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Conserved domains on  [gi|1269612391|ref|NP_001344196|]
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nuclear pore complex protein Nup93 isoform 2 [Mus musculus]

Protein Classification

nuclear pore complex Nup93/Nic96 family protein( domain architecture ID 10513692)

nuclear pore complex Nup93/Nic96 family protein; similar to Homo sapiens Nup93 and Saccharomyces cerevisiae Nic96p which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC), which maintain the correct structure of the complex, and which are key factors in its ordered assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 95-687 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


:

Pssm-ID: 461172  Cd Length: 613  Bit Score: 662.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391  95 KSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFL 174
Cdd:pfam04097   1 RQLVDAWKALAEITGEKPAARSDDPPGRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGVPGNYNKVRAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 175 NIKLpapspGLQDG--------EVEGHPVWALIYYCMRCGDLLAASQVVSRAQHQLG----EFKTWFQEYMNSKDRRLSP 242
Cdd:pfam04097  81 RVRL-----GLKDGawdndnlqIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRkidrSFALYLKAYASSPDRRLPP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 243 ATENKLRLHYRRALRN--NTDPYKRAVYCIIGRCDITD-NQSEVADKTEDYLWLKLNQVCFDDDGTSSP-QDRLTLSQFQ 318
Cdd:pfam04097 156 DLEDRLKLEYNQRIRNapSIDPYKMAVYKIIGRCDLSRrHLESVTLTIEDWLWLQLSLIREDDSRSSEPaSERYTLSDLQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 319 KQLLEdYGESHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLrCHAVHVALVLFELKLLLKSSGQSAQLLSHEPgdpp 398
Cdd:pfam04097 236 SLILE-YGESYFNASSQPGLYFQVLLLTGQFEAAIEYLYRIDNY-VDAVHFAIALAYYGLLRVSDPSSSSPLLSQP---- 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 399 cMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKD--SQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVID 476
Cdd:pfam04097 310 -MRRINFARLIGLYTRDFRASDPREALDYLYLICLNADlgPEQRNLCHEALRELVLETREFALLLGDIRPDGTRIPGLIE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 477 KFTSD---------TKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNK-------ERL 540
Cdd:pfam04097 389 ERLPLiklddeddfLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLSQTDRLQPLKprsdrsvDDP 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 541 KNMALSIAERYRAQGISANKFVD---STFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDE 617
Cdd:pfam04097 469 ILLAQRILERYESNAEISEKVSAknrETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSEVRAKAQAFKNLPDE 548

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 618 IRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRViedrdSQLRSQARALITFAGMIPYRTSGDTNAR 687
Cdd:pfam04097 549 VAKNIPDLLLATMTCLSNQYKQLKNSQYSNEGKRQQL-----DQLRQKAKALMVFAGMIPYRMPRDTYER 613
 
Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 95-687 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


Pssm-ID: 461172  Cd Length: 613  Bit Score: 662.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391  95 KSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFL 174
Cdd:pfam04097   1 RQLVDAWKALAEITGEKPAARSDDPPGRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGVPGNYNKVRAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 175 NIKLpapspGLQDG--------EVEGHPVWALIYYCMRCGDLLAASQVVSRAQHQLG----EFKTWFQEYMNSKDRRLSP 242
Cdd:pfam04097  81 RVRL-----GLKDGawdndnlqIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRkidrSFALYLKAYASSPDRRLPP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 243 ATENKLRLHYRRALRN--NTDPYKRAVYCIIGRCDITD-NQSEVADKTEDYLWLKLNQVCFDDDGTSSP-QDRLTLSQFQ 318
Cdd:pfam04097 156 DLEDRLKLEYNQRIRNapSIDPYKMAVYKIIGRCDLSRrHLESVTLTIEDWLWLQLSLIREDDSRSSEPaSERYTLSDLQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 319 KQLLEdYGESHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLrCHAVHVALVLFELKLLLKSSGQSAQLLSHEPgdpp 398
Cdd:pfam04097 236 SLILE-YGESYFNASSQPGLYFQVLLLTGQFEAAIEYLYRIDNY-VDAVHFAIALAYYGLLRVSDPSSSSPLLSQP---- 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 399 cMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKD--SQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVID 476
Cdd:pfam04097 310 -MRRINFARLIGLYTRDFRASDPREALDYLYLICLNADlgPEQRNLCHEALRELVLETREFALLLGDIRPDGTRIPGLIE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 477 KFTSD---------TKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNK-------ERL 540
Cdd:pfam04097 389 ERLPLiklddeddfLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLSQTDRLQPLKprsdrsvDDP 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 541 KNMALSIAERYRAQGISANKFVD---STFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDE 617
Cdd:pfam04097 469 ILLAQRILERYESNAEISEKVSAknrETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSEVRAKAQAFKNLPDE 548

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 618 IRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRViedrdSQLRSQARALITFAGMIPYRTSGDTNAR 687
Cdd:pfam04097 549 VAKNIPDLLLATMTCLSNQYKQLKNSQYSNEGKRQQL-----DQLRQKAKALMVFAGMIPYRMPRDTYER 613
 
Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 95-687 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


Pssm-ID: 461172  Cd Length: 613  Bit Score: 662.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391  95 KSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFL 174
Cdd:pfam04097   1 RQLVDAWKALAEITGEKPAARSDDPPGRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGVPGNYNKVRAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 175 NIKLpapspGLQDG--------EVEGHPVWALIYYCMRCGDLLAASQVVSRAQHQLG----EFKTWFQEYMNSKDRRLSP 242
Cdd:pfam04097  81 RVRL-----GLKDGawdndnlqIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRkidrSFALYLKAYASSPDRRLPP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 243 ATENKLRLHYRRALRN--NTDPYKRAVYCIIGRCDITD-NQSEVADKTEDYLWLKLNQVCFDDDGTSSP-QDRLTLSQFQ 318
Cdd:pfam04097 156 DLEDRLKLEYNQRIRNapSIDPYKMAVYKIIGRCDLSRrHLESVTLTIEDWLWLQLSLIREDDSRSSEPaSERYTLSDLQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 319 KQLLEdYGESHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLrCHAVHVALVLFELKLLLKSSGQSAQLLSHEPgdpp 398
Cdd:pfam04097 236 SLILE-YGESYFNASSQPGLYFQVLLLTGQFEAAIEYLYRIDNY-VDAVHFAIALAYYGLLRVSDPSSSSPLLSQP---- 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 399 cMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKD--SQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVID 476
Cdd:pfam04097 310 -MRRINFARLIGLYTRDFRASDPREALDYLYLICLNADlgPEQRNLCHEALRELVLETREFALLLGDIRPDGTRIPGLIE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 477 KFTSD---------TKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNK-------ERL 540
Cdd:pfam04097 389 ERLPLiklddeddfLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLSQTDRLQPLKprsdrsvDDP 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 541 KNMALSIAERYRAQGISANKFVD---STFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDE 617
Cdd:pfam04097 469 ILLAQRILERYESNAEISEKVSAknrETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSEVRAKAQAFKNLPDE 548

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612391 618 IRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRViedrdSQLRSQARALITFAGMIPYRTSGDTNAR 687
Cdd:pfam04097 549 VAKNIPDLLLATMTCLSNQYKQLKNSQYSNEGKRQQL-----DQLRQKAKALMVFAGMIPYRMPRDTYER 613
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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