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Conserved domains on  [gi|1016470428|ref|NP_001309225|]
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SID1 transmembrane family member 1 isoform 5 precursor [Homo sapiens]

Protein Classification

SID1 transmembrane family member( domain architecture ID 10623302)

SID1 transmembrane family member similar to Caenorhabditis elegans systemic RNA interference defective protein 1 (SID1) that plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 187-749 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 464057  Cd Length: 599  Bit Score: 849.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 187 QKKDFPGEQFFVVFVIKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVG 266
Cdd:pfam13965  65 QKKDIPSFKFFVVFVVKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVT 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 267 FVHYLRfqrksiDGSFGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDT 345
Cdd:pfam13965 139 FFNYKR------RRSENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 346 MPDIESDKNIIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAH 425
Cdd:pfam13965 184 LADIESDKNVVRTKAFLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAH 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 426 PLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPN 505
Cdd:pfam13965 264 PLGELSAFNNIISNIGYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPN 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 506 YSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQI 585
Cdd:pfam13965 340 YSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQI 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 586 YYMGRFKIdvsdtDLGIFRRAAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLL 665
Cdd:pfam13965 420 YYMGRWKL-----DSGIFRRHLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLI 494

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 666 LYLAFYIIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATAL 745
Cdd:pfam13965 495 LYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIAL 574


                  ....
gi 1016470428 746 FFSF 749
Cdd:pfam13965 575 FFSF 578
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 187-749 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 849.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 187 QKKDFPGEQFFVVFVIKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVG 266
Cdd:pfam13965  65 QKKDIPSFKFFVVFVVKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVT 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 267 FVHYLRfqrksiDGSFGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDT 345
Cdd:pfam13965 139 FFNYKR------RRSENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 346 MPDIESDKNIIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAH 425
Cdd:pfam13965 184 LADIESDKNVVRTKAFLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAH 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 426 PLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPN 505
Cdd:pfam13965 264 PLGELSAFNNIISNIGYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPN 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 506 YSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQI 585
Cdd:pfam13965 340 YSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQI 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 586 YYMGRFKIdvsdtDLGIFRRAAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLL 665
Cdd:pfam13965 420 YYMGRWKL-----DSGIFRRHLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLI 494

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 666 LYLAFYIIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATAL 745
Cdd:pfam13965 495 LYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIAL 574


                  ....
gi 1016470428 746 FFSF 749
Cdd:pfam13965 575 FFSF 578
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 187-749 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 849.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 187 QKKDFPGEQFFVVFVIKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVG 266
Cdd:pfam13965  65 QKKDIPSFKFFVVFVVKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVT 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 267 FVHYLRfqrksiDGSFGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDT 345
Cdd:pfam13965 139 FFNYKR------RRSENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 346 MPDIESDKNIIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAH 425
Cdd:pfam13965 184 LADIESDKNVVRTKAFLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAH 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 426 PLGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPN 505
Cdd:pfam13965 264 PLGELSAFNNIISNIGYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPN 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 506 YSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQI 585
Cdd:pfam13965 340 YSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQI 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 586 YYMGRFKIdvsdtDLGIFRRAAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLL 665
Cdd:pfam13965 420 YYMGRWKL-----DSGIFRRHLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLI 494

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016470428 666 LYLAFYIIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATAL 745
Cdd:pfam13965 495 LYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIAL 574


                  ....
gi 1016470428 746 FFSF 749
Cdd:pfam13965 575 FFSF 578
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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