NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1676325277|ref|NP_001308273|]
View 

transmembrane protein 182 isoform b [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10621382)

PMP-22/EMP/MP20 family protein similar to human voltage-dependent calcium channel gamma-1 regulatory subunit that gives rise to L-type calcium currents in skeletal muscle

Gene Ontology:  GO:0016020

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
2-177 2.63e-41

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


:

Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 137.55  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277   2 IENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPYPFMRGEHNSTSYDSAVIYRGFWAVLMLLGV 81
Cdd:pfam13903  28 NYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PFPTFEEEIVSFSVTSLPGLTRFVQAFAILSL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277  82 VAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQaVADMESYRNMKMKDCldFTPSVLYGWSFFLA 161
Cdd:pfam13903  99 VLIVCGVVCGLLALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVK-LVFEEYFRQWMPEHQ--NNVRISFGWSFALA 175
                         170
                  ....*....|....*.
gi 1676325277 162 PAGIFFSLLAGLLFLV 177
Cdd:pfam13903 176 WAGVVLSLLAGLLFLV 191
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
2-177 2.63e-41

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 137.55  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277   2 IENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPYPFMRGEHNSTSYDSAVIYRGFWAVLMLLGV 81
Cdd:pfam13903  28 NYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PFPTFEEEIVSFSVTSLPGLTRFVQAFAILSL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277  82 VAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQaVADMESYRNMKMKDCldFTPSVLYGWSFFLA 161
Cdd:pfam13903  99 VLIVCGVVCGLLALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVK-LVFEEYFRQWMPEHQ--NNVRISFGWSFALA 175
                         170
                  ....*....|....*.
gi 1676325277 162 PAGIFFSLLAGLLFLV 177
Cdd:pfam13903 176 WAGVVLSLLAGLLFLV 191
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
2-177 2.63e-41

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 137.55  E-value: 2.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277   2 IENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPYPFMRGEHNSTSYDSAVIYRGFWAVLMLLGV 81
Cdd:pfam13903  28 NYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PFPTFEEEIVSFSVTSLPGLTRFVQAFAILSL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676325277  82 VAVVIASFLIICAAPFASHFLYKAGGGSYIAAGILFSLVVMLYVIWVQaVADMESYRNMKMKDCldFTPSVLYGWSFFLA 161
Cdd:pfam13903  99 VLIVCGVVCGLLALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVK-LVFEEYFRQWMPEHQ--NNVRISFGWSFALA 175
                         170
                  ....*....|....*.
gi 1676325277 162 PAGIFFSLLAGLLFLV 177
Cdd:pfam13903 176 WAGVVLSLLAGLLFLV 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH