|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
551-809 |
5.68e-10 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.80 E-value: 5.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 551 PPSGPDTTPAASSESTEqlPNVQVEGPTPNRPRKQLPSFDFNGPYLGPPQSHSLPDLPDQLGSPQVGGSlKPALP---GS 627
Cdd:PHA03247 2618 PPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGS 2694
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 628 LEYMCLPPGGQAQlvPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMA 707
Cdd:PHA03247 2695 LTSLADPPPPPPT--PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 708 SDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAAKSPPGHPAPPV 787
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPP 2847
|
250 260
....*....|....*....|....*
gi 1304473139 788 ASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2848 PSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
346-439 |
1.63e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.41 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 346 PPTLNLTK-NRDSYSLHWETQKMAYSFIEHtFQVQYKKK-SDSWEDSKTENLDRaHSMDLSQLEPDTSYCARVRVKpisn 423
Cdd:cd00063 4 PTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKgSGDWKEVEVTPGSE-TSYTLTGLKPGTEYEFRVRAV---- 77
|
90
....*....|....*.
gi 1304473139 424 YDGIWSKWSEEYTWKT 439
Cdd:cd00063 78 NGGGESPPSESVTVTT 93
|
|
| COG4733 super family |
cl34810 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
105-252 |
9.72e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
The actual alignment was detected with superfamily member COG4733:
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 43.01 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 105 RFSIT----NEDYYSfRPDSDLGIQLmvplaqnvqPPLPKNVSISSSEDRFLLEWSVSLGDAQVSWLSSKD-IEFEVAYK 179
Cdd:COG4733 503 TYTITavqhAPEKYA-AIDAGAFDDV---------PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGaVAYEVEWR 572
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1304473139 180 RLQDSWEDAYSLHTSKFQVnfepkLFLPNSIYAARVRTRlspgsSLSGRPSRW--SPEVHWDSQPGDKAQPQNLQ 252
Cdd:COG4733 573 RDDGNWVSVPRTSGTSFEV-----PGIYAGDYEVRVRAI-----NALGVSSAWaaSSETTVTGKTAPPPAPTGLT 637
|
|
| FN3 super family |
cl21522 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
245-328 |
2.62e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
The actual alignment was detected with superfamily member pfam09067:
Pssm-ID: 473895 Cd Length: 104 Bit Score: 38.17 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 245 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPVAPEEkCSpvVKEPPGASVYTRYHCSLPVPEPSAHSQYT 324
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-CP--LYSTSGANSTRLFICFFPKNDVSLFVPLH 84
|
....
gi 1304473139 325 VSVK 328
Cdd:pfam09067 85 ITVV 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-809 |
5.68e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.80 E-value: 5.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 551 PPSGPDTTPAASSESTEqlPNVQVEGPTPNRPRKQLPSFDFNGPYLGPPQSHSLPDLPDQLGSPQVGGSlKPALP---GS 627
Cdd:PHA03247 2618 PPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGS 2694
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 628 LEYMCLPPGGQAQlvPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMA 707
Cdd:PHA03247 2695 LTSLADPPPPPPT--PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 708 SDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAAKSPPGHPAPPV 787
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPP 2847
|
250 260
....*....|....*....|....*
gi 1304473139 788 ASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2848 PSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
550-809 |
2.94e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.94 E-value: 2.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 550 VPPSGPDTTPAASSESTEQLPNVQVEG------------------PTPNRPRKQLPSFDfnGPYLGPPQSHSLPDLPDQL 611
Cdd:pfam03154 198 GPTPSAPSVPPQGSPATSQPPNQTQSTaaphtliqqtptlhpqrlPSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQM 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 612 G----SPQVGGSLKPALPGSLEYMCLPPGGQAQLVPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENP--PVELSMEEQ 685
Cdd:pfam03154 276 PpmphSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHI 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 686 EArdnPVTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPP 760
Cdd:pfam03154 356 KP---PPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPP 432
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1304473139 761 GFEDYVELPPSVSQAAKSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 809
Cdd:pfam03154 433 VLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
346-439 |
1.63e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.41 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 346 PPTLNLTK-NRDSYSLHWETQKMAYSFIEHtFQVQYKKK-SDSWEDSKTENLDRaHSMDLSQLEPDTSYCARVRVKpisn 423
Cdd:cd00063 4 PTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKgSGDWKEVEVTPGSE-TSYTLTGLKPGTEYEFRVRAV---- 77
|
90
....*....|....*.
gi 1304473139 424 YDGIWSKWSEEYTWKT 439
Cdd:cd00063 78 NGGGESPPSESVTVTT 93
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
105-252 |
9.72e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 43.01 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 105 RFSIT----NEDYYSfRPDSDLGIQLmvplaqnvqPPLPKNVSISSSEDRFLLEWSVSLGDAQVSWLSSKD-IEFEVAYK 179
Cdd:COG4733 503 TYTITavqhAPEKYA-AIDAGAFDDV---------PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGaVAYEVEWR 572
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1304473139 180 RLQDSWEDAYSLHTSKFQVnfepkLFLPNSIYAARVRTRlspgsSLSGRPSRW--SPEVHWDSQPGDKAQPQNLQ 252
Cdd:COG4733 573 RDDGNWVSVPRTSGTSFEV-----PGIYAGDYEVRVRAI-----NALGVSSAWaaSSETTVTGKTAPPPAPTGLT 637
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
341-437 |
1.70e-03 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 38.86 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 341 HIQMEPPTLNLTKNRdsySLHWETQKMAYSfiehtfqVQYKKKSDSWEdsKTENLDRAHSMDLSQLEPDTSYCARVRVK- 419
Cdd:pfam09294 18 NVTVKDPETREGKNL---SLRDLYGSLQYR-------VSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYCVSVQAFs 85
|
90
....*....|....*...
gi 1304473139 420 PISNYDGIWSKWSEEYTW 437
Cdd:pfam09294 86 PLDNKSSQRSPPQCIRTT 103
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
245-328 |
2.62e-03 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 38.17 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 245 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPVAPEEkCSpvVKEPPGASVYTRYHCSLPVPEPSAHSQYT 324
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-CP--LYSTSGANSTRLFICFFPKNDVSLFVPLH 84
|
....
gi 1304473139 325 VSVK 328
Cdd:pfam09067 85 ITVV 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-809 |
5.68e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.80 E-value: 5.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 551 PPSGPDTTPAASSESTEqlPNVQVEGPTPNRPRKQLPSFDFNGPYLGPPQSHSLPDLPDQLGSPQVGGSlKPALP---GS 627
Cdd:PHA03247 2618 PPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR-RRAARptvGS 2694
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 628 LEYMCLPPGGQAQlvPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMA 707
Cdd:PHA03247 2695 LTSLADPPPPPPT--PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 708 SDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVPSGSPALGPPGfedyvELPPSVSQAAKSPPGHPAPPV 787
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG-----PLPPPTSAQPTAPPPPPGPPP 2847
|
250 260
....*....|....*....|....*
gi 1304473139 788 ASSPT---VIPGEPREEVGPASPHP 809
Cdd:PHA03247 2848 PSLPLggsVAPGGDVRRRPPSRSPA 2872
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
550-809 |
2.94e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.94 E-value: 2.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 550 VPPSGPDTTPAASSESTEQLPNVQVEG------------------PTPNRPRKQLPSFDfnGPYLGPPQSHSLPDLPDQL 611
Cdd:pfam03154 198 GPTPSAPSVPPQGSPATSQPPNQTQSTaaphtliqqtptlhpqrlPSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQM 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 612 G----SPQVGGSLKPALPGSLEYMCLPPGGQAQLVPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENP--PVELSMEEQ 685
Cdd:pfam03154 276 PpmphSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlpPAPLSMPHI 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 686 EArdnPVTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGL-----PSAQSPSLCLKLPRVPSGSPALGPP 760
Cdd:pfam03154 356 KP---PPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLsthhpPSAHPPPLQLMPQSQQLPPPPAQPP 432
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1304473139 761 GFEDYVELPPSVSQAAKSPPGHPAPPVASSPT--VIPGEPREEVGPASPHP 809
Cdd:pfam03154 433 VLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhpFVPGGPPPITPPSGPPT 483
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
346-439 |
1.63e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.41 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 346 PPTLNLTK-NRDSYSLHWETQKMAYSFIEHtFQVQYKKK-SDSWEDSKTENLDRaHSMDLSQLEPDTSYCARVRVKpisn 423
Cdd:cd00063 4 PTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKgSGDWKEVEVTPGSE-TSYTLTGLKPGTEYEFRVRAV---- 77
|
90
....*....|....*.
gi 1304473139 424 YDGIWSKWSEEYTWKT 439
Cdd:cd00063 78 NGGGESPPSESVTVTT 93
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
499-807 |
1.38e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 499 PPGSMAAFATKNPALQGPQSRLLAEQQGE--SYAHLEDNNVSPLTIEDPniirVPPSGPDTTPAASSESTEQLPNVQVEG 576
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATplPPGPAAARQASPALPAAP----APPAVPAGPATPGGPARPARPPTTAGP 2766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 577 PTPNRPRkqlpsfdfnGPYLGPPqshslPDLPDQLGSPQVGGSLKPALPGSLEYMCLPPGGQAQLVPLSQVMGQGQAMdv 656
Cdd:PHA03247 2767 PAPAPPA---------APAAGPP-----RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP-- 2830
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 657 qcgsslETSGSPSVEPKENPPVE--LSMEEQEARDNPVtlpiSSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLG 734
Cdd:PHA03247 2831 ------PTSAQPTAPPPPPGPPPpsLPLGGSVAPGGDV----RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 735 LPSAQSPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAAKSPPGHPAPPVASSPTV--------IPGE---PREEVG 803
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVpqpwlgalVPGRvavPRFRVP 2980
|
....
gi 1304473139 804 PASP 807
Cdd:PHA03247 2981 QPAP 2984
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
612-803 |
1.78e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 45.06 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 612 GSPQVGGSLKPALpgSLEYMCLPPGGQAQLVPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPpvelSMEEQEARDNP 691
Cdd:PRK14959 338 GQRRVLTSLEPAM--ALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTP----GTQGPQGTAPA 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 692 VTLPISSGGPeGSMMASDYVTPGDPVLTLPTGPlstslgPSLGLPSAQSPslclklpRVPSGSPALGPPGfedyvelppS 771
Cdd:PRK14959 412 AGMTPSSAAP-ATPAPSAAPSPRVPWDDAPPAP------PRSGIPPRPAP-------RMPEASPVPGAPD---------S 468
|
170 180 190
....*....|....*....|....*....|..
gi 1304473139 772 VSQAAKSPPGHPAPPVASSPTviPGEPREEVG 803
Cdd:PRK14959 469 VASASDAPPTLGDPSDTAEHT--PSGPRTWDG 498
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
667-811 |
2.08e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 667 SPSVEPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPslglPSAQSPSLCLK 746
Cdd:PHA03307 62 CDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASP----PPSPAPDLSEM 137
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1304473139 747 LPRVPSGSPAlgPPGFEDYVELPPSVSQAAKSPPGHPAPPVASSPTVI--PGEPREEVGPASPHPEG 811
Cdd:PHA03307 138 LRPVGSPGPP--PAASPPAAGASPAAVASDAASSRQAALPLSSPEETAraPSSPPAEPPPSTPPAAA 202
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
536-807 |
4.51e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 4.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 536 NVSPLTIEDPNIIRVPPSGPDTTPAASSESTEQLPNVQVEGPTPNRPRKQLPsfdfngpyLGPPQSHSlPDLPDQLGSPQ 615
Cdd:PHA03307 72 PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP--------ASPPPSPA-PDLSEMLRPVG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 616 VGGSLKPALPgsleymclPPGGQAQLVPLSQVMGQGQAMDVQcgSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLP 695
Cdd:PHA03307 143 SPGPPPAASP--------PAAGASPAAVASDAASSRQAALPL--SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 696 ISSGGPEGSMM----------------------------ASDYVTPGDPVLTLPT------GPLSTSLGPSLGLPSAQSP 741
Cdd:PHA03307 213 ISASASSPAPApgrsaaddagasssdssssessgcgwgpENECPLPRPAPITLPTriweasGWNGPSSRPGPASSSSSPR 292
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1304473139 742 SLCLK-LPRVPSGSPALGPPGFEDYVELPPSVSQAAKS--------PPGHPAPPVASSPTviPGEPREEVGPASP 807
Cdd:PHA03307 293 ERSPSpSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSsssessrgAAVSPGPSPSRSPS--PSRPPPPADPSSP 365
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-810 |
5.89e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 5.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 551 PPSGPDTT-PAASSESTEQLPNVQVEGPTPNRPRKQLPSfdfnGPYLGPPQSHSLPDLPDQLGSPQvggslKPALPGSLE 629
Cdd:PHA03247 2685 RRAARPTVgSLTSLADPPPPPPTPEPAPHALVSATPLPP----GPAAARQASPALPAAPAPPAVPA-----GPATPGGPA 2755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 630 YMCLPP---GGQAQLVPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLPIS-SGGPEGSM 705
Cdd:PHA03247 2756 RPARPPttaGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGpLPPPTSAQ 2835
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 706 MASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKLPRVP-------------SGSPALGPPGFEdyvelPPSV 772
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPpvrrlarpavsrsTESFALPPDQPE-----RPPQ 2910
|
250 260 270
....*....|....*....|....*....|....*...
gi 1304473139 773 SQAAKSPPGHPAPPVASSPTVIPGEPREEVGPASPHPE 810
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
551-807 |
7.21e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 551 PPSGPDTTPAASSESTeqlpnvqvegPTPN-RPRkqlPSfdfnGPYLGPPQSHslPDLPDQLGSPQVGGSLKPALPGSLE 629
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSV----------PPPRpAPR---PS----EPAVTSRARR--PDAPPQSARPRAPVDDRGDPRGPAP 2613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 630 YMCLPPGGQAQLVPLSqvmgqgqamdvqcgssletsgSPSVEPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMASD 709
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPP---------------------SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGR 2672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 710 YVTPGDPvltlPTGPLSTSLGPSLGlpsaqsPSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAAKSPPGHP---APP 786
Cdd:PHA03247 2673 AAQASSP----PQRPRRRAARPTVG------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapAPP 2742
|
250 260
....*....|....*....|.
gi 1304473139 787 VASSPTVIPGEPREEVGPASP 807
Cdd:PHA03247 2743 AVPAGPATPGGPARPARPPTT 2763
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
105-252 |
9.72e-04 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 43.01 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 105 RFSIT----NEDYYSfRPDSDLGIQLmvplaqnvqPPLPKNVSISSSEDRFLLEWSVSLGDAQVSWLSSKD-IEFEVAYK 179
Cdd:COG4733 503 TYTITavqhAPEKYA-AIDAGAFDDV---------PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGaVAYEVEWR 572
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1304473139 180 RLQDSWEDAYSLHTSKFQVnfepkLFLPNSIYAARVRTRlspgsSLSGRPSRW--SPEVHWDSQPGDKAQPQNLQ 252
Cdd:COG4733 573 RDDGNWVSVPRTSGTSFEV-----PGIYAGDYEVRVRAI-----NALGVSSAWaaSSETTVTGKTAPPPAPTGLT 637
|
|
| Interfer-bind |
pfam09294 |
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ... |
341-437 |
1.70e-03 |
|
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.
Pssm-ID: 462746 Cd Length: 103 Bit Score: 38.86 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 341 HIQMEPPTLNLTKNRdsySLHWETQKMAYSfiehtfqVQYKKKSDSWEdsKTENLDRAHSMDLSQLEPDTSYCARVRVK- 419
Cdd:pfam09294 18 NVTVKDPETREGKNL---SLRDLYGSLQYR-------VSYWKNSSNGE--KKNTTSTNSFVVLSDLEPGTTYCVSVQAFs 85
|
90
....*....|....*...
gi 1304473139 420 PISNYDGIWSKWSEEYTW 437
Cdd:pfam09294 86 PLDNKSSQRSPPQCIRTT 103
|
|
| EpoR_lig-bind |
pfam09067 |
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ... |
245-328 |
2.62e-03 |
|
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.
Pssm-ID: 401127 Cd Length: 104 Bit Score: 38.17 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 245 KAQPQNLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPVAPEEkCSpvVKEPPGASVYTRYHCSLPVPEPSAHSQYT 324
Cdd:pfam09067 8 PEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKE-CP--LYSTSGANSTRLFICFFPKNDVSLFVPLH 84
|
....
gi 1304473139 325 VSVK 328
Cdd:pfam09067 85 ITVV 88
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
544-807 |
2.75e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.59 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 544 DPNIIRVPPSGPDTTPAASSESTEQLPNVQVEgPTPNRPRKQLPsfdfngPYLGPPQSHSLPDLPDQLGSPQV------- 616
Cdd:PHA03378 644 NVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ-PSPTGANTMLP------IQWAPGTMQPPPRAPTPMRPPAAppgraqr 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 617 -GGSLKPALP--GSLEYMCLPPGGQAQLVPLSQVMGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVT 693
Cdd:PHA03378 717 pAAATGRARPpaAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTP 796
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 694 LPISSGGPeGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPSLCLKL-PRVPSGSPALGP-------PGFEDY 765
Cdd:PHA03378 797 QPPPQAGP-TSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQaAAGPTPSPGSGTsdkivqaPVFYPP 875
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1304473139 766 VELPPSVSQAAKSPPGHPAPPVASSPTVIPGEpREEVGPASP 807
Cdd:PHA03378 876 VLQPIQVMRQLGSVRAAAASTVTQAPTEYTGE-RRGVGPMHP 916
|
|
| IL6Ra-bind |
pfam09240 |
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ... |
250-316 |
2.83e-03 |
|
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.
Pssm-ID: 401252 Cd Length: 96 Bit Score: 37.77 E-value: 2.83e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1304473139 250 NLQCFFDGIQSLHCSWEVWTQTTGSVSFGLFYRPSPVAPEEKCSPVVKEPPgasvyTRYHCSLPVPE 316
Cdd:pfam09240 1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDG-----TRIGCQFDDLE 62
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
665-807 |
2.90e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.61 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 665 SGSPSV--EPKENPPVELSMEEQEARDNPVTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQSPs 742
Cdd:PRK10263 368 TGEPVIapAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA- 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1304473139 743 lclkLPRVPSGSPALGPPGFEDYVELPPSVSQAaksPPGHPAPPVASSPTVIPGEPREEVGPASP 807
Cdd:PRK10263 447 ----WQAEEQQSTFAPQSTYQTEQTYQQPAAQE---PLYQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
634-809 |
4.17e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 634 PPGGQAQLVPLSQVmGQGQAMDVQCGSSLETSGSPSVEPKENPPVELSMEEQEARDNPVTLpISSGgpeGSMMASDYVTP 713
Cdd:pfam03154 171 PPVLQAQSGAASPP-SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL-IQQT---PTLHPQRLPSP 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 714 GDPVLTLPTGPLSTSLGPSlglpSAQSPSLCLKLPRVP----SGSPALGPPGFEDYVELPPSVSQAAKSPPGHPAPPVAS 789
Cdd:pfam03154 246 HPPLQPMTQPPPPSQVSPQ----PLPQPSLHGQMPPMPhslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS 321
|
170 180
....*....|....*....|
gi 1304473139 790 SPTviPGEPREEVGPASPHP 809
Cdd:pfam03154 322 QQR--IHTPPSQSQLQSQQP 339
|
|
| Pur_ac_phosph_N |
pfam16656 |
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ... |
345-431 |
8.03e-03 |
|
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.
Pssm-ID: 465220 [Multi-domain] Cd Length: 93 Bit Score: 36.62 E-value: 8.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304473139 345 EPPTLNLTKNRDSYSLHWETQKMaysfiEHTFQVQYKKKSD---SWEDSKTENLDRA-------HSMDLSQLEPDTSYCA 414
Cdd:pfam16656 2 EQVHLSLTGDSTSMTVSWVTPSA-----VTSPVVQYGTSSSaltSTATATSSTYTTGdggtgyiHRATLTGLEPGTTYYY 76
|
90
....*....|....*..
gi 1304473139 415 RVRvkpisNYDGIWSKW 431
Cdd:pfam16656 77 RVG-----DDNGGWSEV 88
|
|
| |
