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Conserved domains on  [gi|1016081801|ref|NP_001309136|]
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pro-neuregulin-1, membrane-bound isoform isoform III-3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Neuregulin super family cl20026
Neuregulin intracellular region;
327-483 1.76e-83

Neuregulin intracellular region;


The actual alignment was detected with superfamily member pfam02158:

Pssm-ID: 426627  Cd Length: 360  Bit Score: 262.08  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 327 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 406
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 407 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 482
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158

                  .
gi 1016081801 483 R 483
Cdd:pfam02158 159 R 159
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
327-483 1.76e-83

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 262.08  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 327 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 406
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 407 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 482
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158

                  .
gi 1016081801 483 R 483
Cdd:pfam02158 159 R 159
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
327-483 1.76e-83

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 262.08  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 327 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 406
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016081801 407 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 482
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158

                  .
gi 1016081801 483 R 483
Cdd:pfam02158 159 R 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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