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Conserved domains on  [gi|1248026960|ref|NP_001343256|]
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MORN repeat-containing protein 1 isoform 2 [Mus musculus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 1.32e-32

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 121.60  E-value: 1.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642   143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                          90       100
                  ....*....|....*....|....*....
gi 1248026960  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642   223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 1.32e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 121.60  E-value: 1.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642   143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                          90       100
                  ....*....|....*....|....*....
gi 1248026960  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642   223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-108 3.12e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 82.19  E-value: 3.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:PLN03185   49 ISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLG 128

                          90       100
                  ....*....|....*....|....*...
gi 1248026960  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:PLN03185  129 DMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
31-51 4.69e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 4.69e-05
                           10        20
                   ....*....|....*....|.
gi 1248026960   31 VYQGSFHDNKRHGRGQMIFKN 51
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 55-77 1.61e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|...
gi 1248026960  55 YEGDWVRDQRQGHGVLCCADGST 77
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 1.32e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 121.60  E-value: 1.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642   143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                          90       100
                  ....*....|....*....|....*....
gi 1248026960  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642   223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-107 3.97e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 120.06  E-value: 3.97e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642   165 LTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEG 244

                          90       100
                  ....*....|....*....|....*..
gi 1248026960  81 QWHSDVFSGLGSLVHCSGVTYCGMFIN 107
Cdd:COG4642   245 EFKNGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-108 1.29e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 108.12  E-value: 1.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642   119 LEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEG 198

                          90       100
                  ....*....|....*....|....*...
gi 1248026960  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:COG4642   199 EFKNGQRHGQGTYTYADGDRYEGEFKNG 226
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-110 4.10e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 85.01  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642    96 GGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEG 175

                          90       100       110
                  ....*....|....*....|....*....|
gi 1248026960  81 QWHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642   176 EFKNGKRHGQGTLTYANGDVYEGEFKNGQR 205
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-108 3.12e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 82.19  E-value: 3.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:PLN03185   49 ISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLG 128

                          90       100
                  ....*....|....*....|....*...
gi 1248026960  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:PLN03185  129 DMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-110 6.06e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 69.09  E-value: 6.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   6 GGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSD 85
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                          90       100
                  ....*....|....*....|....*
gi 1248026960  86 VFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:PLN03185   88 LKHGLGYQRYPNGDVFEGSWIQGLQ 112
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 3-92 9.57e-13

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.71  E-value: 9.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   3 YKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQW 82
Cdd:PLN03185   97 YPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTW 176

                          90
                  ....*....|
gi 1248026960  83 HSDVFSGLGS 92
Cdd:PLN03185  177 TRGLKDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
3-110 2.31e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 63.05  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960   3 YKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFH-DNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642    74 AAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKkGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGE 153

                          90       100
                  ....*....|....*....|....*....
gi 1248026960  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642   154 FKNGKPHGQGTLTYADGDRYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 22-103 1.08e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 53.30  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248026960  22 GFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTY 101
Cdd:PLN03185    1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTY 80


                  ..
gi 1248026960 102 CG 103
Cdd:PLN03185   81 KG 82
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 45-109 6.35e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 6.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248026960  45 GQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFINGH 109
Cdd:PLN03185    1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGY 65
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
31-51 4.69e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 4.69e-05
                           10        20
                   ....*....|....*....|.
gi 1248026960   31 VYQGSFHDNKRHGRGQMIFKN 51
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 55-77 1.61e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|...
gi 1248026960  55 YEGDWVRDQRQGHGVLCCADGST 77
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 32-54 3.89e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.00  E-value: 3.89e-04
                          10        20
                  ....*....|....*....|...
gi 1248026960  32 YQGSFHDNKRHGRGQMIFKNGDK 54
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
53-74 3.08e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|..
gi 1248026960   53 DKYEGDWVRDQRQGHGVLCCAD 74
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
8-64 5.44e-03

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 36.97  E-value: 5.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1248026960   8 RYEGELSQGLREGQGFLEDQDGQV-YQGSFHDNKRHGRGQMIFKNGD-KYEGDWVRDQR 64
Cdd:COG2849   104 KSEGNYKNGKLHGEWKEYYENGKLkEEGNYKNGKKDGVWKYYDENGKlVKEEEYKNGKK 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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