NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1041214568|ref|NP_001315987|]
View 

C-reactive protein isoform 2 precursor [Homo sapiens]

Protein Classification

LamG domain-containing protein( domain architecture ID 366259)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 19-66 1.49e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00159:

Pssm-ID: 473984  Cd Length: 206  Bit Score: 86.17  E-value: 1.49e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1041214568   19 QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRG 66
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGY 48
 
Name Accession Description Interval E-value
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 19-66 1.49e-22

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 86.17  E-value: 1.49e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1041214568   19 QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRG 66
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGY 48
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 19-63 1.90e-21

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 83.09  E-value: 1.90e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1041214568  19 QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSS 63
Cdd:cd00152     1 QTDLSGKVFVFPKESDTSYVKLKPELPKPLQAFTLCLWVYTDLST 45
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
 25-64 3.50e-20

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 79.77  E-value: 3.50e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1041214568  25 KAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSST 64
Cdd:pfam00354   1 KVFVFPKESDTSYVSLIPELEKPLQNFTLCLRFYTDLSRS 40
 
Name Accession Description Interval E-value
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 19-66 1.49e-22

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 86.17  E-value: 1.49e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1041214568   19 QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRG 66
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGY 48
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 19-63 1.90e-21

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 83.09  E-value: 1.90e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1041214568  19 QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSS 63
Cdd:cd00152     1 QTDLSGKVFVFPKESDTSYVKLKPELPKPLQAFTLCLWVYTDLST 45
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
 25-64 3.50e-20

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 79.77  E-value: 3.50e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1041214568  25 KAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSST 64
Cdd:pfam00354   1 KVFVFPKESDTSYVSLIPELEKPLQNFTLCLRFYTDLSRS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH