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Conserved domains on  [gi|1192727314|ref|NP_001338548|]
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DNA polymerase iota isoform g [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY super family cl28996
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 8-256 5.45e-117

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


The actual alignment was detected with superfamily member cd01703:

Pssm-ID: 452909 [Multi-domain]  Cd Length: 379  Bit Score: 351.39  E-value: 5.45e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314   8 NLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPG 85
Cdd:cd01703   100 NFMDVTEMRLLVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  86 IGYKTAKCLEALGINSVRDLQTFSP---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEE 149
Cdd:cd01703   180 IGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 150 DSFKKCSSEV--EAKNKIEELLASLLNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGT 218
Cdd:cd01703   260 DSYKKCSLEEirEARNKIEELLASLLERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTG 339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1192727314 219 GNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCFCN 256
Cdd:cd01703   340 GNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCFTN 379
Rev1_UBM2 super family cl41665
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ...
 524-549 3.09e-03

Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.


The actual alignment was detected with superfamily member cd19318:

Pssm-ID: 412037  Cd Length: 36  Bit Score: 35.28  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1192727314 524 PSDIDPQVFYELPEAVQKELLAEWKR 549
Cdd:cd19318     9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
 
Name Accession Description Interval E-value
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 8-256 5.45e-117

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 351.39  E-value: 5.45e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314   8 NLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPG 85
Cdd:cd01703   100 NFMDVTEMRLLVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  86 IGYKTAKCLEALGINSVRDLQTFSP---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEE 149
Cdd:cd01703   180 IGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 150 DSFKKCSSEV--EAKNKIEELLASLLNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGT 218
Cdd:cd01703   260 DSYKKCSLEEirEARNKIEELLASLLERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTG 339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1192727314 219 GNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCFCN 256
Cdd:cd01703   340 GNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCFTN 379
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 10-192 3.63e-36

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 137.58  E-value: 3.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIG 87
Cdd:COG0389   105 LDVTGSARLFGSaeAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVG 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEE 167
Cdd:COG0389   184 PKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEA 259

                         170       180
                  ....*....|....*....|....*....
gi 1192727314 168 LLASLLNRVC----QDGRKPHTVRLIIRR 192
Cdd:COG0389   260 ALRRLAERLAerlrRQGLGARTVTVKLRT 288
PRK02406 PRK02406
DNA polymerase IV; Validated
 10-186 7.98e-28

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 114.45  E-value: 7.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIG 87
Cdd:PRK02406   99 LDVTDNKLCIGSatLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIE 166
Cdd:PRK02406  178 KVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRRLYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELP 256

                         170       180
                  ....*....|....*....|...
gi 1192727314 167 EL---LASLLNRVcQDGRKPHTV 186
Cdd:PRK02406  257 RLaekLERRLERA-KPDKRIKTV 278
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 143-257 9.02e-07

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 47.55  E-value: 9.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 143 PQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYssekHYGRESRQCPIPSHviqklgTGNY 221
Cdd:pfam11799   1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS----DFRTITRSVTLPSP------TDDT 70

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1192727314 222 DVMTpmvDILMKLFRNMVNvkmPFHLTLLSVCFCNL 257
Cdd:pfam11799  71 DEIY---RAALRLLRRLYR---GRPVRLLGVSLSNL 100
TIGR03491 TIGR03491
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ...
 79-144 1.54e-04

RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.


Pssm-ID: 274603 [Multi-domain]  Cd Length: 457  Bit Score: 44.24  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  79 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 144
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
Rev1_UBM2 cd19318
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ...
 524-549 3.09e-03

Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.


Pssm-ID: 412037  Cd Length: 36  Bit Score: 35.28  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1192727314 524 PSDIDPQVFYELPEAVQKELLAEWKR 549
Cdd:cd19318     9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
 
Name Accession Description Interval E-value
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 8-256 5.45e-117

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 351.39  E-value: 5.45e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314   8 NLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPG 85
Cdd:cd01703   100 NFMDVTEMRLLVASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  86 IGYKTAKCLEALGINSVRDLQTFSP---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEE 149
Cdd:cd01703   180 IGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 150 DSFKKCSSEV--EAKNKIEELLASLLNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGT 218
Cdd:cd01703   260 DSYKKCSLEEirEARNKIEELLASLLERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTG 339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1192727314 219 GNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCFCN 256
Cdd:cd01703   340 GNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCFTN 379
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 10-255 1.10e-74

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 240.73  E-value: 1.10e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGSQIAAEMREAMYNQLG-LTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIhSLNHIKEIPGIGY 88
Cdd:cd00424   105 LTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTILDPEDLPGFL-SKLPLTDLPGIGA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  89 KTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVE-AKNKIEE 167
Cdd:cd00424   184 VTAKRLEAVGINPIGDLLAASPDALLALWGGVSGERLWYALRGIDDEPLSPPRPRKSFSHERVLPRDSRNAEdARPLLRL 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 168 LLASLLNRVCQDGRKPHTVRLIIRRYSSE--KHYGRESRQCPIPSHViqklgtgnydVMTPMVDILMKLFRNMVNVKMPF 245
Cdd:cd00424   264 LLEKLARRLRRDGRGATRLRLWLRTVDGRwsGHADIPSRSAPRPIST----------EDGELLHALDKLWRALLDDKGPR 333

                         250
                  ....*....|
gi 1192727314 246 HLTLLSVCFC 255
Cdd:cd00424   334 RLRRLGVRLS 343
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 10-212 7.61e-38

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 142.28  E-value: 7.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIG 87
Cdd:cd03586   102 LDVTDYVRLFGSatEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPPEDVEEFLAPL-PVRKIPGVG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF-KKCSSEVEAKNKIE 166
Cdd:cd03586   181 KVTAEKLKELGIKTIGDLAKLDVELLKKLFG-KSGRRLYELARGIDNRPVEPDRERKSIGVERTFsEDLTDPEELLEELL 259

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1192727314 167 ELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHygreSRQCPIPSHV 212
Cdd:cd03586   260 ELAEELAERLRKRGLKGRTVTVKLKYADFSTR----TRSRTLPEPT 301
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 10-192 3.63e-36

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 137.58  E-value: 3.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIG 87
Cdd:COG0389   105 LDVTGSARLFGSaeAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVG 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEE 167
Cdd:COG0389   184 PKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEA 259

                         170       180
                  ....*....|....*....|....*....
gi 1192727314 168 LLASLLNRVC----QDGRKPHTVRLIIRR 192
Cdd:COG0389   260 ALRRLAERLAerlrRQGLGARTVTVKLRT 288
PRK02406 PRK02406
DNA polymerase IV; Validated
 10-186 7.98e-28

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 114.45  E-value: 7.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIG 87
Cdd:PRK02406   99 LDVTDNKLCIGSatLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIE 166
Cdd:PRK02406  178 KVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRRLYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELP 256

                         170       180
                  ....*....|....*....|...
gi 1192727314 167 EL---LASLLNRVcQDGRKPHTV 186
Cdd:PRK02406  257 RLaekLERRLERA-KPDKRIKTV 278
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 19-256 1.11e-24

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 105.47  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  19 VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCL-EAL 97
Cdd:cd01702   124 LGSRIVEEIRQQVYDELGYTCSAGIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLP-ITSIRGLGGKLGEEIiDLL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  98 GINSVRDLQTF--SPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF--KKCSSEVEAKNKIEELLASLL 173
Cdd:cd01702   203 GLPTEGDVAGFrsSESDLQEHFGEKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFpgKTALSTEDVQHWLLVLASELN 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 174 NRVCQD----GRKPHTVRLiirRYSSEKHYGRESRQCPIPSHVIQKLgtgnydvMTPMVDILMKLFRNMVNVKMPFHLTL 249
Cdd:cd01702   283 SRLEDDryenNRRPKTLVL---SLRQRGDGVRRSRSCALPRYDAQKI-------VKDAFKLIKAINEEGLGLAWNYPLTL 352


                  ....*..
gi 1192727314 250 LSVCFCN 256
Cdd:cd01702   353 LSLSFTK 359
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 10-216 5.82e-20

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 91.46  E-value: 5.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVG-SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQT----VLLPESCQHLIHSLNHIKEIP 84
Cdd:cd01700   103 LDLTGSLRFGDlEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYggvvDLTDEEVRDKLLKILPVGDVW 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  85 GIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIsVAQRIQKLSFGEDNSPVILSGPP-QSFSEEDSFKKcssEVEAKN 163
Cdd:cd01700   183 GIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGV-VGERLVRELNGIDCLPLEEYPPPkKSIGSSRSFGR---DVTDLD 258

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1192727314 164 KIEELLASLLNRVC----QDGRKPHTVRLIIR--RYSSEKHYGRESRQCPIPSHVIQKL 216
Cdd:cd01700   259 ELKQALAEYAERAAeklrRQKSVARTISVFIGtsGFSRQPKYYSATNTLPYPTNDTREI 317
PRK03348 PRK03348
DNA polymerase IV; Provisional
 22-193 4.80e-17

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 83.83  E-value: 4.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  22 QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINS 101
Cdd:PRK03348  125 AFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRVVPPGEERELLAPLP-VRRLWGIGPVTEEKLHRLGIET 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 102 VRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEELLASLLNRVCQDG 180
Cdd:PRK03348  204 IGDLAALSEAEVANLLGATVGPALHRLARGIDDRPVAERAEAKQISAESTFAVdLTTRAQLREAIERIAEHAHRRLLKDG 283

                         170
                  ....*....|...
gi 1192727314 181 RKPHTVRLIIRRY 193
Cdd:PRK03348  284 RGARTVTVKLRKS 296
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 21-192 2.67e-15

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 78.12  E-value: 2.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  21 SQIAAEMREAmynqlglTGC---AGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTA-KCLEA 96
Cdd:cd01701   170 EAIRNEIRET-------TGCsasVGIGPNILLARLATRKAKPDGQYHLSAEKVEEFLSQLK-VGDLPGVGSSLAeKLVKL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  97 LG-INSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDS----FKKcssEVEAKNKIEELLAS 171
Cdd:cd01701   242 FGdTCGGLELRSKTKEKLQKVLGPKTGEKLYDYCRGIDDRPVTGEKERKSVSAEINygirFTN---VDDVEQFLQRLSEE 318

                         170       180
                  ....*....|....*....|..
gi 1192727314 172 LLNRVCQDGRKPHTVRL-IIRR 192
Cdd:cd01701   319 LSKRLEESNVTGRQITLkLMKR 340
PRK01216 PRK01216
DNA polymerase IV; Validated
 22-137 3.74e-14

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 74.06  E-value: 3.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  22 QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINS 101
Cdd:PRK01216  123 NLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNK 201

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1192727314 102 VRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPV 137
Cdd:PRK01216  202 LVDTLRIEFDELKGIIGEAKAKYLFSLARNEYNEPV 237
PRK03352 PRK03352
DNA polymerase IV; Validated
 22-191 6.29e-14

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 73.13  E-value: 6.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  22 QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINS 101
Cdd:PRK03352  122 ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRLTDANWMAVMGDRP-TDALWGVGPKTAKRLAALGITT 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 102 VRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVIlSGP--PQSFSEEDSFKK---CSSEVEAknKIEELLASLLNRV 176
Cdd:PRK03352  201 VADLAAADPAELAATFGPTTGPWLLLLARGGGDTEVS-AEPwvPRSRSREVTFPQdltDRAEVES--AVRELARRVLDEV 277

                         170
                  ....*....|....*
gi 1192727314 177 CQDGRKPHTVRLIIR 191
Cdd:PRK03352  278 VAEGRPVTRVAVKVR 292
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 10-211 5.21e-13

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 70.80  E-value: 5.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVF---KPNQQTVLLPESCQHLIHSLNhIKEIP 84
Cdd:PRK03103  109 LDVTGSQKLFGSplEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNFakkNPDGLFTLDKEDVPADLWPLP-VRKLF 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  85 GIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIsVAQRIQKLSFGEDNSPVilsgPPQSFSEEDSFKKCSS---EVEA 161
Cdd:PRK03103  188 GVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGI-NGEVLWRTANGIDYSPV----TPHSLDRQKAIGHQMTlprDYRG 262

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1192727314 162 KNKIEELLASLLNRVCQDGRKPH----TVRLIIRrySSEKHYGRE-SRQCPIPSH 211
Cdd:PRK03103  263 FEEIKVVLLELCEEVCRRARAKGymgrTVSVSLR--GADFDWPTGfSRQMTLPEP 315
PRK01810 PRK01810
DNA polymerase IV; Validated
 23-201 7.51e-13

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 70.44  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  23 IAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSV 102
Cdd:PRK01810  125 IAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTI 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 103 RDLQTFSPKILEKELGISvAQRIQKLSFGEDNSPVilsgPPQSFSEEDS------FKKCSSEV-EAKNKIEELLASLLNR 175
Cdd:PRK01810  204 GDLAKADEHILRAKLGIN-GVRLQRRANGIDDRPV----DPEAIYQFKSvgnsttLSHDMDEEkELLDVLRRLSKSVSKR 278

                         170       180
                  ....*....|....*....|....*.
gi 1192727314 176 VCQDGRKPHTVRLIIrRYSSEKHYGR 201
Cdd:PRK01810  279 LQKKTVVSYNVQIMI-RYHDRRTITR 303
PRK02794 PRK02794
DNA polymerase IV; Provisional
 34-152 1.50e-12

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 69.58  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  34 QLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSlNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKIL 113
Cdd:PRK02794  166 EIGITVSVGLSYNKFLAKIASDLDKPRGFSVIGRAEALAFLAP-KPVGIIWGVGPATAARLARDGIRTIGDLQRADEADL 244

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1192727314 114 EKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF 152
Cdd:PRK02794  245 MRRFG-SMGLRLWRLARGIDDRKVSPDREAKSVSAETTF 282
PRK03858 PRK03858
DNA polymerase IV; Validated
 10-257 2.69e-11

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 65.39  E-value: 2.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLLVG--SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIG 87
Cdd:PRK03858  104 LDVGGLRRISGtpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRELAFLHPLP-VRRLWGVG 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  88 YKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF-KKCSSEVEaknkIE 166
Cdd:PRK03858  183 PVTAAKLRAHGITTVGDVAELPESALVSLLGPAAGRHLHALAHNRDPRRVETGRRRRSVGAQRALgRGPNSPAE----VD 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 167 ELLASLLNRVCQDGRKPH------TVRLiirRYSSekhYGRESRqcpipSHVIqklgtgnyDVMTPMVDILMKLFRNMVN 240
Cdd:PRK03858  259 AVVVALVDRVARRMRAAGrtgrtvVLRL---RFDD---FTRATR-----SHTL--------PRPTASTATLLAAARDLVA 319

                         250       260
                  ....*....|....*....|.
gi 1192727314 241 VKMPFH----LTLLSVCFCNL 257
Cdd:PRK03858  320 AAAPLIaergLTLVGFAVSNL 340
PRK14133 PRK14133
DNA polymerase IV; Provisional
 10-198 5.31e-10

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 61.27  E-value: 5.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  10 LDVLHIRLlVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYK 89
Cdd:PRK14133  107 LDITNIKE-EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKIITEDMIPDILKPLP-ISKVHGIGKK 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  90 TAKCLEALGINSVRDLQTFSPKILEK---ELGISVAQRIQklsfGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIE 166
Cdd:PRK14133  185 SVEKLNNIGIYTIEDLLKLSREFLIEyfgKFGVEIYERIR----GIDYREVEVSRERKSIGKETTLKK---DTKDKEELK 257

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1192727314 167 ELLASLLNRVCQDGRKPH----TVRLIIRRYSSEKH 198
Cdd:PRK14133  258 KYLKDFSNIISEELKKRNlygkTVTVKIKTSDFQTH 293
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 143-257 9.02e-07

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 47.55  E-value: 9.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 143 PQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYssekHYGRESRQCPIPSHviqklgTGNY 221
Cdd:pfam11799   1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS----DFRTITRSVTLPSP------TDDT 70

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1192727314 222 DVMTpmvDILMKLFRNMVNvkmPFHLTLLSVCFCNL 257
Cdd:pfam11799  71 DEIY---RAALRLLRRLYR---GRPVRLLGVSLSNL 100
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 10-54 2.47e-06

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 47.18  E-value: 2.47e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1192727314  10 LDVLHIRLLVGS--QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVS 54
Cdd:pfam00817 101 LDLTGLEKLFGAeeALAKRLRREIAEETGLTCSIGIAPNKLLAKLAS 147
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 23-198 9.68e-06

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 48.48  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  23 IAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVL---LPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGI 99
Cdd:PTZ00205  252 VASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQHDLnlhTRGDVMTYVRDLG-LRSVPGVGKVTEALLKGLGI 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314 100 NSVRDLQT--------FSPKILEKELGISVAqrIQKL-----SFGEDNSPVILSGPPQSFSEEDSFKKcsseVEAKNKIE 166
Cdd:PTZ00205  331 TTLSDIYNrrvelcyiLHNNLFRFLLGASIG--IMQWpdaatAANTENCEGATGGQRKAISSERSFTT----PRTKEGLQ 404

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1192727314 167 ELLASLLNRVCQDGRKPH----TVRLIIrRYSSEKH 198
Cdd:PTZ00205  405 EMVDTVFNGAYEEMRKSElmcrQISLTI-RWASYRY 439
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
26-132 5.29e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 45.91  E-value: 5.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  26 EMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKP-NQQT---VLL--PESCQHLIhSLNHIKEIPGIGYKTAKCLEALGI 99
Cdd:PRK03609  122 EIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwQRQTggvVDLsnLERQRKLL-SLQPVEEVWGVGRRISKKLNAMGI 200

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1192727314 100 NSVRDLQTFSPKILEKELGISVAQRIQKLSfGE 132
Cdd:PRK03609  201 KTALDLADTNIRFIRKHFNVVLERTVRELR-GE 232
TIGR03491 TIGR03491
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ...
 79-144 1.54e-04

RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.


Pssm-ID: 274603 [Multi-domain]  Cd Length: 457  Bit Score: 44.24  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192727314  79 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 144
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 67-99 2.17e-04

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 38.53  E-value: 2.17e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1192727314  67 PESCQHLIHSLNhIKEIPGIGYKTAKCLEALGI 99
Cdd:pfam11798   1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
HHH_5 pfam14520
Helix-hairpin-helix domain;
82-125 1.27e-03

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 37.08  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1192727314  82 EIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRI 125
Cdd:pfam14520   6 SISGIGPKTALALLSAGIGTVEDLAEADVDELAEipGIGEKTAQRI 51
radA PRK04301
DNA repair and recombination protein RadA; Validated
 80-127 2.90e-03

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 39.86  E-value: 2.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1192727314  80 IKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS--VAQRIQK 127
Cdd:PRK04301    8 LEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGesTAAKIIE 57
Rev1_UBM2 cd19318
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ...
 524-549 3.09e-03

Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.


Pssm-ID: 412037  Cd Length: 36  Bit Score: 35.28  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1192727314 524 PSDIDPQVFYELPEAVQKELLAEWKR 549
Cdd:cd19318     9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
PRK10917 PRK10917
ATP-dependent DNA helicase RecG; Provisional
 80-105 5.34e-03

ATP-dependent DNA helicase RecG; Provisional


Pssm-ID: 236794 [Multi-domain]  Cd Length: 681  Bit Score: 39.75  E-value: 5.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 1192727314  80 IKEIPGIGYKTAKCLEALGINSVRDL 105
Cdd:PRK10917   11 LTSLKGVGPKTAEKLAKLGIHTVQDL 36
RecG COG1200
RecG-like helicase [Replication, recombination and repair];
80-105 5.93e-03

RecG-like helicase [Replication, recombination and repair];


Pssm-ID: 440813 [Multi-domain]  Cd Length: 684  Bit Score: 39.65  E-value: 5.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 1192727314  80 IKEIPGIGYKTAKCLEALGINSVRDL 105
Cdd:COG1200     8 LTYLKGVGPKRAKLLAKLGIRTVGDL 33
Cdd1 pfam11731
Pathogenicity locus; Cdd1 is expressed as part of the pathogenicity locus operon in several ...
 74-105 8.53e-03

Pathogenicity locus; Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.


Pssm-ID: 463333 [Multi-domain]  Cd Length: 82  Bit Score: 35.66  E-value: 8.53e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1192727314  74 IHSLNHIKEIPGIGYKTAKCLEALGINSVRDL 105
Cdd:pfam11731   2 RDGLKELQDIPNIGPAIAEDLRLLGIRSPEEL 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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