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Conserved domains on  [gi|1187953363|ref|NP_001337918|]
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sideroflexin-2 [Homo sapiens]

Protein Classification

sideroflexin family transporter( domain architecture ID 10510848)

sideroflexin family transporter is a mitochondrial membrane protein implicated in one-carbon metabolism; similar to sideroflexin-1, which acts as a mitochondrial serine transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
9-322 1.29e-170

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


:

Pssm-ID: 461063  Cd Length: 319  Bit Score: 476.23  E-value: 1.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363   9 NIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNV 88
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363  89 IGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMLT 168
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 169 K--KAPP----LVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMIL 242
Cdd:pfam03820 161 KrlKLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 243 LPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEpYVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPT-TVYFNKGL 319
 
Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
9-322 1.29e-170

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


Pssm-ID: 461063  Cd Length: 319  Bit Score: 476.23  E-value: 1.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363   9 NIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNV 88
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363  89 IGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMLT 168
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 169 K--KAPP----LVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMIL 242
Cdd:pfam03820 161 KrlKLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 243 LPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEpYVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPT-TVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
8-322 7.82e-131

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 375.16  E-value: 7.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363   8 FNIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTqVEQLLYAKKLYDSAFHPDTGEKMN 87
Cdd:TIGR00798   3 FDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASPLT-VDELWRAKKLYDSAFHPDTGEKMF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363  88 VIGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNML 167
Cdd:TIGR00798  82 LPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGLNMM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 168 TKKAP---PLVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMILLP 244
Cdd:TIGR00798 162 VKKSPslsPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMVMPP 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187953363 245 VIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEpYVYFNKGL 322
Cdd:TIGR00798 242 LIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPK-VVYYNKGL 318
 
Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
9-322 1.29e-170

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


Pssm-ID: 461063  Cd Length: 319  Bit Score: 476.23  E-value: 1.29e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363   9 NIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNV 88
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363  89 IGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMLT 168
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 169 K--KAPP----LVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMIL 242
Cdd:pfam03820 161 KrlKLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 243 LPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEpYVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPT-TVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
8-322 7.82e-131

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 375.16  E-value: 7.82e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363   8 FNIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTqVEQLLYAKKLYDSAFHPDTGEKMN 87
Cdd:TIGR00798   3 FDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASPLT-VDELWRAKKLYDSAFHPDTGEKMF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363  88 VIGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNML 167
Cdd:TIGR00798  82 LPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGLNMM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953363 168 TKKAP---PLVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMILLP 244
Cdd:TIGR00798 162 VKKSPslsPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMVMPP 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187953363 245 VIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEpYVYFNKGL 322
Cdd:TIGR00798 242 LIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPK-VVYYNKGL 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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