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Conserved domains on  [gi|1145522054|ref|NP_001335625|]
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phosphomevalonate kinase isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-mevalo_kinase super family cl04466
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 18-111 5.26e-23

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


The actual alignment was detected with superfamily member TIGR01223:

Pssm-ID: 471038  Cd Length: 182  Bit Score: 87.83  E-value: 5.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522054  18 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 97
Cdd:TIGR01223  83 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 162

                          90
                  ....*....|....
gi 1145522054  98 VEQRLEEQLENLIE 111
Cdd:TIGR01223 163 VEQRLEEQLENLIE 176
 
Name Accession Description Interval E-value
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 18-111 5.26e-23

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 87.83  E-value: 5.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522054  18 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 97
Cdd:TIGR01223  83 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 162

                          90
                  ....*....|....
gi 1145522054  98 VEQRLEEQLENLIE 111
Cdd:TIGR01223 163 VEQRLEEQLENLIE 176
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 17-48 2.26e-09

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 50.65  E-value: 2.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1145522054  17 LRKIVEGI--SQPIWLVSDTRRVSDIQWFREAYG 48
Cdd:pfam04275  79 CRAAIEMAdaQKPVWIVSDARRKTDLQWFRENYP 112
 
Name Accession Description Interval E-value
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 18-111 5.26e-23

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 87.83  E-value: 5.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145522054  18 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 97
Cdd:TIGR01223  83 RKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHG 162

                          90
                  ....*....|....
gi 1145522054  98 VEQRLEEQLENLIE 111
Cdd:TIGR01223 163 VEQRLEEQLENLIE 176
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 17-48 2.26e-09

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 50.65  E-value: 2.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1145522054  17 LRKIVEGI--SQPIWLVSDTRRVSDIQWFREAYG 48
Cdd:pfam04275  79 CRAAIEMAdaQKPVWIVSDARRKTDLQWFRENYP 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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