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Conserved domains on  [gi|1254064674|ref|NP_001343872|]
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sulfotransferase 1B1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-289 3.31e-114

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 329.69  E-value: 3.31e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  38 PGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVIT---SKVPMLELSVPGIRI---SGVELLKKTPSPRIIKTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 112 IDLLPKSFWENKCKMIYLARNGKDVAVSYYHFDLMNSINPLPGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKREEHPLLY 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 192 LYYEELKQNPKKEIKKIASFLDKTLDEEALDRIVHHTSFEMMKENPLVNYTHLPTammdhSKSPFMRKGIVGDWKNYFTM 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1254064674 272 TQTEQFDAVYKKKMSGTT 289
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-289 3.31e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 329.69  E-value: 3.31e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  38 PGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVIT---SKVPMLELSVPGIRI---SGVELLKKTPSPRIIKTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 112 IDLLPKSFWENKCKMIYLARNGKDVAVSYYHFDLMNSINPLPGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKREEHPLLY 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 192 LYYEELKQNPKKEIKKIASFLDKTLDEEALDRIVHHTSFEMMKENPLVNYTHLPTammdhSKSPFMRKGIVGDWKNYFTM 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1254064674 272 TQTEQFDAVYKKKMSGTT 289
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-290 6.87e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 126.57  E-value: 6.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  32 EEFQSTPGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVITSK----VPMLELSVPgiRISGVELLKKTPSPrIIK 107
Cdd:PLN02164   73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNphefVPYIEIDFP--FFPSVDVLKDKGNT-LFS 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 108 THLPIDLLPKSFWENKCKMIYLARNGKDVAVSYYHF--DLMNSINPLpGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKRE 185
Cdd:PLN02164  150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlhKERSQQGPL-NSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQ 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 186 EHP--LLYLYYEELKQNPKKEIKKIASFLDK--TLDEE---ALDRIVHHTSFEMMKeNPLVN-----YTHLPTAmmdHSK 253
Cdd:PLN02164  229 ENPdrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEekgVVEKVVKLCSFETLK-NLEANkgekdREDRPAV---YAN 304

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1254064674 254 SPFMRKGIVGDWKNYFTMTQTEQFDAVYKKKMSGTTL 290
Cdd:PLN02164  305 SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-289 3.31e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 329.69  E-value: 3.31e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  38 PGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVIT---SKVPMLELSVPGIRI---SGVELLKKTPSPRIIKTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFnnhNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 112 IDLLPKSFWENKCKMIYLARNGKDVAVSYYHFDLMNSINPLPGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKREEHPLLY 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 192 LYYEELKQNPKKEIKKIASFLDKTLDEEALDRIVHHTSFEMMKENPLVNYTHLPTammdhSKSPFMRKGIVGDWKNYFTM 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1254064674 272 TQTEQFDAVYKKKMSGTT 289
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-290 6.87e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 126.57  E-value: 6.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  32 EEFQSTPGDIVITTYPKSGTTWLSEIVDMVLNDGNVEKCKRDVITSK----VPMLELSVPgiRISGVELLKKTPSPrIIK 107
Cdd:PLN02164   73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNphefVPYIEIDFP--FFPSVDVLKDKGNT-LFS 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 108 THLPIDLLPKSFWENKCKMIYLARNGKDVAVSYYHF--DLMNSINPLpGTWEEYLEKFLAGNVAYGSWFDHVKSWWEKRE 185
Cdd:PLN02164  150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlhKERSQQGPL-NSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQ 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 186 EHP--LLYLYYEELKQNPKKEIKKIASFLDK--TLDEE---ALDRIVHHTSFEMMKeNPLVN-----YTHLPTAmmdHSK 253
Cdd:PLN02164  229 ENPdrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEekgVVEKVVKLCSFETLK-NLEANkgekdREDRPAV---YAN 304

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1254064674 254 SPFMRKGIVGDWKNYFTMTQTEQFDAVYKKKMSGTTL 290
Cdd:PLN02164  305 SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
41-218 4.37e-06

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 46.13  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674  41 IVITTYPKSGTTWLSEIVD----------MVLNDGNVEKCKRDVITSkvpmLELSVPGIRISGVeLLKKTPSpriiktHL 110
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAahpdvrppeeTWFVIPRILALLQAWGKS----LEALARVPSYARW-LCDKSPS------HL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254064674 111 P-IDLL----PKSfwenkcKMIYLARNGKDVAVSyyhfDLMNSINPLPGTWEEYLEKFLAGNVAYgsWFDHVKSWWEKRE 185
Cdd:pfam13469  70 FhLDLLlkafPDA------KFIHLHRDPVDTVIS----SYCSLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARA 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1254064674 186 EHP---LLYLYYEELKQNPKKEIKKIASFLDKTLDE 218
Cdd:pfam13469 138 RVPpgrFLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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