prolyl hydroxylase EGLN2 isoform 2 [Mus musculus]
2OG-Fe(II) oxygenase( domain architecture ID 10653727)
2OG-Fe(II) oxygenase belonging to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily that share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of the target substrate
List of domain hits
Name | Accession | Description | Interval | E-value | |||
P4Hc | smart00702 | Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ... |
172-266 | 3.62e-29 | |||
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor. : Pssm-ID: 214780 Cd Length: 165 Bit Score: 109.01 E-value: 3.62e-29
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Name | Accession | Description | Interval | E-value | |||
P4Hc | smart00702 | Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ... |
172-266 | 3.62e-29 | |||
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor. Pssm-ID: 214780 Cd Length: 165 Bit Score: 109.01 E-value: 3.62e-29
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EGL9 | COG3751 | Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain ... |
172-268 | 3.39e-26 | |||
Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 442965 [Multi-domain] Cd Length: 195 Bit Score: 101.94 E-value: 3.39e-26
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2OG-FeII_Oxy_3 | pfam13640 | 2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ... |
173-266 | 3.26e-23 | |||
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. Pssm-ID: 463943 Cd Length: 94 Bit Score: 91.28 E-value: 3.26e-23
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Name | Accession | Description | Interval | E-value | |||
P4Hc | smart00702 | Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ... |
172-266 | 3.62e-29 | |||
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor. Pssm-ID: 214780 Cd Length: 165 Bit Score: 109.01 E-value: 3.62e-29
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EGL9 | COG3751 | Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain ... |
172-268 | 3.39e-26 | |||
Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 442965 [Multi-domain] Cd Length: 195 Bit Score: 101.94 E-value: 3.39e-26
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2OG-FeII_Oxy_3 | pfam13640 | 2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ... |
173-266 | 3.26e-23 | |||
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. Pssm-ID: 463943 Cd Length: 94 Bit Score: 91.28 E-value: 3.26e-23
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2OG-FeII_Oxy_4 | pfam13661 | 2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ... |
175-265 | 6.79e-07 | |||
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. Pssm-ID: 433386 Cd Length: 98 Bit Score: 46.57 E-value: 6.79e-07
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2OG-FeII_Oxy | pfam03171 | 2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ... |
172-266 | 5.57e-06 | |||
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB. Pssm-ID: 397334 [Multi-domain] Cd Length: 101 Bit Score: 44.37 E-value: 5.57e-06
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Blast search parameters | ||||
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