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Conserved domains on  [gi|1007386230|ref|NP_001308124|]
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F-box-like/WD repeat-containing protein TBL1XR1 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-383 2.91e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 264.58  E-value: 2.91e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgstQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 156
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 157 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 235
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 236 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 314
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1007386230 315 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
8prop_heme_binding_protein super family cl49617
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 357-427 3.55e-03

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


The actual alignment was detected with superfamily member cd20778:

Pssm-ID: 483957 [Multi-domain]  Cd Length: 381  Bit Score: 39.19  E-value: 3.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1007386230 357 PVYSVAfSPDGRYLA---SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS-VCVLDLRK 427
Cdd:cd20778   283 PVFAVA-RPDGRYVWvnfSGPDNDTVQVIDTKTLKVVKTLEPGKRVLHMEFTPRGEAVYISVNDDNkVVVYDTRT 356
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-383 2.91e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 264.58  E-value: 2.91e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgstQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 156
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 157 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 235
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 236 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 314
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1007386230 315 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
77-426 1.53e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.07  E-value: 1.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSGSTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 156
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGH-----------TGAVRSVAFSPDGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 157 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NT 234
Cdd:COG2319   139 SADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 235 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 314
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 315 TGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 394
Cdd:COG2319   299 DGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1007386230 395 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 426
Cdd:COG2319   370 GhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 345-383 9.77e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 9.77e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1007386230  345 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 199-392 1.50e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.99  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 199 VDKTTIIWD-AHTGEAKQQFpfhsapaLDVDWQSNNTFASCSTDMCihvCKLGQDRPIktFQGHTNEVNAIKWDPTGNL- 276
Cdd:PTZ00421   23 VTPSTALWDcSNTIACNDRF-------IAVPWQQLGSTAVLKHTDY---GKLASNPPI--LLGQEGPIIDVAFNPFDPQk 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 277 LASCSDDMTLKIWSMKQ--------DNCVHdLQAHNKEIYTIKWsptgpgtnNPNANLMLASASFDSTVRLWDVDRGICI 348
Cdd:PTZ00421   91 LFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSF--------HPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1007386230 349 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 392
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS 205
WD40 pfam00400
WD domain, G-beta repeat;
345-383 5.55e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 5.55e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1007386230 345 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 357-427 3.55e-03

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 39.19  E-value: 3.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1007386230 357 PVYSVAfSPDGRYLA---SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS-VCVLDLRK 427
Cdd:cd20778   283 PVFAVA-RPDGRYVWvnfSGPDNDTVQVIDTKTLKVVKTLEPGKRVLHMEFTPRGEAVYISVNDDNkVVVYDTRT 356
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-383 2.91e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 264.58  E-value: 2.91e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENstsgstQLVLRHCIREGGqdvpsnkdVTSLDWNSEGTLLATG 156
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG------ELLRTLKGHTGP--------VRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 157 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 235
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 236 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 314
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1007386230 315 TGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
77-426 1.53e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.07  E-value: 1.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSGSTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 156
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGH-----------TGAVRSVAFSPDGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 157 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NT 234
Cdd:COG2319   139 SADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 235 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 314
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 315 TGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 394
Cdd:COG2319   299 DGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1007386230 395 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 426
Cdd:COG2319   370 GhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
75-386 4.97e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 250.21  E-value: 4.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  75 AVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLsensTSGSTQLVLRHcireggqdvpSNKDVTSLDWNSEGTLLA 154
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTG----------HSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 155 TGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 233
Cdd:COG2319   179 SGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 234 -TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 312
Cdd:COG2319   259 rLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1007386230 313 SPTGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQT 386
Cdd:COG2319   339 SPDGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-427 2.30e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.65  E-value: 2.30e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 171 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKL 249
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYlASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 250 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTgpgtnnpnaNLMLA 329
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------GTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 330 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAG 408
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                         250
                  ....*....|....*....
gi 1007386230 409 DKVGASASDGSVCVLDLRK 427
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
64-426 1.01e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.84  E-value: 1.01e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  64 VDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSEnstsgstqlvlrhcIREGGQDVPSNKDVTS 143
Cdd:COG2319    18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA--------------GALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 144 LDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGeakqqfpfhsa 222
Cdd:COG2319    84 VAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 223 paldvdwqsnntfascstdmcihvcklgqdRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQA 302
Cdd:COG2319   153 ------------------------------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 303 HNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 382
Cdd:COG2319   203 HTGAVRSVAFSPDGK---------LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1007386230 383 NTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 426
Cdd:COG2319   274 DLATGELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
151-426 1.15e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 1.15e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 151 TLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 230
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 231 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 309
Cdd:COG2319    88 PDgRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 310 IKWSPTGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 389
Cdd:COG2319   168 VAFSPDG---------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1007386230 390 VHSYRG-TGGIFEVCWNAAGDKVgASAS-DGSVCVLDLR 426
Cdd:COG2319   239 LRTLTGhSGSVRSVAFSPDGRLL-ASGSaDGTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 345-383 9.77e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 9.77e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1007386230  345 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 199-392 1.50e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.99  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 199 VDKTTIIWD-AHTGEAKQQFpfhsapaLDVDWQSNNTFASCSTDMCihvCKLGQDRPIktFQGHTNEVNAIKWDPTGNL- 276
Cdd:PTZ00421   23 VTPSTALWDcSNTIACNDRF-------IAVPWQQLGSTAVLKHTDY---GKLASNPPI--LLGQEGPIIDVAFNPFDPQk 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 277 LASCSDDMTLKIWSMKQ--------DNCVHdLQAHNKEIYTIKWsptgpgtnNPNANLMLASASFDSTVRLWDVDRGICI 348
Cdd:PTZ00421   91 LFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSF--------HPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1007386230 349 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 392
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS 205
PTZ00420 PTZ00420
coronin; Provisional
 71-221 1.83e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 62.66  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  71 PPnkAVVLRGHESEVFICAWNPV-SDLLASGSGDSTARIWNLSENSTSgSTQLVLRHCIREGGQdvpsnKDVTSLDWNSE 149
Cdd:PTZ00420   65 PP--VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDES-VKEIKDPQCILKGHK-----KKISIIDWNPM 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1007386230 150 GT-LLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHS 221
Cdd:PTZ00420  137 NYyIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHD 209
PTZ00420 PTZ00420
coronin; Provisional
 254-343 3.87e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 254 PIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMKQDN----------CVhdLQAHNKEIYTIKWsptgpgtnNP 322
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI--LKGHKKKISIIDW--------NP 135

                          90       100
                  ....*....|....*....|.
gi 1007386230 323 NANLMLASASFDSTVRLWDVD 343
Cdd:PTZ00420  136 MNYYIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-290 5.36e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 5.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1007386230  253 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 290
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
345-383 5.55e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 5.55e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1007386230 345 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 383
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
253-290 3.29e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 3.29e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1007386230 253 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 290
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 262-426 2.15e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 262 TNEVNAIKWDPTGNLLASCSDDMTLKIW---SMKQDNcvHDLQ------AHNKEIYTIKWsptgpgtnNPNANLMLASAS 332
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFeceSIIKDG--RDIHypvvelASRSKLSGICW--------NSYIKSQVASSN 552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 333 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAF-SPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCW-NAAGDK 410
Cdd:PLN00181  553 FEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRS 632

                         170
                  ....*....|....*.
gi 1007386230 411 VGASASDGSVCVLDLR 426
Cdd:PLN00181  633 LAFGSADHKVYYYDLR 648
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 185-393 7.89e-08

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 52.28  E-value: 7.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 185 LKWNKKGNFIL---SAGVDKTTIIWdahTGEakqqfpfhsapaldvdwqsNNTFASCSTDMCIHVCKLGQDRPIKtfqgh 261
Cdd:pfam08662  11 LKWNKNGTYLLvltDTDVDKTGKSY---YGE-------------------TNLYLIGETGGPDCVVELDKEGPIH----- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 262 tnevnAIKWDPTGNLLASCSDDMTLKIwSM--KQDNCVHDLQAHNKEiyTIKWSPTGPgtnnpnanlMLASASFDST--- 336
Cdd:pfam08662  64 -----DVAWSPNGKEFAVIYGYMPAKV-SFfdLKGNVIHSFGEQPRN--TIFWSPFGR---------LVLLAGFGNLagd 126

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1007386230 337 VRLWDVDRGICIHTlTKHQEPVYsVAFSPDGRYLASGS------FDKCVHIWnTQTGALVHSY 393
Cdd:pfam08662 127 IEFWDVVNKKKIAT-AEASNATL-CEWSPDGRYFLTATtaprlrVDNGFKIW-HYNGALVYKY 186
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 184-425 1.27e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 184 ALKWNKKGNFILSAGVDKTTIIWDAHTgEAKQQFPFHSaPALDVD---------WQS--NNTFASCSTDMCIHVCKLGQD 252
Cdd:PLN00181  488 AIGFDRDGEFFATAGVNKKIKIFECES-IIKDGRDIHY-PVVELAsrsklsgicWNSyiKSQVASSNFEGVVQVWDVARS 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 253 RPIKTFQGHTNEVNAIKW---DPTgnLLASCSDDMTLKIWSMKQDNCVHDLQAhNKEIYTIKWsPTGPGTN--------- 320
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYssaDPT--LLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQF-PSESGRSlafgsadhk 641

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 321 -------NPNANL-------------------MLASASFDSTVRLWDVDRGIC------IHTLTKHQEPVYSVAFSPDGR 368
Cdd:PLN00181  642 vyyydlrNPKLPLctmighsktvsyvrfvdssTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDG 721

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1007386230 369 YLASGSFDKCVHIWNTQTGALVHSYR--------------GTGGIFEVCWNAAGDKVGASASDGSVCVLDL 425
Cdd:PLN00181  722 YIATGSETNEVFVYHKAFPMPVLSYKfktidpvsglevddASQFISSVCWRGQSSTLVAANSTGNIKILEM 792
PTZ00421 PTZ00421
coronin; Provisional
 76-235 2.14e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  76 VVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLsENSTSGSTqlvlrhcireggqdVPSNKD-VTSLDWNSEGTLL 153
Cdd:PTZ00421  119 VHLQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDV-ERGKAVEV--------------IKCHSDqITSLEWNLDGSLL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 154 ATGSYDGFARIWT-KDGNLASTLGQHKGPIFA-LKWNKKGNFILSAGVDKT----TIIWDAHTGEAkqqfPFHSapaLDV 227
Cdd:PTZ00421  184 CTTSKDKKLNIIDpRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS----PYST---VDL 256


                  ....*...
gi 1007386230 228 DwQSNNTF 235
Cdd:PTZ00421  257 D-QSSALF 263
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 77-110 3.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1007386230   77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 110
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-341 3.83e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.83e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1007386230  295 NCVHDLQAHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRLWD 341
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK---------YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-207 2.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1007386230  168 DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 207
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
77-110 2.41e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1007386230  77 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 110
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
295-341 2.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1007386230 295 NCVHDLQAHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRLWD 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK---------LLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 144-232 7.42e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 144 LDWNSEGTLLATGSYDG--------FARIWTKDGnlastlGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQ 215
Cdd:pfam12894   1 MSWCPTMDLIALATEDGelllhrlnWQRVWTLSP------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*..
gi 1007386230 216 QFPFHSAPALDVDWQSN 232
Cdd:pfam12894  75 HFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
169-207 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1007386230 169 GNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 207
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 264-371 2.94e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.10  E-value: 2.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230  264 EVNAIKWDPTGNLLASCSDDMTLKiwsmkqdncVHDL----------QAHNKEIYTIKWSPTG-------PGTNNPNAnl 326
Cdd:COG4946    390 RVFNPVWSPDGKKIAFTDNRGRLW---------VVDLasgkvrkvdtDGYGDGISDLAWSPDSkwlayskPGPNQLSQ-- 458

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1007386230  327 mlasasfdstVRLWDVDRGIcIHTLTKHQEPVYSVAFSPDGRYLA 371
Cdd:COG4946    459 ----------IFLYDVETGK-TVQLTDGRYDDGSPAFSPDGKYLY 492
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-165 3.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.06e-04
                           10        20
                   ....*....|....*....|....*...
gi 1007386230  138 NKDVTSLDWNSEGTLLATGSYDGFARIW 165
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
321-425 3.84e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 3.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 321 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPvYSVAFSPDGRYL-----ASGSFDKCVHIWNTQTGALVHSYRG 395
Cdd:COG3391   118 DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGKRLyvansGSNTVSVIVSVIDTATGKVVATIPV 196

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1007386230 396 TGGIFEVCWNAAGDKV--------GASASDGSVCVLDL 425
Cdd:COG3391   197 GGGPVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDL 234
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 268-364 4.10e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 268 IKWDPTGNLLASCSDDMTL--------KIWSMKQDNcvhdlqaHNKEIYTIKWSPTGPgtnnpnanlMLASASFDSTVRL 339
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLSPDK-------EDLEVTSLAWRPDGK---------LLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*
gi 1007386230 340 WDVDRGICIHTLTKHQEPVYSVAFS 364
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
138-165 5.29e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.29e-04
                          10        20
                  ....*....|....*....|....*...
gi 1007386230 138 NKDVTSLDWNSEGTLLATGSYDGFARIW 165
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 239-313 1.76e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 1.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1007386230 239 STDMCIHVCKLGQDRPIKTFQ-GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 313
Cdd:pfam12894  14 TEDGELLLHRLNWQRVWTLSPdKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 169-303 2.80e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 169 GNLAST----LGQhKGPIFALKWNKKGNFIL-SAGVDKTTIIWDAHTGEAKQQFpfhSAPALDVDWQS------------ 231
Cdd:PTZ00421   62 GKLASNppilLGQ-EGPIIDVAFNPFDPQKLfTASEDGTIMGWGIPEEGLTQNI---SDPIVHLQGHTkkvgivsfhpsa 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1007386230 232 NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 303
Cdd:PTZ00421  138 MNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 357-427 3.55e-03

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 39.19  E-value: 3.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1007386230 357 PVYSVAfSPDGRYLA---SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS-VCVLDLRK 427
Cdd:cd20778   283 PVFAVA-RPDGRYVWvnfSGPDNDTVQVIDTKTLKVVKTLEPGKRVLHMEFTPRGEAVYISVNDDNkVVVYDTRT 356
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
312-423 3.91e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.91  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007386230 312 WSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPvYSVAFSPDGRYL-ASGSFDKCVHIWNTQTGALV 390
Cdd:COG3391    67 VADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVV 145

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1007386230 391 HSYRGTGGIFEVCWNAAGDKV-GASASDGSVCVL 423
Cdd:COG3391   146 ATIPVGAGPHGIAVDPDGKRLyVANSGSNTVSVI 179
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 322-382 4.57e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 4.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1007386230 322 PNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 382
Cdd:pfam20426  91 PSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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