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Conserved domains on  [gi|1276740363|ref|NP_001344919|]
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zinc finger protein 758 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.90e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.90e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740363  12 LLTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-525 9.04e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 203 KPYKCSECNKCFTLKSNLGIHQKIHTGKKPYRCFD--CDKCFTNKYNLRTHQRIHSGEKPYKCSecDKCFIQKFSLITHQ 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 281 RIHTGEKPYKCSECDKCftNKSDLRGHQRVHTGEKPYKCSECD------KCFTHKGSLSIHHRLHSGEKPYKCSECDkcf 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSSH--SLPPSSRDPQLPDLLSISNLRNNPlpgnnsSSVNTPQSNSLHPPLPANSLSKDPSSNL--- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 355 tqkcNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRSHKKIHTGEKPYKCSECDKCFTHKFSLSIHQRLHSGEKPYKCSEC 434
Cdd:COG5048   185 ----SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 435 DKCFTQK--CNLLIHQRIHTEK-----KPYKCSECDKCFIQKCSLLIHQR--IHTGE--KPYKCAE--CAKCFTDKSDLI 501
Cdd:COG5048   261 PRSSLPTasSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340
                  ....*....|....*....|....
gi 1276740363 502 NHQRIHTGEKPYKCSECDKCFTHK 525
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFS 364
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.90e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.90e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740363  12 LLTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.63e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.63e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740363   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.33e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1276740363  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-525 9.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 203 KPYKCSECNKCFTLKSNLGIHQKIHTGKKPYRCFD--CDKCFTNKYNLRTHQRIHSGEKPYKCSecDKCFIQKFSLITHQ 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 281 RIHTGEKPYKCSECDKCftNKSDLRGHQRVHTGEKPYKCSECD------KCFTHKGSLSIHHRLHSGEKPYKCSECDkcf 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSSH--SLPPSSRDPQLPDLLSISNLRNNPlpgnnsSSVNTPQSNSLHPPLPANSLSKDPSSNL--- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 355 tqkcNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRSHKKIHTGEKPYKCSECDKCFTHKFSLSIHQRLHSGEKPYKCSEC 434
Cdd:COG5048   185 ----SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 435 DKCFTQK--CNLLIHQRIHTEK-----KPYKCSECDKCFIQKCSLLIHQR--IHTGE--KPYKCAE--CAKCFTDKSDLI 501
Cdd:COG5048   261 PRSSLPTasSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340
                  ....*....|....*....|....
gi 1276740363 502 NHQRIHTGEKPYKCSECDKCFTHK 525
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-412 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 387 DLRSHKKIHTGEKPYKCSECDKCFTH 412
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.90e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.90e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740363  12 LLTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.63e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.63e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740363   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.33e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.33e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1276740363  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-525 9.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 203 KPYKCSECNKCFTLKSNLGIHQKIHTGKKPYRCFD--CDKCFTNKYNLRTHQRIHSGEKPYKCSecDKCFIQKFSLITHQ 280
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 281 RIHTGEKPYKCSECDKCftNKSDLRGHQRVHTGEKPYKCSECD------KCFTHKGSLSIHHRLHSGEKPYKCSECDkcf 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSSH--SLPPSSRDPQLPDLLSISNLRNNPlpgnnsSSVNTPQSNSLHPPLPANSLSKDPSSNL--- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 355 tqkcNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRSHKKIHTGEKPYKCSECDKCFTHKFSLSIHQRLHSGEKPYKCSEC 434
Cdd:COG5048   185 ----SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 435 DKCFTQK--CNLLIHQRIHTEK-----KPYKCSECDKCFIQKCSLLIHQR--IHTGE--KPYKCAE--CAKCFTDKSDLI 501
Cdd:COG5048   261 PRSSLPTasSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340
                  ....*....|....*....|....
gi 1276740363 502 NHQRIHTGEKPYKCSECDKCFTHK 525
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFS 364
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-543 2.19e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 234 RCFDCDKC---FTNKYNLRTHQRIHSGEKPYKCS--ECDKCFIQKFSLITHQRIHTGEKPYKCSecDKCFTNKSDLRGHQ 308
Cdd:COG5048    32 RPDSCPNCtdsFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 309 RVHTGEKPykcSECDKCFTHKGSLSIHHRLHSgeKPYKCSECDKCFTQKCNLLTHQRIHTGEKPYKC---AECDKCFTNR 385
Cdd:COG5048   110 LSSSSSNS---NDNNLLSSHSLPPSSRDPQLP--DLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLpanSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 386 SDLRSHKKIHTGEKPYKCSECDKcFTHKFSLSIHQRLHSGEKPYKCSECDKCFTQKCNLLIHQrihTEKKPYKCSECDKC 465
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS---SLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 466 FI-----QKCSLLIHQRIHTGE-----KPYKCAECAKCFTDKSDLINHQR--IHTGE--KPYKCSE--CDKCFTHKCSLS 529
Cdd:COG5048   261 PRsslptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1276740363 530 IHQGIHARAKLKKY 543
Cdd:COG5048   341 RHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-393 2.54e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 313 GEKPYKCS--ECDKCFTHKGSLSiHHRLHSgekpykcsECDKCFTQKCNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRS 390
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLK-YHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1276740363 391 HKK 393
Cdd:COG5189   417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-535 8.81e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 194 SHQRMHTGEKPYKCS--ECNKCFTLKSNLGIHQKIHTGKKPYRCfdCDKCFTNKYNLRTHQRIHSGEKPYKCSECDKC-- 269
Cdd:COG5048    51 RHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHsl 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 270 -------------FIQKFSLITHQRIHTGEKPYKCS----------ECDKCFTNKSDLRGHQRVHTGEKPYKCSECDKCF 326
Cdd:COG5048   129 ppssrdpqlpdllSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSS 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 327 THKGSLSIHHRLHSGEKPYKCSECDKCFtqKCNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRSHKKIHTG--------- 397
Cdd:COG5048   209 YSIPSSSSDQNLENSSSSLPLTTNSQLS--PKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNEsdsssekgf 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 398 EKPYKCSECDKCFTHKFSLSIHQR--LHSGE--KPYKCSE--CDKCFTQKCNLLIHQRIHTEKKPYKCSECDKCFIQ--- 468
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspl 366

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276740363 469 ----KCSLLIHQRIHTGEKPYKCAECAKCFTDKSDLI----NHQRIHTGEKPYKCSECDKCFTHKCSLSIHQGIH 535
Cdd:COG5048   367 lnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNlslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-460 1.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 287 KPYKCSECDKCFTNKSDLRGHQR--VHTGE--KPYKCSE--CDKCFTHKGSLSIHHRLHSGEKPYKC--SECDKCFTQKC 358
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 359 NLLTHQRI--HTGEKPYKCAECDKCFTNRSDLRSHKkihtgekpykcsecdkcfthkFSLSIHQRLHSGEKPYKCSECDK 436
Cdd:COG5048   368 NNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSN---------------------LSLHIITHLSFRPYNCKNPPCSK 426

                         170       180
                  ....*....|....*....|....
gi 1276740363 437 CFTQKCNLLIHQRIHTEKKPYKCS 460
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 229-312 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 229 GKKPYRC--FDCDKCFTNKYNLRTHqRIHSgekpykcsECDKCFIQKFSLITHQRIHTGEKPYKCSECDKCFTNKSDLRG 306
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1276740363 307 HqRVHT 312
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-412 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 387 DLRSHKKIHTGEKPYKCSECDKCFTH 412
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-340 9.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276740363 285 GEKPYKCS--ECDKCFTNKSDLR-----GHQRVHTGE--------------KPYKCSECDKCFTHKGSLSiHHRLHS 340
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKyhmlhGHQNQKLHEnpspekmnifsakdKPYRCEVCDKRYKNLNGLK-YHRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-464 9.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 397 GEKPYKCS--ECDKCFTHKFSLSIHqRLHSgekpykcsECDKCFTQKCNLLIHQRIHTEKKPYKCSECDK 464
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 314-424 9.94e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740363 314 EKPYKCSECDKCFTHKGSLSIHH---RLHS-GEKPYKCS--ECDKCFTQKcNLLTHQRIHtgekpykcAECDKCFTNRSD 387
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDTpsrMLKVkDGKPYKCPveGCNKKYKNQ-NGLKYHMLH--------GHQNQKLHENPS 385

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1276740363 388 LRSHKKIHTGEKPYKCSECDKCFTHKFSLSIHqRLHS 424
Cdd:COG5189   386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 247 NLRTHQRIHSGEKPYKCSECDKCFIQ 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 359 NLLTHQRIHTGEKPYKCAECDKCFTN 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 3.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 499 DLINHQRIHTGEKPYKCSECDKCFTH 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
191-215 3.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.82e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740363 191 DLRSHQRMHTGEKPYKCSECNKCFT 215
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 4.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 275 SLITHQRIHTGEKPYKCSECDKCFTN 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 4.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740363 303 DLRGHQRVHTGEKPYKCSECDKCFTH 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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