NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1248494042|ref|NP_001343296|]
View 

transcription elongation factor A protein-like 1 [Mus musculus]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
93-165 2.59e-14

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 64.97  E-value: 2.59e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248494042  93 QPPCGVGKHKLEEGSFKERLARIRPQFIGDIHGRNLSNEEMIQAADEL----EEMKRVRNKLMIMHWKAK--RSRPYPI 165
Cdd:pfam04538  25 EDLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREGDDMerfgEEMRELRQKLREQQWRQRphRDHHYPF 103
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
93-165 2.59e-14

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 64.97  E-value: 2.59e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248494042  93 QPPCGVGKHKLEEGSFKERLARIRPQFIGDIHGRNLSNEEMIQAADEL----EEMKRVRNKLMIMHWKAK--RSRPYPI 165
Cdd:pfam04538  25 EDLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREGDDMerfgEEMRELRQKLREQQWRQRphRDHHYPF 103
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
93-165 2.59e-14

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 64.97  E-value: 2.59e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248494042  93 QPPCGVGKHKLEEGSFKERLARIRPQFIGDIHGRNLSNEEMIQAADEL----EEMKRVRNKLMIMHWKAK--RSRPYPI 165
Cdd:pfam04538  25 EDLEGGEPRKPRGNTRRGRVRQSVPNFREDIPNRHLSPEEMMREGDDMerfgEEMRELRQKLREQQWRQRphRDHHYPF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH