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Conserved domains on  [gi|1233054956|ref|NP_001341577|]
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N-glycosylase/DNA lyase isoform 1d [Homo sapiens]

Protein Classification

N-glycosylase/DNA lyase( domain architecture ID 706404)

N-glycosylase/DNA lyase specifically removes oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine or 7-oxoG) from DNA

CATH:  1.10.1670.10|1.10.340.30
EC:  3.2.2.-|4.2.99.18
Gene Ontology:  GO:0140078|GO:0004518|GO:0006284|GO:0034039|GO:0003684
PubMed:  10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ogg super family cl28533
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 11-189 3.69e-96

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00588:

Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 282.57  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  11 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ-VWTLTQTEEQLHCTVYRGDKsqas 86
Cdd:TIGR00588   1 MGHR--------WASIPIPRSELRLDLVLRSGQSFRWRwEESPAHWSGllVIADQpVWTLTQTEEQLLCTVYRGDK---- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  87 rPTPDELEA-VRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQA 165
Cdd:TIGR00588  69 -PTQDELETkLEKYFQLDVSLAQLYTHWGSVDKHFQYVAQKFQGVRLLRQDPFECLISFICSSNNNIARITRMVERLCQA 147

                         170       180
                  ....*....|....*....|....
gi 1233054956 166 FGPRLIQLDDVTYHGFPSLQALAG 189
Cdd:TIGR00588 148 FGPRLITLDGVTYHGFPSLHALTG 171
 
Name Accession Description Interval E-value
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 11-189 3.69e-96

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 282.57  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  11 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ-VWTLTQTEEQLHCTVYRGDKsqas 86
Cdd:TIGR00588   1 MGHR--------WASIPIPRSELRLDLVLRSGQSFRWRwEESPAHWSGllVIADQpVWTLTQTEEQLLCTVYRGDK---- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  87 rPTPDELEA-VRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQA 165
Cdd:TIGR00588  69 -PTQDELETkLEKYFQLDVSLAQLYTHWGSVDKHFQYVAQKFQGVRLLRQDPFECLISFICSSNNNIARITRMVERLCQA 147

                         170       180
                  ....*....|....*....|....
gi 1233054956 166 FGPRLIQLDDVTYHGFPSLQALAG 189
Cdd:TIGR00588 148 FGPRLITLDGVTYHGFPSLHALTG 171
OGG_N pfam07934
8-oxoguanine DNA glycosylase, N-terminal domain; The presence of 8-oxoguanine residues in DNA ...
 25-141 1.74e-44

8-oxoguanine DNA glycosylase, N-terminal domain; The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organized into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.


Pssm-ID: 429744  Cd Length: 115  Bit Score: 144.30  E-value: 1.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  25 SIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQasRPTPDELEAVRKYFQLDV 104
Cdd:pfam07934   1 KLLISKEELDLKKTLLCGQSFRWKRTENTSYTGVIGGRVVELKQDEDDLIYRCVNDSDPL--LKEEDFESILSDYFDLDV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233054956 105 TLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECL 141
Cdd:pfam07934  79 DLEKLYEDWSKKDPLFKKAADKFTGIRILRQDPWETL 115
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 52-188 2.62e-16

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 74.92  E-value: 2.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  52 PAHWSGVLADQVW----------TLTQTEEQLHCTVyrgdksqasrptPDELEAVRKYFQLDVTLAQLYHHWGSvDSHFQ 121
Cdd:COG0122     1 PFDLDATLDDGTWrrlpdgpgvvRMRPGGDALEVEL------------AEAVARLRRLLDLDDDLEAIAALAAR-DPVLA 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1233054956 122 EVAQKFQGVRLLR-QDPIECLFSFICSSNNNIARITGMVERLCQAFGPRlIQLDDVTYHGFPSLQALA 188
Cdd:COG0122    68 PLIERYPGLRLPRrPDPFEALVRAILGQQVSVAAARTIWRRLVALFGEP-IEGPGGGLYAFPTPEALA 134
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 139-168 3.74e-05

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 42.23  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1233054956 139 ECLFSFICSSNNNIARITGMVERLCQAFGP 168
Cdd:cd00056     2 EVLVSEILSQQTTDKAVNKAYERLFERYGP 31
 
Name Accession Description Interval E-value
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 11-189 3.69e-96

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 282.57  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  11 MGHRtlastpalWASIPCPRSELRLDLVLPSGQSFRWR-EQSPAHWSG--VLADQ-VWTLTQTEEQLHCTVYRGDKsqas 86
Cdd:TIGR00588   1 MGHR--------WASIPIPRSELRLDLVLRSGQSFRWRwEESPAHWSGllVIADQpVWTLTQTEEQLLCTVYRGDK---- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  87 rPTPDELEA-VRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQA 165
Cdd:TIGR00588  69 -PTQDELETkLEKYFQLDVSLAQLYTHWGSVDKHFQYVAQKFQGVRLLRQDPFECLISFICSSNNNIARITRMVERLCQA 147

                         170       180
                  ....*....|....*....|....
gi 1233054956 166 FGPRLIQLDDVTYHGFPSLQALAG 189
Cdd:TIGR00588 148 FGPRLITLDGVTYHGFPSLHALTG 171
OGG_N pfam07934
8-oxoguanine DNA glycosylase, N-terminal domain; The presence of 8-oxoguanine residues in DNA ...
 25-141 1.74e-44

8-oxoguanine DNA glycosylase, N-terminal domain; The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organized into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.


Pssm-ID: 429744  Cd Length: 115  Bit Score: 144.30  E-value: 1.74e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  25 SIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQasRPTPDELEAVRKYFQLDV 104
Cdd:pfam07934   1 KLLISKEELDLKKTLLCGQSFRWKRTENTSYTGVIGGRVVELKQDEDDLIYRCVNDSDPL--LKEEDFESILSDYFDLDV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233054956 105 TLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECL 141
Cdd:pfam07934  79 DLEKLYEDWSKKDPLFKKAADKFTGIRILRQDPWETL 115
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 52-188 2.62e-16

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 74.92  E-value: 2.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233054956  52 PAHWSGVLADQVW----------TLTQTEEQLHCTVyrgdksqasrptPDELEAVRKYFQLDVTLAQLYHHWGSvDSHFQ 121
Cdd:COG0122     1 PFDLDATLDDGTWrrlpdgpgvvRMRPGGDALEVEL------------AEAVARLRRLLDLDDDLEAIAALAAR-DPVLA 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1233054956 122 EVAQKFQGVRLLR-QDPIECLFSFICSSNNNIARITGMVERLCQAFGPRlIQLDDVTYHGFPSLQALA 188
Cdd:COG0122    68 PLIERYPGLRLPRrPDPFEALVRAILGQQVSVAAARTIWRRLVALFGEP-IEGPGGGLYAFPTPEALA 134
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 139-168 3.74e-05

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 42.23  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1233054956 139 ECLFSFICSSNNNIARITGMVERLCQAFGP 168
Cdd:cd00056     2 EVLVSEILSQQTTDKAVNKAYERLFERYGP 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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