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Conserved domains on  [gi|1015809694|ref|NP_001309102|]
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transport and Golgi organization protein 2 homolog isoform g [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in ...
32-161 2.70e-46

Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.


:

Pssm-ID: 428613  Cd Length: 255  Bit Score: 152.02  E-value: 2.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809694  32 KGDVICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAI 111
Cdd:pfam05742 127 GSKSLAYISNRGNPTPDQLSPGIHGLSNSLLDTPWPKVERGKRLFEELIEESVELSEDELIEELFDLLSDDT-LPRDPEL 205
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809694 112 EDQGGEYVQPMlskyAAVCVRCP----GYGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 206 PDTGPEWERLL----SSIFIPPIppggRYGTRSQTVILVDKEGKVTFIERTLYD 255
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in ...
32-161 2.70e-46

Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.


Pssm-ID: 428613  Cd Length: 255  Bit Score: 152.02  E-value: 2.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809694  32 KGDVICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAI 111
Cdd:pfam05742 127 GSKSLAYISNRGNPTPDQLSPGIHGLSNSLLDTPWPKVERGKRLFEELIEESVELSEDELIEELFDLLSDDT-LPRDPEL 205
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809694 112 EDQGGEYVQPMlskyAAVCVRCP----GYGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 206 PDTGPEWERLL----SSIFIPPIppggRYGTRSQTVILVDKEGKVTFIERTLYD 255
NRDE COG3332
Uncharacterized conserved protein, contains NRDE domain [Function unknown];
38-164 9.22e-20

Uncharacterized conserved protein, contains NRDE domain [Function unknown];


Pssm-ID: 225869  Cd Length: 270  Bit Score: 83.40  E-value: 9.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809694  38 YYGNRGEPdPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLnNEEAQLPDPAIEDQG-G 116
Cdd:COG3332   131 YYVNRSET-PRKLLPGYYGLSNGFLDSPWPKVKKARAALAELLAENIEHDEEKIISSCLQLL-ADSSLAPDGQLPDTGvG 208
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1015809694 117 EYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFTERSM--MDKDL 164
Cdd:COG3332   209 VEWERLLS---TIFIPGPYYGTRASTVLRVSKDGTVTFIERVFgpSGEDV 255
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in ...
32-161 2.70e-46

Transport and Golgi organisation 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.


Pssm-ID: 428613  Cd Length: 255  Bit Score: 152.02  E-value: 2.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809694  32 KGDVICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAI 111
Cdd:pfam05742 127 GSKSLAYISNRGNPTPDQLSPGIHGLSNSLLDTPWPKVERGKRLFEELIEESVELSEDELIEELFDLLSDDT-LPRDPEL 205
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809694 112 EDQGGEYVQPMlskyAAVCVRCP----GYGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 206 PDTGPEWERLL----SSIFIPPIppggRYGTRSQTVILVDKEGKVTFIERTLYD 255
NRDE COG3332
Uncharacterized conserved protein, contains NRDE domain [Function unknown];
38-164 9.22e-20

Uncharacterized conserved protein, contains NRDE domain [Function unknown];


Pssm-ID: 225869  Cd Length: 270  Bit Score: 83.40  E-value: 9.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809694  38 YYGNRGEPdPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLnNEEAQLPDPAIEDQG-G 116
Cdd:COG3332   131 YYVNRSET-PRKLLPGYYGLSNGFLDSPWPKVKKARAALAELLAENIEHDEEKIISSCLQLL-ADSSLAPDGQLPDTGvG 208
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1015809694 117 EYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFTERSM--MDKDL 164
Cdd:COG3332   209 VEWERLLS---TIFIPGPYYGTRASTVLRVSKDGTVTFIERVFgpSGEDV 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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