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Conserved domains on  [gi|1219185053|ref|NP_001340588|]
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WD repeat-containing protein 20 isoform 15 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
100-265 1.41e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 453027 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 100 KSRVTCVKWVPGSEsLFLVAHSSGNMYLYNVEHT------CGTTAP--HYQLLKQGESFAV----HTCKSKSTRNPLLKW 167
Cdd:cd00200     9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGellrtlKGHTGPvrDVAASADGTYLASgssdKTIRLWDLETGECVR 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 168 TVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDC 245
Cdd:cd00200    88 TLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
                         170       180
                  ....*....|....*....|
gi 1219185053 246 RVIARGHGHKSWVSVVAFDP 265
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
151-519 3.09e-06

WD40 repeat [General function prediction only];


:

Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.70  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 151 AVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ-DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGK-YI 228
Cdd:COG2319   135 TVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLI 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 229 VTGGEDDLVTVWSFVDCRVIARG-HGHKSWVsVVAFDPYttsveeGDPMEFSGSDEDFQ-DLLHFGRDRANSTQSRLSKR 306
Cdd:COG2319   215 ASGSSDGTIRLWDLSTGKLLRSTlSGHSDSV-VSSFSPD------GSLLASGSSDGTIRlWDLRSSSSLLRTLSGHSSSV 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 307 NSTDSRPVSvtYRFGSVGQDTQLCLWDLTEDILFphqPLSRARTHTN-VMNATSPPAGSNgnsvttpgnsvppplprsns 385
Cdd:COG2319   288 LSVAFSPDG--KLLASGSSDGTVRLWDLETGKLL---SSLTLKGHEGpVSSLSFSPDGSL-------------------- 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 386 lphsavsnagskssvmdgaIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISskSSDKLNLVTKTKTDPAktlgtplc 465
Cdd:COG2319   343 -------------------LVSGGSDDGTIRLWDLRTGKPLKTLEGHSNVLSVS--FSPDGRVVSSGSTDGT-------- 393
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1219185053 466 PRMEDVPLLEPLICKKIAHERLTVLIFLEDC--IVTACQEGFICTWGRPGKVVSFN 519
Cdd:COG2319   394 VRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGksLASGSSDNTIRLWDLKTSLKSVS 449
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
100-265 1.41e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 100 KSRVTCVKWVPGSEsLFLVAHSSGNMYLYNVEHT------CGTTAP--HYQLLKQGESFAV----HTCKSKSTRNPLLKW 167
Cdd:cd00200     9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGellrtlKGHTGPvrDVAASADGTYLASgssdKTIRLWDLETGECVR 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 168 TVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDC 245
Cdd:cd00200    88 TLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
                         170       180
                  ....*....|....*....|
gi 1219185053 246 RVIARGHGHKSWVSVVAFDP 265
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
98-340 5.28e-11

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 64.72  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053  98 IDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTaphyqllkqgeSFAVHTCKSKStrnpllkwtvgegalneF 177
Cdd:COG2319   153 GHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGKPLS-----------TLAGHTDPVSS-----------------L 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 178 AFSPDGKF-LACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCR-VIARGHGHK 255
Cdd:COG2319   205 AFSPDGGLlIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSSSsLLRTLSGHS 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 256 SWVSVVAFDPYTTSVeegdpmeFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR--PVSVTYRFGSVGQDTQLCLWD 333
Cdd:COG2319   285 SSVLSVAFSPDGKLL-------ASGSSDGTVRLWDLETGKLLSSLTLKGHEGPVSSLsfSPDGSLLVSGGSDDGTIRLWD 357

                  ....*..
gi 1219185053 334 LTEDILF 340
Cdd:COG2319   358 LRTGKPL 364
WD40 COG2319
WD40 repeat [General function prediction only];
151-519 3.09e-06

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.70  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 151 AVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ-DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGK-YI 228
Cdd:COG2319   135 TVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLI 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 229 VTGGEDDLVTVWSFVDCRVIARG-HGHKSWVsVVAFDPYttsveeGDPMEFSGSDEDFQ-DLLHFGRDRANSTQSRLSKR 306
Cdd:COG2319   215 ASGSSDGTIRLWDLSTGKLLRSTlSGHSDSV-VSSFSPD------GSLLASGSSDGTIRlWDLRSSSSLLRTLSGHSSSV 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 307 NSTDSRPVSvtYRFGSVGQDTQLCLWDLTEDILFphqPLSRARTHTN-VMNATSPPAGSNgnsvttpgnsvppplprsns 385
Cdd:COG2319   288 LSVAFSPDG--KLLASGSSDGTVRLWDLETGKLL---SSLTLKGHEGpVSSLSFSPDGSL-------------------- 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 386 lphsavsnagskssvmdgaIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISskSSDKLNLVTKTKTDPAktlgtplc 465
Cdd:COG2319   343 -------------------LVSGGSDDGTIRLWDLRTGKPLKTLEGHSNVLSVS--FSPDGRVVSSGSTDGT-------- 393
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1219185053 466 PRMEDVPLLEPLICKKIAHERLTVLIFLEDC--IVTACQEGFICTWGRPGKVVSFN 519
Cdd:COG2319   394 VRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGksLASGSSDNTIRLWDLKTSLKSVS 449
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
204-241 3.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1219185053  204 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
204-241 1.99e-04

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1219185053 204 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
100-265 1.41e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 100 KSRVTCVKWVPGSEsLFLVAHSSGNMYLYNVEHT------CGTTAP--HYQLLKQGESFAV----HTCKSKSTRNPLLKW 167
Cdd:cd00200     9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGellrtlKGHTGPvrDVAASADGTYLASgssdKTIRLWDLETGECVR 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 168 TVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDC 245
Cdd:cd00200    88 TLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
                         170       180
                  ....*....|....*....|
gi 1219185053 246 RVIARGHGHKSWVSVVAFDP 265
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSP 187
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
171-265 2.06e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 171 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIAR 250
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
                          90
                  ....*....|....*
gi 1219185053 251 GHGHKSWVSVVAFDP 265
Cdd:cd00200   215 LRGHENGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
171-265 1.23e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 171 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIAR 250
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
                          90
                  ....*....|....*
gi 1219185053 251 GHGHKSWVSVVAFDP 265
Cdd:cd00200   257 LSGHTNSVTSLAWSP 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
100-241 6.42e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 6.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 100 KSRVTCVKWVPGSESLFLVAhSSGNMYLYNVEhtcgttaphyqllkqgESFAVHTCKSKstrnpllkwtvgEGALNEFAF 179
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS----------------TGKCLGTLRGH------------ENGVNSVAF 227
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1219185053 180 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
205-270 2.87e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 2.87e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1219185053 205 LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSV 270
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL 66
WD40 COG2319
WD40 repeat [General function prediction only];
98-340 5.28e-11

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 64.72  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053  98 IDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTaphyqllkqgeSFAVHTCKSKStrnpllkwtvgegalneF 177
Cdd:COG2319   153 GHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGKPLS-----------TLAGHTDPVSS-----------------L 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 178 AFSPDGKF-LACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCR-VIARGHGHK 255
Cdd:COG2319   205 AFSPDGGLlIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSSSsLLRTLSGHS 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 256 SWVSVVAFDPYTTSVeegdpmeFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR--PVSVTYRFGSVGQDTQLCLWD 333
Cdd:COG2319   285 SSVLSVAFSPDGKLL-------ASGSSDGTVRLWDLETGKLLSSLTLKGHEGPVSSLsfSPDGSLLVSGGSDDGTIRLWD 357

                  ....*..
gi 1219185053 334 LTEDILF 340
Cdd:COG2319   358 LRTGKPL 364
WD40 COG2319
WD40 repeat [General function prediction only];
99-241 1.19e-07

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 53.94  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053  99 DKSRVTCVKWVPgSESLFLVAHSSGNMYLYNVEhTCGTTAPHYQLLKQGESFAVHTCK-------SKSTRNPLLKWTVGE 171
Cdd:COG2319   283 HSSSVLSVAFSP-DGKLLASGSSDGTVRLWDLE-TGKLLSSLTLKGHEGPVSSLSFSPdgsllvsGGSDDGTIRLWDLRT 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 172 G----------ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:COG2319   361 GkplktleghsNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWD 440
WD40 COG2319
WD40 repeat [General function prediction only];
151-519 3.09e-06

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.70  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 151 AVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ-DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGK-YI 228
Cdd:COG2319   135 TVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLI 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 229 VTGGEDDLVTVWSFVDCRVIARG-HGHKSWVsVVAFDPYttsveeGDPMEFSGSDEDFQ-DLLHFGRDRANSTQSRLSKR 306
Cdd:COG2319   215 ASGSSDGTIRLWDLSTGKLLRSTlSGHSDSV-VSSFSPD------GSLLASGSSDGTIRlWDLRSSSSLLRTLSGHSSSV 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 307 NSTDSRPVSvtYRFGSVGQDTQLCLWDLTEDILFphqPLSRARTHTN-VMNATSPPAGSNgnsvttpgnsvppplprsns 385
Cdd:COG2319   288 LSVAFSPDG--KLLASGSSDGTVRLWDLETGKLL---SSLTLKGHEGpVSSLSFSPDGSL-------------------- 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053 386 lphsavsnagskssvmdgaIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISskSSDKLNLVTKTKTDPAktlgtplc 465
Cdd:COG2319   343 -------------------LVSGGSDDGTIRLWDLRTGKPLKTLEGHSNVLSVS--FSPDGRVVSSGSTDGT-------- 393
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1219185053 466 PRMEDVPLLEPLICKKIAHERLTVLIFLEDC--IVTACQEGFICTWGRPGKVVSFN 519
Cdd:COG2319   394 VRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGksLASGSSDNTIRLWDLKTSLKSVS 449
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
204-241 3.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1219185053  204 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
204-241 1.99e-04

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1219185053 204 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 241
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
99-240 6.32e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 6.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053  99 DKSR-VTCVKWV-PGSESLFLVAHSSGNMYLYNVEhtcgttaphyqllkQGESFAVHTCKSKSTRNPLLKWTVGegaLNE 176
Cdd:cd22857    28 DKSKaVQALSIAdRESEPLLAVARKNGTVEVLDPE--------------NGDLLASFSDSEPATKLSEEDHFVG---LHL 90
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1219185053 177 FafspDGKFLACVSQdGFLRVFNFDSVELHG---TMKSYFGGLLCvCW--SPDGKYIVTGGEDDLVTVW 240
Cdd:cd22857    91 F----SGTLLTCTSK-GSLRSTKLPDDSTASsspTAWVCLGGNLL-CMrvDPNENYFAFGGKEVELNVW 153
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
99-248 1.83e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 40.31  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219185053  99 DKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCgttaphyqllkqGESFAVHTCKSKSTRNPLLKWTVGegaLNEFa 178
Cdd:cd22850    33 LSNAVQRLSLVDRSDPLLLVARRNGNGEVYVLSPVD------------GELFELLSSIEGLTRSKEEDKFVG---LHLL- 96
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1219185053 179 fsPDGKFLACVSQDGFLRVFNFDSV---ELHGTMKSYFGGLLCVC--WSPDGKYIVTGGEDDLVTVW----SFVDCRVI 248
Cdd:cd22850    97 --RSLGLLTCATKSGLLHIIDLEDSkkdSLEVKAPLTLPGFLSAFrvNPTDEGVFAYGGKENDLKLWdlekDFLKLKQI 173
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
160-199 5.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1219185053  160 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFN 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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