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Conserved domains on  [gi|1017029444|ref|NP_001309727|]
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phosphatidylcholine transfer protein isoform 2 [Rattus norvegicus]

Protein Classification

SRPBCC family protein( domain architecture ID 51693)

SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) family protein may have a deep hydrophobic ligand-binding pocket

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRPBCC super family cl14643
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC ...
 1-98 6.42e-59

START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


The actual alignment was detected with superfamily member cd08910:

Pssm-ID: 472699  Cd Length: 207  Bit Score: 180.76  E-value: 6.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKSFDGQMVAYWEVKYPFPLSNRDYVYTRQRRDLDVDGRKIYVVLAQNISVPQFPEKSGVIRV 80
Cdd:cd08910    70 MDLEYRKQWDQYVKELYEKECDGETVIYWEVKYPFPLSNRDYVYIRQRRDLDVEGRKIWVILARSTSLPQLPEKPGVIRV 149

                          90
                  ....*....|....*...
gi 1017029444  81 KQYKQSLAIESDGKKGSR 98
Cdd:cd08910   150 KQYKQSLAIESDGKKGSK 167
 
Name Accession Description Interval E-value
START_STARD2-like cd08910
Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes ...
 1-98 6.42e-59

Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may have a mitochondrial function.


Pssm-ID: 176919  Cd Length: 207  Bit Score: 180.76  E-value: 6.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKSFDGQMVAYWEVKYPFPLSNRDYVYTRQRRDLDVDGRKIYVVLAQNISVPQFPEKSGVIRV 80
Cdd:cd08910    70 MDLEYRKQWDQYVKELYEKECDGETVIYWEVKYPFPLSNRDYVYIRQRRDLDVEGRKIWVILARSTSLPQLPEKPGVIRV 149

                          90
                  ....*....|....*...
gi 1017029444  81 KQYKQSLAIESDGKKGSR 98
Cdd:cd08910   150 KQYKQSLAIESDGKKGSK 167
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 1-98 6.51e-17

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 72.85  E-value: 6.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444    1 MDLDYRKKWDQYVK--ELYEKSFDGQMVAYWEVKYPF-PLSNRDYVYTRQRRdldVDGRKIYVVLAQNISVPQFPEKSGV 77
Cdd:smart00234  65 DDLEYRPEWDKNVAkaETLEVIDNGTVIYHYVSKFAAgPVSPRDFVFVRYWR---EDEDGSYAVVDVSVTHPTSPPESGY 141

                           90       100
                   ....*....|....*....|.
gi 1017029444   78 IRVKQYKQSLAIESDGKKGSR 98
Cdd:smart00234 142 VRAENLPSGLLIEPLGNGPSK 162
START pfam01852
START domain;
1-98 3.52e-15

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 68.58  E-value: 3.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVK--ELYEKSFDGQMVAYWEVKYPF--PLSNRDYVYTRQRRdldVDGRKIYVVLAQNISVPQFPEKSG 76
Cdd:pfam01852  64 KDMEYRAQWDKDVRsaETLEVISSGGDLQYYVAALVApsPLSPRDFVFLRYWR---RLGGGVYVIVDRSVTHPQFPPSSG 140

                          90       100
                  ....*....|....*....|..
gi 1017029444  77 VIRVKQYKQSLAIESDGKKGSR 98
Cdd:pfam01852 141 YVRAERLPSGYLIQPCGNGPSK 162
 
Name Accession Description Interval E-value
START_STARD2-like cd08910
Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes ...
 1-98 6.42e-59

Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may have a mitochondrial function.


Pssm-ID: 176919  Cd Length: 207  Bit Score: 180.76  E-value: 6.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKSFDGQMVAYWEVKYPFPLSNRDYVYTRQRRDLDVDGRKIYVVLAQNISVPQFPEKSGVIRV 80
Cdd:cd08910    70 MDLEYRKQWDQYVKELYEKECDGETVIYWEVKYPFPLSNRDYVYIRQRRDLDVEGRKIWVILARSTSLPQLPEKPGVIRV 149

                          90
                  ....*....|....*...
gi 1017029444  81 KQYKQSLAIESDGKKGSR 98
Cdd:cd08910   150 KQYKQSLAIESDGKKGSK 167
START_STARD2_7-like cd08870
Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily ...
 1-98 9.51e-25

Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP), and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


Pssm-ID: 176879  Cd Length: 209  Bit Score: 93.60  E-value: 9.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKSFD---GQMVAYWEVKYPFPLSNRDYVYTRQRRDLDvdgRKIYVVLAQNISVPQFPEkSGV 77
Cdd:cd08870    71 WDDEYRKKWDETVIEHETLEEDeksGTEIVRWVKKFPFPLSDREYVIARRLWESD---DRSYVCVTKGVPYPSVPR-SGR 146

                          90       100
                  ....*....|....*....|...
gi 1017029444  78 IRVKQYKQSLAIES--DGKKGSR 98
Cdd:cd08870   147 KRVDDYESSLVIRAvkGDGQGSA 169
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 1-98 6.51e-17

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 72.85  E-value: 6.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444    1 MDLDYRKKWDQYVK--ELYEKSFDGQMVAYWEVKYPF-PLSNRDYVYTRQRRdldVDGRKIYVVLAQNISVPQFPEKSGV 77
Cdd:smart00234  65 DDLEYRPEWDKNVAkaETLEVIDNGTVIYHYVSKFAAgPVSPRDFVFVRYWR---EDEDGSYAVVDVSVTHPTSPPESGY 141

                           90       100
                   ....*....|....*....|.
gi 1017029444   78 IRVKQYKQSLAIESDGKKGSR 98
Cdd:smart00234 142 VRAENLPSGLLIEPLGNGPSK 162
START_STARD7-like cd08911
Lipid-binding START domain of mammalian STARD7 and related proteins; This subgroup includes ...
 1-89 3.54e-16

Lipid-binding START domain of mammalian STARD7 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD7 (also known as gestational trophoblastic tumor 1/GTT1). It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of phosphatidycholine (PtdCho) to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers, it showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


Pssm-ID: 176920  Cd Length: 207  Bit Score: 71.17  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKSFD---GQMVAYWEVKYPFPLSNRDYVYTRqRRDLDVDgRKIYVVLAQNISVPQFPEKSGV 77
Cdd:cd08911    66 LDLEYRKKWDATAVELEVVDEDpetGSEIIYWEMQWPKPFANRDYVYVR-RYIIDEE-NKLIVIVSKAVQHPSYPESPKK 143

                          90
                  ....*....|..
gi 1017029444  78 IRVKQYKQSLAI 89
Cdd:cd08911   144 VRVEDYWSYMVI 155
START pfam01852
START domain;
1-98 3.52e-15

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 68.58  E-value: 3.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVK--ELYEKSFDGQMVAYWEVKYPF--PLSNRDYVYTRQRRdldVDGRKIYVVLAQNISVPQFPEKSG 76
Cdd:pfam01852  64 KDMEYRAQWDKDVRsaETLEVISSGGDLQYYVAALVApsPLSPRDFVFLRYWR---RLGGGVYVIVDRSVTHPQFPPSSG 140

                          90       100
                  ....*....|....*....|..
gi 1017029444  77 VIRVKQYKQSLAIESDGKKGSR 98
Cdd:pfam01852 141 YVRAERLPSGYLIQPCGNGPSK 162
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 1-98 1.67e-12

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 61.20  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYE-KSFDGQM-VAYWEVKYPFPLSNRDYVYTRQRRDLDVDGrkiYVVLAQNISVPQFPEKSGVI 78
Cdd:cd00177    59 MDIDLRKKWDKNFEEFEViEEIDEHTdIIYYKTKPPWPVSPRDFVYLRRRRKLDDGT---YVIVSKSVDHDSHPKEKGYV 135

                          90       100
                  ....*....|....*....|
gi 1017029444  79 RVKQYKQSLAIESDGKKGSR 98
Cdd:cd00177   136 RAEIKLSGWIIEPLDPGKTK 155
START_STARD10-like cd08871
Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes ...
 1-97 3.96e-10

Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).


Pssm-ID: 176880  Cd Length: 222  Bit Score: 54.95  E-value: 3.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017029444   1 MDLDYRKKWDQYVKELYEKsfdGQM-----VAYWEVKYPFPLSNRDYVYTRQRRDLDVDgrkiYVVLaqNISV--PQFPE 73
Cdd:cd08871    68 HDPEYRKTWDSNMIESFDI---CQLnpnndIGYYSAKCPKPLKNRDFVNLRSWLEFGGE----YIIF--NHSVkhKKYPP 138

                          90       100
                  ....*....|....*....|....
gi 1017029444  74 KSGVIRVKQYKQSLAIESDGKKGS 97
Cdd:cd08871   139 RKGFVRAISLLTGYLIRPTGPKGC 162
START_1 cd08876
Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid ...
 8-84 2.56e-04

Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs), it is known which lipids bind in this pocket; these include cholesterol (STARD1, -3, -4, and -5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2, -7, and -10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes, including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease.


Pssm-ID: 176885  Cd Length: 195  Bit Score: 38.79  E-value: 2.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1017029444   8 KWDQYVKE--LYEKSFDGQMVAYWEVKYPFPLSNRDYVyTRQRRDLDVDgRKIYVVLAQNISVPqFPEKSGVIRVKQYK 84
Cdd:cd08876    68 QWMPNCKEsrVLKRTDDNERSVYTVIDLPWPVKDRDMV-LRSTTEQDAD-DGSVTITLEAAPEA-LPEQKGYVRIKTVE 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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