NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1252004226|ref|NP_001343444|]
View 

sulfotransferase 4A1 isoform 2 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-230 2.08e-59

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 189.48  E-value: 2.08e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1252004226 194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHC 230
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHL 197
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-230 2.08e-59

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 189.48  E-value: 2.08e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1252004226 194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHC 230
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHL 197
PLN02164 PLN02164
sulfotransferase
 21-215 3.35e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 96.91  E-value: 3.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  21 EFHGVR-LPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164   54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164  134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1252004226 166 MndklGYGSWFEHVQEFWEHRMDA--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164  211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
106-228 5.92e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 37.30  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 106 RLIKSHLPY---RFLPSDLHNGDSKVIYMARNpkDLV---VSYY------QFH-----RSLRTMSYRGTFQEFCRrfmnd 168
Cdd:COG4424    81 KLFWDQLPRllqRALRLLAAFPDLKFIHLTRR--DKLaqaVSLViaqqtgQWHsdaddALAPTAPPEYDAEEIAR----- 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1252004226 169 klgygsWFEHVQEF---WEHRMDAN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIE 228
Cdd:COG4424   154 ------LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-230 2.08e-59

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 189.48  E-value: 2.08e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1252004226 194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHC 230
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHL 197
PLN02164 PLN02164
sulfotransferase
 21-215 3.35e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 96.91  E-value: 3.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  21 EFHGVR-LPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164   54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164  134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1252004226 166 MndklGYGSWFEHVQEFWEHRMDA--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164  211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
Sulfotransfer_3 pfam13469
Sulfotransferase family;
50-216 2.72e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 58.07  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226  50 IVTYPKSGTSLLQEVVylvsqGADPDEIGLM----NIDEQLPVLEYPQPGLDIIKELTSP--RLIK---SHLPY-----R 115
Cdd:pfam13469   3 IVGLPRSGTTLLHRLL-----AAHPDVRPPEetwfVIPRILALLQAWGKSLEALARVPSYarWLCDkspSHLFHldlllK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 116 FLPsdlhngDSKVIYMARNPKDLVV-SYYQFHRSLRTmSYRGTFQEFCRRFMNDklgygsWFEHVQEFWEHRM---DANV 191
Cdd:pfam13469  78 AFP------DAKFIHLHRDPVDTVIsSYCSLFGFTLS-SYSTAFLRDIGLALAR------WSRAYERLMAARArvpPGRF 144

                         170       180
                  ....*....|....*....|....*
gi 1252004226 192 LFLKYEDMHRDLVTMVEQLARFLGV 216
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLGL 169
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
106-228 5.92e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 37.30  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252004226 106 RLIKSHLPY---RFLPSDLHNGDSKVIYMARNpkDLV---VSYY------QFH-----RSLRTMSYRGTFQEFCRrfmnd 168
Cdd:COG4424    81 KLFWDQLPRllqRALRLLAAFPDLKFIHLTRR--DKLaqaVSLViaqqtgQWHsdaddALAPTAPPEYDAEEIAR----- 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1252004226 169 klgygsWFEHVQEF---WEHRMDAN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIE 228
Cdd:COG4424   154 ------LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH