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Conserved domains on  [gi|1057503230|ref|NP_001317147|]
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cyclin-Y-like protein 1 isoform 3 [Homo sapiens]

Protein Classification

cyclin-Y family protein( domain architecture ID 15334342)

cyclin-Y family protein similar to cyclin-Y, which is a cell cycle regulator that regulates cyclin dependent kinases (CDKs)

CATH:  1.10.472.10
Gene Ontology:  GO:0061575|GO:0019901|GO:0045859|GO:0060828
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNY_like cd20540
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ...
 186-282 1.49e-57

cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410243  Cd Length: 97  Bit Score: 182.04  E-value: 1.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 186 PEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDIT 265
Cdd:cd20540     1 PSHEDIYRFVLTLFSAAQLTAECAIVTLIYIERLIEYAEIDLHPSNWRRIVLGALLLASKVWDDQAVWNVDFAKILPILT 80

                          90
                  ....*....|....*..
gi 1057503230 266 VEDMNEMERHFLELLQF 282
Cdd:cd20540    81 VEDLNRLERSFLELLQF 97
 
Name Accession Description Interval E-value
CYCLIN_CCNY_like cd20540
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ...
 186-282 1.49e-57

cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410243  Cd Length: 97  Bit Score: 182.04  E-value: 1.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 186 PEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDIT 265
Cdd:cd20540     1 PSHEDIYRFVLTLFSAAQLTAECAIVTLIYIERLIEYAEIDLHPSNWRRIVLGALLLASKVWDDQAVWNVDFAKILPILT 80

                          90
                  ....*....|....*..
gi 1057503230 266 VEDMNEMERHFLELLQF 282
Cdd:cd20540    81 VEDLNRLERSFLELLQF 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 194-285 1.66e-12

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 63.69  E-value: 1.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 194 FVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDicPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKD-ITVEDMNEM 272
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVP--KNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNaYTREEILRM 114

                          90
                  ....*....|...
gi 1057503230 273 ERHFLELLQFNIN 285
Cdd:pfam00134 115 ERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 193-278 7.93e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 52.21  E-value: 7.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230  193 RFVRTLFSAAQLTAECAIVTLVYLERllTYAEIDICPTNWKRIVLGAILLASKVWDDQaVWNVDYCQILKDITVEDMNEM 272
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDR--FLSDYKFLKYSPSLIAAAALYLASKTEETP-PWTKELVHYTGYFTEEEILRM 77


                   ....*.
gi 1057503230  273 ERHFLE 278
Cdd:smart00385  78 ERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNY_like cd20540
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ...
 186-282 1.49e-57

cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410243  Cd Length: 97  Bit Score: 182.04  E-value: 1.49e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 186 PEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDIT 265
Cdd:cd20540     1 PSHEDIYRFVLTLFSAAQLTAECAIVTLIYIERLIEYAEIDLHPSNWRRIVLGALLLASKVWDDQAVWNVDFAKILPILT 80

                          90
                  ....*....|....*..
gi 1057503230 266 VEDMNEMERHFLELLQF 282
Cdd:cd20540    81 VEDLNRLERSFLELLQF 97
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 191-282 1.38e-16

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 74.23  E-value: 1.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 191 IYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNW--KRIVLGAILLASKVWDDQAVWNVDYCQILKdITVED 268
Cdd:cd20557     2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGQEGspYRLFLVALMLASKYLDDESYSNKSWAEISG-LPVRE 80

                          90
                  ....*....|....
gi 1057503230 269 MNEMERHFLELLQF 282
Cdd:cd20557    81 LNAMEREFLEALDW 94
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 194-285 1.66e-12

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 63.69  E-value: 1.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 194 FVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDicPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKD-ITVEDMNEM 272
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVP--KNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNaYTREEILRM 114

                          90
                  ....*....|...
gi 1057503230 273 ERHFLELLQFNIN 285
Cdd:pfam00134 115 ERLILETLNFDLS 127
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 191-287 2.86e-11

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 59.49  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 191 IYRFVRTLFSAAQLTAECAIVTLVYLERLL-TYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQIlKDITVEDM 269
Cdd:cd20558     5 ILDYLERIVKYCPCSPECFLLALIYIDRLIaTINGFVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYAKV-GGVSVSEL 83

                          90
                  ....*....|....*...
gi 1057503230 270 NEMERHFLELLQFNINVP 287
Cdd:cd20558    84 NKLELEFLFLLDFDLHVS 101
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 191-298 1.94e-09

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 55.09  E-value: 1.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 191 IYRFVRTLFSAAQLTAECAIVTLVYLERLL-TYAEIDICPTNWKRIVLGAILLASKVWDDqAVWNVDYCQILKDITVEDM 269
Cdd:cd20604    15 IASYLERIFKYTNCSPSCFVVAYVYIDRFIhKQPGLPISSLNVHRLLITSVMVAAKFLDD-LYYNNAYYAKVGGVSTEEL 93

                          90       100
                  ....*....|....*....|....*....
gi 1057503230 270 NEMERHFLELLQFNINVPASVYAKYYFDL 298
Cdd:cd20604    94 NRLELEFLFLLDFKLNVTVSVFESYCCHL 122
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 193-278 7.93e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 52.21  E-value: 7.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230  193 RFVRTLFSAAQLTAECAIVTLVYLERllTYAEIDICPTNWKRIVLGAILLASKVWDDQaVWNVDYCQILKDITVEDMNEM 272
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDR--FLSDYKFLKYSPSLIAAAALYLASKTEETP-PWTKELVHYTGYFTEEEILRM 77


                   ....*.
gi 1057503230  273 ERHFLE 278
Cdd:smart00385  78 ERLLLE 83
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 202-284 2.06e-04

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 41.28  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 202 AQLTAECAIVTLVYLERLLT---YAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQIlKDITVEDMNEMERHFLE 278
Cdd:pfam08613  65 CPSSPAVLLSALIYLDRLVKrcdSEAFVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAKV-GGISLHELNHLEIDFLF 143


                  ....*.
gi 1057503230 279 LLQFNI 284
Cdd:pfam08613 144 LVDFDL 149
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 191-274 6.41e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 35.46  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503230 191 IYRFVRTLFSAAQLTAECAIVTLVYLERLltYAEIDICPTNWKRIVLGAILLASKVWDDqAVWNVDYCQILkDITVEDMN 270
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRF--LSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVS-GVSEKELR 77


                  ....
gi 1057503230 271 EMER 274
Cdd:cd00043    78 KAEK 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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