|
Name |
Accession |
Description |
Interval |
E-value |
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
2-652 |
1.12e-171 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 511.22 E-value: 1.12e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 2 AMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLL-HGCSS-- 77
Cdd:TIGR00396 198 ELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVeKAAENnp 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 78 -----VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImANPDLEG-SLDSKIGIPSTSSEDTRLAQALGLP 144
Cdd:TIGR00396 274 kvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-ANYVLMEyGTGAVMGVPAHDERDFEFAQKYGLP 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 145 YSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHC 215
Cdd:TIGR00396 353 IKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHC 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 216 PACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFG 295
Cdd:TIGR00396 433 EDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFD 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 296 SALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAP 375
Cdd:TIGR00396 513 KEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYP-PNGK-VPADVLTERDEKG 590
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 376 VCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIE 455
Cdd:TIGR00396 591 KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWN--ESGLEGARRFLDRVWNLVYEITG 668
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 456 ArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLhspefEDALCA 534
Cdd:TIGR00396 669 E------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALM-----LEYLKG 737
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPQHVaqDQ 614
Cdd:TIGR00396 738 FVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETALVE-DKTLIVVQVNGKFRAKITVPKDA--DE 804
|
650 660 670
....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 652
Cdd:TIGR00396 805 EQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; |
5-652 |
4.18e-143 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 223569 [Multi-domain] Cd Length: 814 Bit Score: 436.33 E-value: 4.18e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 5 DALADL-PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSS------ 77
Cdd:COG0495 208 DKLATLwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEIVSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtpl 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 78 ----VKKALQKALV-------PGRDCLTPVMAVSMLTLQEVPIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPY 145
Cdd:COG0495 284 vaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKIPVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 146 SEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPAC 218
Cdd:COG0495 363 KKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRCGLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDC 442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 219 GPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPrcKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSA 297
Cdd:COG0495 443 GVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP--DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDRE 519
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 298 LADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvc 377
Cdd:COG0495 520 EFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKDEPFKKLITQGMV------------LGEEG---------- 577
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 378 aktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEar 457
Cdd:COG0495 578 -----------EKMSKSKGNVVDPEEAVEKYGADTVRLYIMFAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE-- 642
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 458 tsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCA 534
Cdd:COG0495 643 ----------KLVEELTKEQGKedrWLL-HRTIKKVTEDFEARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALET 711
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQ 614
Cdd:COG0495 712 WVRLLAPFAPHIAEELWEELGN-----------EGFVSNAPWPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADE 777
|
650 660 670
....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 652
Cdd:COG0495 778 EKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-643 |
3.93e-108 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 348.74 E-value: 3.93e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 9 DLPEwyGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLhgcSSVKKALQKALV 87
Cdd:PLN02563 288 DWPE--SIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLVVAPEHPLL---SSLTTAEQKEAV 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 88 PG------------RDCL--------TPVMAVSMLTLQEVPI-------------VIMAnpdlegsldskigIPSTSSED 134
Cdd:PLN02563 363 EEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIwvadyvlgsygtgAIMA-------------VPAHDTRD 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 135 TRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWL 199
Cdd:PLN02563 430 FEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWL 508
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 200 ISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVD 276
Cdd:PLN02563 509 FARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAG 588
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQ--- 353
Cdd:PLN02563 589 SCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEvey 668
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 354 -TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPEEIVAQYGIDTIR 414
Cdd:PLN02563 669 tAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPDDVVSEYGADSLR 747
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 415 LYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEYKnaVIAQVTTHf 494
Cdd:PLN02563 748 LYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLHK--CIAKVTEE- 820
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 TEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLCDHyawDSGVMLQ 574
Cdd:PLN02563 821 IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRLGH---SNSLAYE 882
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 575 AWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSP 643
Cdd:PLN02563 883 PWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVP 948
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
195-429 |
6.04e-61 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 205.94 E-value: 6.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWL-ISRQRYWGTPIPIvhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDT 273
Cdd:cd00812 163 QENWIgCSRQRYWGTPIPW-------------------------------------------------------TDTMES 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 274 FVDSAWYYFRYTDPHNTQSP------FGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQ 347
Cdd:cd00812 188 LSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQ 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 348 GLIKGQTfrlpsgqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00812 267 GMVLLEG----------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312
|
..
gi 1143076967 428 LW 429
Cdd:cd00812 313 DW 314
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
197-430 |
1.71e-14 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 395082 [Multi-domain] Cd Length: 603 Bit Score: 76.69 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVD 276
Cdd:pfam00133 419 DWCISRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFS 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SA-WYYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtf 355
Cdd:pfam00133 494 SGsWPFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV----- 557
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 356 RLPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 430
Cdd:pfam00133 558 RDEQGR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
2-652 |
1.12e-171 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 511.22 E-value: 1.12e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 2 AMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLL-HGCSS-- 77
Cdd:TIGR00396 198 ELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVeKAAENnp 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 78 -----VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImANPDLEG-SLDSKIGIPSTSSEDTRLAQALGLP 144
Cdd:TIGR00396 274 kvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-ANYVLMEyGTGAVMGVPAHDERDFEFAQKYGLP 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 145 YSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHC 215
Cdd:TIGR00396 353 IKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHC 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 216 PACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFG 295
Cdd:TIGR00396 433 EDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFD 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 296 SALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAP 375
Cdd:TIGR00396 513 KEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYP-PNGK-VPADVLTERDEKG 590
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 376 VCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIE 455
Cdd:TIGR00396 591 KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWN--ESGLEGARRFLDRVWNLVYEITG 668
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 456 ArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLhspefEDALCA 534
Cdd:TIGR00396 669 E------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALM-----LEYLKG 737
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPQHVaqDQ 614
Cdd:TIGR00396 738 FVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETALVE-DKTLIVVQVNGKFRAKITVPKDA--DE 804
|
650 660 670
....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 652
Cdd:TIGR00396 805 EQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; |
5-652 |
4.18e-143 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 223569 [Multi-domain] Cd Length: 814 Bit Score: 436.33 E-value: 4.18e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 5 DALADL-PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSS------ 77
Cdd:COG0495 208 DKLATLwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEIVSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtpl 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 78 ----VKKALQKALV-------PGRDCLTPVMAVSMLTLQEVPIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPY 145
Cdd:COG0495 284 vaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKIPVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 146 SEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPAC 218
Cdd:COG0495 363 KKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRCGLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDC 442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 219 GPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPrcKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSA 297
Cdd:COG0495 443 GVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP--DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDRE 519
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 298 LADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvc 377
Cdd:COG0495 520 EFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKDEPFKKLITQGMV------------LGEEG---------- 577
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 378 aktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEar 457
Cdd:COG0495 578 -----------EKMSKSKGNVVDPEEAVEKYGADTVRLYIMFAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE-- 642
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 458 tsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCA 534
Cdd:COG0495 643 ----------KLVEELTKEQGKedrWLL-HRTIKKVTEDFEARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALET 711
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQ 614
Cdd:COG0495 712 WVRLLAPFAPHIAEELWEELGN-----------EGFVSNAPWPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADE 777
|
650 660 670
....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 652
Cdd:COG0495 778 EKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-643 |
3.93e-108 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 348.74 E-value: 3.93e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 9 DLPEwyGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLhgcSSVKKALQKALV 87
Cdd:PLN02563 288 DWPE--SIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLVVAPEHPLL---SSLTTAEQKEAV 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 88 PG------------RDCL--------TPVMAVSMLTLQEVPI-------------VIMAnpdlegsldskigIPSTSSED 134
Cdd:PLN02563 363 EEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIwvadyvlgsygtgAIMA-------------VPAHDTRD 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 135 TRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWL 199
Cdd:PLN02563 430 FEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWL 508
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 200 ISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVD 276
Cdd:PLN02563 509 FARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAG 588
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQ--- 353
Cdd:PLN02563 589 SCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEvey 668
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 354 -TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPEEIVAQYGIDTIR 414
Cdd:PLN02563 669 tAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPDDVVSEYGADSLR 747
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 415 LYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEYKnaVIAQVTTHf 494
Cdd:PLN02563 748 LYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLHK--CIAKVTEE- 820
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 TEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLCDHyawDSGVMLQ 574
Cdd:PLN02563 821 IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRLGH---SNSLAYE 882
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 575 AWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSP 643
Cdd:PLN02563 883 PWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVP 948
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
195-429 |
6.04e-61 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 205.94 E-value: 6.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWL-ISRQRYWGTPIPIvhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDT 273
Cdd:cd00812 163 QENWIgCSRQRYWGTPIPW-------------------------------------------------------TDTMES 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 274 FVDSAWYYFRYTDPHNTQSP------FGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQ 347
Cdd:cd00812 188 LSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQ 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 348 GLIKGQTfrlpsgqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00812 267 GMVLLEG----------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312
|
..
gi 1143076967 428 LW 429
Cdd:cd00812 313 DW 314
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; |
193-597 |
3.02e-33 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 223599 [Multi-domain] Cd Length: 877 Bit Score: 136.61 E-value: 3.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPlQDLPVILpsiasltgrggsplataleWVNCSCPrcKGSAKRETDTMD 272
Cdd:COG0525 394 ENIRDWCISRQLWWGHRIPVWYCKECGNVVVA-EEEPEDP-------------------AAAEKCP--KEELEQDEDVLD 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSAWYYFrYTDPHNTQSPFgsaLADFWmPVDLYIGGkeHAVMH--LFYARFLS-HFCHDqkmvkhrEPFHKLLAQGL 349
Cdd:COG0525 452 TWFSSSLWPF-STLGWPEETPD---LKKFY-PTDLLVTG--HDIIFfwVARMIMRGlHLTGE-------VPFKDVYIHGL 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 350 IKGqtfrlPSGqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:COG0525 518 VRD-----EQG----------------------------RKMSKSKGNVIDPLDVIDKYGADALRFTLASLASPGRDINF 564
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 430 DvkTDALPGVLRWQQRLWSLtTRFIEARTSGTVPQPQLLNSKEKTkaqNLWEYK--NAVIAQVTTHFtEDFALNSVVSQL 507
Cdd:COG0525 565 D--EKRVEGYRNFLNKLWNA-TRFVLMNLDDLGPDDLDLLALSLA---DRWILSrlNETVKEVTEAL-DNYRFDEAARAL 637
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 508 MGL------------------SSALSQASQRVVLHSpefedALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyawds 569
Cdd:COG0525 638 YEFiwndfcdwylelakprlyGGEEEKRAARATLYY-----VLDTLLRLLHPFMPFITEEIWQKLPGTES---------- 702
|
410 420
....*....|....*....|....*...
gi 1143076967 570 gVMLQAWPTVDSQFLQKPDMVQMAVLIN 597
Cdd:COG0525 703 -IHLASWPEVDEELIDEEAEKEFELLKE 729
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
193-584 |
2.74e-29 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 124.02 E-value: 2.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSiasltgrggsPLATALEWvncscprckgsaKRETDTMD 272
Cdd:TIGR00422 394 RNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDKT----------NTGPSVEL------------EQDTDVLD 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSAWYYFRYTD-PHNTqspfgSALADFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLIK 351
Cdd:TIGR00422 452 TWFSSSLWPFSTLGwPDET-----KDLKKFY-PTDLLVTGYDIIFFWVARMIFRSLALTGQV------PFKEVYIHGLVR 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 352 GQTFRlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDV 431
Cdd:TIGR00422 520 DEQGR---------------------------------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDW 566
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 432 KTdaLPGVLRWQQRLWSlTTRFIEARTSGtvpQPQLLNSKEKTKAQNLWEYK--NAVIAQVTTHFtEDFALNSVVS---- 505
Cdd:TIGR00422 567 KR--VESARNFLNKLWN-ASRFVLMNLSD---DLELSGGEEKLSLADRWILSklNRTIKEVRKAL-DKYRFAEAAKalye 639
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 506 ----------------QLMGLSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLtlvpsklcdHYAWDS 569
Cdd:TIGR00422 640 fiwndfcdwyielvkyRLYNGNEAEKKAARDTLYY------VLDKALRLLHPFMPFITEEIWQHF---------KEGADS 704
|
410
....*....|....*
gi 1143076967 570 gVMLQAWPTVDSQFL 584
Cdd:TIGR00422 705 -IMLQSYPVVDAEFV 718
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
197-580 |
1.35e-27 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 118.76 E-value: 1.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVilpsiasltgrggSPLATALEWvnCSCPRC-KGSAKRETDTMDTF 274
Cdd:PRK13208 397 DWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPV-------------DPTKDEPPG--YKCPQCgSPGFEGETDVMDTW 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDS---AWYYFRYTDPHntqspfgsalaDFWM---PVDLYIGGkehavmH------LFYARFLSHFCHDQKmvkhrePFH 342
Cdd:PRK13208 462 ATSsitPLIVTGWERDE-----------DLFEkvfPMDLRPQG------HdiirtwLFYTILRAYLLTGKL------PWK 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 343 KLLaqglIkgqtfrlpSGQCLKkEDidftGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILfAAP 422
Cdd:PRK13208 519 NIM----I--------SGMVLD-PD----G----------------KKMSKSKGNVVTPEELLEKYGADAVRYWAA-SAR 564
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 423 PEKDILWDVKTdaLPGVLRWQQRLWSLtTRFIEARTSGTVPQPqllnsKEKTKAQNLW--EYKNAVIAQVTTHF------ 494
Cdd:PRK13208 565 LGSDTPFDEKQ--VKIGRRLLTKLWNA-SRFVLHFSADPEPDK-----AEVLEPLDRWilAKLAKVVEKATEALenydfa 636
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 -----TEDFALNS--------VVSQLMGLSSALSQASQRVVLHSpefedALCALLVMAAPLAPHVTSELWagltlvpskl 561
Cdd:PRK13208 637 kaleeIESFFWHVfcddylelVKSRAYGEDEEEEQKSARYTLYT-----VLDTLLRLLAPFLPFITEEVW---------- 701
|
410
....*....|....*....
gi 1143076967 562 cdHYAWDSGVMLQAWPTVD 580
Cdd:PRK13208 702 --SWLYGGSVHRASWPEPD 718
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; |
196-583 |
9.33e-26 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 223138 [Multi-domain] Cd Length: 933 Bit Score: 113.07 E-value: 9.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLpviLPSIASLTGRGGSplaTAL--EWVNC---SCPRCKGSAKRETDT 270
Cdd:COG0060 455 PDWCISRQRYWGVPIPVWYCKETGEILVITEEL---EELVGQLVEEKGI---DDWhrPDIDEllpPCPEDGKEYRRVPDV 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 271 MDTFVDSawyyfrytdphntqspfGSAladFWmpvdlyiggkehAVMHLF----YARFLSHFC---HDQkmvkHREPFHK 343
Cdd:COG0060 529 LDVWFDS-----------------GST---PY------------AVLHPRenlkFPALFADFYlegSDQ----TRGWFYS 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 344 LLAQGLIkgqTF-RLPSGQCLKkedIDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 422
Cdd:COG0060 573 SLLTSTA---LFgRAPYKNVLT---HGFV------------LDEKGRKMSKSLGNVVDPQDVIDKYGADILRLWVASSDY 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 423 PE-----KDILWDVKTdalpgVLRwqqRLWsLTTRFIEARTSGTVPQPQLLnSKEKTKAQNLW--EYKNAVIAQVTTHFt 495
Cdd:COG0060 635 WEdlrfsDEILKQVRE-----VYR---KIR-NTYRFLLGNLDDFDPKKDAV-LPEELRELDRWilSRLNSLVKEVREAY- 703
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 496 EDFALNSVVSQLMG-----LSS----------------ALSQASQRVVLHspefeDALCALLVMAAPLAPHVTSELWAGL 554
Cdd:COG0060 704 ENYDFHKVVRALMNfvsedLSNwyldiikdrlyteaadSPDRRAAQTTLY-----HILKALVRLLAPILPFTAEEIWQNL 778
|
410 420
....*....|....*....|....*....
gi 1143076967 555 TlvpsklcdHYAWDSGVMLQAWPTVDSQF 583
Cdd:COG0060 779 P--------GERKEESVHLEDWPEVDEEL 799
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
429-554 |
1.52e-24 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 98.83 E-value: 1.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 429 WDvkTDALPGVLRWQQRLWSLTTRFIEARTSGTVPQpqllnsKEKTKAQNLWEYKNAVIAQVTTHFtEDFALNSVVSQLM 508
Cdd:cd07958 1 WS--DSGVEGAYRFLNRVWRLVTELAEALAAPAAAA------ELSEEDKELRRKLHKTIKKVTEDI-ERLRFNTAIAALM 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1143076967 509 GLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGL 554
Cdd:cd07958 72 ELVNALYKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
193-429 |
2.46e-23 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 102.32 E-value: 2.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIasltgrggsplatalewvNCSCPRCKGSA-KRETDTM 271
Cdd:cd00817 207 ENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAA------------------PEACVPCGGEElKQDEDVL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 272 DTFVDSA-WYYFRYTDPHNTQSpfgsaLADFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLI 350
Cdd:cd00817 269 DTWFSSSlWPFSTLGWPEETKD-----LKKFY-PTSLLVTGHDIIFFWVARMIMRGLKLTGKL------PFKEVYLHGLV 336
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 351 KGqtfrlpsgqclkkEDidftgpapvcaktkeklevtWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:cd00817 337 RD-------------ED--------------------GRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
196-591 |
1.83e-22 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 102.45 E-value: 1.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPvpvplqdlPVILPSIASL------TGRGGSPLATA---LEWVNCSCPRCkGSAKR 266
Cdd:TIGR00392 461 PDWCISRQRYWGIPIPIWYCEDTGE--------PIVVGSIEELielielKGIDAWFEDLHrdfLDKITLKSGDG-GEYRR 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 267 ETDTMDTFVDS--AWyyfrYTDPHNtqsPFGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKL 344
Cdd:TIGR00392 532 VPDVLDVWFDSgsMP----YASIHY---PFENEKFKEVFPADFILEG------------------SDQ----TRGWFYSS 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 345 LAQGLIkgQTFRLPSGQCLKKediDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPpe 424
Cdd:TIGR00392 583 LAIGTA--LFGQAPYKNVITH---GFT------------LDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDP-- 643
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 425 kdilWD---VKTDALPGVLRWQQRLWSLTTRFI--EARTSGTVPQPQLLnSKEKTKAQNLW--EYKNAVIAQVTTHFtED 497
Cdd:TIGR00392 644 ----WEdlrFSDEILKQVVEKYRKIRWNTYRFLltYANLDKFDPLFNSV-AVEKFPEEDRWilSRLNSLVEEVNEAL-EK 717
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 498 FALNSVVSQLMG-----LSS----------------ALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLTL 556
Cdd:TIGR00392 718 YNFHKVLRALQDfiveeLSNwyiriirdrlyceakdNDKRAAQTTLYY------ALLTLVRLLAPFLPHTAEEIYQNLPG 791
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1143076967 557 VPSKlcdhyawdSGVMLQAWPTVDSQFL-----QKPDMVQ 591
Cdd:TIGR00392 792 GEEE--------ESVHLNLWPEVDEEFIdealeANMAIVR 823
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
195-427 |
3.67e-17 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 83.05 E-value: 3.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWLISRQRYWGTPIPIVHCPACGPVPVplqdlpvilpsiasltgrggsplatalewvncscprckgsaKRETDTMDTF 274
Cdd:cd00818 189 RRDWCISRQRYWGTPIPVWYCEDCGEVLV-----------------------------------------RRVPDVLDVW 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDS--AWYYFRytdpHNtqsPFGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKLLAQGLIkg 352
Cdd:cd00818 228 FDSgsMPYAQL----HY---PFENEDFEELFPADFILEG------------------SDQ----TRGWFYSLLLLSTA-- 276
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1143076967 353 qTF-RLPSGQCLKKEDI-DFTGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00818 277 -LFgKAPYKNVIVHGFVlDEDG----------------RKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
195-429 |
3.48e-16 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 79.77 E-value: 3.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWLISRQRYWGTPIPivhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDTF 274
Cdd:cd00668 178 LLDWAISRQRYWGTPLP--------------------------------------------------------EDVFDVW 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDSAWYYFRYTDphntqSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLShfchdqKMVKHREPFHKLLAQGLIKGqt 354
Cdd:cd00668 202 FDSGIGPLGSLG-----YPEEKEWFKDSYPADWHLIGKDILRGWANFWITML------VALFGEIPPKNLLVHGFVLD-- 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 355 frlPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:cd00668 269 ---EGGQ----------------------------KMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
193-583 |
7.34e-16 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 81.30 E-value: 7.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPAcGPVPVPLQDLpvilpsiasltgrggsplatalewvncsCPRCKGSAKRETDTMD 272
Cdd:PRK05729 396 ENIQDWCISRQLWWGHRIPAWYDED-GEVYVGREEP----------------------------EAREKALLTQDEDVLD 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSA--------WyyfrytdPHNTQspfgsALADFWmPVDLYIGGkehavmH--LFY--AR--FLSHFCHDQKmvkhr 338
Cdd:PRK05729 447 TWFSSAlwpfstlgW-------PEKTE-----DLKRFY-PTSVLVTG------FdiIFFwvARmiMMGLHFTGQV----- 502
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 339 ePFHKLLAQGLI---KGQtfrlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRL 415
Cdd:PRK05729 503 -PFKDVYIHGLVrdeQGR------------------------------------KMSKSKGNVIDPLDLIDKYGADALRF 545
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 416 YILFAAPPEKDILWDVKtdalpgvlRWQQ------RLWSlTTRFIEARTSGTVPqPQLLNSKEKTKAqNLW---EYkNAV 486
Cdd:PRK05729 546 TLAALASPGRDIRFDEE--------RVEGyrnfanKLWN-ASRFVLMNLEGADV-GELPDPEELSLA-DRWilsRL-NRT 613
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 487 IAQVTTHFtEDFALNSVVSQLMG-----------------LSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSE 549
Cdd:PRK05729 614 VAEVTEAL-DKYRFDEAARALYEfiwnefcdwylelakpvLQEAAKRATRATLAY------VLEQILRLLHPFMPFITEE 686
|
410 420 430
....*....|....*....|....*....|....
gi 1143076967 550 LWAGLTlvpsklcdHYAWDSGVMLQAWPTVDSQF 583
Cdd:PRK05729 687 LWQKLA--------PLGIEESIMLAPWPEADEAI 712
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
197-430 |
1.71e-14 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 395082 [Multi-domain] Cd Length: 603 Bit Score: 76.69 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVD 276
Cdd:pfam00133 419 DWCISRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFS 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SA-WYYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtf 355
Cdd:pfam00133 494 SGsWPFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV----- 557
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 356 RLPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 430
Cdd:pfam00133 558 RDEQGR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
389-554 |
1.19e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 67.60 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD------ILWDVKTDALPGVL-RWQQRLWSLTTRFIEartsGT 461
Cdd:PRK11893 298 EKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDgdfsreAFINRINADLANDLgNLAQRTLSMIAKNFD----GK 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 462 VPQPQLLNSKEktkaQNLWEYKNAVIAQVTTHFtEDFALNSVVSQLMGLSSALSQ--ASQR-VVL---HSPEFEDALCAL 535
Cdd:PRK11893 374 VPEPGALTEAD----EALLEAAAALLERVRAAM-DNLAFDKALEAILALVRAANKyiDEQApWSLaktDPERLATVLYTL 448
|
170 180
....*....|....*....|....*.
gi 1143076967 536 L-------VMAAPLAPHVTSELWAGL 554
Cdd:PRK11893 449 LevlrgiaVLLQPVMPELAAKILDQL 474
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
195-581 |
4.39e-11 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 66.17 E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWLISRQRYWGTPIPIVHCPACGPVPVPLQdlpvilPSiasltgrggsplatalewvncSCPRCKGSAKRE-TDTMDT 273
Cdd:PRK14900 413 IHDWCISRQLWWGHQIPAWYCPDGHVTVARET------PE---------------------ACSTCGKAELRQdEDVLDT 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 274 FVDSA-WYYFRYTDPHNTQSpfgsaLADFWmPVDLYIGGkeHAVMHLFYARFLS---HFCHDQkmvkhrePFHKLLAQGL 349
Cdd:PRK14900 466 WFSSGlWPFSTMGWPEQTDT-----LRTFY-PTSVMETG--HDIIFFWVARMMMmglHFMGEV-------PFRTVYLHPM 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 350 IKgqtfrlpsgqclkkediDFTGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDIlw 429
Cdd:PRK14900 531 VR-----------------DEKG----------------QKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDI-- 575
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 430 DVKTDALPGVLRWQQRLW-------------------------SLTTRFIEARTSGTVPQpqllnSKEKTKAQNLWEYKN 484
Cdd:PRK14900 576 KLAKERIEGYRAFANKLWnasrfalmnlsgyqergedparlarTPADRWILARLQRAVNE-----TVEALEAFRFNDAAN 650
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 485 AVIAQVTTHFTeDFALNSVVSQLMGLSSALSQASQRVVLHSpefedaLCALLVMAAPLAPHVTSELWAGLTLVPSKlcdh 564
Cdd:PRK14900 651 AVYAFVWHELC-DWYIELAKEALASEDPEARRSVQAVLVHC------LQTSYRLLHPFMPFITEELWHVLRAQVGA---- 719
|
410
....*....|....*..
gi 1143076967 565 YAWDSGVMLQAWPTVDS 581
Cdd:PRK14900 720 SAWADSVLAAEYPRKGE 736
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; |
389-569 |
2.79e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 223221 [Multi-domain] Cd Length: 558 Bit Score: 63.06 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDIL--WD-----VKTDaLPGVLrwqQRLWSLTTRFIEARTSGT 461
Cdd:COG0143 332 QKMSKSRGNVVDPDELLEQYGVDALRYYLARELPEGSDGDfsWEdfverVNAD-LANKL---GNLANRTLGFINKYFDGV 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 462 VPQPQLLNSKEKTKaqnLWEYKNAVIAQVTTHFtEDFALNSVVSQLMGLSSALS---QASQRVVLHSPEFEDALCALL-- 536
Cdd:COG0143 408 VPAAGAPDLEEDEE---LLALAREALEAVAEAM-EKYEFRKALEEIMALASRANkyiDEQAPWKLAKEDKRERLATVLyl 483
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1143076967 537 ---------VMAAPLAPHVTSELWAGLTLVPSKlcDHYAWDS 569
Cdd:COG0143 484 alelvrvlaILLYPFMPETAEKIWDQLGLEEDA--RNFTWLG 523
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
22-181 |
5.27e-10 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 59.10 E-value: 5.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 22 HWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSVKKALQK---------------AL 86
Cdd:pfam13603 2 NWIGRSEGAEITFPV----EGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAfieeckntseiertsET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 87 VPGRDCLTPVMAVSMLTLQEVPIVImANPDLE--GSlDSKIGIPSTSSEDTRLAQALGLPYSEVIEaSPDGTE------- 157
Cdd:pfam13603 78 KEKEGVFTGLYAIHPITGEKIPIWI-ANFVLMeyGT-GAVMAVPAHDQRDFEFAKKYNLPIKPVIQ-PEDGDLdldimte 154
|
170 180 190
....*....|....*....|....*....|
gi 1143076967 158 ------RLSGSAEFTGMTRQDAFVALTRKA 181
Cdd:pfam13603 155 ayteegILVNSGEFDGLDSEEAKEAIIKKL 184
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
389-426 |
2.20e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.00 E-value: 2.20e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD 426
Cdd:cd00814 279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. ... |
484-600 |
3.44e-08 |
|
Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 52.79 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 484 NAVIAQVTTHFtEDFALNSVVSQLM-GLSSALS----QASQRVVLHSPEFEDA-------LCALLVMAAPLAPHVTSELW 551
Cdd:pfam08264 9 NKLIKEVTEAY-ENYRFNTAAQALYeFFWNDLSdwylELIKDRLYGEEPDSRAqttlyevLETLLRLLAPFMPFITEELW 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1143076967 552 AGLTlvpsklcdhyawdsgVMLQAWPTV----DSQFLQKPDMVQMAVLINNKA 600
Cdd:pfam08264 88 QKES---------------IHLAPWPEDaeleEAELEEAFELRQEIVQAIRKL 125
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
389-551 |
6.38e-07 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 52.56 E-value: 6.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdALPGVLRWQQRLWSLTTRFIEARTSGTVPQPQL- 467
Cdd:PRK12300 576 KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREK--EVESVRRQLERFYELAKELIEIGGEEELRFIDKw 653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 468 ----LNS--KEKTKAQNLWEYKNAVIaqvtthfTEDFALNSVVSQLMGLSSALSQASQRVVLHspefedalcALLVMAAP 541
Cdd:PRK12300 654 llsrLNRiiKETTEAMESFQTRDAVQ-------EAFYELLNDLRWYLRRVGEANNKVLREVLE---------IWIRLLAP 717
|
170
....*....|
gi 1143076967 542 LAPHVTSELW 551
Cdd:PRK12300 718 FTPHLAEELW 727
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
389-422 |
7.61e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.11 E-value: 7.61e-07
10 20 30
....*....|....*....|....*....|....
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 422
Cdd:PRK12267 298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVP 331
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
389-427 |
1.63e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 50.75 E-value: 1.63e-06
10 20 30
....*....|....*....|....*....|....*....
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:pfam09334 323 GKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDT 361
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
196-418 |
2.82e-06 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 50.74 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPVpvplqdlpVILPSIASLTGRGGSPLATAL-----EWVNCSCPRCKG--SAKRET 268
Cdd:PTZ00427 569 KDWCISRNRYWGTPIPIWADEKMETV--------ICVESIKHLEELSGVKNINDLhrhfiDHIEIKNPKGKTypKLKRIP 640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 269 DTMDTFVDSAwyYFRYTDPHntqSPFGSALADFW--MPVDLYIGGKEHAVMHLFYARFLSHFCHDqkmvkhREPFHKLLA 346
Cdd:PTZ00427 641 EVFDCWFESG--SMPYAKVH---YPFSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVISTLLFD------KAPFKNLIC 709
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1143076967 347 QGLIkgqtfrlpsgqclkkedidftgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 418
Cdd:PTZ00427 710 NGLV---------------------------------LASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
196-418 |
1.62e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 48.18 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPVpvplqdlpVILPSIASLTgrggsplatalewvncscprcKGSAKRETDTMDTFV 275
Cdd:PLN02882 465 RDWAVSRSRFWGTPLPIWISDDGEEV--------VVIGSIAELE---------------------KLSGVKVTDLHRHFI 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 276 DsawyyfRYTDPHNTQSPFG-----SALADFW-----MPvdlyiggkeHAVMH-------LFYARFLSHF---CHDQKmv 335
Cdd:PLN02882 516 D------HITIPSSRGPEFGvlrrvDDVFDCWfesgsMP---------YAYIHypfenkeLFEKNFPADFvaeGLDQT-- 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 336 khREPFHKL--LAQGLIKGQTFR--LPSGQCLkKEDidftgpapvcaktkeklevtWEKMSKSKHNGVDPEEIVAQYGID 411
Cdd:PLN02882 579 --RGWFYTLmvLSTALFDKPAFKnlICNGLVL-AED--------------------GKKMSKSLKNYPDPNEVIDKYGAD 635
|
....*..
gi 1143076967 412 TIRLYIL 418
Cdd:PLN02882 636 ALRLYLI 642
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
196-588 |
6.57e-05 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 46.30 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPvpvPLQDLPVIlPSIASLTGRGGSPLATALEWVNCSCPRCKGSA---KRETDTMD 272
Cdd:PLN02843 467 SDWCISRQRTWGVPIPVFYHVETKE---PLMNEETI-AHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAsdyEKGTDTMD 542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSawyyfrytdphntqspfGSALA-------DFWMPVDLYIGGKEHavmH--LFYARFLSHFChdqkmVKHREPFHK 343
Cdd:PLN02843 543 VWFDS-----------------GSSWAgvlgsreGLSYPADLYLEGSDQ---HrgWFQSSLLTSVA-----TKGKAPYKS 597
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 344 LLAQGLI---KGQtfrlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIV---------AQYGID 411
Cdd:PLN02843 598 VLTHGFVldeKGF------------------------------------KMSKSLGNVVDPRLVIeggknqkqePAYGAD 641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 412 TIRLYILFAappekdilwDVKTDALPGVLRWQQ-----RLWSLTTRFI-----EARTSGTVPQPQL----------LNSK 471
Cdd:PLN02843 642 VLRLWVASV---------DYTGDVLIGPQILKQmsdiyRKLRGTLRYLlgnlhDWKPDNAVPYEDLpsidkyalfqLENV 712
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 472 EKTKAQNLWEYKNAVIAQVTTHFT----EDFALNSVVSQLM--GLSSALSQASQRVVLHspefedALCALLVMAAPLAPH 545
Cdd:PLN02843 713 VNEIEESYDNYQFFKIFQILQRFTivdlSNFYLDVAKDRLYvgGTTSFTRRSCQTVLAA------HLLSLLRAIAPILPH 786
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1143076967 546 VTSELWAGLTLVPSKlcdhyAWDSGVMLQAWPTVDSQFLQKPD 588
Cdd:PLN02843 787 LAEDAWQNLPFQEDG-----SAAESVFEAGWPTPNEEWLSFPA 824
|
|
|