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Conserved domains on  [gi|1143076967|ref|NP_001335097|]
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probable leucine--tRNA ligase, mitochondrial isoform 2 [Mus musculus]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
2-652 1.12e-171

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member TIGR00396:

Pssm-ID: 444652 [Multi-domain]  Cd Length: 842  Bit Score: 511.22  E-value: 1.12e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   2 AMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLL-HGCSS-- 77
Cdd:TIGR00396 198 ELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVeKAAENnp 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  78 -----VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImANPDLEG-SLDSKIGIPSTSSEDTRLAQALGLP 144
Cdd:TIGR00396 274 kvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-ANYVLMEyGTGAVMGVPAHDERDFEFAQKYGLP 352
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 145 YSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHC 215
Cdd:TIGR00396 353 IKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHC 432
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 216 PACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFG 295
Cdd:TIGR00396 433 EDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFD 512
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 296 SALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAP 375
Cdd:TIGR00396 513 KEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYP-PNGK-VPADVLTERDEKG 590
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 376 VCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIE 455
Cdd:TIGR00396 591 KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWN--ESGLEGARRFLDRVWNLVYEITG 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 456 ArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLhspefEDALCA 534
Cdd:TIGR00396 669 E------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALM-----LEYLKG 737
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPQHVaqDQ 614
Cdd:TIGR00396 738 FVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETALVE-DKTLIVVQVNGKFRAKITVPKDA--DE 804
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 652
Cdd:TIGR00396 805 EQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
 
Name Accession Description Interval E-value
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
2-652 1.12e-171

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 511.22  E-value: 1.12e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   2 AMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLL-HGCSS-- 77
Cdd:TIGR00396 198 ELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVeKAAENnp 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  78 -----VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImANPDLEG-SLDSKIGIPSTSSEDTRLAQALGLP 144
Cdd:TIGR00396 274 kvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-ANYVLMEyGTGAVMGVPAHDERDFEFAQKYGLP 352
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 145 YSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHC 215
Cdd:TIGR00396 353 IKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHC 432
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 216 PACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFG 295
Cdd:TIGR00396 433 EDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFD 512
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 296 SALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAP 375
Cdd:TIGR00396 513 KEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYP-PNGK-VPADVLTERDEKG 590
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 376 VCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIE 455
Cdd:TIGR00396 591 KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWN--ESGLEGARRFLDRVWNLVYEITG 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 456 ArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLhspefEDALCA 534
Cdd:TIGR00396 669 E------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALM-----LEYLKG 737
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPQHVaqDQ 614
Cdd:TIGR00396 738 FVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETALVE-DKTLIVVQVNGKFRAKITVPKDA--DE 804
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 652
Cdd:TIGR00396 805 EQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
5-652 4.18e-143

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223569 [Multi-domain]  Cd Length: 814  Bit Score: 436.33  E-value: 4.18e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   5 DALADL-PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSS------ 77
Cdd:COG0495   208 DKLATLwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEIVSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtpl 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  78 ----VKKALQKALV-------PGRDCLTPVMAVSMLTLQEVPIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPY 145
Cdd:COG0495   284 vaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKIPVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPI 362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 146 SEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPAC 218
Cdd:COG0495   363 KKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRCGLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDC 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 219 GPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPrcKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSA 297
Cdd:COG0495   443 GVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP--DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDRE 519
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 298 LADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvc 377
Cdd:COG0495   520 EFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKDEPFKKLITQGMV------------LGEEG---------- 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 378 aktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEar 457
Cdd:COG0495   578 -----------EKMSKSKGNVVDPEEAVEKYGADTVRLYIMFAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE-- 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 458 tsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCA 534
Cdd:COG0495   643 ----------KLVEELTKEQGKedrWLL-HRTIKKVTEDFEARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALET 711
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQ 614
Cdd:COG0495   712 WVRLLAPFAPHIAEELWEELGN-----------EGFVSNAPWPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADE 777
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 652
Cdd:COG0495   778 EKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
PLN02563 PLN02563
aminoacyl-tRNA ligase
9-643 3.93e-108

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 348.74  E-value: 3.93e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   9 DLPEwyGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLhgcSSVKKALQKALV 87
Cdd:PLN02563  288 DWPE--SIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLVVAPEHPLL---SSLTTAEQKEAV 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  88 PG------------RDCL--------TPVMAVSMLTLQEVPI-------------VIMAnpdlegsldskigIPSTSSED 134
Cdd:PLN02563  363 EEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIwvadyvlgsygtgAIMA-------------VPAHDTRD 429
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 135 TRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWL 199
Cdd:PLN02563  430 FEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWL 508
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 200 ISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVD 276
Cdd:PLN02563  509 FARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAG 588
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQ--- 353
Cdd:PLN02563  589 SCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEvey 668
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 354 -TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPEEIVAQYGIDTIR 414
Cdd:PLN02563  669 tAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPDDVVSEYGADSLR 747
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 415 LYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEYKnaVIAQVTTHf 494
Cdd:PLN02563  748 LYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLHK--CIAKVTEE- 820
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 TEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLCDHyawDSGVMLQ 574
Cdd:PLN02563  821 IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRLGH---SNSLAYE 882
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 575 AWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSP 643
Cdd:PLN02563  883 PWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVP 948
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
195-429 6.04e-61

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 205.94  E-value: 6.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWL-ISRQRYWGTPIPIvhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDT 273
Cdd:cd00812   163 QENWIgCSRQRYWGTPIPW-------------------------------------------------------TDTMES 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 274 FVDSAWYYFRYTDPHNTQSP------FGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQ 347
Cdd:cd00812   188 LSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQ 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 348 GLIKGQTfrlpsgqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00812   267 GMVLLEG----------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312

                  ..
gi 1143076967 428 LW 429
Cdd:cd00812   313 DW 314
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
197-430 1.71e-14

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 395082 [Multi-domain]  Cd Length: 603  Bit Score: 76.69  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVD 276
Cdd:pfam00133 419 DWCISRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFS 493
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SA-WYYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtf 355
Cdd:pfam00133 494 SGsWPFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV----- 557
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 356 RLPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 430
Cdd:pfam00133 558 RDEQGR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
 
Name Accession Description Interval E-value
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
2-652 1.12e-171

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 511.22  E-value: 1.12e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   2 AMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLL-HGCSS-- 77
Cdd:TIGR00396 198 ELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKITVFTTRPDTIFGVTYLALAPEHPLVeKAAENnp 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  78 -----VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImANPDLEG-SLDSKIGIPSTSSEDTRLAQALGLP 144
Cdd:TIGR00396 274 kvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-ANYVLMEyGTGAVMGVPAHDERDFEFAQKYGLP 352
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 145 YSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHC 215
Cdd:TIGR00396 353 IKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHC 432
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 216 PACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFG 295
Cdd:TIGR00396 433 EDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFD 512
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 296 SALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAP 375
Cdd:TIGR00396 513 KEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLINQGMVLGFYYP-PNGK-VPADVLTERDEKG 590
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 376 VCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIE 455
Cdd:TIGR00396 591 KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWN--ESGLEGARRFLDRVWNLVYEITG 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 456 ArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLhspefEDALCA 534
Cdd:TIGR00396 669 E------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKKEALM-----LEYLKG 737
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQFLQKpDMVQMAVLINNKACGKIPVPQHVaqDQ 614
Cdd:TIGR00396 738 FVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDETALVE-DKTLIVVQVNGKFRAKITVPKDA--DE 804
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 652
Cdd:TIGR00396 805 EQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
5-652 4.18e-143

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223569 [Multi-domain]  Cd Length: 814  Bit Score: 436.33  E-value: 4.18e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   5 DALADL-PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSS------ 77
Cdd:COG0495   208 DKLATLwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEIVSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtpl 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  78 ----VKKALQKALV-------PGRDCLTPVMAVSMLTLQEVPIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPY 145
Cdd:COG0495   284 vaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKIPVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPI 362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 146 SEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPAC 218
Cdd:COG0495   363 KKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRCGLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDC 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 219 GPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPrcKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSA 297
Cdd:COG0495   443 GVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP--DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDRE 519
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 298 LADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvc 377
Cdd:COG0495   520 EFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKDEPFKKLITQGMV------------LGEEG---------- 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 378 aktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEar 457
Cdd:COG0495   578 -----------EKMSKSKGNVVDPEEAVEKYGADTVRLYIMFAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE-- 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 458 tsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCA 534
Cdd:COG0495   643 ----------KLVEELTKEQGKedrWLL-HRTIKKVTEDFEARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALET 711
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 535 LLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQ 614
Cdd:COG0495   712 WVRLLAPFAPHIAEELWEELGN-----------EGFVSNAPWPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADE 777
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 1143076967 615 DKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 652
Cdd:COG0495   778 EKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
PLN02563 PLN02563
aminoacyl-tRNA ligase
9-643 3.93e-108

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 348.74  E-value: 3.93e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967   9 DLPEwyGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLhgcSSVKKALQKALV 87
Cdd:PLN02563  288 DWPE--SIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLVVAPEHPLL---SSLTTAEQKEAV 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  88 PG------------RDCL--------TPVMAVSMLTLQEVPI-------------VIMAnpdlegsldskigIPSTSSED 134
Cdd:PLN02563  363 EEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIwvadyvlgsygtgAIMA-------------VPAHDTRD 429
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 135 TRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWL 199
Cdd:PLN02563  430 FEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWL 508
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 200 ISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVD 276
Cdd:PLN02563  509 FARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAG 588
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQ--- 353
Cdd:PLN02563  589 SCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEvey 668
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 354 -TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPEEIVAQYGIDTIR 414
Cdd:PLN02563  669 tAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPDDVVSEYGADSLR 747
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 415 LYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEYKnaVIAQVTTHf 494
Cdd:PLN02563  748 LYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLHK--CIAKVTEE- 820
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 TEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLCDHyawDSGVMLQ 574
Cdd:PLN02563  821 IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRLGH---SNSLAYE 882
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 575 AWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSP 643
Cdd:PLN02563  883 PWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVP 948
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
195-429 6.04e-61

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 205.94  E-value: 6.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWL-ISRQRYWGTPIPIvhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDT 273
Cdd:cd00812   163 QENWIgCSRQRYWGTPIPW-------------------------------------------------------TDTMES 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 274 FVDSAWYYFRYTDPHNTQSP------FGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQ 347
Cdd:cd00812   188 LSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQ 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 348 GLIKGQTfrlpsgqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00812   267 GMVLLEG----------------------------------EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312

                  ..
gi 1143076967 428 LW 429
Cdd:cd00812   313 DW 314
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
193-597 3.02e-33

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223599 [Multi-domain]  Cd Length: 877  Bit Score: 136.61  E-value: 3.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPlQDLPVILpsiasltgrggsplataleWVNCSCPrcKGSAKRETDTMD 272
Cdd:COG0525   394 ENIRDWCISRQLWWGHRIPVWYCKECGNVVVA-EEEPEDP-------------------AAAEKCP--KEELEQDEDVLD 451
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSAWYYFrYTDPHNTQSPFgsaLADFWmPVDLYIGGkeHAVMH--LFYARFLS-HFCHDqkmvkhrEPFHKLLAQGL 349
Cdd:COG0525   452 TWFSSSLWPF-STLGWPEETPD---LKKFY-PTDLLVTG--HDIIFfwVARMIMRGlHLTGE-------VPFKDVYIHGL 517
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 350 IKGqtfrlPSGqclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:COG0525   518 VRD-----EQG----------------------------RKMSKSKGNVIDPLDVIDKYGADALRFTLASLASPGRDINF 564
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 430 DvkTDALPGVLRWQQRLWSLtTRFIEARTSGTVPQPQLLNSKEKTkaqNLWEYK--NAVIAQVTTHFtEDFALNSVVSQL 507
Cdd:COG0525   565 D--EKRVEGYRNFLNKLWNA-TRFVLMNLDDLGPDDLDLLALSLA---DRWILSrlNETVKEVTEAL-DNYRFDEAARAL 637
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 508 MGL------------------SSALSQASQRVVLHSpefedALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyawds 569
Cdd:COG0525   638 YEFiwndfcdwylelakprlyGGEEEKRAARATLYY-----VLDTLLRLLHPFMPFITEEIWQKLPGTES---------- 702
                         410       420
                  ....*....|....*....|....*...
gi 1143076967 570 gVMLQAWPTVDSQFLQKPDMVQMAVLIN 597
Cdd:COG0525   703 -IHLASWPEVDEELIDEEAEKEFELLKE 729
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
193-584 2.74e-29

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 124.02  E-value: 2.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSiasltgrggsPLATALEWvncscprckgsaKRETDTMD 272
Cdd:TIGR00422 394 RNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDKT----------NTGPSVEL------------EQDTDVLD 451
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSAWYYFRYTD-PHNTqspfgSALADFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLIK 351
Cdd:TIGR00422 452 TWFSSSLWPFSTLGwPDET-----KDLKKFY-PTDLLVTGYDIIFFWVARMIFRSLALTGQV------PFKEVYIHGLVR 519
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 352 GQTFRlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDV 431
Cdd:TIGR00422 520 DEQGR---------------------------------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDW 566
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 432 KTdaLPGVLRWQQRLWSlTTRFIEARTSGtvpQPQLLNSKEKTKAQNLWEYK--NAVIAQVTTHFtEDFALNSVVS---- 505
Cdd:TIGR00422 567 KR--VESARNFLNKLWN-ASRFVLMNLSD---DLELSGGEEKLSLADRWILSklNRTIKEVRKAL-DKYRFAEAAKalye 639
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 506 ----------------QLMGLSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLtlvpsklcdHYAWDS 569
Cdd:TIGR00422 640 fiwndfcdwyielvkyRLYNGNEAEKKAARDTLYY------VLDKALRLLHPFMPFITEEIWQHF---------KEGADS 704
                         410
                  ....*....|....*
gi 1143076967 570 gVMLQAWPTVDSQFL 584
Cdd:TIGR00422 705 -IMLQSYPVVDAEFV 718
valS PRK13208
valyl-tRNA synthetase; Reviewed
197-580 1.35e-27

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 118.76  E-value: 1.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVilpsiasltgrggSPLATALEWvnCSCPRC-KGSAKRETDTMDTF 274
Cdd:PRK13208  397 DWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPV-------------DPTKDEPPG--YKCPQCgSPGFEGETDVMDTW 461
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDS---AWYYFRYTDPHntqspfgsalaDFWM---PVDLYIGGkehavmH------LFYARFLSHFCHDQKmvkhrePFH 342
Cdd:PRK13208  462 ATSsitPLIVTGWERDE-----------DLFEkvfPMDLRPQG------HdiirtwLFYTILRAYLLTGKL------PWK 518
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 343 KLLaqglIkgqtfrlpSGQCLKkEDidftGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILfAAP 422
Cdd:PRK13208  519 NIM----I--------SGMVLD-PD----G----------------KKMSKSKGNVVTPEELLEKYGADAVRYWAA-SAR 564
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 423 PEKDILWDVKTdaLPGVLRWQQRLWSLtTRFIEARTSGTVPQPqllnsKEKTKAQNLW--EYKNAVIAQVTTHF------ 494
Cdd:PRK13208  565 LGSDTPFDEKQ--VKIGRRLLTKLWNA-SRFVLHFSADPEPDK-----AEVLEPLDRWilAKLAKVVEKATEALenydfa 636
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 495 -----TEDFALNS--------VVSQLMGLSSALSQASQRVVLHSpefedALCALLVMAAPLAPHVTSELWagltlvpskl 561
Cdd:PRK13208  637 kaleeIESFFWHVfcddylelVKSRAYGEDEEEEQKSARYTLYT-----VLDTLLRLLAPFLPFITEEVW---------- 701
                         410
                  ....*....|....*....
gi 1143076967 562 cdHYAWDSGVMLQAWPTVD 580
Cdd:PRK13208  702 --SWLYGGSVHRASWPEPD 718
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
196-583 9.33e-26

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223138 [Multi-domain]  Cd Length: 933  Bit Score: 113.07  E-value: 9.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLpviLPSIASLTGRGGSplaTAL--EWVNC---SCPRCKGSAKRETDT 270
Cdd:COG0060   455 PDWCISRQRYWGVPIPVWYCKETGEILVITEEL---EELVGQLVEEKGI---DDWhrPDIDEllpPCPEDGKEYRRVPDV 528
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 271 MDTFVDSawyyfrytdphntqspfGSAladFWmpvdlyiggkehAVMHLF----YARFLSHFC---HDQkmvkHREPFHK 343
Cdd:COG0060   529 LDVWFDS-----------------GST---PY------------AVLHPRenlkFPALFADFYlegSDQ----TRGWFYS 572
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 344 LLAQGLIkgqTF-RLPSGQCLKkedIDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 422
Cdd:COG0060   573 SLLTSTA---LFgRAPYKNVLT---HGFV------------LDEKGRKMSKSLGNVVDPQDVIDKYGADILRLWVASSDY 634
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 423 PE-----KDILWDVKTdalpgVLRwqqRLWsLTTRFIEARTSGTVPQPQLLnSKEKTKAQNLW--EYKNAVIAQVTTHFt 495
Cdd:COG0060   635 WEdlrfsDEILKQVRE-----VYR---KIR-NTYRFLLGNLDDFDPKKDAV-LPEELRELDRWilSRLNSLVKEVREAY- 703
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 496 EDFALNSVVSQLMG-----LSS----------------ALSQASQRVVLHspefeDALCALLVMAAPLAPHVTSELWAGL 554
Cdd:COG0060   704 ENYDFHKVVRALMNfvsedLSNwyldiikdrlyteaadSPDRRAAQTTLY-----HILKALVRLLAPILPFTAEEIWQNL 778
                         410       420
                  ....*....|....*....|....*....
gi 1143076967 555 TlvpsklcdHYAWDSGVMLQAWPTVDSQF 583
Cdd:COG0060   779 P--------GERKEESVHLEDWPEVDEEL 799
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
429-554 1.52e-24

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 98.83  E-value: 1.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 429 WDvkTDALPGVLRWQQRLWSLTTRFIEARTSGTVPQpqllnsKEKTKAQNLWEYKNAVIAQVTTHFtEDFALNSVVSQLM 508
Cdd:cd07958     1 WS--DSGVEGAYRFLNRVWRLVTELAEALAAPAAAA------ELSEEDKELRRKLHKTIKKVTEDI-ERLRFNTAIAALM 71
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1143076967 509 GLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGL 554
Cdd:cd07958    72 ELVNALYKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
193-429 2.46e-23

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 102.32  E-value: 2.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIasltgrggsplatalewvNCSCPRCKGSA-KRETDTM 271
Cdd:cd00817   207 ENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAA------------------PEACVPCGGEElKQDEDVL 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 272 DTFVDSA-WYYFRYTDPHNTQSpfgsaLADFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLI 350
Cdd:cd00817   269 DTWFSSSlWPFSTLGWPEETKD-----LKKFY-PTSLLVTGHDIIFFWVARMIMRGLKLTGKL------PFKEVYLHGLV 336
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1143076967 351 KGqtfrlpsgqclkkEDidftgpapvcaktkeklevtWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:cd00817   337 RD-------------ED--------------------GRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
ileS TIGR00392
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ...
196-591 1.83e-22

isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273054 [Multi-domain]  Cd Length: 861  Bit Score: 102.45  E-value: 1.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPvpvplqdlPVILPSIASL------TGRGGSPLATA---LEWVNCSCPRCkGSAKR 266
Cdd:TIGR00392 461 PDWCISRQRYWGIPIPIWYCEDTGE--------PIVVGSIEELielielKGIDAWFEDLHrdfLDKITLKSGDG-GEYRR 531
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 267 ETDTMDTFVDS--AWyyfrYTDPHNtqsPFGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKL 344
Cdd:TIGR00392 532 VPDVLDVWFDSgsMP----YASIHY---PFENEKFKEVFPADFILEG------------------SDQ----TRGWFYSS 582
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 345 LAQGLIkgQTFRLPSGQCLKKediDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPpe 424
Cdd:TIGR00392 583 LAIGTA--LFGQAPYKNVITH---GFT------------LDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDP-- 643
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 425 kdilWD---VKTDALPGVLRWQQRLWSLTTRFI--EARTSGTVPQPQLLnSKEKTKAQNLW--EYKNAVIAQVTTHFtED 497
Cdd:TIGR00392 644 ----WEdlrFSDEILKQVVEKYRKIRWNTYRFLltYANLDKFDPLFNSV-AVEKFPEEDRWilSRLNSLVEEVNEAL-EK 717
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 498 FALNSVVSQLMG-----LSS----------------ALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLTL 556
Cdd:TIGR00392 718 YNFHKVLRALQDfiveeLSNwyiriirdrlyceakdNDKRAAQTTLYY------ALLTLVRLLAPFLPHTAEEIYQNLPG 791
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1143076967 557 VPSKlcdhyawdSGVMLQAWPTVDSQFL-----QKPDMVQ 591
Cdd:TIGR00392 792 GEEE--------ESVHLNLWPEVDEEFIdealeANMAIVR 823
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
195-427 3.67e-17

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 83.05  E-value: 3.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWLISRQRYWGTPIPIVHCPACGPVPVplqdlpvilpsiasltgrggsplatalewvncscprckgsaKRETDTMDTF 274
Cdd:cd00818   189 RRDWCISRQRYWGTPIPVWYCEDCGEVLV-----------------------------------------RRVPDVLDVW 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDS--AWYYFRytdpHNtqsPFGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKLLAQGLIkg 352
Cdd:cd00818   228 FDSgsMPYAQL----HY---PFENEDFEELFPADFILEG------------------SDQ----TRGWFYSLLLLSTA-- 276
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1143076967 353 qTF-RLPSGQCLKKEDI-DFTGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:cd00818   277 -LFgKAPYKNVIVHGFVlDEDG----------------RKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
195-429 3.48e-16

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 79.77  E-value: 3.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 195 LKDWLISRQRYWGTPIPivhcpacgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDTF 274
Cdd:cd00668   178 LLDWAISRQRYWGTPLP--------------------------------------------------------EDVFDVW 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 275 VDSAWYYFRYTDphntqSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLShfchdqKMVKHREPFHKLLAQGLIKGqt 354
Cdd:cd00668   202 FDSGIGPLGSLG-----YPEEKEWFKDSYPADWHLIGKDILRGWANFWITML------VALFGEIPPKNLLVHGFVLD-- 268
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 355 frlPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 429
Cdd:cd00668   269 ---EGGQ----------------------------KMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
valS PRK05729
valyl-tRNA synthetase; Reviewed
193-583 7.34e-16

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 81.30  E-value: 7.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 193 NKLKDWLISRQRYWGTPIPIVHCPAcGPVPVPLQDLpvilpsiasltgrggsplatalewvncsCPRCKGSAKRETDTMD 272
Cdd:PRK05729  396 ENIQDWCISRQLWWGHRIPAWYDED-GEVYVGREEP----------------------------EAREKALLTQDEDVLD 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSA--------WyyfrytdPHNTQspfgsALADFWmPVDLYIGGkehavmH--LFY--AR--FLSHFCHDQKmvkhr 338
Cdd:PRK05729  447 TWFSSAlwpfstlgW-------PEKTE-----DLKRFY-PTSVLVTG------FdiIFFwvARmiMMGLHFTGQV----- 502
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 339 ePFHKLLAQGLI---KGQtfrlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRL 415
Cdd:PRK05729  503 -PFKDVYIHGLVrdeQGR------------------------------------KMSKSKGNVIDPLDLIDKYGADALRF 545
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 416 YILFAAPPEKDILWDVKtdalpgvlRWQQ------RLWSlTTRFIEARTSGTVPqPQLLNSKEKTKAqNLW---EYkNAV 486
Cdd:PRK05729  546 TLAALASPGRDIRFDEE--------RVEGyrnfanKLWN-ASRFVLMNLEGADV-GELPDPEELSLA-DRWilsRL-NRT 613
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 487 IAQVTTHFtEDFALNSVVSQLMG-----------------LSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSE 549
Cdd:PRK05729  614 VAEVTEAL-DKYRFDEAARALYEfiwnefcdwylelakpvLQEAAKRATRATLAY------VLEQILRLLHPFMPFITEE 686
                         410       420       430
                  ....*....|....*....|....*....|....
gi 1143076967 550 LWAGLTlvpsklcdHYAWDSGVMLQAWPTVDSQF 583
Cdd:PRK05729  687 LWQKLA--------PLGIEESIMLAPWPEADEAI 712
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
197-430 1.71e-14

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 395082 [Multi-domain]  Cd Length: 603  Bit Score: 76.69  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 197 DWLISRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVD 276
Cdd:pfam00133 419 DWCISRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFS 493
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 277 SA-WYYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtf 355
Cdd:pfam00133 494 SGsWPFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV----- 557
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1143076967 356 RLPSGQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 430
Cdd:pfam00133 558 RDEQGR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
389-554 1.19e-11

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 67.60  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD------ILWDVKTDALPGVL-RWQQRLWSLTTRFIEartsGT 461
Cdd:PRK11893  298 EKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDgdfsreAFINRINADLANDLgNLAQRTLSMIAKNFD----GK 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 462 VPQPQLLNSKEktkaQNLWEYKNAVIAQVTTHFtEDFALNSVVSQLMGLSSALSQ--ASQR-VVL---HSPEFEDALCAL 535
Cdd:PRK11893  374 VPEPGALTEAD----EALLEAAAALLERVRAAM-DNLAFDKALEAILALVRAANKyiDEQApWSLaktDPERLATVLYTL 448
                         170       180
                  ....*....|....*....|....*.
gi 1143076967 536 L-------VMAAPLAPHVTSELWAGL 554
Cdd:PRK11893  449 LevlrgiaVLLQPVMPELAAKILDQL 474
valS PRK14900
valyl-tRNA synthetase; Provisional
195-581 4.39e-11

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 66.17  E-value: 4.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  195 LKDWLISRQRYWGTPIPIVHCPACGPVPVPLQdlpvilPSiasltgrggsplatalewvncSCPRCKGSAKRE-TDTMDT 273
Cdd:PRK14900   413 IHDWCISRQLWWGHQIPAWYCPDGHVTVARET------PE---------------------ACSTCGKAELRQdEDVLDT 465
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  274 FVDSA-WYYFRYTDPHNTQSpfgsaLADFWmPVDLYIGGkeHAVMHLFYARFLS---HFCHDQkmvkhrePFHKLLAQGL 349
Cdd:PRK14900   466 WFSSGlWPFSTMGWPEQTDT-----LRTFY-PTSVMETG--HDIIFFWVARMMMmglHFMGEV-------PFRTVYLHPM 530
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  350 IKgqtfrlpsgqclkkediDFTGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDIlw 429
Cdd:PRK14900   531 VR-----------------DEKG----------------QKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDI-- 575
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  430 DVKTDALPGVLRWQQRLW-------------------------SLTTRFIEARTSGTVPQpqllnSKEKTKAQNLWEYKN 484
Cdd:PRK14900   576 KLAKERIEGYRAFANKLWnasrfalmnlsgyqergedparlarTPADRWILARLQRAVNE-----TVEALEAFRFNDAAN 650
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  485 AVIAQVTTHFTeDFALNSVVSQLMGLSSALSQASQRVVLHSpefedaLCALLVMAAPLAPHVTSELWAGLTLVPSKlcdh 564
Cdd:PRK14900   651 AVYAFVWHELC-DWYIELAKEALASEDPEARRSVQAVLVHC------LQTSYRLLHPFMPFITEELWHVLRAQVGA---- 719
                          410
                   ....*....|....*..
gi 1143076967  565 YAWDSGVMLQAWPTVDS 581
Cdd:PRK14900   720 SAWADSVLAAEYPRKGE 736
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
389-569 2.79e-10

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223221 [Multi-domain]  Cd Length: 558  Bit Score: 63.06  E-value: 2.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDIL--WD-----VKTDaLPGVLrwqQRLWSLTTRFIEARTSGT 461
Cdd:COG0143   332 QKMSKSRGNVVDPDELLEQYGVDALRYYLARELPEGSDGDfsWEdfverVNAD-LANKL---GNLANRTLGFINKYFDGV 407
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 462 VPQPQLLNSKEKTKaqnLWEYKNAVIAQVTTHFtEDFALNSVVSQLMGLSSALS---QASQRVVLHSPEFEDALCALL-- 536
Cdd:COG0143   408 VPAAGAPDLEEDEE---LLALAREALEAVAEAM-EKYEFRKALEEIMALASRANkyiDEQAPWKLAKEDKRERLATVLyl 483
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1143076967 537 ---------VMAAPLAPHVTSELWAGLTLVPSKlcDHYAWDS 569
Cdd:COG0143   484 alelvrvlaILLYPFMPETAEKIWDQLGLEEDA--RNFTWLG 523
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
22-181 5.27e-10

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 59.10  E-value: 5.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  22 HWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSVKKALQK---------------AL 86
Cdd:pfam13603   2 NWIGRSEGAEITFPV----EGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAfieeckntseiertsET 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  87 VPGRDCLTPVMAVSMLTLQEVPIVImANPDLE--GSlDSKIGIPSTSSEDTRLAQALGLPYSEVIEaSPDGTE------- 157
Cdd:pfam13603  78 KEKEGVFTGLYAIHPITGEKIPIWI-ANFVLMeyGT-GAVMAVPAHDQRDFEFAKKYNLPIKPVIQ-PEDGDLdldimte 154
                         170       180       190
                  ....*....|....*....|....*....|
gi 1143076967 158 ------RLSGSAEFTGMTRQDAFVALTRKA 181
Cdd:pfam13603 155 ayteegILVNSGEFDGLDSEEAKEAIIKKL 184
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
389-426 2.20e-08

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 56.00  E-value: 2.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD 426
Cdd:cd00814   279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. ...
484-600 3.44e-08

Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 52.79  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 484 NAVIAQVTTHFtEDFALNSVVSQLM-GLSSALS----QASQRVVLHSPEFEDA-------LCALLVMAAPLAPHVTSELW 551
Cdd:pfam08264   9 NKLIKEVTEAY-ENYRFNTAAQALYeFFWNDLSdwylELIKDRLYGEEPDSRAqttlyevLETLLRLLAPFMPFITEELW 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1143076967 552 AGLTlvpsklcdhyawdsgVMLQAWPTV----DSQFLQKPDMVQMAVLINNKA 600
Cdd:pfam08264  88 QKES---------------IHLAPWPEDaeleEAELEEAFELRQEIVQAIRKL 125
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
389-551 6.38e-07

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 52.56  E-value: 6.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdALPGVLRWQQRLWSLTTRFIEARTSGTVPQPQL- 467
Cdd:PRK12300  576 KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREK--EVESVRRQLERFYELAKELIEIGGEEELRFIDKw 653
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 468 ----LNS--KEKTKAQNLWEYKNAVIaqvtthfTEDFALNSVVSQLMGLSSALSQASQRVVLHspefedalcALLVMAAP 541
Cdd:PRK12300  654 llsrLNRiiKETTEAMESFQTRDAVQ-------EAFYELLNDLRWYLRRVGEANNKVLREVLE---------IWIRLLAP 717
                         170
                  ....*....|
gi 1143076967 542 LAPHVTSELW 551
Cdd:PRK12300  718 FTPHLAEELW 727
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
389-422 7.61e-07

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 52.11  E-value: 7.61e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 422
Cdd:PRK12267  298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVP 331
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
389-427 1.63e-06

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 50.75  E-value: 1.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1143076967 389 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 427
Cdd:pfam09334 323 GKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDT 361
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
196-418 2.82e-06

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 50.74  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  196 KDWLISRQRYWGTPIPIVHCPACGPVpvplqdlpVILPSIASLTGRGGSPLATAL-----EWVNCSCPRCKG--SAKRET 268
Cdd:PTZ00427   569 KDWCISRNRYWGTPIPIWADEKMETV--------ICVESIKHLEELSGVKNINDLhrhfiDHIEIKNPKGKTypKLKRIP 640
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  269 DTMDTFVDSAwyYFRYTDPHntqSPFGSALADFW--MPVDLYIGGKEHAVMHLFYARFLSHFCHDqkmvkhREPFHKLLA 346
Cdd:PTZ00427   641 EVFDCWFESG--SMPYAKVH---YPFSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVISTLLFD------KAPFKNLIC 709
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1143076967  347 QGLIkgqtfrlpsgqclkkedidftgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 418
Cdd:PTZ00427   710 NGLV---------------------------------LASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
PLN02882 PLN02882
aminoacyl-tRNA ligase
196-418 1.62e-05

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 48.18  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  196 KDWLISRQRYWGTPIPIVHCPACGPVpvplqdlpVILPSIASLTgrggsplatalewvncscprcKGSAKRETDTMDTFV 275
Cdd:PLN02882   465 RDWAVSRSRFWGTPLPIWISDDGEEV--------VVIGSIAELE---------------------KLSGVKVTDLHRHFI 515
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  276 DsawyyfRYTDPHNTQSPFG-----SALADFW-----MPvdlyiggkeHAVMH-------LFYARFLSHF---CHDQKmv 335
Cdd:PLN02882   516 D------HITIPSSRGPEFGvlrrvDDVFDCWfesgsMP---------YAYIHypfenkeLFEKNFPADFvaeGLDQT-- 578
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967  336 khREPFHKL--LAQGLIKGQTFR--LPSGQCLkKEDidftgpapvcaktkeklevtWEKMSKSKHNGVDPEEIVAQYGID 411
Cdd:PLN02882   579 --RGWFYTLmvLSTALFDKPAFKnlICNGLVL-AED--------------------GKKMSKSLKNYPDPNEVIDKYGAD 635

                   ....*..
gi 1143076967  412 TIRLYIL 418
Cdd:PLN02882   636 ALRLYLI 642
PLN02843 PLN02843
isoleucyl-tRNA synthetase
196-588 6.57e-05

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 46.30  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 196 KDWLISRQRYWGTPIPIVHCPACGPvpvPLQDLPVIlPSIASLTGRGGSPLATALEWVNCSCPRCKGSA---KRETDTMD 272
Cdd:PLN02843  467 SDWCISRQRTWGVPIPVFYHVETKE---PLMNEETI-AHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAsdyEKGTDTMD 542
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 273 TFVDSawyyfrytdphntqspfGSALA-------DFWMPVDLYIGGKEHavmH--LFYARFLSHFChdqkmVKHREPFHK 343
Cdd:PLN02843  543 VWFDS-----------------GSSWAgvlgsreGLSYPADLYLEGSDQ---HrgWFQSSLLTSVA-----TKGKAPYKS 597
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 344 LLAQGLI---KGQtfrlpsgqclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIV---------AQYGID 411
Cdd:PLN02843  598 VLTHGFVldeKGF------------------------------------KMSKSLGNVVDPRLVIeggknqkqePAYGAD 641
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 412 TIRLYILFAappekdilwDVKTDALPGVLRWQQ-----RLWSLTTRFI-----EARTSGTVPQPQL----------LNSK 471
Cdd:PLN02843  642 VLRLWVASV---------DYTGDVLIGPQILKQmsdiyRKLRGTLRYLlgnlhDWKPDNAVPYEDLpsidkyalfqLENV 712
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076967 472 EKTKAQNLWEYKNAVIAQVTTHFT----EDFALNSVVSQLM--GLSSALSQASQRVVLHspefedALCALLVMAAPLAPH 545
Cdd:PLN02843  713 VNEIEESYDNYQFFKIFQILQRFTivdlSNFYLDVAKDRLYvgGTTSFTRRSCQTVLAA------HLLSLLRAIAPILPH 786
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1143076967 546 VTSELWAGLTLVPSKlcdhyAWDSGVMLQAWPTVDSQFLQKPD 588
Cdd:PLN02843  787 LAEDAWQNLPFQEDG-----SAAESVFEAGWPTPNEEWLSFPA 824
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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