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Conserved domains on  [gi|1270111451|ref|NP_001344295|]
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zinc finger protein 791 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 8.70e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.70e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1270111451   3 SVTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLASV 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-467 1.28e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451  94 ITSGGKPYSCSV--CGKGFMLCSSLTRHVRAHPGHELagfkcgekRFKCKECRATFSYLKSFQRHERTHAGESPYRCKHC 171
Cdd:COG5048    55 SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS--------DLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 172 GKTFIYFQPFQTHERTHIGEQLYQCKHC-GKGLSSPGSLRIHQRIHTGEKPYVCEKCGKAFSCPSSIQIHERTH------ 244
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSenspls 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 245 ---------------TGEKPYKCKECGkaFISRTSVKTHMVTH-SGDANKPHKCEHCGKAF-LRPCFLRVHTRIHTGE-- 305
Cdd:COG5048   207 ssysipssssdqnleNSSSSLPLTTNS--QLSPKSLLSQSPSSlSSSDSSSSASESPRSSLpTASSQSSSPNESDSSSek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 306 ---KPYVCKQCGKAFRCSTSMQIHKRT--HTGE--KPYKCKE--CGKAFSAHSAFRVHRRVHTGEKPYKC--RDCGKAF- 373
Cdd:COG5048   285 gfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFs 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 374 ICLTYCRA----HERKHSGEKSYECD--QCGKAFVSLENFRRHVKTHAEDTPY--KCKECGKAFVFLSALQAHERIHTGE 445
Cdd:COG5048   365 PLLNNEPPqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         410       420
                  ....*....|....*....|..
gi 1270111451 446 KPYECEQCGKTFRCSSYVQVHR 467
Cdd:COG5048   445 APLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 444-527 3.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 444 GEKPYECE--QCGKTFRCSSYVQVHRRI-HTGEKPYECKECGKTFIYSTSfrghmrmhtgEKPYKCKGCEKAFRLGSSLK 520
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1270111451 521 RHeRTHS 527
Cdd:COG5189   416 YH-RKHS 421
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 8.70e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.70e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1270111451   3 SVTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLASV 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-61 1.87e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 1.87e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1270111451    4 VTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLASVASELEDQDVSNQYRIQEE 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-42 1.07e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.66  E-value: 1.07e-15
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1270111451   4 VTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLAS 42
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-467 1.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451  94 ITSGGKPYSCSV--CGKGFMLCSSLTRHVRAHPGHELagfkcgekRFKCKECRATFSYLKSFQRHERTHAGESPYRCKHC 171
Cdd:COG5048    55 SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS--------DLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 172 GKTFIYFQPFQTHERTHIGEQLYQCKHC-GKGLSSPGSLRIHQRIHTGEKPYVCEKCGKAFSCPSSIQIHERTH------ 244
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSenspls 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 245 ---------------TGEKPYKCKECGkaFISRTSVKTHMVTH-SGDANKPHKCEHCGKAF-LRPCFLRVHTRIHTGE-- 305
Cdd:COG5048   207 ssysipssssdqnleNSSSSLPLTTNS--QLSPKSLLSQSPSSlSSSDSSSSASESPRSSLpTASSQSSSPNESDSSSek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 306 ---KPYVCKQCGKAFRCSTSMQIHKRT--HTGE--KPYKCKE--CGKAFSAHSAFRVHRRVHTGEKPYKC--RDCGKAF- 373
Cdd:COG5048   285 gfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFs 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 374 ICLTYCRA----HERKHSGEKSYECD--QCGKAFVSLENFRRHVKTHAEDTPY--KCKECGKAFVFLSALQAHERIHTGE 445
Cdd:COG5048   365 PLLNNEPPqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         410       420
                  ....*....|....*....|..
gi 1270111451 446 KPYECEQCGKTFRCSSYVQVHR 467
Cdd:COG5048   445 APLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 444-527 3.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 444 GEKPYECE--QCGKTFRCSSYVQVHRRI-HTGEKPYECKECGKTFIYSTSfrghmrmhtgEKPYKCKGCEKAFRLGSSLK 520
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1270111451 521 RHeRTHS 527
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 9.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.61e-04
                          10        20
                  ....*....|....*....|....*
gi 1270111451 322 SMQIHKRTHTGEKPYKCKECGKAFS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 3.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 1270111451 462 YVQVHRRIHTGEKPYECKECGKTFIY 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 8.70e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.70e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1270111451   3 SVTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLASV 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-61 1.87e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 1.87e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1270111451    4 VTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLASVASELEDQDVSNQYRIQEE 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-42 1.07e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.66  E-value: 1.07e-15
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1270111451   4 VTFEDVCVTFTQEEWDLLRPVQKKLYKDVMWETVRNLAS 42
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-467 1.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451  94 ITSGGKPYSCSV--CGKGFMLCSSLTRHVRAHPGHELagfkcgekRFKCKECRATFSYLKSFQRHERTHAGESPYRCKHC 171
Cdd:COG5048    55 SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS--------DLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 172 GKTFIYFQPFQTHERTHIGEQLYQCKHC-GKGLSSPGSLRIHQRIHTGEKPYVCEKCGKAFSCPSSIQIHERTH------ 244
Cdd:COG5048   127 SLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSenspls 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 245 ---------------TGEKPYKCKECGkaFISRTSVKTHMVTH-SGDANKPHKCEHCGKAF-LRPCFLRVHTRIHTGE-- 305
Cdd:COG5048   207 ssysipssssdqnleNSSSSLPLTTNS--QLSPKSLLSQSPSSlSSSDSSSSASESPRSSLpTASSQSSSPNESDSSSek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 306 ---KPYVCKQCGKAFRCSTSMQIHKRT--HTGE--KPYKCKE--CGKAFSAHSAFRVHRRVHTGEKPYKC--RDCGKAF- 373
Cdd:COG5048   285 gfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFs 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 374 ICLTYCRA----HERKHSGEKSYECD--QCGKAFVSLENFRRHVKTHAEDTPY--KCKECGKAFVFLSALQAHERIHTGE 445
Cdd:COG5048   365 PLLNNEPPqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         410       420
                  ....*....|....*....|..
gi 1270111451 446 KPYECEQCGKTFRCSSYVQVHR 467
Cdd:COG5048   445 APLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-522 1.52e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451  99 KPYSCSVCGKGFMLCSSLTRHVRAHPGhelagfkcgEKRFKC--KECRATFSYLKSFQRHERTHAGESPYRCKHCGKTFI 176
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTG---------EKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 177 YFQPFQTHER-THIGEQLYQCKHCGKGLSSPGSLRIHQRIHTGEKPYVCEKCGKAF----SCPSSIQIHERTHTGEKPYK 251
Cdd:COG5048   103 SKASSSSLSSsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 252 CKecgkafisrtSVKTHMVTHSGDANKPHkCEHCGKAFLRPCFLRVHTRIHTgEKPYVCKQCGKAFRCSTSMQIHKRTHT 331
Cdd:COG5048   183 NL----------SLLISSNVSTSIPSSSE-NSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 332 GEKPYKCKECG------KAFSAHSAFRVHRRVHTG-EKPYKCRDCGKAFICLTYCRAHERK--HSGEKSYECDQ----CG 398
Cdd:COG5048   251 SDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 399 KAFVSLENFRRHVKTHAEDTPYKCK--ECGKAFVFLSA------LQAHERIHTgEKPYECE--QCGKTFRCSSYVQVHRR 468
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1270111451 469 IHTGEKPYECK--ECGKTFIYSTSFRGHMRMHTGEKPYKCKGCeKAFRLGSSLKRH 522
Cdd:COG5048   410 THLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-527 4.54e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 220 KPYVCEKCGKAFSCPSSIQIHERTHTGEKPYKC--KECGKAFISRTSVKTHMVTHSGDANKphkcEHCGKAFLRPCFLRV 297
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD----LNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 298 HTRIHTGEKPYV---CKQCGKAFRCSTSMQI--HKRTHTGEKPYK-CKECGKAFSAHSAFRV-HRRVHTGEKPYKCRDcg 370
Cdd:COG5048   108 SSLSSSSSNSNDnnlLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS-- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 371 kaficltyCRAHERKHSGEKSYECDQCGKAFVSLENFRRHVKTHAEDTPYKCKECGKAF----VFLSALQAHERIHTGEK 446
Cdd:COG5048   186 --------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 447 PYECEQCGKTFRCSSYVQVHR--RIHTG-EKPYECKECGKTFIYSTSFRGHMRM--HTGE--KPYKC--KGCEKAFRLGS 517
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESdsSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRND 337

                         330
                  ....*....|
gi 1270111451 518 SLKRHERTHS 527
Cdd:COG5048   338 ALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-527 1.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 183 THERTHIGEQLYQCKH--CGKGLSSPGSLRIHQRIHTGEKPYVCEK-CGKAFSCPSSIQIHERTHTGEKPYKCKECGKAF 259
Cdd:COG5048    51 RHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 260 ISRTSVKTHMVTHSgdaNKPHKCEHCGKAFLRPCFLRVHTrIHTGEKPYVCKQCGKAFRCSTSmqiHKRTHTGEKPYKCK 339
Cdd:COG5048   131 SSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSL-HPPLPANSLSKDPSSNLSLLIS---SNVSTSIPSSSENS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 340 ECGKAFSAHSAFRVHRRVHTgEKPYKCRDCGKAFICLTYCR------AHERKHSGEKSYECDQCGKAFVSLENFRRHVKT 413
Cdd:COG5048   204 PLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASSQSSSPNESDSSS 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 414 H-AEDTPYKCKECGKAFVFLSALQAHER--IHTGE--KPYEC--EQCGKTFRCSSYVQVHRRIHTGEKPYECKECGKTFI 486
Cdd:COG5048   283 EkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 487 YSTSF----RGHMRMHTGEKP-----------------------------------YKCKGCEKAFRLGSSLKRHERTHS 527
Cdd:COG5048   363 FSPLLnnepPQSLQQYKDLKNdkksetlsnscirnfkrdsnlslhiithlsfrpynCKNPPCSKSFNRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 444-527 3.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 444 GEKPYECE--QCGKTFRCSSYVQVHRRI-HTGEKPYECKECGKTFIYSTSfrghmrmhtgEKPYKCKGCEKAFRLGSSLK 520
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1270111451 521 RHeRTHS 527
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 9.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.61e-04
                          10        20
                  ....*....|....*....|....*
gi 1270111451 322 SMQIHKRTHTGEKPYKCKECGKAFS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1270111451 434 ALQAHERIHTGEKPYECEQCGKTFRC 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*
gi 1270111451 295 LRVHTRIHTGEKPYVCKQCGKAFRC 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 246-331 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1270111451 246 GEKPYKCK--ECGKAFISRTSVKTHMVT-HSGDANKPHKCEHCGKAFLrpcflrvhtrihTGEKPYVCKQCGKAFRCSTS 322
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFS------------AKDKPYRCEVCDKRYKNLNG 413


                  ....*....
gi 1270111451 323 MQIHkRTHT 331
Cdd:COG5189   414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-233 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1270111451 208 SLRIHQRIHTGEKPYVCEKCGKAFSC 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-261 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|..
gi 1270111451 240 HERTHTGEKPYKCKECGKAFIS 261
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 3.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 1270111451 462 YVQVHRRIHTGEKPYECKECGKTFIY 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-335 3.70e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1270111451 275 DANKPHKCEHCGKAFLRPCFLRVHTRIHTGEKPYVCKQCGKAFRCSTSMQ--IHKRTHTGEKP 335
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-513 4.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.95e-03
                          10        20
                  ....*....|....*....|
gi 1270111451 494 HMRMHTGEKPYKCKGCEKAF 513
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 5.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 1270111451 350 AFRVHRRVHTGEKPYKCRDCGKAFIC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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