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Conserved domains on  [gi|1327850579|ref|NP_001346671|]
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low-density lipoprotein receptor-related protein 11 isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 69-172 6.87e-39

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


:

Pssm-ID: 129004  Cd Length: 93  Bit Score: 135.27  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579   69 GPREDCPGAggtavYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVpapmpaPRC 148
Cdd:smart00765   1 SPGEDCLGR-----FRVLENAIIRTEESLSAGARFLKSPIAVNTWEDCVRACCSTPNCNLAVFELRREDAE------GNC 69

                           90       100
                   ....*....|....*....|....
gi 1327850579  149 YLFNCTARGRSVCKFAPLRGYRTY 172
Cdd:smart00765  70 YLFNCTYPGKEVCKFKPHEGYTSY 93
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 191-280 1.34e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


:

Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  191 KPPVSKAGKDVVLHLPtdgvvldgreSSDDHAIVLYEWTLqqGDPSSVD-----MKVPQPGTlrlsrlkegaYIFQLTVT 265
Cdd:smart00089   7 SPTVGVAGESVTFTAT----------SSDDGSIVSYTWDF--GDGTSSTgptvtHTYTKPGT----------YTVTLTVT 64

                           90
                   ....*....|....*
gi 1327850579  266 DSVGqrsSDNVSVTV 280
Cdd:smart00089  65 NAVG---SASATVTV 76
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 69-172 6.87e-39

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 135.27  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579   69 GPREDCPGAggtavYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVpapmpaPRC 148
Cdd:smart00765   1 SPGEDCLGR-----FRVLENAIIRTEESLSAGARFLKSPIAVNTWEDCVRACCSTPNCNLAVFELRREDAE------GNC 69

                           90       100
                   ....*....|....*....|....
gi 1327850579  149 YLFNCTARGRSVCKFAPLRGYRTY 172
Cdd:smart00765  70 YLFNCTYPGKEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 72-171 4.03e-36

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 127.81  E-value: 4.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  72 EDCPGAggtavYRAVPDTIIRTQDSIAAGASFLRaPGSVRGWRQCVTACCSEPSCSVAVVQLPRGpsvpAPMPAPRCYLF 151
Cdd:pfam07502   1 ESCLED-----FTGVEDFIIDTEDSVKNGATFLS-SPEVSSARDCVRACCSTPRCNLAVFEERPG----GEDAIPSCYLF 70

                          90       100
                  ....*....|....*....|
gi 1327850579 152 NCTARGRSVCKFAPLRGYRT 171
Cdd:pfam07502  71 NCLYPSRFVCKFAPHKGYTS 90
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 191-280 1.34e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  191 KPPVSKAGKDVVLHLPtdgvvldgreSSDDHAIVLYEWTLqqGDPSSVD-----MKVPQPGTlrlsrlkegaYIFQLTVT 265
Cdd:smart00089   7 SPTVGVAGESVTFTAT----------SSDDGSIVSYTWDF--GDGTSSTgptvtHTYTKPGT----------YTVTLTVT 64

                           90
                   ....*....|....*
gi 1327850579  266 DSVGqrsSDNVSVTV 280
Cdd:smart00089  65 NAVG---SASATVTV 76
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 185-280 2.74e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 42.48  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579 185 PRPDEDKPPVSKAGKDVVLHLPtdgvvldgreSSDDHAIVLYEWTLqqGDPSsvdMKVPQPGTLRLSRLKEGAYIFQLTV 264
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSAS----------DSSGGSIVSYKWDF--GDGE---VSSSGEPTVTHTYTKPGTYTVTLTV 65

                          90
                  ....*....|....*.
gi 1327850579 265 TDSVGQRSSDNVSVTV 280
Cdd:cd00146    66 TNAVGSSSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 192-280 1.01e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 38.02  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579 192 PPVSKAGKDVVLHlPTDGVVLDGRESSD-DHAIVLYEWTLqqGDPSSVDMKVP-----QPGTlrlsrlkegaYIFQLTVT 265
Cdd:pfam18911   3 APVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDF--GDGTTATGANVshtyaAPGT----------YTVTLTVT 69

                          90
                  ....*....|....*.
gi 1327850579 266 DSVG-QRSSDNVSVTV 280
Cdd:pfam18911  70 DDSGaSNSTATDTVTV 85
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 192-280 2.28e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 40.41  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  192 PPVSKAGKDVVLHLPTDgVVLDGRESSD-DHAIVLYEWTlQQGDP----SSVDMKVPQPGTLRLSrlKEGAYIFQLTVTD 266
Cdd:NF038112  1187 RPVANAGPDQTVLERTT-VTLNGSGSFDpDGDPLTYAWT-QVSGPavtlTGADTATPSFTAPEVT--ADTVLTFQLVVSD 1262

                           90
                   ....*....|....
gi 1327850579  267 SVGQRSSDNVSVTV 280
Cdd:NF038112  1263 GTKTSAPDTVTVLV 1276
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 193-284 4.93e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 39.64  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  193 PVSKAGKDVVLHlPTDGVVLDGRESSDDHAIVLYEWTlQQGDP----SSVDMKVPqpgTLRLSRLKEGAYI-FQLTVTDS 267
Cdd:NF038112  1470 PVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT-QVAGPsvtlTGADSAKL---TFTAPEVSADTTLtFSLTVTDG 1544

                           90
                   ....*....|....*..
gi 1327850579  268 VGQRSSDNVSVTVLPRP 284
Cdd:NF038112  1545 SGSSGPVVVTVTVKNVN 1561
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 69-172 6.87e-39

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 135.27  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579   69 GPREDCPGAggtavYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVpapmpaPRC 148
Cdd:smart00765   1 SPGEDCLGR-----FRVLENAIIRTEESLSAGARFLKSPIAVNTWEDCVRACCSTPNCNLAVFELRREDAE------GNC 69

                           90       100
                   ....*....|....*....|....
gi 1327850579  149 YLFNCTARGRSVCKFAPLRGYRTY 172
Cdd:smart00765  70 YLFNCTYPGKEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 72-171 4.03e-36

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 127.81  E-value: 4.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  72 EDCPGAggtavYRAVPDTIIRTQDSIAAGASFLRaPGSVRGWRQCVTACCSEPSCSVAVVQLPRGpsvpAPMPAPRCYLF 151
Cdd:pfam07502   1 ESCLED-----FTGVEDFIIDTEDSVKNGATFLS-SPEVSSARDCVRACCSTPRCNLAVFEERPG----GEDAIPSCYLF 70

                          90       100
                  ....*....|....*....|
gi 1327850579 152 NCTARGRSVCKFAPLRGYRT 171
Cdd:pfam07502  71 NCLYPSRFVCKFAPHKGYTS 90
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 191-280 1.34e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  191 KPPVSKAGKDVVLHLPtdgvvldgreSSDDHAIVLYEWTLqqGDPSSVD-----MKVPQPGTlrlsrlkegaYIFQLTVT 265
Cdd:smart00089   7 SPTVGVAGESVTFTAT----------SSDDGSIVSYTWDF--GDGTSSTgptvtHTYTKPGT----------YTVTLTVT 64

                           90
                   ....*....|....*
gi 1327850579  266 DSVGqrsSDNVSVTV 280
Cdd:smart00089  65 NAVG---SASATVTV 76
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 185-280 2.74e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 42.48  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579 185 PRPDEDKPPVSKAGKDVVLHLPtdgvvldgreSSDDHAIVLYEWTLqqGDPSsvdMKVPQPGTLRLSRLKEGAYIFQLTV 264
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSAS----------DSSGGSIVSYKWDF--GDGE---VSSSGEPTVTHTYTKPGTYTVTLTV 65

                          90
                  ....*....|....*.
gi 1327850579 265 TDSVGQRSSDNVSVTV 280
Cdd:cd00146    66 TNAVGSSSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 192-280 1.01e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 38.02  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579 192 PPVSKAGKDVVLHlPTDGVVLDGRESSD-DHAIVLYEWTLqqGDPSSVDMKVP-----QPGTlrlsrlkegaYIFQLTVT 265
Cdd:pfam18911   3 APVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDF--GDGTTATGANVshtyaAPGT----------YTVTLTVT 69

                          90
                  ....*....|....*.
gi 1327850579 266 DSVG-QRSSDNVSVTV 280
Cdd:pfam18911  70 DDSGaSNSTATDTVTV 85
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 192-280 2.28e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 40.41  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  192 PPVSKAGKDVVLHLPTDgVVLDGRESSD-DHAIVLYEWTlQQGDP----SSVDMKVPQPGTLRLSrlKEGAYIFQLTVTD 266
Cdd:NF038112  1187 RPVANAGPDQTVLERTT-VTLNGSGSFDpDGDPLTYAWT-QVSGPavtlTGADTATPSFTAPEVT--ADTVLTFQLVVSD 1262

                           90
                   ....*....|....
gi 1327850579  267 SVGQRSSDNVSVTV 280
Cdd:NF038112  1263 GTKTSAPDTVTVLV 1276
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 193-284 4.93e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 39.64  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327850579  193 PVSKAGKDVVLHlPTDGVVLDGRESSDDHAIVLYEWTlQQGDP----SSVDMKVPqpgTLRLSRLKEGAYI-FQLTVTDS 267
Cdd:NF038112  1470 PVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT-QVAGPsvtlTGADSAKL---TFTAPEVSADTTLtFSLTVTDG 1544

                           90
                   ....*....|....*..
gi 1327850579  268 VGQRSSDNVSVTVLPRP 284
Cdd:NF038112  1545 SGSSGPVVVTVTVKNVN 1561
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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