|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
1-423 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 724.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVF 80
Cdd:cd17382 3 MAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 81 GAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGI 160
Cdd:cd17382 83 GLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 161 LVQYTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVYAI 240
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVYAI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 241 IVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGM 320
Cdd:cd17382 198 IVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGM 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 321 EATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREE 400
Cdd:cd17382 278 EATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREE 357
|
410 420
....*....|....*....|...
gi 1240700454 401 WQYVFLIAALVHYGGVIFYALFA 423
Cdd:cd17382 358 WQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
1-423 |
1.56e-175 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 499.07 E-value: 1.56e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-------VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASR 73
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNtstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 74 LAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVI 153
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 154 AMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgamekfktpwrkFFT 233
Cdd:cd17318 163 AMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW---------------------------------------------FFL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 234 SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIM 313
Cdd:cd17318 198 VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 314 NCGGFGMEATLLLVVGY-SHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 392
Cdd:cd17318 278 TSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAI 357
|
410 420 430
....*....|....*....|....*....|..
gi 1240700454 393 TKNK-SREEWQYVFLIAALVHYGGVIFYALFA 423
Cdd:cd17318 358 VKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
1-423 |
8.36e-126 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 372.58 E-value: 8.36e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVI---------------KEKAKFNWDPETVGMIHGSFFWGYIITQI 65
Cdd:cd17381 4 LAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSnacpehssspsvehnETGKKYDWDAETQGWILGSFFYGYIITQI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 66 PGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFC 145
Cdd:cd17381 84 PGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 146 GSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgamekfk 225
Cdd:cd17381 164 GAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW---------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 226 tpwrkFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILS 305
Cdd:cd17381 204 -----IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 306 TTTVRKIMNCGGFGMEATLLLVVGYSHTRGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMV 384
Cdd:cd17381 279 TVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMV 358
|
410 420 430
....*....|....*....|....*....|....*....
gi 1240700454 385 CPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFA 423
Cdd:cd17381 359 GPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
4-423 |
1.12e-98 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 301.78 E-value: 1.12e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 4 LGFCISFGIRCNLGVAIVDMVNnstihrggkvikekaKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA 83
Cdd:cd17380 6 LATCICYADRVNMPIAIVPMAK---------------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 84 ILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ 163
Cdd:cd17380 71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 164 YTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVYAIIVA 243
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVWLIYL---------------------------------------------PPVWAIIVA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 244 NFCRSWTFYLLLISQPAYFEEVFGfEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQIlSTTTVRKIMNCGGFGMEAT 323
Cdd:cd17380 186 HFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPAL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 324 LLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA-MTKNKSreeWQ 402
Cdd:cd17380 264 FLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WS 340
|
410 420
....*....|....*....|.
gi 1240700454 403 YVFLIAALVHYGGVIFYALFA 423
Cdd:cd17380 341 LVFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
1-436 |
6.87e-94 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 293.19 E-value: 6.87e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMVN------------NSTIHRGGKVIKEK-----AKFNWDPETVGMIHGSFFWGYIIT 63
Cdd:TIGR00894 13 FCSFRLFLSFLLHICNVIIIAQRIClsltmvamvnkeNSTDLACLSAENELdniknPNFKWSGALQGLILSSHFYGQIII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 64 QIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTS 143
Cdd:TIGR00894 93 QIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 144 FCGSYAGAVIAMPLAGILVQYT-GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESanllGAME 222
Cdd:TIGR00894 173 TSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ----KGST 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 223 KFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQ 302
Cdd:TIGR00894 249 RQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSK 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 303 ILSTTTVRKIMN-CGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLS 381
Cdd:TIGR00894 329 TLSLTAARKIFNgIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIG 408
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1240700454 382 GMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEET 436
Cdd:TIGR00894 409 GLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
4-418 |
6.12e-44 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 158.89 E-value: 6.12e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 4 LGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA 83
Cdd:cd17319 10 LAYVINYLDRVNISVAAPTI---------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 84 ILLTSTLNMLIpSAARVHYGcVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ 163
Cdd:cd17319 75 MLLWSLFTALT-GFATSLTS-LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 164 YTGWSSVFYVYGSFGMVWYMFWLLVSYEspakhptitdeerryieesigesanllgamekfktpwrkfftsmpVYAIIVA 243
Cdd:cd17319 153 LFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------------------------VWGLALG 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 244 NFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQilstttvRKIMNCGGFGMEAT 323
Cdd:cd17319 188 YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVIIIGLLLAAV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 324 LLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQ 402
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340
|
410
....*....|....*.
gi 1240700454 403 YVFLIAALVHYGGVIF 418
Cdd:cd17319 341 FLFLAAVALLAALLVL 356
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-423 |
3.15e-43 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 156.95 E-value: 3.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVF 80
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 81 GAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGI 160
Cdd:COG2271 79 AIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 161 LVQYTGWSSVFYVYGSFGMVW--YMFWLLvsyespakhptitdeerryieesigesanllgamekfktpwrkfftsmpvy 238
Cdd:COG2271 157 LLAAFGWRAAFLILGLPGLLLalLRFWLL--------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 239 aiIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKqilstttvRKIMNCGGF 318
Cdd:COG2271 186 --ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RKLVLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 319 GMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPIIVGAMTKNKS 397
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
410 420
....*....|....*....|....*.
gi 1240700454 398 reeWQYVFLIAALVHYGGVIFYALFA 423
Cdd:COG2271 336 ---YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-384 |
3.15e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.08 E-value: 3.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYP 121
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 122 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD 201
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 202 EERRyieesigesanllgameKFKTPWRKFFTSmPVYAIIVANFCRSWTFYLLLISQPAYfEEVFGFEISKVGMLSAVPH 281
Cdd:pfam07690 185 EARL-----------------SLIVAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 282 LVMTIIVPIGGQIADFLRSKQILstttvrkIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLD 361
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 1240700454 362 IAP-RYASILMGISNGVGTLSGMV 384
Cdd:pfam07690 319 LAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
42-419 |
8.93e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.36 E-value: 8.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYP 121
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 122 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY--TGWSSVFYVYGSFGMVWYMFWLLVsYESPAKHPTI 199
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV-VPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 200 TDEERRYIEesigesanllgamekFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAV 279
Cdd:cd06174 183 KNEEASSKS---------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 280 PHLVMTIIVPIGGQIADFLRSkqilstttVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNH 359
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 360 LDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknKSREEWQYVFLIAALVHYGGVIFY 419
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-382 |
1.45e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.45 E-value: 1.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 40 AKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVT 119
Cdd:COG2814 38 ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 120 YPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwymFWLLVsyespakhpti 199
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL---ALLLL----------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 200 tdeeRRYIEESIGESAnllgamEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAV 279
Cdd:COG2814 182 ----LRLLPESRPAAR------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 280 PHLVMTIIVPIGGQIADFLRSKQILStttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNH 359
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....
gi 1240700454 360 LDIAP-RYASILMGISNGVGTLSG 382
Cdd:COG2814 322 AELAPpEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-423 |
4.32e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 100.73 E-value: 4.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 49 VGMIHGSFFWGYIITQIPGGYIASRLAANR--VFGAAILLTSTLnmLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGI 126
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL--LFAFAT--SYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 127 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLVsyespakhptitdeerRY 206
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL--ALVLAL----------------LL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 207 IEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 286
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 287 IVPIGGQIAD-FLRSKQILstttvrkimncggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL--DIA 363
Cdd:cd17325 251 SQPPAGKLSDrIGRKPLIL-------------IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1240700454 364 PRYA-SILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVHYGGVIFYALFA 423
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-411 |
8.40e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 100.34 E-value: 8.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 1 MSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVF 80
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 81 GAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGI 160
Cdd:COG2223 74 LIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 161 LVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesiGESANLLGAMEKFKTPWrkfftsmpVYAI 240
Cdd:COG2223 152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA-------------AAKASLRDQLEALRDPR--------FWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 241 IVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSkqilstttvRKIMNCGGFGM 320
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRVLLIVFALM 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 321 EATLLLVVGYSHTRGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMtkNKSRE 399
Cdd:COG2223 282 ALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL--LDATG 359
|
410
....*....|..
gi 1240700454 400 EWQYVFLIAALV 411
Cdd:COG2223 360 SYTAAFLVFAVL 371
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
56-388 |
1.03e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 72.67 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 56 FFWGYIITQIPGGYIASRLAANRVFGAAILLTSTlnMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLE 135
Cdd:cd17327 50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL--LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 136 RSRLATTSFCGSYAGAVIamplaGILVQY-----------TGWSSVFYVYG--SFGM-VWYMFWLLVsyeSPAKHPTITD 201
Cdd:cd17327 128 QAKRIAFFYAAAGLGSIF-----GGLLAYgvfkilgvgglAGWRWLFIIEGliTIIIgLVIFFWLPD---NPSKAWFLTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 202 EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFEISKVG 274
Cdd:cd17327 200 EEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 275 MLSAVPHLVMTIIVPIGGQIADFLRSKQILSTttvrkIMNCggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISG 354
Cdd:cd17327 272 LLSVPIGALGAVSLLIAALLSDRFKKRGLFAI-----FACV--LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILL 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 1240700454 355 FNVNhlDIAPRYAS--ILMGISNGVGTLSGMVCPII 388
Cdd:cd17327 345 SWIS--SNCAGYTKraTVLAIMLIFYNVGNIVAPQI 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
39-392 |
2.54e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.62 E-value: 2.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 39 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGV 118
Cdd:TIGR00895 44 SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG--MVWY-MFWLLVSYE-SPA 194
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPllLLLLlMRFLPESIDfLVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 195 KHPTITDEERRYIEESIGESANLLGAMEKFKTP-WRKFF-------TSMPVYAIIVANFCRSWTFYLLLISQPaYFEEVF 266
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGtKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 267 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILstttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVG 346
Cdd:TIGR00895 281 GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-----------LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1240700454 347 FsgFAISGFNVNHLDIAPRYASIL----MGISNGVGTLSGMVCPIIVGAM 392
Cdd:TIGR00895 350 F--FVNGGQSGLYALMALFYPTAIratgVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
79-423 |
1.55e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 79 VFGAAILLTSTLNMLIpsaarvhygcviFVRILQGLVEGVTYPACHGIWSKWAPPLERSRL-----ATTSFcgsyaGAVI 153
Cdd:cd17473 77 IGGVAGLFLDSLYALL------------ASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqsAAMSL-----GGVV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 154 AMPLAGILVQYtGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesigesaNLLGAMEKFKTPWRkfft 233
Cdd:cd17473 140 FLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPARKSKSA-----------------ASPGAATAAALPWK---- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 234 smPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvphlVMTIIVPIGGQIADFLRSKqilstTTVRKIM 313
Cdd:cd17473 198 --RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALA----IASLAGAIGALLFGRLKRR-----LGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 314 nCGGFGMEATLLLVVGYSHTRGVAISFLVLaVGFsGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPIIVG 390
Cdd:cd17473 267 -AIGFALMALGFLLLALASGLWVVLLGAIL-AGL-GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLG 343
|
330 340 350
....*....|....*....|....*....|...
gi 1240700454 391 AMTKNKSREewQYVFLIAALVHYGGVIFYALFA 423
Cdd:cd17473 344 PLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-225 |
2.66e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 65.09 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 49 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACHGIWS 128
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGIFQGMGWPPCGRTVT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 129 KWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ-YTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKhPTITDEERRYI 207
Cdd:TIGR00881 110 KWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPN 188
|
170
....*....|....*...
gi 1240700454 208 EESIGESANLLGAMEKFK 225
Cdd:TIGR00881 189 EEPDGDAEKKEEELTKKQ 206
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
42-188 |
1.53e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.14 E-value: 1.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILL---TSTLNMLIPSAArvhygCVIFVRILQGLVEGV 118
Cdd:COG0477 44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLfglASLLCGLAPSPE-----LLIAARALQGIGAGG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLV 188
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
35-392 |
8.75e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 60.31 E-value: 8.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 35 VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTST---LNMLIPSaarvhYGCVIFVRIL 111
Cdd:cd17316 24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLatlLIGLLPT-----PILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 112 QGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILV----QYTGWSSVFYVYGSFGMV-WYMFWL 186
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALLaLLLRRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 187 LVsyespakhptitdeerryieesigesanllgamekfktpwrkfftsmpvyAIIVANFCRSWTFYLLLISQPAYFEEVF 266
Cdd:cd17316 179 TL--------------------------------------------------LLILLWFFISFGYYGLTTFLPTYLQTVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 267 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVg 346
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI- 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1240700454 347 FSGFAISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPIIVGAM 392
Cdd:cd17316 278 LSFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-410 |
3.91e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.33 E-value: 3.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGVTYP 121
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 122 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG---MVWYMFWLlvsyespakhPT 198
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAllaALLLWRLL----------PS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 199 ITDEERRyieeSIGESANLLGAmekFKTPwrKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvfgfeiSKVGMLSA 278
Cdd:cd17324 177 LPPKKPG----SLGLLSSLLLL---LRNP--RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS------SAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 279 VPHLVMTIIVPIGGQIADFLRSKQILSTttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFsGFAISGFNVN 358
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHSALQTR 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1240700454 359 HLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAAL 410
Cdd:cd17324 312 VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG---WAGVGWVGAA 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
240-435 |
3.06e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 3.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 240 IIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttVRKIMNCGGFG 319
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG---------RRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 320 MEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSre 399
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-- 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 1240700454 400 eWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEE 435
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-424 |
3.07e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.63 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 39 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTStLNMLIPSAARvHYGCVIFVRILQGLVEGV 118
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA-LGLLLFALAP-SYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLATTSFCGSyAGAVIAMPLAGILVQY---TGWSSVFYVYGSFGMVWYMFWLLVSYespak 195
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 196 hPTITDEErryiEESIGESANLLGAmekFKTPwrkfftsmPVYAIIVANFC--------RSWTfylllisqPAYFEEVFG 267
Cdd:COG0738 187 -PEIEEEE----EEAAGSAASLKSL---LKNP--------RLLLGGLAIFLyvgaegaiGDWL--------PLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 268 FEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgMEATLLLVVGYSHTRGVAISFLVLAvgf 347
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLALV--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 348 sGFAISGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVhYGGVIFYALFA 423
Cdd:COG0738 310 -GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVC-YLLILLLALAL 384
|
.
gi 1240700454 424 S 424
Cdd:COG0738 385 K 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
135-392 |
3.12e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 3.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 135 ERSRLATTSFCGSYAGAVIAMPLAGILVQY------TGWSSVFYVYGSFGMV--WYMFWLLVSYESPAKHPTitdeerry 206
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLafLLTFFGTKERPVPEEEKV-------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 207 ieesigesanllgameKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 286
Cdd:COG2211 216 ----------------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 287 IVPIGGQIADFLRSKQILstttvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVgfSGFAISGFNVNHL----DI 362
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDV 347
|
250 260 270
....*....|....*....|....*....|....*...
gi 1240700454 363 AP--------RYASILMGISNGVGTLSGMVCPIIVGAM 392
Cdd:COG2211 348 VDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
45-193 |
9.65e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.20 E-value: 9.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 45 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACH 124
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNGLFQSMGWPPCV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1240700454 125 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 193
Cdd:cd17312 114 KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-422 |
1.51e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 49 VGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAILLTSTLNMLIPSAARVhygcVIFVRILQGLVEGVTYPACHGI 126
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 127 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEER-- 204
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRaf 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 205 -RYIEESIGESANLLgamekfktpwrkFFTSMPVYAIIvanfcrswTFYlllisqPAYFEEVFgfeISKVGMLSAVPHLV 283
Cdd:cd17489 189 rRLVEKKVLPPALIL------------FLASIAYGAIS--------TFL------PLYAAERG---ISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 284 MTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHT-RGVAISFLVLAVGFsGFAISGFNVNHLDI 362
Cdd:cd17489 240 LLLSRPFSGKLSDRKG----------PKTVIIPGLLLLALGLLLLSFAGSpWMLLLAAVLYGLGF-GLLFPALQALAVDL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1240700454 363 APRYA-SILMGISNGVGTLSGMVCPIIVGAMTknksrEEWQY--VFLIAALVHYGGVIFYALF 422
Cdd:cd17489 309 VPPHRrGAANGTFFIFFDLGIGLGGLLLGLVA-----ELFGYraMFLLAAVVVLLALVLYIFL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-193 |
3.83e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.10 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 39 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRL-AANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVrILQGLVEG 117
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALL-FLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1240700454 118 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 193
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
106-347 |
1.80e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 46.90 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 106 IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMpLAGILVQYT---------GWSSVFYVYGS 176
Cdd:cd17367 105 LLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLAL-GVLLVLQHTlgedqmaawGWRIPFLLGGV 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 177 FGMVwyMFWLlvsyespakhptitdeeRRYIEESIgESANLLGAMEKFKTPWRKFFtSMPVYAIIVANFCRSWT--FYLL 254
Cdd:cd17367 184 LAVV--VLWL-----------------RRGLEETE-SFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTlaFYTW 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 255 LISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggFGMEATLLLVVGYSHTR 334
Cdd:cd17367 243 TTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGI--------GGTLATVPLLSALDHTD 314
|
250
....*....|...
gi 1240700454 335 GVAISFLVLAVGF 347
Cdd:cd17367 315 SPYTAFALVLVGL 327
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-190 |
4.06e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.65 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 45 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYPACH 124
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 125 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYV------------------YGSFGMVWYMFWL 186
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggvpplillpllrgtlllWVTFFMGLLLVYL 189
|
....
gi 1240700454 187 LVSY 190
Cdd:cd17365 190 LNSW 193
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-411 |
6.58e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 227 PWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILst 306
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 307 ttvrkimnCGGFGMEATLLLVVGYSHTrgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 381
Cdd:COG2814 79 --------LLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
|
170 180 190
....*....|....*....|....*....|
gi 1240700454 382 GMVCPIIVGAMTKNKSreeWQYVFLIAALV 411
Cdd:COG2814 147 PALGPLLGGLLADLFG---WRWVFLVNAVL 173
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-180 |
7.86e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 7.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 41 KFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTY 120
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1240700454 121 PACHGIWSKWAPPLERSR-LATTSFCGSyAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMV 180
Cdd:cd17325 307 PATLALLADIVPPEGRGTaMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
44-425 |
8.12e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.93 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 44 WDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFV--RILQGLVEGVTYP 121
Cdd:cd17345 35 LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQGMGWP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 122 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTG---WSSVFYVYGSFGMVWYMFWLLVSYESPAKH-- 196
Cdd:cd17345 115 PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEgl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 197 PTITDEERRYIEESIGEsanllgAMEKFKTPWRKFFTSM----PVYAIIVAN----FCR----SWTfylllisqPAYFEE 264
Cdd:cd17345 195 PPIEEYKGDYPEEADGE------EEEQELSAWEIFVKYVlknkLLWYIAIANvfvyLVRygilDWA--------PTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 265 VFGFEISKVGM------LSAVPHlvmTIIVpigGQIAD-FLRSKqilstttvRKIMNCggFGMEATLLLVVGYSHTRGVA 337
Cdd:cd17345 261 VKGFSKAQAMWafslfeWAAIPG---TLLA---GWLSDkLFKGR--------RAPTGI--IFMILVIVALIVYWLAPNVL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 338 ISFLVLAvgFSGFAISG----FNVNHLDIAPRYAsilmgisngVGTLSGM--VCPIIVGAMTKNksreewqyvFLIAALV 411
Cdd:cd17345 325 VDLIALI--ALGFLIYGpvmlIGLQALELVPKKA---------AGTAAGLtgLFGYLGGSVLAT---------ALIGIIV 384
|
410
....*....|....*.
gi 1240700454 412 -HYG-GVIFYALFASG 425
Cdd:cd17345 385 dHFGwNGGFIVLLASC 400
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
204-384 |
3.29e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 204 RRYIEESIGESANLLGAMEKFKTPWRkfftsmPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvpHLV 283
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWR------ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL--FLF 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 284 MTII-VPIGGQIADFLRSKQILSTTTVrkimncggfgmeATLLLVVGYSHTRGVAISFLVLAVGFsgFAISGFNVNHL-- 360
Cdd:cd17478 242 AGAIgTLIGGPLSDRFGRRRVIIASLL------------LAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVla 307
|
170 180
....*....|....*....|....*....
gi 1240700454 361 -DIAPRYA----SILMGISNGVGTLSGMV 384
Cdd:cd17478 308 qELLPGNVglasGLMMGLSFGLGGIGAPV 336
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
245-440 |
3.34e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 245 FCRSWTFYLLLISQPAY--FEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADflrskqilsTTTVRKIMNCGGFGMEA 322
Cdd:cd06174 3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD---------RFGRRPVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 323 TLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSrEEWQ 402
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 1240700454 403 YVFLIAALVhyGGVIFYALFASGEKQPWADPEETSEEK 440
Cdd:cd06174 153 AVFLIAAAL--ALLAAILLLLVVPDPPESARAKNEEAS 188
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
42-296 |
4.16e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITqIP-GGYIASRLAANRVFGAAIL---LTSTLNMLIPSAARVhygcvIFVRILQGLVEG 117
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALAlftLGSLLCGLAPNLASL-----IIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 118 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwymfwllvsyespakhp 197
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL----------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 198 titdeerryieesigesANLLGAMEKFKTPWRKFFTSMpVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFEISKVGMLS 277
Cdd:cd17503 163 -----------------ALLLAPLLDLRLFKDRNFTLG-LLLSFLLGLGLFGAMFLL----PLYLQNVLGYSAFESGLVL 220
|
250
....*....|....*....
gi 1240700454 278 AVPHLVMTIIVPIGGQIAD 296
Cdd:cd17503 221 APGGLASAILSPLVGRLLD 239
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-422 |
7.07e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 7.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 45 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV---FGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYP 121
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLlilADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 122 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYG-SFGMVWYMFWLLvsyesPAKHPTIT 200
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlSFLLSALLLLFI-----RRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 201 DEERRYIEESIGESanllgamekfktpWRKFFTSMPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFEISKVGMLSAV 279
Cdd:cd06173 187 GESSSLLLRDLREG-------------LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGLLLAA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 280 PhlvmtiivPIGGQIADFLRSKqILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNH 359
Cdd:cd06173 253 F--------GVGALLGALLLGR-LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1240700454 360 LDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknkSREEWQYVFLIAALVHYGGVIFYALF 422
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA---DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
67-175 |
9.03e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.49 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 67 GGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCG 146
Cdd:PRK11551 70 GGRLADRIGRKRILIVSVALFGLFSLATAQAWD--FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147
|
90 100
....*....|....*....|....*....
gi 1240700454 147 SYAGAVIAMPLAGILVQYTGWSSVFYVYG 175
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIFYVGG 176
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-409 |
1.17e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.06 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 40 AKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANR-VFGAAILltSTLNMLIPSAARVHYGCVIFVRILQGLVEGV 118
Cdd:cd17353 31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKaILIGGIL--FGLGFILSAFAISLPLLFLGYGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPplERSRLAT-TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGS-FGMVWYMFWLLVSYESPAKH 196
Cdd:cd17353 109 GYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIGAFLIRDPPKGWV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 197 PTITDEERRYIEESIGEsanllgamekfKTPWRKFFTsmPVYAIIVANFCRSWTFYLLLISQPAYF-EEVFGFEISKVGM 275
Cdd:cd17353 187 PPGVDPLANNAENSPRD-----------YTPREMLRT--PTFWLLWLMFFLNATAGLMLIGQAKPIgQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 276 LSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimnCGGFGMeatLLLVvgysHTRGVAISFlVLAVGFSGFAISGF 355
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL-----IQGVAM---FLLP----FIGSVAVLF-VLGVALIGFCYGGG 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1240700454 356 nvnhLDIAPRYASILMGISNgVGT----------LSGMVCPIIVGAMTKNKSreeWQYVFLIAA 409
Cdd:cd17353 321 ----FALFPALTADFFGTKN-AGTnygllytakgVGGLIGPIIAAYVLYTGG---YNAAFIIAA 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
65-392 |
1.20e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 65 IPGGYIASRLAANRVF--GAAI-LLTSTLNMLIPSAArvhygCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLAT 141
Cdd:cd17321 49 LLAGRLGDRFGRKRVFliGLALfGLASLLCALAPSLA-----FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 142 TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLvsyespakhptitdeerryieesigesanllgam 221
Cdd:cd17321 124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---------------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 222 ekfktpwRKFFTSMpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSavphLVMTIIVPIGGQIADFLrsk 301
Cdd:cd17321 168 -------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL----LPLALAMLVAAPLAGRL--- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 302 qiLSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV-GF-SGFAISGFNVNHLDIAPR-YASILMGISNGVG 378
Cdd:cd17321 228 --ADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLlGLgLGLFATPLTNAALSSVPKeKAGAASGILNTAR 305
|
330
....*....|....
gi 1240700454 379 TLSGMVCPIIVGAM 392
Cdd:cd17321 306 QLGGALGVALLGAL 319
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
105-392 |
1.80e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.64 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 105 VIFVRILQGLVEGVTyPACHGIWSKWAPPlERSRLATTSFCGSYA-GAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwym 183
Cdd:cd17504 87 LIAGRALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 184 FWLLVsyespakhPTITdeeRRYIEESIGESANLLGAMEKfktpwrkfFTSMPVYAIIVAnfcrswtfyllLISQPAYFE 263
Cdd:cd17504 162 LAALV--------PLID---LRLLRRRNVLLANITALLAG--------FGMFMVFQLLPQ-----------LLQLPTPTG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 264 evFGFEISKVGMLSAVPHLVMTIIVPIGGQIAdflrskqilSTTTVRKIMNCGGFGMeATLLLVVGYSHTRGVAISF--L 341
Cdd:cd17504 212 --FGLGITEAGLLLLPGALVMLIAGPLAGRLI---------ARVGPRRVLLIGLVIS-AVGLLLLALLHSSLWALVValL 279
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1240700454 342 VLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 392
Cdd:cd17504 280 LIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
39-173 |
2.52e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 39 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 118
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGG 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY----TGWSSVFYV 173
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLL 162
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-391 |
2.66e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.91 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 48 TVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIW 127
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS--YPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 128 SKWAPPLERSrLAT----TSFcgSYAGAVIAMPLAGILVQYtGWSSVFYVYGSFGMVW-YMFWL-LVSYESPAKHPTITD 201
Cdd:cd17475 110 MRWFPPRERG-LAMgirqTGV--PLGGALAAALLPPLALHY-GWRAAFVVAGLVSILAaVLFWLfYREPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 202 EERRYIEESIGESANLLGAmekfktpWRKFFTSMPVYAIIVanfcrswtfYLLLisqpaYFEEVFGFEISKVGMLsavph 281
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIA-------IAGALLVAPQFALLT---------FLLL-----FLHDHLGLSVVAAGAL----- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 282 LVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL- 360
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVa 319
|
330 340 350
....*....|....*....|....*....|..
gi 1240700454 361 DIAP-RYASILMGISNGVGTLSGMVCPIIVGA 391
Cdd:cd17475 320 ESAGpEQAGTALGLANTINFIGIAIGPPLFGL 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-384 |
3.00e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAI-LLTSTLNMLIPSaarvhYGCVIFVRILQGLVEGV 118
Cdd:cd17320 29 LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLfILASLLCALASS-----IEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLAttsfcgSYAGAVIAM-----PLAG-ILVQYTGWSSVFYVYGSFGMV---WYMFWLlvs 189
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIF------SLLMMILAIapalaPLLGgLLLLFFGWRAIFVFLALLGLLlllLVLLFL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 190 yespakhPTITDEERRyieeSIGESANLLGAMEKFKTpwRKFFTSMPVYAIIVAnfcrswTFYLLLISQPAYFEEVFGFE 269
Cdd:cd17320 175 -------PETLPEEKR----KPLLSSLLRAYKRVLKN--RRFLGYALALGLSFA------GLFAYLAAAPFIYIEQLGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 270 ISKVGMLsavphLVMTIIVPIGGQIAdflrSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVG--F 347
Cdd:cd17320 236 PAQFGLL-----FALNAIALILGSLL----NGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFliF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1240700454 348 SGFAISGFNVNHLDIAPRY-----ASILMG-ISNGVGTLSGMV 384
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPhvagtASALLGfLQFLIGALAGAL 349
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
49-390 |
3.40e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 49 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAA--RVHYGCVIFVRILQGLVEGVTYPACHGI 126
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPsiYLFVVLMFLAGLGAGILDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 127 WSKWAPplerSRLATTSFCGSyAGAVIAMPLAGILV-QYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERR 205
Cdd:cd17333 113 FEESSA----TRLNVLHGFFG-LGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 206 YIEESIGESAN---LLGAMEKFktpwrkfftsmpVYAIIVANFCrSWTfylllisqPAYFEEVFGFEISKVGMLSAVPHL 282
Cdd:cd17333 188 FSASASRLLRNpsiILGALALF------------LYVGAETAFS-SWV--------PSYLVEKKHVSDGLAGYLLSGFWV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 283 VMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgmEATLLLVVGYSHTRGVAISFLVLAVGFSGFAI-SGFNVNHLD 361
Cdd:cd17333 247 GITIGRLLGGPISRRIKPHTLLVLSGS-----------GALLGLLILLLAPTLVVGLVATALLGLFMAALfPTILSLGIS 315
|
330 340
....*....|....*....|....*....
gi 1240700454 362 IAPRYASILMGISNGVGTLSGMVCPIIVG 390
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-411 |
3.81e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.47 E-value: 3.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 42 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLtstlnMLIPSAARV---HYGCVIFVRILQGLVEGV 118
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL-----LAAGLLLRSlapSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 119 TYPACHGIWSKWAPplERSRLATTSF-CGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHP 197
Cdd:COG2807 123 GNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 198 TITDEERryieesigesanllgamekFKTPWRkfftSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLS 277
Cdd:COG2807 201 AAPAAAS-------------------LRSLWR----SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 278 AVPHLVMTIIVPIGGQIADFLRSKQILSTTtvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGfSGFAISGFNV 357
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGDRRPLLLL-------LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLI 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1240700454 358 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM---TKNksreeWQYVFLIAALV 411
Cdd:COG2807 329 GLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALhdaTGS-----WTAALLLLAAL 380
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
50-422 |
4.43e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.63 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 50 GMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVhygcVIFVRI--LQGLVEGVTYPACHGIW 127
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSV----WVFSILwfLNGLAQGLGWPPCAKIL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 128 SKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYI 207
Cdd:cd17343 117 RKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 208 EESIGESANLLGAMEKFKTP--WRKFFTSMPVYAIIVAnfCRSWTfYLLLI---SQPAYFE-------EVFGFeiskVGM 275
Cdd:cd17343 197 GKKKKSPRGESTLKELLLSPflWLLSLGYLVVFGVKTA--VTDWG-QLFLIqdkGQSALTGssfmsslEVGGF----VGS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 276 LSAvphlvmtiivpigGQIADFLRSKQILST------TTVRKIMncggFGMEATL--LLVVGYSHTRGVAISFLVLAVGF 347
Cdd:cd17343 270 IAA-------------GYLSDWAVAKHGSSSrgnprmPLALVFM----AGLTVSLhlFRVHITSDSSELFILLLGFLIGF 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1240700454 348 SGFA-ISGFNVNHLDIAPryaSILMGISNGVGTLSGMVCPIIVG-AMTKNKSREEWQYVFLIAALVHYGGVIFYALF 422
Cdd:cd17343 333 SLYGpIAIFGVIANESAP---SHLCGTSHAIVALAANVGGVLAGlPFSYIAKHYDWRTAFLLLEILCAITVVILFLL 406
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
39-154 |
9.68e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 9.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240700454 39 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 118
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGL 312
|
90 100 110
....*....|....*....|....*....|....*.
gi 1240700454 119 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIA 154
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| |
