cry1cry2 background 1, is a SR-like splicing factor required for phytochrome B (phyB) signal transduction and involved in phyB-dependent alternative splicing. This subfamily also includes protein RRC1-like, which may also function as a SR-like splicing factor. SR family splicing factors are characterized by the presence of a domain rich in arginine and serine dipeptides, called the RS domain. This model represents the cwf21 domain of RRC1 and similar proteins. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410598  Cd Length: 50  Bit Score: 37.05  E-value: 1.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 995970183 403 MSEEKRAKLREIELKVMKFQDELEsgKRPKKPGQSFQEQVEHYRDKLL 450
Cdd:cd21371    1 ADEERRQKLRQVEVAVMEYRESLE--EQGMKNKEEIERKVAEHRKRLE 46
CID_Pcf11 cd16982
CID (CTD-Interacting Domain) of Pcf11; Pcf11 is conserved across eukaryotes. The best studied ...
 110-203 2.85e-03

CID (CTD-Interacting Domain) of Pcf11; Pcf11 is conserved across eukaryotes. The best studied protein is Saccharomyces cerevisiae Pcf11, also called protein 1 of CF I, an essential subunit of the cleavage factor IA (CFIA) complex which is required for polyadenylation-dependent pre-mRNA 3'-end processing and RNA polymerase (Pol) II (RNAP II) transcription termination. Human Pcf11, also referred to as pre-mRNA cleavage complex 2 protein Pcf11, has been shown to enhance degradation of RNAP II-associated nascent RNA and transcriptional termination. The family also includes plant PCFS4 (Pcf11-similar-4 protein or Polyadenylation and cleavage factor homolog 4) and Caenorhabditis elegans Polyadenylation and cleavage factor homolog 11. CID binds tightly to the carboxy-terminal domain (CTD) of RNAP II. Pcf11 CID preferentially interacts with CTD phosphorylated at Ser2. During transcription, RNAP II synthesizes eukaryotic messenger RNA. Transcription is coupled to RNA processing through the CTD, which consists of up to 52 repeats of the sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. CID contains eight alpha-helices in a right-handed superhelical arrangement, which closely resembles that of the VHS domains and ARM (Armadillo) repeat proteins, except for its two amino-terminal helices.


Pssm-ID: 340779  Cd Length: 127  Bit Score: 37.93  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995970183 110 EEILRGLT-PRKNDIGDAMVFCLNNAEAAEEIVDCITEslSILKTPLPKKIARLYLVSDVLYNssakVANAsyYRKFFET 188
Cdd:cd16982    5 RSALAELTfNSKPIINNLTMLAEENIQAAQAIVEAIEE--RIRKVPPEQKLPALYLLDSIVKN----VGGP--YTSLFSP 76

                         90
                 ....*....|....*
gi 995970183 189 KLCQIFSDlnaTYRT 203
Cdd:cd16982   77 NLVDLFLD---AYRL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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