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Conserved domains on  [gi|1108846868|ref|NP_001334370|]
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very low-density lipoprotein receptor isoform c precursor [Mus musculus]

Protein Classification

LDLa and Ldl_recept_b domain-containing protein( domain architecture ID 10819527)

protein containing domains LDLa, FXa_inhibition, LY, and Ldl_recept_b

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 2.59e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.59e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1108846868 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 3.87e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.11  E-value: 3.87e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 196 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868  33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 4.04e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.04e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-524 6.84e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.84e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1108846868 486 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 524
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-147 1.03e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 112 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 147
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.69e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.69e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868   71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 2.90e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.90e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1108846868 151 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 3.24e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1108846868  551 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.26e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.26e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1108846868 440 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.63e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1108846868 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.32e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.32e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1108846868 279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.81e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.54e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 3.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1108846868 665 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1108846868  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 2.59e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.59e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1108846868 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 3.87e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.11  E-value: 3.87e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 196 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868  33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 4.04e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.04e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 4.20e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 4.20e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 198 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-524 6.84e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.84e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1108846868 486 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 524
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-147 1.03e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 112 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 147
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-147 3.30e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.30e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 113 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 147
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.69e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.69e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868   71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-506 4.75e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 4.75e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1108846868  467 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 506
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 7.36e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 7.36e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868  32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.08e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.08e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868   32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 1.09e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.09e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868  72 CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.29e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.29e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1108846868  70 KTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-229 1.40e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  197 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 229
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-550 2.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1108846868  509 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 550
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 2.90e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.90e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1108846868 151 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 3.10e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.10e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 237 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 3.24e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1108846868  551 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-183 3.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.30e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  151 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-144 3.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.78e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  112 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 144
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.26e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.26e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1108846868 440 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 152-183 4.40e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.40e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868 152 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 6.09e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.09e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  236 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.63e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1108846868 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.32e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.32e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1108846868 279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 572-613 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1108846868 572 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 613
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.81e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 5.74e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 5.74e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1108846868  279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 9.53e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 9.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1108846868 279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.54e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
484-631 1.68e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 484 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 559
Cdd:COG3391    80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 560 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 631
Cdd:COG3391   151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 2.43e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.43e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1108846868 355 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 385
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 3.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1108846868 665 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 474-640 1.65e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 474 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 540
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 541 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 616
Cdd:cd14963   135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                         170       180
                  ....*....|....*....|....
gi 1108846868 617 YWIDGENEAVYGANKfTGSELATL 640
Cdd:cd14963   209 YVVDNLSHRVYVFDE-QGKELFTF 231
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 3.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868 355 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 383
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1108846868  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 2.59e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 72.96  E-value: 2.59e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1108846868 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 3.87e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 61.11  E-value: 3.87e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 196 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868  33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 4.04e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.04e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1108846868 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 4.20e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 4.20e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 198 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-524 6.84e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 6.84e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1108846868 486 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 524
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-147 1.03e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.03e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 112 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 147
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-147 3.30e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.30e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 113 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 147
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.69e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.69e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868   71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 467-506 4.75e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 4.75e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1108846868  467 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 506
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 7.36e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 7.36e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868  32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.08e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.08e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868   32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 1.09e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.09e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868  72 CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.29e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.29e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1108846868  70 KTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-229 1.40e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  197 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 229
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-550 2.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1108846868  509 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 550
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 2.90e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.90e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1108846868 151 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 3.10e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.10e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1108846868 237 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 3.24e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1108846868  551 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-183 3.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.30e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  151 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-144 3.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.78e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  112 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 144
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.26e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.26e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1108846868 440 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 152-183 4.40e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.40e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868 152 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 6.09e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.09e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  236 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.63e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1108846868 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 8.32e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.32e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1108846868 279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 572-613 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1108846868 572 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 613
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.81e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1108846868 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 5.74e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 5.74e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1108846868  279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 9.53e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 9.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1108846868 279 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 309
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.54e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1108846868  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
484-631 1.68e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 484 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 559
Cdd:COG3391    80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 560 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 631
Cdd:COG3391   151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 2.43e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.43e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1108846868 355 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 385
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 3.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.46  E-value: 3.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1108846868 665 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
434-574 5.54e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 5.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 434 DADIAAQKLFWADLSQKAIfsASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGAKRKFLFNSD 513
Cdd:COG3391    74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1108846868 514 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTEDI---QWPNGITLDLVKSRLY 574
Cdd:COG3391   150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 438-596 5.79e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 438 AAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNvyNPAAIAVD-----WV---YKTIYWTDAASKTISVATLDGAKRKFL 509
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSG--RPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 510 FNsDLRepasiaVDPlSGFVYWSDwgepakiekagMNGFDRRP------------LVTEDIQWPNGITLDLVKSRLYWLD 577
Cdd:COG3386    95 PN-DGV------VDP-DGRLYFTD-----------MGEYLPTGalyrvdpdgslrVLADGLTFPNGIAFSPDGRTLYVAD 155

                         170       180
                  ....*....|....*....|...
gi 1108846868 578 SKLHMLSSVDLNGQ----DRRIV 596
Cdd:COG3386   156 TGAGRIYRFDLDADgtlgNRRVF 178
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
402-535 1.38e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 402 LIFTNRRD--IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSasIDDKVGRHFKMIDNVYNPAAIAV 479
Cdd:COG3391    82 LYVANSGSgrVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAGPHGIAV 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1108846868 480 DWVYKTIYWTDAASKTIS--VATLDGAKRKFLFNSDLRE-PASIAVDPLSGFVYWSDWG 535
Cdd:COG3391   160 DPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGgPVGVAVSPDGRRLYVANRG 218
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 474-640 1.65e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 474 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 540
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 541 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 616
Cdd:cd14963   135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                         170       180
                  ....*....|....*....|....
gi 1108846868 617 YWIDGENEAVYGANKfTGSELATL 640
Cdd:cd14963   209 YVVDNLSHRVYVFDE-QGKELFTF 231
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 430-533 2.63e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108846868 430 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHFKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGA 504
Cdd:cd14962    16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1108846868 505 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 533
Cdd:cd14962    89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 3.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1108846868 355 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 383
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-387 6.25e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.91  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|....*...
gi 1108846868 360 QNPGICSQICINLKGGYKCECSRGYQMD 387
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQ 30
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1108846868  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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